P Jagiello

Summary

Country: Germany

Publications

  1. pmc Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    BMC Med Genet 5:7. 2004
  2. pmc Association study with Wegener granulomatosis of the human phospholipase Cgamma2 gene
    Peter Jagiello
    Department of Human Genetics, Ruhr University Bochum Germany
    J Negat Results Biomed 4:1. 2005
  3. ncbi request reprint New genomic region for Wegener's granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes
    Peter Jagiello
    Department of Human Genetics, Ruhr University, Universitätstrasse 150, 44801 Bochum, Germany
    Hum Genet 114:468-77. 2004
  4. ncbi request reprint Complex genetics of Wegener granulomatosis
    Peter Jagiello
    Department of Human Genetics, Ruhr University Bochum, Universitaetsstrasse 150, 44801 Bochum, Germany
    Autoimmun Rev 4:42-7. 2005
  5. ncbi request reprint Association study of Wegener granulomatosis and the functionally relevant A645G polymorphism in the bactericidal/permeability increasing protein (BPI) gene
    P Jagiello
    Department of Human Genetics, Ruhr University, Bochum, Germany
    Int J Immunogenet 32:3-6. 2005
  6. ncbi request reprint The Wegener's granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping
    M Heckmann
    Ruhr University, Human Genetics, MA5 39, 44780 Bochum, Germany
    Ann Rheum Dis 67:972-9. 2008
  7. ncbi request reprint Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups
    D A Akkad
    Department of Human Genetics, Ruhr University, 44801 Bochum, Germany
    Int J Immunogenet 33:59-61. 2006
  8. ncbi request reprint A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease
    S E N Wagenleiter
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    Int J Immunogenet 32:323-4. 2005
  9. pmc On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors
    Sonja E N Wagenleiter
    Department of Human Genetics, Ruhr University, Bochum, Germany
    J Negat Results Biomed 4:8. 2005
  10. doi request reprint ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    J Mol Med (Berl) 86:485-90. 2008

Collaborators

Detail Information

Publications17

  1. pmc Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    BMC Med Genet 5:7. 2004
    ..Recently an association of Glutathione S-Transferase Omega 1 (GSTO1) and possibly of GSTO2 with AO was demonstrated for, both, Alzheimer's (AD) and Parkinson's disease (PD)...
  2. pmc Association study with Wegener granulomatosis of the human phospholipase Cgamma2 gene
    Peter Jagiello
    Department of Human Genetics, Ruhr University Bochum Germany
    J Negat Results Biomed 4:1. 2005
    ..In addition, we screened indirectly for disease association via 4 microsatellites with pooled DNA in the PLCgamma-2 gene...
  3. ncbi request reprint New genomic region for Wegener's granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes
    Peter Jagiello
    Department of Human Genetics, Ruhr University, Universitätstrasse 150, 44801 Bochum, Germany
    Hum Genet 114:468-77. 2004
    ..Thus, our data demonstrate that EAS may be a valuable alternative approach for determining genetic predisposition factors in multifactorial diseases...
  4. ncbi request reprint Complex genetics of Wegener granulomatosis
    Peter Jagiello
    Department of Human Genetics, Ruhr University Bochum, Universitaetsstrasse 150, 44801 Bochum, Germany
    Autoimmun Rev 4:42-7. 2005
    ..WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches...
  5. ncbi request reprint Association study of Wegener granulomatosis and the functionally relevant A645G polymorphism in the bactericidal/permeability increasing protein (BPI) gene
    P Jagiello
    Department of Human Genetics, Ruhr University, Bochum, Germany
    Int J Immunogenet 32:3-6. 2005
    ..Thus BPI polymorphisms do not appear to contribute to genetic predisposition to WG. Moreover, our data do not suggest a genetic background for the generation of BPI-ANCAs in WG...
  6. ncbi request reprint The Wegener's granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping
    M Heckmann
    Ruhr University, Human Genetics, MA5 39, 44780 Bochum, Germany
    Ann Rheum Dis 67:972-9. 2008
    ..A genomic region on chromosome 6p21.3, including HLA-DPB1, has been linked to Wegener's granulomatosis (WG). The basis of this association is difficult to evaluate because of the complex haplotype block architecture of this region...
  7. ncbi request reprint Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups
    D A Akkad
    Department of Human Genetics, Ruhr University, 44801 Bochum, Germany
    Int J Immunogenet 33:59-61. 2006
    ..The recently reported association in a northern population of the MHC2TA variation with these autoimmune diseases is not evident in the German population...
  8. ncbi request reprint A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease
    S E N Wagenleiter
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    Int J Immunogenet 32:323-4. 2005
    ..This study revealed evidence that PTPN22 variation may have no influence in the genetic predisposition to CD, at least not in another well-characterized Caucasian cohort...
  9. pmc On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors
    Sonja E N Wagenleiter
    Department of Human Genetics, Ruhr University, Bochum, Germany
    J Negat Results Biomed 4:8. 2005
    ..Using this step-wise process we were unable to demonstrate evidence for genetic predisposition of the chosen apoptosis- and immunity-related genes with respect to susceptibility for CD...
  10. doi request reprint ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    J Mol Med (Berl) 86:485-90. 2008
    ....
  11. ncbi request reprint Screening for candidate gene regions in narcolepsy using a microsatellite based approach and pooled DNA
    Stefan Wieczorek
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    J Mol Med (Berl) 82:696-705. 2004
    ..These results, although exploratory and still to be confirmed in independent samples, support a complex pathogenetic model for narcolepsy, including disturbances of neurotransmission rather than involvement of autoimmunity...
  12. ncbi request reprint The PTPN22 620W allele is a risk factor for Wegener's granulomatosis
    Peter Jagiello
    Ruhr University, Bochum, Germany
    Arthritis Rheum 52:4039-43. 2005
    ..This study therefore examined whether the functionally relevant PTPN22 polymorphism is associated with Wegener's granulomatosis (WG)...
  13. ncbi request reprint Refining the results of a whole-genome screen based on 4666 microsatellite markers for defining predisposition factors for multiple sclerosis
    René Gödde
    Department of Human Genetics, St Josef Hospital, Ruhr University, Bochum, Germany
    Electrophoresis 25:2212-8. 2004
    ..Therefore, in the near future comprehensive whole-genome screens may rather be performed by typing single nucleotide polymorphisms on chip-based platforms...
  14. pmc On the Wegener granulomatosis associated region on chromosome 6p21.3
    Paweł Szyld
    Human Genetics, Ruhr University, Bochum, Germany
    BMC Med Genet 7:21. 2006
    ..The latter polymorphism has been evaluated here as it appears as a HLA independent susceptibility factor in another granulomatous disorder, sarcoidosis...
  15. ncbi request reprint A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity
    P Jagiello
    Human Genetics, Ruhr University, Bochum, Germany
    Hum Mutat 21:630-5. 2003
    ..Finally, we report on the presence of novel splice variants observed in lymphoblastoid cells and muscle tissue of normal subjects and patients...
  16. ncbi request reprint Polymorphisms of the tumor necrosis factor receptors: no association with narcolepsy in German patients
    Stefan Wieczorek
    Department of Human Genetics, Ruhr University of Bochum, 44780, Bochum, Germany
    J Mol Med (Berl) 81:87-90. 2003
    ..Our findings contrast to those previously published and thus provide evidence for genetic heterogeneity between different narcolepsy populations...
  17. ncbi request reprint Glutathione-S-transferase polymorphism, metallothionein expression, and mercury levels among students in Austria
    Claudia Gundacker
    Medical University of Vienna, Center for Public Health, Dept of Ecotoxicology, Waehringer Strasse 10, A 1090 Vienna, Austria
    Sci Total Environ 385:37-47. 2007
    ..Humans accumulate heavy metals primarily as a result of lifestyle and environmental contamination. However, not all humans experience the estimated individual exposure. This suggests the presence of genetic regulatory mechanisms...