Claudius Jacobshagen

Summary

Country: Germany

Publications

  1. ncbi Hotline update of clinical trials and registries presented at the American College of Cardiology Congress 2010: ACCORD, INVEST, NAVIGATOR, RACE II, SORT OUT III, CSP-474, DOSE, ASPIRE and more
    C Jacobshagen
    Georg August Universitat Gottingen, Herzzentrum, Abt Kardiologie und Pneumologie, Robert Koch Str 40, 37075, Gottingen, Germany
    Clin Res Cardiol 99:337-44. 2010
  2. ncbi Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction
    Claudius Jacobshagen
    Department of Cardiology, University of Gottingen, Gottingen, Germany
    Eur J Heart Fail 10:334-42. 2008
  3. ncbi Effects of large volume, ice-cold intravenous fluid infusion on respiratory function in cardiac arrest survivors
    Claudius Jacobshagen
    Department of Cardiology and Pneumology, Georg August University, Gottingen, Germany
    Resuscitation 80:1223-8. 2009
  4. ncbi Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium
    Claudius Jacobshagen
    Department of Cardiology und Pneumology, Heart Center, Georg August University, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Clin Res Cardiol 99:267-76. 2010
  5. ncbi Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP)
    Bernhard Unsöld
    Department of Cardiology and Pneumology, Georg August University of Gottingen, Germany
    Eur J Heart Fail 14:430-7. 2012
  6. ncbi Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na(+) current
    Samuel Sossalla
    Department of Cardiology and Pneumology Heart Center, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Basic Res Cardiol 106:263-72. 2011
  7. ncbi Proteome changes in CaMKIIδC-overexpressing cardiac myocytes
    Peter Schott
    Department of Cardiology and Pneumology, Heart Center, Georg August University, Gottingen, Germany
    Cardiovasc Pathol 19:e241-50. 2010
  8. ncbi Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo
    Cornelia Grebe
    Department of Cardiology and Pulmonology, Georg August University, Robert Koch Str 40, 37075 Gottingen, Germany
    Cardiovasc Res 90:521-8. 2011
  9. ncbi The risk-to-benefit ratio of transcatheter aortic valve implantation in specific patient cohorts: a single-centre experience
    Miriam Puls
    Department of Cardiology and Pneumology, Georg August University of Goettingen, Gottingen, Germany
    Clin Res Cardiol 101:553-63. 2012
  10. ncbi Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels
    Stefan Wagner
    Department of Cardiology and Pneumology, , , Germany
    J Clin Invest 116:3127-38. 2006

Collaborators

Detail Information

Publications15

  1. ncbi Hotline update of clinical trials and registries presented at the American College of Cardiology Congress 2010: ACCORD, INVEST, NAVIGATOR, RACE II, SORT OUT III, CSP-474, DOSE, ASPIRE and more
    C Jacobshagen
    Georg August Universitat Gottingen, Herzzentrum, Abt Kardiologie und Pneumologie, Robert Koch Str 40, 37075, Gottingen, Germany
    Clin Res Cardiol 99:337-44. 2010
    ....
  2. ncbi Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction
    Claudius Jacobshagen
    Department of Cardiology, University of Gottingen, Gottingen, Germany
    Eur J Heart Fail 10:334-42. 2008
    ..It reduces load-induced LV dilation, contractile dysfunction and mortality in vivo. This may have clinical implications for the prevention and treatment of maladaptive hypertrophy and its progression to HF in humans...
  3. ncbi Effects of large volume, ice-cold intravenous fluid infusion on respiratory function in cardiac arrest survivors
    Claudius Jacobshagen
    Department of Cardiology and Pneumology, Georg August University, Gottingen, Germany
    Resuscitation 80:1223-8. 2009
    ..A larger, randomized and prospective study is required to assess the efficacy and safety of ice-cold fluid infusion for the induction of therapeutic hypothermia...
  4. ncbi Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium
    Claudius Jacobshagen
    Department of Cardiology und Pneumology, Heart Center, Georg August University, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Clin Res Cardiol 99:267-76. 2010
    ..Mechanistically, we demonstrate that hypothermia improves contractility in failing human myocardium most likely by increasing Ca(2+)-sensitivity...
  5. ncbi Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP)
    Bernhard Unsöld
    Department of Cardiology and Pneumology, Georg August University of Gottingen, Germany
    Eur J Heart Fail 14:430-7. 2012
    ..Muscle LIM protein (MLP) null mice are often used as a model for human dilated cardiomyopathy. So far, little is known about the time course and pathomechanisms leading to the development of the adult phenotype...
  6. ncbi Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na(+) current
    Samuel Sossalla
    Department of Cardiology and Pneumology Heart Center, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Basic Res Cardiol 106:263-72. 2011
    ..Thus, late I(Na) inhibition appears to be a promising option for diastolic dysfunction and arrhythmias in HF where CaMKII is found to be increased...
  7. ncbi Proteome changes in CaMKIIδC-overexpressing cardiac myocytes
    Peter Schott
    Department of Cardiology and Pneumology, Heart Center, Georg August University, Gottingen, Germany
    Cardiovasc Pathol 19:e241-50. 2010
    ..These altered proteins may act individually as contributors to heart failure, which is observed after overexpression of CaMKIIδ(C) in genetically altered mice...
  8. ncbi Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo
    Cornelia Grebe
    Department of Cardiology and Pulmonology, Georg August University, Robert Koch Str 40, 37075 Gottingen, Germany
    Cardiovasc Res 90:521-8. 2011
    ..The hypothesis tested in this study was that DYRK1A prevents calcineurin/NFAT-mediated cardiac hypertrophy in vivo...
  9. ncbi The risk-to-benefit ratio of transcatheter aortic valve implantation in specific patient cohorts: a single-centre experience
    Miriam Puls
    Department of Cardiology and Pneumology, Georg August University of Goettingen, Gottingen, Germany
    Clin Res Cardiol 101:553-63. 2012
    ..However, information on the identification of patients gaining most benefit from this procedure is still limited. The aim of this study was to evaluate safety and efficacy of TAVI in different patient cohorts...
  10. ncbi Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels
    Stefan Wagner
    Department of Cardiology and Pneumology, , , Germany
    J Clin Invest 116:3127-38. 2006
    ..In mice, enhanced CaMKIIdelta(C) activity predisposed to VT. Thus, CaMKII-dependent regulation of Na(+) channel function may contribute to arrhythmogenesis in HF...
  11. ncbi Inhibition of PI3K improves contractility in alpha1-adrenergically stimulated myocardium
    Claudius Jacobshagen
    Department of Cardiology and Pneumology, Heart Center, Georg August University Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    Front Biosci 13:6841-9. 2008
    ..This may have clinical implications for the treatment of decreased cardiac function in acute heart failure...
  12. ncbi Accuracy of 64-multidetector computed tomography coronary angiography in patients with symptomatic atrial fibrillation prior to pulmonary vein isolation
    Christian Sohns
    Department of Cardiology and Pneumology, Heart Center, Georg August University, Robert Koch Strasse 40, Gottingen, Germany
    Eur Heart J Cardiovasc Imaging 13:263-70. 2012
    ....
  13. ncbi Ranolazine for the treatment of heart failure with preserved ejection fraction: background, aims, and design of the RALI-DHF study
    Claudius Jacobshagen
    Department of Cardiology and Pneumology, Georg August University, Robert Koch Strasse 40, Gottingen, Germany
    Clin Cardiol 34:426-32. 2011
    ..So far, there has been no specific treatment for impaired left ventricular (LV) relaxation. Data from in vitro and animal studies indicate that ranolazine improves diastolic function by inhibiting the late sodium current...
  14. ncbi Visualization of transcoronary ablation of septal hypertrophy in patients with hypertrophic obstructive cardiomyopathy: a comparison between cardiac MRI, invasive measurements and echocardiography
    Christian Sohns
    Department of Cardiology and Pneumology Heart Center, Georg August University Goettingen, Robert Koch Str 40, 37075, Goettingen, Germany
    Clin Res Cardiol 99:359-68. 2010
    ..The aim of this study was to visualize the feasibility, success and short-term results of TASH on the basis of cardiac MRI (CMR) in comparison with cardiac catheterization and echocardiography...
  15. ncbi Reduction in treatment times through formalized data feedback: results from a prospective multicenter study of ST-segment elevation myocardial infarction
    Karl Heinrich Scholz
    Department of Cardiology, St Bernward Hospital, Hildesheim, Germany
    JACC Cardiovasc Interv 5:848-57. 2012
    ..This study sought to evaluate the effect of systematic data analysis and standardized feedback on treatment times and outcome in a prospective multicenter trial...