Klaudia Brix

Summary

Affiliation: Jacobs University Bremen
Country: Germany

Publications

  1. ncbi request reprint Trafficking of lysosomal cathepsin B-green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment
    Martin Linke
    Institut für Zellbiologie and Bonner Forum Biomedizin, Universitat Bonn, Ulrich Haberland Str 61a, D 53121 Bonn, Germany
    J Cell Sci 115:4877-89. 2002
  2. ncbi request reprint Cysteine cathepsins: cellular roadmap to different functions
    Klaudia Brix
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biochimie 90:194-207. 2008
  3. pmc Molecules important for thyroid hormone synthesis and action - known facts and future perspectives
    Klaudia Brix
    Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Thyroid Res 4:S9. 2011
  4. doi request reprint Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP
    Maria Arampatzidou
    School of Engineering and Science, Research Center MOLIFE Molecular Life Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biol Chem 392:983-93. 2011
  5. ncbi request reprint Imaging of protease functions--current guide to spotting cysteine cathepsins in classical and novel scenes of action in mammalian epithelial cells and tissues
    Maria Arampatzidou
    School of Engineering and Science, Jacobs University Bremen, 28759 Bremen, Germany
    Ital J Anat Embryol 116:1-19. 2011
  6. doi request reprint Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases
    Anna Vreemann
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biol Chem 390:481-92. 2009
  7. doi request reprint Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon
    Maria Arampatzidou
    School of Engineering and Science, ResearchCenter MOLIFE Molecular Life Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biol Chem 393:1391-403. 2012
  8. pmc Nuclear cysteine cathepsin variants in thyroid carcinoma cells
    Sofia Tedelind
    Research Center of Molecular Life Science, School of Engineering and Science, Jacobs University Bremen, Bremen, Germany
    Biol Chem 391:923-35. 2010
  9. doi request reprint Intestine-specific expression of green fluorescent protein-tagged cathepsin B: proof-of-principle experiments
    Kristina Mayer
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biol Chem 389:1085-96. 2008
  10. pmc Coordination of genomic structure and transcription by the main bacterial nucleoid-associated protein HU
    Michael Berger
    School of Engineering and Science, Jacobs University, Campus Ring 1, D 28759 Bremen, Germany
    EMBO Rep 11:59-64. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Trafficking of lysosomal cathepsin B-green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment
    Martin Linke
    Institut für Zellbiologie and Bonner Forum Biomedizin, Universitat Bonn, Ulrich Haberland Str 61a, D 53121 Bonn, Germany
    J Cell Sci 115:4877-89. 2002
    ....
  2. ncbi request reprint Cysteine cathepsins: cellular roadmap to different functions
    Klaudia Brix
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biochimie 90:194-207. 2008
    ..Such understanding will provide a foundation for future research investigating the involvement of these peptidases with their substrates, inhibitors, and the intertwined proteolytic networks at the hubs of complex biological systems...
  3. pmc Molecules important for thyroid hormone synthesis and action - known facts and future perspectives
    Klaudia Brix
    Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Thyroid Res 4:S9. 2011
    ..The objective of this review is to summarise the recent findings in thyroid hormone synthesis and action and to discuss their implications for diagnosis of thyroid disease and for treatment of patients...
  4. doi request reprint Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP
    Maria Arampatzidou
    School of Engineering and Science, Research Center MOLIFE Molecular Life Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biol Chem 392:983-93. 2011
    ..However, transgenic expression of chimeric cathepsin B could not be visualized because it was not translated in situ although the transgene was maintained over several generations...
  5. ncbi request reprint Imaging of protease functions--current guide to spotting cysteine cathepsins in classical and novel scenes of action in mammalian epithelial cells and tissues
    Maria Arampatzidou
    School of Engineering and Science, Jacobs University Bremen, 28759 Bremen, Germany
    Ital J Anat Embryol 116:1-19. 2011
    ..Besides localisation, it is now feasible to study in situ enzymatic activity at the various levels of subcellular compartments, cells, tissues, and even whole organisms including mouse...
  6. doi request reprint Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases
    Anna Vreemann
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biol Chem 390:481-92. 2009
    ....
  7. doi request reprint Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon
    Maria Arampatzidou
    School of Engineering and Science, ResearchCenter MOLIFE Molecular Life Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biol Chem 393:1391-403. 2012
    ..These results are important with regard to oral administration of cathepsin K inhibitors that are currently under investigation in clinical trials...
  8. pmc Nuclear cysteine cathepsin variants in thyroid carcinoma cells
    Sofia Tedelind
    Research Center of Molecular Life Science, School of Engineering and Science, Jacobs University Bremen, Bremen, Germany
    Biol Chem 391:923-35. 2010
    ..As deduced from co-localization studies and in vitro degradation assays, we suggest that nuclear variants of cathepsins are involved in the development of thyroid malignancies through modification of DNA-associated proteins...
  9. doi request reprint Intestine-specific expression of green fluorescent protein-tagged cathepsin B: proof-of-principle experiments
    Kristina Mayer
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biol Chem 389:1085-96. 2008
    ..Our proof-of-principle studies confirm the suitability of this approach in visualizing protease transport in Cdx1-positive tissues of the gastrointestinal tract...
  10. pmc Coordination of genomic structure and transcription by the main bacterial nucleoid-associated protein HU
    Michael Berger
    School of Engineering and Science, Jacobs University, Campus Ring 1, D 28759 Bremen, Germany
    EMBO Rep 11:59-64. 2010
    ..Our data thus implicate HU in coordinating the global genomic structure and function by regulating the spatial distribution of RNA polymerase in the nucleoid...
  11. pmc Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions
    Silvia Jordans
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, Research II, Bremen, Germany
    BMC Biochem 10:23. 2009
    ....
  12. doi request reprint Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice
    Stephanie Dauth
    School of Engineering and Science, Research Center MOLIFE, Molecular Life Science, Jacobs University Bremen, Campus Ring 1, D 28759 Bremen, Germany
    Biol Chem 393:959-70. 2012
    ..Thus, lack of cathepsin K in astroglia-rich cultures appears not to affect metabolic supply functions of astrocytes but to facilitate the maturation of oligodendrocytes...
  13. pmc Cathepsin B trafficking in thyroid carcinoma cells
    Sofia Tedelind
    School of Engineering and Science, Research Center for Molecular Life Science, Jacobs University Bremen, 28759 Bremen, Germany
    Thyroid Res 4:S2. 2011
    ..However, cathepsin B has also been localized to the extrafollicular space in thyroid cancer tissue, and is therefore suggested to promote invasiveness and metastasis in thyroid carcinomas through e.g. extracellular matrix degradation...
  14. doi request reprint Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study
    Vanya D Uzunova
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, D 28759, Bremen, Germany
    Org Biomol Chem 8:2037-42. 2010
    ..The combined results indicate a sufficiently low toxicity to encourage further exploration of CB[n] as additives for medicinal and pharmaceutical use...
  15. doi request reprint Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation
    Kristina Mayer
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biol Chem 390:471-80. 2009
    ..We conclude that our apparatus for mechanical manipulation can be used to approach surgical trauma, thereby focusing on epithelial cells of the intestine mucosa...
  16. pmc Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits
    Stephanie Dauth
    School of Engineering and Science, Research Center MOLIFE Molecular Life Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
    BMC Neurosci 12:74. 2011
    ..Cathepsin K has been recently detected in brain parenchyma and it has been linked to neurobehavioral disorders such as schizophrenia. Thus, the study of the functions that cathepsin K fulfils in the brain becomes highly relevant...
  17. ncbi request reprint HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration
    Heiko Büth
    School of Engineering and Science, International University Bremen, Bremen, Germany
    Eur J Cell Biol 83:781-95. 2004
    ..Thus, our results strongly suggest that cell surface-associated cathepsin B is a protease that contributes to the remodelling of the extracellular matrix and thereby promotes keratinocyte migration during wound healing...
  18. doi request reprint LRP1 modulates APP trafficking along early compartments of the secretory pathway
    Elaine Waldron
    Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration, Johannes Gutenberg University Mainz, 55099 Mainz, Germany
    Neurobiol Dis 31:188-97. 2008
    ..In addition, we provide evidence that APP metabolism occurs in close conjunction with LRP1 trafficking, highlighting a new role of lipoprotein receptors in neurodegenerative diseases...
  19. ncbi request reprint DNA accelerates the inhibition of human cathepsin V by serpins
    Poh Chee Ong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Biol Chem 282:36980-6. 2007
    ..This represents the first example of modulation of serpin inhibition of cysteine proteases by a co-factor and reveals a mechanism for differential regulation of cathepsin proteolytic activity in a DNA-rich environment...
  20. pmc Thyroid functions of mouse cathepsins B, K, and L
    Bianca Friedrichs
    Institut für Zellbiologie and Bonner Forum Biomedizin, Universitat Bonn, Bonn, Germany
    J Clin Invest 111:1733-45. 2003
    ..Cathepsin K(-/-)/L(-/-) mice had significantly reduced levels of free thyroxine, indicating that utilization of luminal thyroglobulin for thyroxine liberation is mediated by a combinatory action of cathepsins K and L...