Research Topics
Genomes and GenesSpecies | S JacobSummaryCountry: Germany Publications
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Publications
Antihypertensive therapy and insulin sensitivity: do we have to redefine the role of beta-blocking agents?S Jacob
Department of Endocrinology, IV Medical Clinic, Eberhard Karls University, Tubingen, Germany
Am J Hypertens 11:1258-65. 1998..Although conventional beta-blocker treatment was able to take care of the former, the latter got worse; the newer vasodilating beta-blocker generation seems to be capable of successfully treating both of them...- Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trialS Jacob
Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl and City Hospital, Baden Baden, Germany
Free Radic Biol Med 27:309-14. 1999..The results suggest that oral administration of alpha-lipoic acid can improve insulin sensitivity in patients with type-2 diabetes. The encouraging findings of this pilot trial need to be substantiated by further investigations... - Beta-blocking agents in patients with insulin resistance: effects of vasodilating beta-blockersS Jacob
Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
Blood Press 8:261-8. 1999..Therefore, the beneficial characteristics of these newer beta-adrenoreceptor blockers suggest that the vasodilating beta-blocking agents could be advantageous for hypertensive patients with insulin resistance or type 2 diabetes... - A novel use of the hyperinsulinemic-euglycemic clamp technique to estimate insulin sensitivity of systemic lipolysisM Stumvoll
Department of Endocrinology and Metabolism, , , Germany
Horm Metab Res 33:89-95. 2001..In healthy subjects, the parameter best suited to estimate the insulin EC50 (by linear correlation) was the percentage decrease of glycerol Ra at 60 min... - Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humansM Stumvoll
Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
J Clin Endocrinol Metab 85:3740-5. 2000..Inadequate suppression of im lipolysis resulting in excessive local availability of free fatty acids may represent a novel mechanism contributing to the pathogenesis of impaired glucose disposal, i.e. insulin resistance, in muscle... - Serum adiponectin levels predict the effect of short-term dietary interventions on insulin sensitivity in humansC Thamer
Department of Endocrinology and Metabolism, Eberhard-Karls-University, , Germany
Diabetologia 47:1303-5. 2004..Thus it is possible that the restriction of dietary fat and a diet high in carbohydrates might be particularly effective in subjects with low adiponectin such as obese or Type 2 diabetic individuals... - The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populationsM Stumvoll
Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
Exp Clin Endocrinol Diabetes 112:253-7. 2004..We conclude, that the Gly482Ser variant in PGC-1 is not associated with diabetes-related traits or skeletal muscle fiber type composition in a non-diabetic German and Dutch population... - Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humansO P Bachmann
Department of Endocrinology and Metabolism, Eberhard-Karls University, , Germany
Diabetes 50:2579-84. 2001..Similar effects could be induced by a high-fat diet, thereby underlining the physiological relevance of these observations... - The beta2-adrenergic modulator celiprolol reduces insulin resistance in obese Zucker ratsS Jacob
Department of Endocrinology, Eberhard Karls University, Tubingen, Germany
Life Sci 64:2071-9. 1999.... - Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposalM Stumvoll
Department of Endocrinology and Metabolism, Eberhard Karls Universitat, D 72076 Tubingen, Germany
J Lipid Res 42:1782-8. 2001..Neither of the polymorphisms we identified in the coding region, however, contributed measurably to the biological variation of insulin sensitivity in our lean, healthy population... - Impaired non-esterified fatty acid suppression is associated with endothelial dysfunction in insulin resistant subjectsB M Balletshofer
Department of Endocrinology and Metabolism, , Germany
Horm Metab Res 33:428-31. 2001..As insulin resistance of lipolysis is a feature of the insulin resistance syndrome, these results suggest that elevated NEFA concentrations could play a role linking endothelial dysfunction and insulin resistance in vivo... - Utilisation of intramyocellular lipids (IMCLs) during exercise as assessed by proton magnetic resonance spectroscopy (1H-MRS)K Brechtel
Department of Endocrinology and Metabolism, , Germany
Horm Metab Res 33:63-6. 2001..However, exercise of similar duration but higher workload (> 80% VO2max) does not reduce IMCL. These data suggest that both exercise duration and workload are important factors in determining the reduction of IMCL... - An interleaved sampling strategy for MR spectroscopy in vivo: applications on human calf musculatureJ Machannab
Radiologische Klinik, Abteilung für Radiologische Diagnostik, Eberhard Karls Universitat Tubingen, Tubingen, Germany
Magn Reson Imaging 18:189-97. 2000..59 +/- 0.19 x 10(-3) mm(2)/s versus 1.20 +/- 0.08 x 10(-3) mm(2)/s in m. tib. ant.). Magnetization transfer experiments with various RF preparation pulse amplitudes led to very similar results for m. tib. ant. and m. soleus... - Relationship between serum adiponectin concentration and intramyocellular lipid stores in humansC Thamer
Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
Horm Metab Res 34:646-9. 2002..These results are consistent with animal data, where adiponectin could be shown to enhance lipid oxidation and reduce muscle triglycerides... - Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivityM Stumvoll
Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
Diabetes 50:876-81. 2001.... 
Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe StudyLuc F Van Gaal
Department of Diabetology, Metabolism, and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10, B 2650 Edegem Antwerp, Belgium
Eur Heart J 29:1761-71. 2008..We report the 2 year efficacy and tolerability data of rimonabant...- The PPARgamma2 polymorphism pro12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patientsS Jacob
Dept of Endocrinology, University of Tubingen, Germany
Horm Metab Res 32:413-6. 2000..9) compared to the control group (6.1 +/- 0.7, p = 0.097). In conclusion, these data suggest that the PPARgamma2-Pro12Ala mutation is associated with better insulin sensitivity of glucose disposal and possibly, also of antilipolysis... - Fast elevation of the intramyocellular lipid content in the presence of circulating free fatty acids and hyperinsulinemia: a dynamic 1H-MRS studyK Brechtel
Department of Diagnostic Radiology, University of Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany
Magn Reson Med 45:179-83. 2001..The present study shows for the first time that only the combination of high concentrations of FFAs and insulin lead to marked storage of lipids in skeletal muscle cells in humans. Magn Reson Med 45:179-183, 2001... - [Reduced insulin effect in subclinical fatty liver]C Thamer
, Stoffwechselkrankheiten und Endokrinologie, , Tuebingen
Dtsch Med Wochenschr 129:872-5. 2004..The correlation of liver fat content with insulin sensitivity was found in the absence of clinical steatosis and was independent of body fat content... - A novel nonsense mutation in GCK exon 9 co-segregates with diabetes phenotypeB Knebel
Institute for Clinical Biochemistry and Pathobiochemistry, , Auf'm Hennekamp 65, , Germany
Exp Clin Endocrinol Diabetes 112:298-301. 2004..The latter mutation has an autosomal dominant inheritance pattern. Accordingly, this novel mutation segregates with diabetes phenotype in this family... - Angiotensin converting enzyme inhibitors and modulation of skeletal muscle insulin resistanceE J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721-0093, USA
Diabetes Obes Metab 5:214-22. 2003 - [The importance of rehabilitation with cardiovascular diabetic patients after surgical interventions]S Jacob
Forum für vaskuläre Medizin e V, Brombeerweg 6, 78048 Villingen Schwenningen
Clin Res Cardiol 95:i103-9. 2006..Recent studies indicate that a multimodal and aggressive approach in CV diabetic patients can markedly improve their prognosis... - Increased low grade inflammatory serum markers in patients with Polycystic ovary syndrome (PCOS) and their relationship to PPARgamma gene variantsB Knebel
Institute of Clinical Biochemistry and Pathobiochemistry, Heinrich Heine University Duesseldorf, Leibniz, Germany
Exp Clin Endocrinol Diabetes 116:481-6. 2008..So, alterations in inflammatory serum markers appear to be a feature of PCOS per se, and are independent of PPAR gamma variants...