S Jacob

Summary

Country: Germany

Publications

  1. ncbi Antihypertensive therapy and insulin sensitivity: do we have to redefine the role of beta-blocking agents?
    S Jacob
    Department of Endocrinology, IV Medical Clinic, Eberhard Karls University, Tubingen, Germany
    Am J Hypertens 11:1258-65. 1998
  2. ncbi Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial
    S Jacob
    Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl and City Hospital, Baden Baden, Germany
    Free Radic Biol Med 27:309-14. 1999
  3. ncbi Beta-blocking agents in patients with insulin resistance: effects of vasodilating beta-blockers
    S Jacob
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Blood Press 8:261-8. 1999
  4. ncbi A novel use of the hyperinsulinemic-euglycemic clamp technique to estimate insulin sensitivity of systemic lipolysis
    M Stumvoll
    Department of Endocrinology and Metabolism, , , Germany
    Horm Metab Res 33:89-95. 2001
  5. ncbi Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
    J Clin Endocrinol Metab 85:3740-5. 2000
  6. ncbi Serum adiponectin levels predict the effect of short-term dietary interventions on insulin sensitivity in humans
    C Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Diabetologia 47:1303-5. 2004
  7. ncbi The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations
    M Stumvoll
    Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 112:253-7. 2004
  8. ncbi Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans
    O P Bachmann
    Department of Endocrinology and Metabolism, Eberhard-Karls University, , Germany
    Diabetes 50:2579-84. 2001
  9. ncbi The beta2-adrenergic modulator celiprolol reduces insulin resistance in obese Zucker rats
    S Jacob
    Department of Endocrinology, Eberhard Karls University, Tubingen, Germany
    Life Sci 64:2071-9. 1999
  10. ncbi Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, D 72076 Tubingen, Germany
    J Lipid Res 42:1782-8. 2001

Collaborators

Detail Information

Publications23

  1. ncbi Antihypertensive therapy and insulin sensitivity: do we have to redefine the role of beta-blocking agents?
    S Jacob
    Department of Endocrinology, IV Medical Clinic, Eberhard Karls University, Tubingen, Germany
    Am J Hypertens 11:1258-65. 1998
    ..Although conventional beta-blocker treatment was able to take care of the former, the latter got worse; the newer vasodilating beta-blocker generation seems to be capable of successfully treating both of them...
  2. ncbi Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial
    S Jacob
    Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl and City Hospital, Baden Baden, Germany
    Free Radic Biol Med 27:309-14. 1999
    ..The results suggest that oral administration of alpha-lipoic acid can improve insulin sensitivity in patients with type-2 diabetes. The encouraging findings of this pilot trial need to be substantiated by further investigations...
  3. ncbi Beta-blocking agents in patients with insulin resistance: effects of vasodilating beta-blockers
    S Jacob
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Blood Press 8:261-8. 1999
    ..Therefore, the beneficial characteristics of these newer beta-adrenoreceptor blockers suggest that the vasodilating beta-blocking agents could be advantageous for hypertensive patients with insulin resistance or type 2 diabetes...
  4. ncbi A novel use of the hyperinsulinemic-euglycemic clamp technique to estimate insulin sensitivity of systemic lipolysis
    M Stumvoll
    Department of Endocrinology and Metabolism, , , Germany
    Horm Metab Res 33:89-95. 2001
    ..In healthy subjects, the parameter best suited to estimate the insulin EC50 (by linear correlation) was the percentage decrease of glycerol Ra at 60 min...
  5. ncbi Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
    J Clin Endocrinol Metab 85:3740-5. 2000
    ..Inadequate suppression of im lipolysis resulting in excessive local availability of free fatty acids may represent a novel mechanism contributing to the pathogenesis of impaired glucose disposal, i.e. insulin resistance, in muscle...
  6. ncbi Serum adiponectin levels predict the effect of short-term dietary interventions on insulin sensitivity in humans
    C Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Diabetologia 47:1303-5. 2004
    ..In the present study we tested whether plasma adiponectin concentrations influence changes in insulin sensitivity induced by a short-term dietary intervention in humans...
  7. ncbi The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations
    M Stumvoll
    Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 112:253-7. 2004
    ..We conclude, that the Gly482Ser variant in PGC-1 is not associated with diabetes-related traits or skeletal muscle fiber type composition in a non-diabetic German and Dutch population...
  8. ncbi Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans
    O P Bachmann
    Department of Endocrinology and Metabolism, Eberhard-Karls University, , Germany
    Diabetes 50:2579-84. 2001
    ..Similar effects could be induced by a high-fat diet, thereby underlining the physiological relevance of these observations...
  9. ncbi The beta2-adrenergic modulator celiprolol reduces insulin resistance in obese Zucker rats
    S Jacob
    Department of Endocrinology, Eberhard Karls University, Tubingen, Germany
    Life Sci 64:2071-9. 1999
    ....
  10. ncbi Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, D 72076 Tubingen, Germany
    J Lipid Res 42:1782-8. 2001
    ..Neither of the polymorphisms we identified in the coding region, however, contributed measurably to the biological variation of insulin sensitivity in our lean, healthy population...
  11. ncbi Impaired non-esterified fatty acid suppression is associated with endothelial dysfunction in insulin resistant subjects
    B M Balletshofer
    Department of Endocrinology and Metabolism, , Germany
    Horm Metab Res 33:428-31. 2001
    ..As insulin resistance of lipolysis is a feature of the insulin resistance syndrome, these results suggest that elevated NEFA concentrations could play a role linking endothelial dysfunction and insulin resistance in vivo...
  12. ncbi Utilisation of intramyocellular lipids (IMCLs) during exercise as assessed by proton magnetic resonance spectroscopy (1H-MRS)
    K Brechtel
    Department of Endocrinology and Metabolism, , Germany
    Horm Metab Res 33:63-6. 2001
    ..However, exercise of similar duration but higher workload (> 80% VO2max) does not reduce IMCL. These data suggest that both exercise duration and workload are important factors in determining the reduction of IMCL...
  13. ncbi Relationship between serum adiponectin concentration and intramyocellular lipid stores in humans
    C Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Horm Metab Res 34:646-9. 2002
    ..These results are consistent with animal data, where adiponectin could be shown to enhance lipid oxidation and reduce muscle triglycerides...
  14. ncbi An interleaved sampling strategy for MR spectroscopy in vivo: applications on human calf musculature
    J Machannab
    Radiologische Klinik, Abteilung für Radiologische Diagnostik, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Magn Reson Imaging 18:189-97. 2000
    ..59 +/- 0.19 x 10(-3) mm(2)/s versus 1.20 +/- 0.08 x 10(-3) mm(2)/s in m. tib. ant.). Magnetization transfer experiments with various RF preparation pulse amplitudes led to very similar results for m. tib. ant. and m. soleus...
  15. ncbi Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 50:876-81. 2001
    ....
  16. doi Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study
    Luc F Van Gaal
    Department of Diabetology, Metabolism, and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10, B 2650 Edegem Antwerp, Belgium
    Eur Heart J 29:1761-71. 2008
    ..We report the 2 year efficacy and tolerability data of rimonabant...
  17. ncbi The PPARgamma2 polymorphism pro12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients
    S Jacob
    Dept of Endocrinology, University of Tubingen, Germany
    Horm Metab Res 32:413-6. 2000
    ..9) compared to the control group (6.1 +/- 0.7, p = 0.097). In conclusion, these data suggest that the PPARgamma2-Pro12Ala mutation is associated with better insulin sensitivity of glucose disposal and possibly, also of antilipolysis...
  18. ncbi Fast elevation of the intramyocellular lipid content in the presence of circulating free fatty acids and hyperinsulinemia: a dynamic 1H-MRS study
    K Brechtel
    Department of Diagnostic Radiology, University of Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany
    Magn Reson Med 45:179-83. 2001
    ..The present study shows for the first time that only the combination of high concentrations of FFAs and insulin lead to marked storage of lipids in skeletal muscle cells in humans. Magn Reson Med 45:179-183, 2001...
  19. ncbi [Reduced insulin effect in subclinical fatty liver]
    C Thamer
    Abteilung für klinische Chemie, Stoffwechselkrankheiten und Endokrinologie, Medizinische Universitätsklinik Tübingen, Tuebingen
    Dtsch Med Wochenschr 129:872-5. 2004
    ....
  20. ncbi A novel nonsense mutation in GCK exon 9 co-segregates with diabetes phenotype
    B Knebel
    Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 112:298-301. 2004
    ..The latter mutation has an autosomal dominant inheritance pattern. Accordingly, this novel mutation segregates with diabetes phenotype in this family...
  21. ncbi Angiotensin converting enzyme inhibitors and modulation of skeletal muscle insulin resistance
    E J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Diabetes Obes Metab 5:214-22. 2003
  22. ncbi [The importance of rehabilitation with cardiovascular diabetic patients after surgical interventions]
    S Jacob
    Forum für vaskuläre Medizin e V, Brombeerweg 6, 78048 Villingen Schwenningen
    Clin Res Cardiol 95:i103-9. 2006
    ..Recent studies indicate that a multimodal and aggressive approach in CV diabetic patients can markedly improve their prognosis...
  23. ncbi Increased low grade inflammatory serum markers in patients with Polycystic ovary syndrome (PCOS) and their relationship to PPARgamma gene variants
    B Knebel
    Institute of Clinical Biochemistry and Pathobiochemistry, Heinrich Heine University Duesseldorf, Leibniz, Germany
    Exp Clin Endocrinol Diabetes 116:481-6. 2008
    ..So, alterations in inflammatory serum markers appear to be a feature of PCOS per se, and are independent of PPAR gamma variants...