Christian Jacob

Summary

Country: Germany

Publications

  1. ncbi request reprint Internalizing and externalizing behavior in adult ADHD
    Christian Jacob
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wurzburg, Germany
    Atten Defic Hyperact Disord 6:101-10. 2014
  2. ncbi request reprint Acetylcholine-metabolizing butyrylcholinesterase (BCHE) copy number and single nucleotide polymorphisms and their role in attention-deficit/hyperactivity syndrome
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080 Wuerzburg, Germany Electronic address
    J Psychiatr Res 47:1902-8. 2013
  3. pmc A molecular signature in blood identifies early Parkinson's disease
    Leonid Molochnikov
    Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mol Neurodegener 7:26. 2012
  4. doi request reprint Peter Riederer "70th birthday" neurobiological foundations of modern addiction treatment
    Christian Jacob
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    J Neural Transm 120:55-64. 2013
  5. doi request reprint PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD
    Christian Jacob
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Atten Defic Hyperact Disord 4:145-52. 2012
  6. doi request reprint A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:317-26. 2010
  7. ncbi request reprint The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 20:547-52. 2006
  8. doi request reprint Association analysis of Rgs7 variants with panic disorder
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    J Neural Transm 116:1523-8. 2009
  9. doi request reprint Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety
    Agnieszka Gajewska
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, D 97080 Wuerzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 40:115-21. 2013
  10. ncbi request reprint Evidence for unaltered brain electrical topography during prefrontal response control in cycloid psychoses
    Ann Christine Ehlis
    Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry and Psychotherapy, University Hospital of Wuerzburg Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Int J Psychophysiol 55:165-78. 2005

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Internalizing and externalizing behavior in adult ADHD
    Christian Jacob
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wurzburg, Germany
    Atten Defic Hyperact Disord 6:101-10. 2014
    ..Internalizing and externalizing behavior notably affected psychosocial status to a similar extent. The frequency of both internalizing and externalizing behavior in AADHD might reflect an underlying emotional regulation disorder. ..
  2. ncbi request reprint Acetylcholine-metabolizing butyrylcholinesterase (BCHE) copy number and single nucleotide polymorphisms and their role in attention-deficit/hyperactivity syndrome
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080 Wuerzburg, Germany Electronic address
    J Psychiatr Res 47:1902-8. 2013
    ..As we were not able to replicate the SNP association, our findings should be considered preliminary and call for larger studies in extended phenotypes...
  3. pmc A molecular signature in blood identifies early Parkinson's disease
    Leonid Molochnikov
    Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mol Neurodegener 7:26. 2012
    ..We aim to assess whether a gene signature could be detected in blood from early/mild PD patients that could support the diagnosis of early PD, focusing on genes found particularly altered in the substantia nigra of sporadic PD...
  4. doi request reprint Peter Riederer "70th birthday" neurobiological foundations of modern addiction treatment
    Christian Jacob
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    J Neural Transm 120:55-64. 2013
    ..However, the question remains unsolved whether an individualized approach is feasible and how subgroups should be defined...
  5. doi request reprint PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD
    Christian Jacob
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Atten Defic Hyperact Disord 4:145-52. 2012
    ..Nevertheless, as all those conditions are comorbid, PPP2R2C might reflect a common underlying neurobiological risk factor...
  6. doi request reprint A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:317-26. 2010
    ..Further replication studies, however, are necessary to validate the apparent complexity of G x E interactions in disorders of human personality...
  7. ncbi request reprint The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 20:547-52. 2006
    ..The results of this first study of TPH2 in panic disorder argue against an importance of allelic variation of TPH2 in the pathogenesis of panic disorder with or without agoraphobia...
  8. doi request reprint Association analysis of Rgs7 variants with panic disorder
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    J Neural Transm 116:1523-8. 2009
    ..Our results argue against a major role of Rgs7 gene variants in the pathogenesis of PD, but are consistent with a minor gender-specific effect on PD, particularly PDAgP...
  9. doi request reprint Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety
    Agnieszka Gajewska
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, D 97080 Wuerzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 40:115-21. 2013
    ....
  10. ncbi request reprint Evidence for unaltered brain electrical topography during prefrontal response control in cycloid psychoses
    Ann Christine Ehlis
    Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry and Psychotherapy, University Hospital of Wuerzburg Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Int J Psychophysiol 55:165-78. 2005
    ..This study aimed at examining if cycloid psychoses-unlike schizophrenias-involve a normal brain-electrical topography during a task demanding prefrontal response control...
  11. ncbi request reprint Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department for Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 10:309-20. 2007
    ..These findings implicate alterations of 5-HT synthesis in emotion regulation and confirm TPH2 as a susceptibility and/or modifier gene of affective spectrum disorders...
  12. doi request reprint Reduced NoGo-anteriorisation during continuous performance test in deletion syndrome 22q11.2
    Marcel Romanos
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinic of Wuerzburg, Fuechsleinstrasse 15, 97074 Wuerzburg, Germany
    J Psychiatr Res 44:768-74. 2010
    ..Despite recent reports of structural alterations of the ACC in DS22q11.2 our findings suggest that response-inhibition mediated by the ACC is not impaired in DS22q11.2...
  13. doi request reprint Adenosine A(2A) receptor gene: evidence for association of risk variants with panic disorder and anxious personality
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Albert Schweitzer Strasse 11, 48149 Muenster, Germany
    J Psychiatr Res 44:930-7. 2010
    ..Our data provide further support for an important role of ADORA2A variants in the pathogenesis of anxiety disorders and anxious personality reflecting their potential as basic susceptibility factors...
  14. doi request reprint Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation
    Katharina Domschke
    Department of Psychiatry and Psychotherapy, University of Muenster, Albert Schweitzer Campus 1, Gebaeude A9, 48149 Muenster, Germany
    Psychopharmacology (Berl) 222:533-41. 2012
    ..2006) and attenuating the stimulatory effects of NPS in rodents (Boeck et al., 2010)...
  15. doi request reprint Neural correlates of performance monitoring in adult patients with attention deficit hyperactivity disorder (ADHD)
    Martin J Herrmann
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 11:457-64. 2010
    ....
  16. doi request reprint Neurobiological and psychophysiological correlates of emotional dysregulation in ADHD patients
    Martin J Herrmann
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Germany
    Atten Defic Hyperact Disord 2:233-9. 2010
    ..The relevance of the observed dysregulation in emotional processing and psychophysiological reactions with regard to theoretical constructs of ADHD-specific emotional dysregulation versus comorbidity will be discussed...
  17. doi request reprint Diminished prefrontal oxygenation with normal and above-average verbal fluency performance in adult ADHD
    Martin Schecklmann
    University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    J Psychiatr Res 43:98-106. 2008
    ..High verbal competence in our samples could contribute to these findings. One speculative and post hoc explanation aims at the clinically well-known phenomenon of hyperfocusing in patients with ADHD...
  18. ncbi request reprint Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women
    Katharina Domschke
    Department of Psychiatry, University of Munster, Germany
    Int J Neuropsychopharmacol 7:183-8. 2004
    ..Our data support a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women...
  19. pmc Emotional deficits in adult ADHD patients: an ERP study
    Martin J Herrmann
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuechsleinstr 15, 97080 Wurzburg, Germany
    Soc Cogn Affect Neurosci 4:340-5. 2009
    ..Our data indicate that ADHD patients show less reactivity to positive visual stimuli which might be relevant in the context of described dysfunctions of the motivational-reward system in ADHD...
  20. pmc Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma
    Benedikt Klauke
    Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
    PLoS ONE 7:e39709. 2012
    ....
  21. pmc ADORA2A Gene variation, caffeine, and emotional processing: a multi-level interaction on startle reflex
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 37:759-69. 2012
    ..The present findings may eventually aid in improving primary and secondary prevention by sharpening the risk profiles of anxiety-prone individuals...
  22. doi request reprint Evaluation of the efficacy and effectiveness of a structured disorder tailored psychotherapy in ADHD in adults: study protocol of a randomized controlled multicentre trial
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Atten Defic Hyperact Disord 2:203-12. 2010
    ..The trial is funded by the German Federal Ministry of Research and Education (01GV0606) and is part of the German network for the treatment of ADHD in children and adults (ADHD-NET)...
  23. ncbi request reprint Reduced prefrontal oxygenation in Alzheimer disease during verbal fluency tasks
    Martin J Herrmann
    University Hospital of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    Am J Geriatr Psychiatry 16:125-35. 2008
    ..As previous research suggested changes in functional brain activation in prefrontal brain areas of patients with dementia, the aim of this study was to replicate these findings by means of multichannel NIRS...
  24. doi request reprint A randomized controlled multicenter trial on the multimodal treatment of adult attention-deficit hyperactivity disorder: enrollment and characteristics of the study sample
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Hauptstrasse 5, 79104, Freiburg, Germany
    Atten Defic Hyperact Disord 6:35-47. 2014
    ....
  25. pmc A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity
    Annette Conzelmann
    Department of Psychology Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Marcusstr 9 11, 97070 Wurzburg, Germany
    Psychopharmacology (Berl) 224:573-9. 2012
    ..However, the association of eCB system with emotional-motivational reactivity is complex and bidirectional due to upcoming compensatory processes...
  26. ncbi request reprint Chromosome 4q31-34 panic disorder risk locus: association of neuropeptide Y Y5 receptor variants
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:510-6. 2008
    ..However, in order to allow for conclusive evaluation of the present finding and to exclude a false positive result, further studies in larger, independent, preferably family based samples are warranted...
  27. doi request reprint Altered frontal and temporal brain function during olfactory stimulation in adult attention-deficit/hyperactivity disorder
    Martin Schecklmann
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wurzburg, University of Wurzburg, Wurzburg, Germany
    Neuropsychobiology 63:66-76. 2011
    ..Some investigations suggested alterations in olfactory processing (identification and sensitivity) in childhood and adult ADHD...
  28. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder
    Rainald Mossner
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 9:437-42. 2006
    ..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD...
  29. doi request reprint Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
    Klaus Peter Lesch
    ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1573-85. 2008
    ..g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability...
  30. doi request reprint A randomized controlled multicentre trial on the treatment for ADHD in mothers and children: enrolment and basic characteristics of the study sample
    Thomas Jans
    Department of Child and Adolescent Psychiatry, University Hospital Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Atten Defic Hyperact Disord 5:29-40. 2013
    ..Nevertheless, for our trial we were able to collect a sample comparable to routine psychiatric outpatient settings (registration: CCT-ISRCTN73911400, funding: BMBF-01GV0605)...
  31. doi request reprint Neural hyporesponsiveness and hyperresponsiveness during immediate and delayed reward processing in adult attention-deficit/hyperactivity disorder
    Michael M Plichta
    Department of Psychiatry, Psychosomatics and Psychotherapy, Laboratory for Psychophysiology and Functional Imaging, Institute of Psychology, Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Biol Psychiatry 65:7-14. 2009
    ..Dysfunctional reward processing, accompanied by a limited ability to tolerate reward delays, has been proposed as an important feature in attention-deficit/hyperactivity disorder (ADHD)...
  32. ncbi request reprint Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia
    Claudia Rothe
    Department of Psychiatry, University of Munster, Germany
    Int J Neuropsychopharmacol 7:189-92. 2004
    ..03, n=101). In conclusion, our findings do not support a major contribution of this polymorphism to the pathogenesis of panic disorder, but provide evidence for a possible role in the subgroup with agoraphobia...
  33. ncbi request reprint Structured group psychotherapy in adults with attention deficit hyperactivity disorder: results of an open multicentre study
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    J Nerv Ment Dis 195:1013-9. 2007
    ..In this multicenter study, the therapy program showed therapist-independent effects and seemed to be disorder-specific. This warrants the effort of organizing further controlled studies...
  34. ncbi request reprint The Wuerzburg Research Initiative on Adult Attention-Deficit/Hyperactivity Disorder (WURIN-AADHD): multi-layered evaluation of long-term course
    Christian Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 256:i12-20. 2006
    ....
  35. ncbi request reprint Beneficial effect of atypical antipsychotics on prefrontal brain function in acute psychotic disorders
    Ann Christine Ehlis
    Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry and Psychotherapy, University Hospital of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 255:299-307. 2005
    ..These results are in line with the notion that atypical antipsychotics may exert a beneficial effect on prefrontal brain function...