Hiroaki Iwata

Summary

Country: Germany

Publications

  1. doi request reprint Bullous pemphigoid: role of complement and mechanisms for blister formation within the lamina lucida
    Hiroaki Iwata
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Exp Dermatol 22:381-5. 2013
  2. doi request reprint GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisita
    Unni Krishna S R L Samavedam
    Department of Dermatology, University of Lubeck, 23563 Lübeck, Germany
    J Immunol 192:559-71. 2014
  3. doi request reprint Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters
    Artem Vorobyev
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 135:1565-73. 2015
  4. doi request reprint B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita
    Hiroaki Iwata
    Department of Dermatology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 191:2978-88. 2013
  5. pmc Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisita
    Benjamin Tiburzy
    Institute for Systemic Inflammation Research ISEF, University of Lubeck, Lubeck, Germany
    PLoS ONE 8:e83631. 2013
  6. doi request reprint Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules
    Hengameh Sadeghi
    Department of Dermatology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 194:3656-63. 2015
  7. doi request reprint Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury
    Michael Kasperkiewicz
    Department of Dermatology, University of Lubeck, Germany
    J Pathol 228:8-19. 2012

Collaborators

Detail Information

Publications7

  1. doi request reprint Bullous pemphigoid: role of complement and mechanisms for blister formation within the lamina lucida
    Hiroaki Iwata
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Exp Dermatol 22:381-5. 2013
    ....
  2. doi request reprint GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisita
    Unni Krishna S R L Samavedam
    Department of Dermatology, University of Lubeck, 23563 Lübeck, Germany
    J Immunol 192:559-71. 2014
    ..We demonstrate that GM-CSF modulates both autoantibody production and skin blistering in a prototypical organ-specific autoimmune disease. ..
  3. doi request reprint Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters
    Artem Vorobyev
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 135:1565-73. 2015
    ..In addition, using COL7-humanized mice, we provide in vivo evidence of pathogenicity of autoantibodies binding to human COL7. ..
  4. doi request reprint B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita
    Hiroaki Iwata
    Department of Dermatology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 191:2978-88. 2013
    ..Collectively, we demonstrate the pathogenic relevance of Abs targeting the vWFA2 domain of COL7 and show the requirement of APC-induced CD4 T cells to induce experimental EBA. ..
  5. pmc Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisita
    Benjamin Tiburzy
    Institute for Systemic Inflammation Research ISEF, University of Lubeck, Lubeck, Germany
    PLoS ONE 8:e83631. 2013
    ..These results indicate that inflamed lymph nodes can harbor pathogenic plasma cells exhibiting distinct properties and hence may resemble a so far neglected site for chronic autoantibody production. ..
  6. doi request reprint Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules
    Hengameh Sadeghi
    Department of Dermatology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 194:3656-63. 2015
    ..e., when skin lesions had already developed) improved experimental EBA, IL-1 appears to be a potential therapeutic target for EBA and related AIBDs. ..
  7. doi request reprint Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury
    Michael Kasperkiewicz
    Department of Dermatology, University of Lubeck, Germany
    J Pathol 228:8-19. 2012
    ..Our findings both genetically and functionally identify a novel disease-related molecule, FcγRIV, in an autoantibody-mediated disorder, which may be of importance for the development of novel targeted therapies...