S Irniger

Summary

Country: Germany

Publications

  1. ncbi Preventing fatal destruction: inhibitors of the anaphase-promoting complex in meiosis
    Stefan Irniger
    Institute of Microbiology and Genetics, Georg August University, Gottingen, Germany
    Cell Cycle 5:405-15. 2006
  2. ncbi The Ime2 protein kinase family in fungi: more duties than just meiosis
    Stefan Irniger
    Institute of Microbiology and Genetics, Georg August University, Grisebachstr 8, D 37077 Gottingen, Germany
    Mol Microbiol 80:1-13. 2011
  3. ncbi The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase
    S Irniger
    Research Institute of Molecular Pathology, Vienna, Austria
    J Cell Sci 110:1523-31. 1997
  4. ncbi Cyclin destruction in mitosis: a crucial task of Cdc20
    Stefan Irniger
    Institute of Microbiology and Genetics, Georg August University, Grisebachstr 8, D 37077 Gottingen, Germany
    FEBS Lett 532:7-11. 2002
  5. ncbi Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p
    M Baumer
    Institute of Microbiology and Genetics, Georg August University, Grisebachstrasse 8, D 37077 Gottingen, Germany
    J Biol Chem 275:38929-37. 2000
  6. ncbi Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast
    S Irniger
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 81:269-78. 1995
  7. ncbi Glucose and ras activity influence the ubiquitin ligases APC/C and SCF in Saccharomyces cerevisiae
    S Irniger
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    Genetics 154:1509-21. 2000
  8. ncbi Inhibition of APC-mediated proteolysis by the meiosis-specific protein kinase Ime2
    Melanie Bolte
    Institute of Microbiology and Genetics, Georg-August-University, Grisebachstrasse 8, , Germany
    Proc Natl Acad Sci U S A 99:4385-90. 2002
  9. ncbi Fungal development and the COP9 signalosome
    Gerhard H Braus
    Institut fur Mikrobiologie und Genetik, Abteilung Molekulare Mikrobiologie und Genetik, Georg August Universitat, Grisebachstr 8, D 37077 Gottingen, Germany
    Curr Opin Microbiol 13:672-6. 2010
  10. ncbi A process independent of the anaphase-promoting complex contributes to instability of the yeast S phase cyclin Clb5
    Fatih Sari
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    J Biol Chem 282:26614-22. 2007

Collaborators

  • Gerhard H Braus
  • K Nasmyth
  • Fatih Sari
  • Melanie Bolte
  • Patrick Dieckhoff
  • Özgür Bayram
  • Ralph Pries
  • A W Strittmatter
  • M Baumer
  • Wibke Meyer
  • Melanie Heinrich
  • Yasemin Sancak
  • Cindy Krause
  • Katrin Bömeke
  • Patrick Steigemann
  • Olav Grundmann
  • P Steigemann
  • M Kunzler

Detail Information

Publications17

  1. ncbi Preventing fatal destruction: inhibitors of the anaphase-promoting complex in meiosis
    Stefan Irniger
    Institute of Microbiology and Genetics, Georg August University, Gottingen, Germany
    Cell Cycle 5:405-15. 2006
    ..Inhibitors of APC/C also mediate the cytostatic factor induced metaphase II arrest of oocytes. This review highlights the current knowledge about the role and relevance of these diverse regulators of the meiotic APC/C...
  2. ncbi The Ime2 protein kinase family in fungi: more duties than just meiosis
    Stefan Irniger
    Institute of Microbiology and Genetics, Georg August University, Grisebachstr 8, D 37077 Gottingen, Germany
    Mol Microbiol 80:1-13. 2011
    ..Thus, Ime2-related kinases exhibit an amazing variety in controlling sexual developmental programs in fungi...
  3. ncbi The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase
    S Irniger
    Research Institute of Molecular Pathology, Vienna, Austria
    J Cell Sci 110:1523-31. 1997
    ..Degradation of Clb2p, Clb3p and Clb5p depends on the APC. This suggests that accumulation of any one of the six B-type cyclin proteins could account for the precocious replication of cdc16 and cdc23 mutants...
  4. ncbi Cyclin destruction in mitosis: a crucial task of Cdc20
    Stefan Irniger
    Institute of Microbiology and Genetics, Georg August University, Grisebachstr 8, D 37077 Gottingen, Germany
    FEBS Lett 532:7-11. 2002
    ..Remarkably, a complete inactivation of cyclin-dependent kinases seems to be not essential. This review discusses recent novel insights into cyclin destruction and its implications for the mitotic exit...
  5. ncbi Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p
    M Baumer
    Institute of Microbiology and Genetics, Georg August University, Grisebachstrasse 8, D 37077 Gottingen, Germany
    J Biol Chem 275:38929-37. 2000
    ..We suggest that Ubs1p may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity...
  6. ncbi Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast
    S Irniger
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 81:269-78. 1995
    ..Proteolysis of CLB2 is initiated in early anaphase, but a fraction of CLB2 remains stable until anaphase is complete...
  7. ncbi Glucose and ras activity influence the ubiquitin ligases APC/C and SCF in Saccharomyces cerevisiae
    S Irniger
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    Genetics 154:1509-21. 2000
    ..We conclude that glucose and Ras proteins influence the APC/C and the SCF complex in an opposite manner. These ubiquitin ligases might represent novel targets for modulating cell division in response to growth conditions...
  8. ncbi Inhibition of APC-mediated proteolysis by the meiosis-specific protein kinase Ime2
    Melanie Bolte
    Institute of Microbiology and Genetics, Georg-August-University, Grisebachstrasse 8, , Germany
    Proc Natl Acad Sci U S A 99:4385-90. 2002
    ..Our findings suggest that Ime2 represents an unstable, meiosis-specific regulator of APC(Cdh1)...
  9. ncbi Fungal development and the COP9 signalosome
    Gerhard H Braus
    Institut fur Mikrobiologie und Genetik, Abteilung Molekulare Mikrobiologie und Genetik, Georg August Universitat, Grisebachstr 8, D 37077 Gottingen, Germany
    Curr Opin Microbiol 13:672-6. 2010
    ..In contrast to plants and animals, CSN is not essential for fungal viability. Therefore fungi are suitable models to study CSN composition, activity and cellular functions and its role in light controlled development...
  10. ncbi A process independent of the anaphase-promoting complex contributes to instability of the yeast S phase cyclin Clb5
    Fatih Sari
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    J Biol Chem 282:26614-22. 2007
    ..These different modes apparently have overlapping functions in restricting Clb5 levels in a normal cell cycle, but APC/C function is essential in the presence of abnormally high Clb5 levels...
  11. ncbi Smt3/SUMO and Ubc9 are required for efficient APC/C-mediated proteolysis in budding yeast
    Patrick Dieckhoff
    Institute of Microbiology and Genetics, Georg-August-University, Grisebachstr. 8, D-37077 Goettingen, Germany
    Mol Microbiol 51:1375-87. 2004
    ..We conclude that SUMOylation is needed for efficient proteolysis mediated by APC/C in budding yeast...
  12. ncbi Induction of jlbA mRNA synthesis for a putative bZIP protein of Aspergillus nidulans by amino acid starvation
    A W Strittmatter
    Institut fur Mikrobiologie und Genetik, Georg August Universitat, Gottingen, Germany
    Curr Genet 39:327-34. 2001
    ..This induction is partially dependent and partially independent on the presence of the transcription factor CPCA. Therefore jlbA is a novel gene of A. nidulans which is transcriptionally activated by amino acid starvation conditions...
  13. ncbi The C-terminal region of the meiosis-specific protein kinase Ime2 mediates protein instability and is required for normal spore formation in budding yeast
    Fatih Sari
    Institute of Microbiology and Genetics, Georg August University, Grisebachstr 8, D 37077 Gottingen, Germany
    J Mol Biol 378:31-43. 2008
    ..We conclude that downregulation of Ime2 kinase activity mediated by the C-terminal domain is required for the efficient production of normal four-spore asci. Our data suggest a role for Ime2 in spore number control in S. cerevisiae...
  14. ncbi Synergistic inhibition of APC/C by glucose and activated Ras proteins can be mediated by each of the Tpk1-3 proteins in Saccharomyces cerevisiae
    Melanie Bolte
    Institute of Microbiology and Genetics, Georg August University, Grisebachstr 8, D 37077 Gottingen, Germany
    Microbiology 149:1205-16. 2003
    ..However, Tpk2 seems to inhibit APC/C function more efficiently than Tpk1 and Tpk3. Finally, evidence is provided that Cdc20 is involved in APC/C regulation by the cAMP/PKA pathway...
  15. ncbi The protein kinase ImeB is required for light-mediated inhibition of sexual development and for mycotoxin production in Aspergillus nidulans
    Özgür Bayram
    Institute of Microbiology and Genetics, Georg August University, Grisebachstr 8, D 37077 Gottingen, Germany
    Mol Microbiol 71:1278-95. 2009
    ..This sequence element is essential for ImeB function. We conclude that ImeB is a mitogen-activated protein kinase-related protein kinase required for the co-ordinated control of light-dependent development with mycotoxin production...
  16. ncbi Controlling transcription by destruction: the regulation of yeast Gcn4p stability
    Stefan Irniger
    Institute of Microbiology and Genetics, Georg-August-University, Grisebachstrasse 8, , Germany
    Curr Genet 44:8-18. 2003
    ..The past few years have revealed many novel insights into these regulatory processes. Here, we summarise current knowledge about the factors and mechanisms regulating Gcn4p stability...
  17. ncbi Amino acid-dependent Gcn4p stability regulation occurs exclusively in the yeast nucleus
    Ralph Pries
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    Eukaryot Cell 1:663-72. 2002
    ..Therefore, there is a strict spatial separation of protein synthesis and degradation of Gcn4p in yeast. Control of protein stabilization which antagonizes Gcn4p function is restricted to the nucleus...