Research Topics
Genomes and Genes | Thomas RenneSummaryAffiliation: Institute for Clinical Biochemistry and Pathobiochemistry Country: Germany Publications
| Collaborators
|
Detail Information
Publications
In vivo roles of factor XIIThomas Renne
Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, Stockholm, Sweden
Blood 120:4296-303. 2012..The goal of this review is to summarize the in vivo functions of FXII, with special focus to its functions in thrombosis and vascular biology...
Fine mapping of the H-kininogen binding site in plasma prekallikrein apple domain 2Thomas Renne
Institute of Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University at Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
Int Immunopharmacol 2:1867-73. 2002..This sequence is conserved in the A2 domain of the related protease factor XI, explaining the unusual strong cross-reactivity of PHK6 with factor XI, as well as the similar HK-binding characteristics of PPK and factor XI...
Factor XI deficiency in animal modelsT Renne
Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden
J Thromb Haemost 7:79-83. 2009..This review focuses on the role of factor XI, and its deficiency states as novel target for prevention of thrombosis with low bleeding risk in animal models...- The intrinsic pathway of coagulation is essential for thrombus stability in miceThomas Renne
Institute for Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
Blood Cells Mol Dis 36:148-51. 2006..These findings demonstrate that FXII-mediated fibrin formation is crucial for pathological arterial thrombosis but not for hemostasis and suggest that FXII could be an ideal target for safe anticoagulation... - Local bradykinin formation is controlled by glycosaminoglycansThomas Renne
Institute for Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University Wuerzburg, Wuerzburg, Germany
J Immunol 175:3377-85. 2005..By this means, fragments arising from HK processing propagate bradykinin generation, revealing a novel regulatory level for the kallikrein-kinin system... - Defective thrombus formation in mice lacking coagulation factor XIIThomas Renne
Institute of Clinical Biochemistry and Pathobiochemistry, Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
J Exp Med 202:271-81. 2005..The results establish FXII as essential for thrombus formation, and identify FXII as a novel target for antithrombotic therapy... - The procoagulant and proinflammatory plasma contact systemThomas Renne
Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
Semin Immunopathol 34:31-41. 2012..Here we present an overview about the plasma contact system in occlusive and inflammatory disease and its contribution to health and pathology... - Role of Factor XII in hemostasis and thrombosis: clinical implicationsThomas Renne
Institute for Clinical Biochemistry and Pathobiochemistry Division, Julius Maximilians University Würzburg, Josef Schneider Strasse 2 Building, D 97080 Wurzburg, Germany
Expert Rev Cardiovasc Ther 5:733-41. 2007.... - Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasisChristoph Kleinschnitz
Department of Neurology, Institute for Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, 97080 Wurzburg, Germany
J Exp Med 203:513-8. 2006..As FXII appears to be instrumental in pathologic fibrin formation but dispensable for hemostasis, FXII inhibition may offer a selective and safe strategy for preventing stroke and other thromboembolic diseases... - Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexesPeter M Benz
Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, D 97080 Wurzburg, Germany
J Cell Biol 180:205-19. 2008..We propose that alphaII-spectrin-VASP complexes regulate cortical actin cytoskeleton assembly with implications for vascular permeability... - Differential VASP phosphorylation controls remodeling of the actin cytoskeletonPeter M Benz
Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
J Cell Sci 122:3954-65. 2009..The data show that VASP functions are precisely regulated by differential phosphorylation and provide new insights into cytoskeletal control by serine/threonine kinase-dependent signaling pathways... - Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivoChris Oschatz
Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Immunity 34:258-68. 2011..Allergen exposure triggered edema attacks in hereditary angioedema patients, lacking C1 esterase inhibitor. The data indicate that heparin-initiated bradykinin formation plays a fundamental role in mast cell-mediated diseases... - Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammationFurat Raslan
Department of Neurosurgery, University of Wurzburg, Wurzburg, Germany
J Cereb Blood Flow Metab 30:1477-86. 2010..We conclude that B1R inhibition may offer a novel therapeutic strategy after acute brain injuries... - Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosisChristoph Kleinschnitz
Department of Neurology, University of Wurzburg, Germany
Stroke 39:1262-8. 2008..Although the ensuing activation of platelets is well established, their contribution for thrombosis and tissue damage has not formally been proved... - Factor XI and XII as antithrombotic targetsFelicitas Müller
Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet, University Hospital, Stockholm, Sweden
Curr Opin Hematol 18:349-55. 2011..This review focuses on new targets for anticoagulation that are associated with minimal or no therapy-associated increased bleeding... - Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edemaMadeleine Austinat
Department of Neurology, Julius Maximilians University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
Stroke 40:285-93. 2009..The effects of kinins are mediated by 2 different receptors (B1 and B2 receptor [B1R and B2R]) and comprise induction of edema formation and release of proinflammatory mediators... - The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarctionDavid Varga-Szabo
Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
J Exp Med 205:1583-91. 2008..These results establish STIM1 as an important mediator in the pathogenesis of ischemic cardio- and cerebrovascular events... - Gene disruption of Spred-2 causes dwarfismKarin Bundschu
Institut für Klinische Biochemie und Pathobiochemie, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
J Biol Chem 280:28572-80. 2005..Our observations suggest a model in which loss of Spred-2 inhibits bone growth by inhibiting chondrocyte differentiation through up-regulation of the MAPK signaling pathway... - Platelet polyphosphates are proinflammatory and procoagulant mediators in vivoFelicitas Müller
Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm S 171 76, Sweden
Cell 139:1143-56. 2009..The data identify polyP as a new class of mediator having fundamental roles in platelet-driven proinflammatory and procoagulant disorders... - Platelet polyphosphates: the nexus of primary and secondary hemostasisFelicitas Müller
Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden
Scand J Clin Lab Invest 71:82-6. 2011..Targeting polyphosphate-mediated factor XII activation offers the exciting possibility for a safe anticoagulation with minimal therapy-associated bleeding... - Prostaglandin-induced VASP phosphorylation controls alpha II-spectrin breakdown in apoptotic cellsPeter M Benz
Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
Int Immunopharmacol 8:319-24. 2008..Our findings may therefore provide the molecular basis for PGE2-induced apoptosis in pathological events... - Novel roles for factor XII-driven plasma contact activation systemFelicitas Müller
SFB 688 and Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
Curr Opin Hematol 15:516-21. 2008.... - The plasma contact system 2.0Coen Maas
Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
Semin Thromb Hemost 37:375-81. 2011..Here we present an overview about contact system activators and their contributions to health and pathology... - Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasmaJulia Johne
1. Institute of Clinical Biochemistry and Pathobiochemistry, Josef-Schneider-Strasse 2, , , Germany
Biol Chem 387:173-8. 2006..In summary, our data suggest that FXII-initiated protease cascades may proceed on platelet surfaces, with implications for inflammation and clotting... - Transmission of oxLDL-derived lipid peroxide radicals into membranes of vascular cells is the main inducer of oxLDL-mediated oxidative stressThomas E Hansen-Hagge
Department of Medicine, Division of Nephrology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Atherosclerosis 197:602-11. 2008..The novel data may help to design adequate therapeutic strategies against oxLDL-induced cardiovascular diseases... - Expression and subcellular localization of Spred proteins in mouse and human tissuesCatherine M Engelhardt
Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
Histochem Cell Biol 122:527-38. 2004..Furthermore, it becomes most likely that Spred-2 is involved in the regulation of secretory pathways... - Hereditary angioedema: a bradykinin-mediated swelling disorderJenny Björkqvist
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Thromb Haemost 109:368-74. 2013..The review summarises current knowledge on the pathophysiology of hereditary angiodema and focuses on recent experimental and pharmacological findings that have led to a better understanding and new treatments for the disease... - Regulatory mechanisms of the plasma contact systemCoen Maas
Department for Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
Thromb Res 129:S73-6. 2012..Here, we provide a condensed overview on mechanisms involved in activation and regulation of the contact system. These recent findings will help us to better understand the role of the enigmatic system for health and disease... - AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoproteinConstanze Blume
Institute for Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
J Biol Chem 282:4601-12. 2007..These findings suggest that VASP is a new AMPK substrate, that VASP Thr-278 phosphorylation translates metabolic signals into actin cytoskeleton rearrangements, and that this signaling system becomes down-regulated in diabetic vessels... - Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractilityNatalie Burkard
Department of Internal Medicine I, University of Wuerzburg, Wuerzburg, Germany
Circ Res 100:e32-44. 2007..We suggest that nNOS might suppress the function of L-type Ca(2+)-channels and in turn reduces Ca(2+)-transients which accounts for the negative inotropic effect...