Thomas Renne

Summary

Affiliation: Institute for Clinical Biochemistry and Pathobiochemistry
Country: Germany

Publications

  1. pmc Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes
    Peter M Benz
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, D 97080 Wurzburg, Germany
    J Cell Biol 180:205-19. 2008
  2. pmc Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
    Christoph Kleinschnitz
    Department of Neurology, Institute for Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, 97080 Wurzburg, Germany
    J Exp Med 203:513-8. 2006
  3. doi request reprint Plasma kallikrein: the bradykinin-producing enzyme
    J Björkqvist
    Thomas Renné, MD, PhD, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna L1 00, SE 171 76 Stockholm, Sweden, Tel 46 8 517 73390, Fax 46 310376, E mail
    Thromb Haemost 110:399-407. 2013
  4. pmc In vivo roles of factor XII
    Thomas Renne
    Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Blood 120:4296-303. 2012
  5. doi request reprint The procoagulant and proinflammatory plasma contact system
    Thomas Renne
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Semin Immunopathol 34:31-41. 2012
  6. ncbi request reprint Role of Factor XII in hemostasis and thrombosis: clinical implications
    Thomas Renne
    Institute for Clinical Biochemistry and Pathobiochemistry Division, Julius Maximilians University Würzburg, Josef Schneider Strasse 2 Building, D 97080 Wurzburg, Germany
    Expert Rev Cardiovasc Ther 5:733-41. 2007
  7. ncbi request reprint Fine mapping of the H-kininogen binding site in plasma prekallikrein apple domain 2
    Thomas Renne
    Institute of Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University at Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Int Immunopharmacol 2:1867-73. 2002
  8. doi request reprint Factor XI deficiency in animal models
    T Renne
    Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden
    J Thromb Haemost 7:79-83. 2009
  9. ncbi request reprint The intrinsic pathway of coagulation is essential for thrombus stability in mice
    Thomas Renne
    Institute for Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Blood Cells Mol Dis 36:148-51. 2006
  10. ncbi request reprint Local bradykinin formation is controlled by glycosaminoglycans
    Thomas Renne
    Institute for Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University Wuerzburg, Wuerzburg, Germany
    J Immunol 175:3377-85. 2005

Collaborators

Detail Information

Publications35

  1. pmc Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes
    Peter M Benz
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, D 97080 Wurzburg, Germany
    J Cell Biol 180:205-19. 2008
    ..We propose that alphaII-spectrin-VASP complexes regulate cortical actin cytoskeleton assembly with implications for vascular permeability...
  2. pmc Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
    Christoph Kleinschnitz
    Department of Neurology, Institute for Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, 97080 Wurzburg, Germany
    J Exp Med 203:513-8. 2006
    ..As FXII appears to be instrumental in pathologic fibrin formation but dispensable for hemostasis, FXII inhibition may offer a selective and safe strategy for preventing stroke and other thromboembolic diseases...
  3. doi request reprint Plasma kallikrein: the bradykinin-producing enzyme
    J Björkqvist
    Thomas Renné, MD, PhD, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna L1 00, SE 171 76 Stockholm, Sweden, Tel 46 8 517 73390, Fax 46 310376, E mail
    Thromb Haemost 110:399-407. 2013
    ..Targeting PK offers novel strategies not previously appreciated to interfere with thrombosis and vascular inflammation in a broad variety of diseases. ..
  4. pmc In vivo roles of factor XII
    Thomas Renne
    Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Blood 120:4296-303. 2012
    ..The goal of this review is to summarize the in vivo functions of FXII, with special focus to its functions in thrombosis and vascular biology...
  5. doi request reprint The procoagulant and proinflammatory plasma contact system
    Thomas Renne
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Semin Immunopathol 34:31-41. 2012
    ..Here we present an overview about the plasma contact system in occlusive and inflammatory disease and its contribution to health and pathology...
  6. ncbi request reprint Role of Factor XII in hemostasis and thrombosis: clinical implications
    Thomas Renne
    Institute for Clinical Biochemistry and Pathobiochemistry Division, Julius Maximilians University Würzburg, Josef Schneider Strasse 2 Building, D 97080 Wurzburg, Germany
    Expert Rev Cardiovasc Ther 5:733-41. 2007
    ....
  7. ncbi request reprint Fine mapping of the H-kininogen binding site in plasma prekallikrein apple domain 2
    Thomas Renne
    Institute of Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University at Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Int Immunopharmacol 2:1867-73. 2002
    ..This sequence is conserved in the A2 domain of the related protease factor XI, explaining the unusual strong cross-reactivity of PHK6 with factor XI, as well as the similar HK-binding characteristics of PPK and factor XI...
  8. doi request reprint Factor XI deficiency in animal models
    T Renne
    Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden
    J Thromb Haemost 7:79-83. 2009
    ..This review focuses on the role of factor XI, and its deficiency states as novel target for prevention of thrombosis with low bleeding risk in animal models...
  9. ncbi request reprint The intrinsic pathway of coagulation is essential for thrombus stability in mice
    Thomas Renne
    Institute for Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Blood Cells Mol Dis 36:148-51. 2006
    ..These findings demonstrate that FXII-mediated fibrin formation is crucial for pathological arterial thrombosis but not for hemostasis and suggest that FXII could be an ideal target for safe anticoagulation...
  10. ncbi request reprint Local bradykinin formation is controlled by glycosaminoglycans
    Thomas Renne
    Institute for Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University Wuerzburg, Wuerzburg, Germany
    J Immunol 175:3377-85. 2005
    ..By this means, fragments arising from HK processing propagate bradykinin generation, revealing a novel regulatory level for the kallikrein-kinin system...
  11. pmc Defective thrombus formation in mice lacking coagulation factor XII
    Thomas Renne
    Institute of Clinical Biochemistry and Pathobiochemistry, Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
    J Exp Med 202:271-81. 2005
    ..The results establish FXII as essential for thrombus formation, and identify FXII as a novel target for antithrombotic therapy...
  12. ncbi request reprint Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma
    Julia Johne
    1 Institute of Clinical Biochemistry and Pathobiochemistry, Josef Schneider Strasse 2, University of Wurzburg, D 97080 Wurzburg, Germany
    Biol Chem 387:173-8. 2006
    ..In summary, our data suggest that FXII-initiated protease cascades may proceed on platelet surfaces, with implications for inflammation and clotting...
  13. pmc Differential VASP phosphorylation controls remodeling of the actin cytoskeleton
    Peter M Benz
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
    J Cell Sci 122:3954-65. 2009
    ..The data show that VASP functions are precisely regulated by differential phosphorylation and provide new insights into cytoskeletal control by serine/threonine kinase-dependent signaling pathways...
  14. doi request reprint Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosis
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Germany
    Stroke 39:1262-8. 2008
    ..Although the ensuing activation of platelets is well established, their contribution for thrombosis and tissue damage has not formally been proved...
  15. doi request reprint Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo
    Chris Oschatz
    Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Immunity 34:258-68. 2011
    ..Allergen exposure triggered edema attacks in hereditary angioedema patients, lacking C1 esterase inhibitor. The data indicate that heparin-initiated bradykinin formation plays a fundamental role in mast cell-mediated diseases...
  16. pmc Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation
    Furat Raslan
    Department of Neurosurgery, University of Wurzburg, Wurzburg, Germany
    J Cereb Blood Flow Metab 30:1477-86. 2010
    ..We conclude that B1R inhibition may offer a novel therapeutic strategy after acute brain injuries...
  17. doi request reprint Zinc-dependent contact system activation induces vascular leakage and hypotension in rodents
    Jenny Björkqvist
    Division of Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Biol Chem 394:1195-204. 2013
    ..The data characterize dextran sulfate as a potent in vivo activator of factor XII with implications for bradykinin-mediated vascular permeability and blood pressure control...
  18. doi request reprint Hereditary angioedema: a bradykinin-mediated swelling disorder
    Jenny Björkqvist
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Thromb Haemost 109:368-74. 2013
    ..The review summarises current knowledge on the pathophysiology of hereditary angiodema and focuses on recent experimental and pharmacological findings that have led to a better understanding and new treatments for the disease...
  19. doi request reprint Factor XI and XII as antithrombotic targets
    Felicitas Müller
    Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet, University Hospital, Stockholm, Sweden
    Curr Opin Hematol 18:349-55. 2011
    ..This review focuses on new targets for anticoagulation that are associated with minimal or no therapy-associated increased bleeding...
  20. doi request reprint Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema
    Madeleine Austinat
    Department of Neurology, Julius Maximilians University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Stroke 40:285-93. 2009
    ..The effects of kinins are mediated by 2 different receptors (B1 and B2 receptor [B1R and B2R]) and comprise induction of edema formation and release of proinflammatory mediators...
  21. ncbi request reprint Gene disruption of Spred-2 causes dwarfism
    Karin Bundschu
    Institut für Klinische Biochemie und Pathobiochemie, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Biol Chem 280:28572-80. 2005
    ..Our observations suggest a model in which loss of Spred-2 inhibits bone growth by inhibiting chondrocyte differentiation through up-regulation of the MAPK signaling pathway...
  22. pmc The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction
    David Varga-Szabo
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
    J Exp Med 205:1583-91. 2008
    ..These results establish STIM1 as an important mediator in the pathogenesis of ischemic cardio- and cerebrovascular events...
  23. ncbi request reprint AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein
    Constanze Blume
    Institute for Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 282:4601-12. 2007
    ..These findings suggest that VASP is a new AMPK substrate, that VASP Thr-278 phosphorylation translates metabolic signals into actin cytoskeleton rearrangements, and that this signaling system becomes down-regulated in diabetic vessels...
  24. doi request reprint Prostaglandin-induced VASP phosphorylation controls alpha II-spectrin breakdown in apoptotic cells
    Peter M Benz
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Int Immunopharmacol 8:319-24. 2008
    ..Our findings may therefore provide the molecular basis for PGE2-induced apoptosis in pathological events...
  25. pmc Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy
    Peter M Benz
    Institute of Physiology I, University of Wurzburg, D 97070 Wurzburg, Germany
    Cell Commun Signal 11:56. 2013
    ..In the present study, we analyzed the physiological functions of Mena and VASP in the heart and also investigated the role of the proteins in the organization of cytoplasmic actin networks...
  26. pmc Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo
    Felicitas Müller
    Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm S 171 76, Sweden
    Cell 139:1143-56. 2009
    ..The data identify polyP as a new class of mediator having fundamental roles in platelet-driven proinflammatory and procoagulant disorders...
  27. doi request reprint Platelet polyphosphates: the nexus of primary and secondary hemostasis
    Felicitas Müller
    Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden
    Scand J Clin Lab Invest 71:82-6. 2011
    ..Targeting polyphosphate-mediated factor XII activation offers the exciting possibility for a safe anticoagulation with minimal therapy-associated bleeding...
  28. doi request reprint Crosstalk of the plasma contact system with bacteria
    Katrin Faye Nickel
    Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Thromb Res 130:S78-83. 2012
    ..The present review summarizes the role of the contact system and its activation for bacterial infections...
  29. doi request reprint Novel roles for factor XII-driven plasma contact activation system
    Felicitas Müller
    SFB 688 and Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
    Curr Opin Hematol 15:516-21. 2008
    ....
  30. doi request reprint The plasma contact system 2.0
    Coen Maas
    Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Semin Thromb Hemost 37:375-81. 2011
    ..Here we present an overview about contact system activators and their contributions to health and pathology...
  31. ncbi request reprint Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility
    Natalie Burkard
    Department of Internal Medicine I, University of Wuerzburg, Wuerzburg, Germany
    Circ Res 100:e32-44. 2007
    ..We suggest that nNOS might suppress the function of L-type Ca(2+)-channels and in turn reduces Ca(2+)-transients which accounts for the negative inotropic effect...
  32. doi request reprint A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk
    Magnus Larsson
    Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, SE 171 76 Stockholm, Sweden
    Sci Transl Med 6:222ra17. 2014
    ..These data establish that targeting of FXIIa is a safe mode of thromboprotection in bypass systems, and provide a clinically relevant anticoagulation strategy that is not complicated by excess bleeding. ..
  33. ncbi request reprint Transmission of oxLDL-derived lipid peroxide radicals into membranes of vascular cells is the main inducer of oxLDL-mediated oxidative stress
    Thomas E Hansen-Hagge
    Department of Medicine, Division of Nephrology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Atherosclerosis 197:602-11. 2008
    ..The novel data may help to design adequate therapeutic strategies against oxLDL-induced cardiovascular diseases...
  34. ncbi request reprint Expression and subcellular localization of Spred proteins in mouse and human tissues
    Catherine M Engelhardt
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Histochem Cell Biol 122:527-38. 2004
    ..Furthermore, it becomes most likely that Spred-2 is involved in the regulation of secretory pathways...
  35. doi request reprint Regulatory mechanisms of the plasma contact system
    Coen Maas
    Department for Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Thromb Res 129:S73-6. 2012
    ..Here, we provide a condensed overview on mechanisms involved in activation and regulation of the contact system. These recent findings will help us to better understand the role of the enigmatic system for health and disease...