Elsebet Østergaard Nielsen
Affiliation: Institute of Interdisciplinary Isotope Research
- Norchloro-fluoro-homoepibatidine: specificity to neuronal nicotinic acetylcholine receptor subtypes in vitroWinnie Deuther-Conrad
Institute of Interdisciplinary Isotope Research, Permoserstrasse 15, D 04318, Leipzig, Germany
Farmaco 59:785-92. 2004..However, because the affinity of both NCFHEB-enantiomers to human alpha3beta4 nAChR is up to 65 times lower than that of epibatidine, the alpha4beta2 subtype-specificity of NCFHEB is increased up to 1,400% compared to epibatidine...
- Autoradiography of 2-[18F]F-A-85380 on nicotinic acetylcholine receptors in the porcine brain in vitroWinnie Deuther-Conrad
Institute of Interdisciplinary Isotope Research, Radiopharmacy, 04318 Leipzig, Germany
Synapse 59:201-10. 2006..The autoradiographic data confirmed the suitability of swine as a model for the evaluation of radioligands designed for imaging of nAChR subtypes in the living brain...
- Norchloro-fluoro-homoepibatidine (NCFHEB) - a promising radioligand for neuroimaging nicotinic acetylcholine receptors with PETW Deuther-Conrad
Institute of Interdisciplinary Isotope Research, Permoserstrasse 15, 04318 Leipzig, Germany
Eur Neuropsychopharmacol 18:222-9. 2008..The data indicate that (+)- and (-)-[(18)F]NCFHEB have potential for further development as PET tracers...
- Molecular imaging of alpha7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743Winnie Deuther-Conrad
Institute of Interdisciplinary Isotope Research, Leipzig, Germany
Eur J Nucl Med Mol Imaging 36:791-800. 2009..It was our goal to radiolabel the alpha7 nAChR agonist 4-[5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-yl]-1,4-diaza-bicyclo[3.2.2]nonane (NS10743) and to assess the selectivity of [(18)F]NS10743 binding site occupancy in animal experiments...