Elsebet Østergaard Nielsen

Summary

Affiliation: Institute of Interdisciplinary Isotope Research
Country: Germany

Publications

  1. ncbi Norchloro-fluoro-homoepibatidine: specificity to neuronal nicotinic acetylcholine receptor subtypes in vitro
    Winnie Deuther-Conrad
    Institute of Interdisciplinary Isotope Research, Permoserstrasse 15, D 04318, Leipzig, Germany
    Farmaco 59:785-92. 2004
  2. ncbi Autoradiography of 2-[18F]F-A-85380 on nicotinic acetylcholine receptors in the porcine brain in vitro
    Winnie Deuther-Conrad
    Institute of Interdisciplinary Isotope Research, Radiopharmacy, 04318 Leipzig, Germany
    Synapse 59:201-10. 2006
  3. ncbi Norchloro-fluoro-homoepibatidine (NCFHEB) - a promising radioligand for neuroimaging nicotinic acetylcholine receptors with PET
    W Deuther-Conrad
    Institute of Interdisciplinary Isotope Research, Permoserstrasse 15, 04318 Leipzig, Germany
    Eur Neuropsychopharmacol 18:222-9. 2008
  4. ncbi Molecular imaging of alpha7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743
    Winnie Deuther-Conrad
    Institute of Interdisciplinary Isotope Research, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:791-800. 2009

Detail Information

Publications4

  1. ncbi Norchloro-fluoro-homoepibatidine: specificity to neuronal nicotinic acetylcholine receptor subtypes in vitro
    Winnie Deuther-Conrad
    Institute of Interdisciplinary Isotope Research, Permoserstrasse 15, D 04318, Leipzig, Germany
    Farmaco 59:785-92. 2004
    ..However, because the affinity of both NCFHEB-enantiomers to human alpha3beta4 nAChR is up to 65 times lower than that of epibatidine, the alpha4beta2 subtype-specificity of NCFHEB is increased up to 1,400% compared to epibatidine...
  2. ncbi Autoradiography of 2-[18F]F-A-85380 on nicotinic acetylcholine receptors in the porcine brain in vitro
    Winnie Deuther-Conrad
    Institute of Interdisciplinary Isotope Research, Radiopharmacy, 04318 Leipzig, Germany
    Synapse 59:201-10. 2006
    ..The autoradiographic data confirmed the suitability of swine as a model for the evaluation of radioligands designed for imaging of nAChR subtypes in the living brain...
  3. ncbi Norchloro-fluoro-homoepibatidine (NCFHEB) - a promising radioligand for neuroimaging nicotinic acetylcholine receptors with PET
    W Deuther-Conrad
    Institute of Interdisciplinary Isotope Research, Permoserstrasse 15, 04318 Leipzig, Germany
    Eur Neuropsychopharmacol 18:222-9. 2008
    ..The data indicate that (+)- and (-)-[(18)F]NCFHEB have potential for further development as PET tracers...
  4. ncbi Molecular imaging of alpha7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743
    Winnie Deuther-Conrad
    Institute of Interdisciplinary Isotope Research, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:791-800. 2009
    ..It was our goal to radiolabel the alpha7 nAChR agonist 4-[5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-yl]-1,4-diaza-bicyclo[3.2.2]nonane (NS10743) and to assess the selectivity of [(18)F]NS10743 binding site occupancy in animal experiments...