Richard Ivell

Summary

Affiliation: Institute for Hormone and Fertility Research
Country: Germany

Publications

  1. ncbi Acute regulation of the bovine gene for the steroidogenic acute regulatory protein in ovarian theca and adrenocortical cells
    R Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529 Hamburg, Germany
    J Mol Endocrinol 24:109-18. 2000
  2. ncbi Progressive inactivation of the haploid expressed gene for the sperm-specific endozepine-like peptide (ELP) through primate evolution
    R Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529, Hamburg, Germany
    Gene 255:335-45. 2000
  3. ncbi Endocrinology. This hormone has been relaxin' too long!
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529 Hamburg, Germany
    Science 295:637-8. 2002
  4. ncbi Post-meiotic gene products as targets for male contraception
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Falkenried 88, 20251 Hamburg, Germany
    Mol Cell Endocrinol 216:65-74. 2004
  5. ncbi The evolution of the endozepine-like peptide (ELP) in the mammalian testis
    R Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Reprod Domest Anim 36:278-81. 2001
  6. pmc Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates
    Richard Ivell
    Institute for Hormone and Fertility Research at the University of Hamburg, Falkenried 88, 20251 Hamburg, Germany
    Reprod Biol Endocrinol 1:114. 2003
  7. ncbi Reproductive biology of the relaxin-like factor (RLF/INSL3)
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, 22529 Hamburg, Germany
    Biol Reprod 67:699-705. 2002
  8. ncbi Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Falkenreid 88, 20251 Hamburg, Germany
    Endocrinology 144:3130-7. 2003
  9. pmc Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells
    Norbert Walther
    Institute for Hormone and Fertility Research, University of Hamburg, Falkenried 88, D 20251 Hamburg, Germany
    Reprod Biol Endocrinol 4:64. 2006
  10. ncbi Transcriptional regulation of the bovine oxytocin receptor gene
    Ralph Telgmann
    Institute for Hormone and Fertility Research University of Hamburg, 22529 Hamburg, Germany
    Biol Reprod 68:1015-26. 2003

Collaborators

Detail Information

Publications39

  1. ncbi Acute regulation of the bovine gene for the steroidogenic acute regulatory protein in ovarian theca and adrenocortical cells
    R Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529 Hamburg, Germany
    J Mol Endocrinol 24:109-18. 2000
    ..More distal promoter regions may be involved in modulating the specificity of expression by combining enhancer and inhibitory functions...
  2. ncbi Progressive inactivation of the haploid expressed gene for the sperm-specific endozepine-like peptide (ELP) through primate evolution
    R Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529, Hamburg, Germany
    Gene 255:335-45. 2000
    ....
  3. ncbi Endocrinology. This hormone has been relaxin' too long!
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529 Hamburg, Germany
    Science 295:637-8. 2002
  4. ncbi Post-meiotic gene products as targets for male contraception
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Falkenried 88, 20251 Hamburg, Germany
    Mol Cell Endocrinol 216:65-74. 2004
    ..It is therefore to be expected that soon several new targets for a potential post-meiotic male contraceptive will become available for pharmaceutical development...
  5. ncbi The evolution of the endozepine-like peptide (ELP) in the mammalian testis
    R Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Reprod Domest Anim 36:278-81. 2001
    ..Current research is looking at both the function of the ELP protein and the haploid regulation of the gene...
  6. pmc Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates
    Richard Ivell
    Institute for Hormone and Fertility Research at the University of Hamburg, Falkenried 88, 20251 Hamburg, Germany
    Reprod Biol Endocrinol 1:114. 2003
    ....
  7. ncbi Reproductive biology of the relaxin-like factor (RLF/INSL3)
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, 22529 Hamburg, Germany
    Biol Reprod 67:699-705. 2002
    ..Recently, a novel 7-transmembrane domain receptor (LGR8 or Great) has been tentatively identified as the RLF receptor, and its deletion in mice leads also to cryptorchidism...
  8. ncbi Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Falkenreid 88, 20251 Hamburg, Germany
    Endocrinology 144:3130-7. 2003
    ..Thus, perinatal expression of this enzyme in fetal Leydig cells may contribute to protecting these cells from estrogens and encourage androgen formation...
  9. pmc Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells
    Norbert Walther
    Institute for Hormone and Fertility Research, University of Hamburg, Falkenried 88, D 20251 Hamburg, Germany
    Reprod Biol Endocrinol 4:64. 2006
    ..Two activating functions, AF-1 and AF-2, have been described to function in a cooperative manner to recruit transcriptional coactivators to the promoter regions of NR5A1-controlled genes...
  10. ncbi Transcriptional regulation of the bovine oxytocin receptor gene
    Ralph Telgmann
    Institute for Hormone and Fertility Research University of Hamburg, 22529 Hamburg, Germany
    Biol Reprod 68:1015-26. 2003
    ..Of many factors tested or analyzed, these components of the IFN system are the only ones found to significantly influence the transcription of the bovine OTR gene...
  11. ncbi SPEER--a new family of testis-specific genes from the mouse
    Andrej Nikolai Spiess
    Institute for Hormone and Fertility Research, University of Hamburg, 22529 Hamburg, Germany
    Biol Reprod 68:2044-54. 2003
    ....
  12. ncbi Constitutive regulation of the Insl3 gene in rat Leydig cells
    Helen Sadeghian
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Mol Cell Endocrinol 241:10-20. 2005
    ....
  13. ncbi Relaxin and phosphodiesterases collaborate during decidualization
    Olaf Bartscha
    Institute for Hormone and Fertility Research, University of Hamburg, D 20251 Hamburg, Germany
    Ann N Y Acad Sci 1030:479-92. 2004
    ....
  14. ncbi Phosphodiesterase 4 inhibition synergizes with relaxin signaling to promote decidualization of human endometrial stromal cells
    Olaf Bartsch
    Institute for Hormone and Fertility Research, University of Hamburg, 20251 Hamburg, Germany
    J Clin Endocrinol Metab 89:324-34. 2004
    ....
  15. ncbi Trehalose is a potent PCR enhancer: lowering of DNA melting temperature and thermal stabilization of taq polymerase by the disaccharide trehalose
    Andrej Nikolai Spiess
    Institute for Hormone and Fertility Research, Centre of Innovative Medicine, Falkenried 88, 20251 Hamburg, Germany
    Clin Chem 50:1256-9. 2004
  16. ncbi A novel molecular assay to discriminate transcriptional effects caused by xenoestrogens
    Mohammad Kazem Koohi
    Institute for Hormone and Fertility Research, University of Hamburg, 20246 Hamburg, Germany
    Mol Cell Endocrinol 276:45-54. 2007
    ..This assay matrix has been used to examine a selection of phytoestrogens and xenobiotics, thereby providing new information on the mechanism of action of some of these substances in breast cancer cells...
  17. ncbi The molecular basis of cryptorchidism
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529 Hamburg
    Mol Hum Reprod 9:175-81. 2003
    ..Considering its frequency in newborn children, and the severity of the untreated condition (infertility and often testicular cancer) these new findings should generate new information on possible causes and treatments...
  18. ncbi Relaxin peptides are new global players
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529 Hamburg, Germany
    Trends Endocrinol Metab 13:343-8. 2002
    ..Finally, the recent cloning of the RLX receptors now provides the basis for a new molecular pharmacology for these peptide hormones, and preliminary studies suggest that their signal transduction is both interesting and unusual...
  19. ncbi Relaxin signaling from natural receptors
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Hamburg, 20246, Germany
    Ann N Y Acad Sci 1041:280-7. 2005
    ..It is therefore important to distinguish between immediate early effects, short to mid-term responses, and long-term responses likely the consequences of specific gene upregulation...
  20. pmc Amplified RNA degradation in T7-amplification methods results in biased microarray hybridizations
    Andrej Nikolai Spiess
    Institute for Hormone and Fertility Research, Centre of Innovative Medicine, Falkenried 88, 20251 Hamburg, Germany
    BMC Genomics 4:44. 2003
    ..We describe here an amplification-time dependent degradation of aRNA in prolonged standard T7 amplification protocols, that results in lower average size aRNA and decreased yields...
  21. ncbi A highly efficient method for long-chain cDNA synthesis using trehalose and betaine
    Andrej Nikolai Spiess
    Institute for Hormone and Fertility Research, Grandweg 64, Hamburg, 22529, Germany
    Anal Biochem 301:168-74. 2002
    ..The application of betaine in combination with trehalose should prove useful in all laboratory methods relying on full-length cDNA. (USA)...
  22. ncbi Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway
    Ravinder Anand-Ivell
    School of Molecular and Biomedical Sciences, University of Adelaide, SA 5005, Australia
    Mol Cell Endocrinol 272:1-13. 2007
    ....
  23. ncbi Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism
    Katrine Bay
    University Department of Growth and Reproduction, Rigshospitalet, GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:4020-7. 2007
    ..The Leydig cell hormone insulin-like factor 3 (INSL3) is important for testicular descent. Currently INSL3 levels in cord blood, in serum throughout childhood, and in relation to congenital cryptorchidism are unknown...
  24. ncbi Peripheral INSL3 concentrations decline with age in a large population of Australian men
    Ravinder Anand-Ivell
    School of Molecular and Biomedical Science and Research Centre for Reproductive Health, University of Adelaide, SA, Australia
    Int J Androl 29:618-26. 2006
    ..Its decline with age reflects a decline in the properties of the Leydig cell population only, and emphasizes a gonadal component in the age-related decrease in androgen production...
  25. ncbi Diverse signalling mechanisms used by relaxin in natural cells and tissues: the evolution of a "neohormone"
    Richard Ivell
    Centre for Reproductive Health and School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia
    Adv Exp Med Biol 612:26-33. 2007
    ..Finally, in tissues where relaxin is known to be effective, there is often also local relaxin induction, amplifying the effects of the endocrine hormone...
  26. ncbi Neohormone systems as exciting targets for drug development
    Richard Ivell
    Trends Endocrinol Metab 17:123. 2006
  27. ncbi International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides
    Ross A Bathgate
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    Pharmacol Rev 58:7-31. 2006
    ..The brain distribution of RXFP3 receptors suggests that actions at these receptors have the potential for the development of antianxiety and antiobesity drugs...
  28. ncbi Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis
    Ravinder J K Anand-Ivell
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia
    Biol Reprod 74:945-53. 2006
    ..Therefore, the INSL3/LGR8 system represents a further paracrine hormone-receptor system in the testis, which conveys information about Leydig cell status to germ cells, and possibly as part of an autocrine feedback loop...
  29. ncbi Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate
    I Kim Mahood
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, UK
    Int J Androl 29:148-54; discussion 181-5. 2006
    ..It is therefore concluded that the ITLCs are bona fide LCs that are abnormally located within the seminiferous tubules of DBP-exposed rats in post-natal life...
  30. ncbi Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate
    Chris McKinnell
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Academic Centre, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 146:4536-44. 2005
    ....
  31. ncbi Dynamic changes in the expression of relaxin-like factor (INSL3), cholesterol side-chain cleavage cytochrome p450, and 3beta-hydroxysteroid dehydrogenase in bovine ovarian follicles during growth and atresia
    Helen F Irving-Rodgers
    Department of Medicine, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia
    Biol Reprod 66:934-43. 2002
    ..We conclude that the expression of pro-RLF in the theca interna is switched off as follicles enlarge or enter atresia, whereas the expression of steroidogenic enzymes is maintained in the theca interna...
  32. ncbi Testis-specific expression of rat mitochondrial glycerol-3-phosphate dehydrogenase in haploid male germ cells
    Joachim M Weitzel
    Institute of Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, D 20246 Hamburg, Germany
    Biol Reprod 68:699-707. 2003
    ..Our results indicate that rat mGPDH is expressed by a testis-specific promoter from haploid male germ cells in a stage-specific manner...
  33. pmc Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility
    Ben Davies
    Center for Cardiovascular Research Institute for Pharmacology and Toxicology, Charite University Medicine, Berlin, Germany
    Mol Cell Biol 24:8642-8. 2004
    ..The fertility phenotype of HE6 knockout mice identifies this receptor as a potential nonsteroidal, nontesticular target for future male contraceptives and identifies an in vivo function for a member of this unusual gene family...
  34. ncbi Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor
    Karel De Gendt
    Laboratory for Experimental Medicine and Endocrinology, Department of Developmental Biology, Catholic University of Leuven, Belgium
    Endocrinology 146:4117-26. 2005
    ..These results show that loss of androgen action on SC has major consequences for LC development, and this could be mediated indirectly via platelet-derived growth factor-A and/or estrogens/EST...
  35. ncbi Receptors for relaxin family peptides
    Ross A Bathgate
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
    Ann N Y Acad Sci 1041:61-76. 2005
    ....
  36. ncbi Insulin-like factor 3: where are we now?
    Richard Ivell
    School of Molecular and Biomedical Science, University of Adelaide, SA Adelaide 5005, Australia
    Ann N Y Acad Sci 1041:486-96. 2005
    ..It is also an indicator of differentiation status not only for Leydig cells but also for the theca interna cells of the ovary...
  37. ncbi Immunohistochemical localization of relaxin-like factor/insulin-like peptide-3 in the bovine corpus luteum
    Nicole Nichols
    Department of Animal Sciences, University of Florida, P O Box 11910, Gainesville, FL 32611, USA
    Ann N Y Acad Sci 1041:506-9. 2005
    ..No staining was observed in small and large steroidogenic luteal cells, indicating a nonsteroidogenic source of luteal relaxin-like factor. Definitive cell type identification is currently being determined via electron microscopy...
  38. ncbi Intraadrenal adrenocorticotropin production in a case of bilateral macronodular adrenal hyperplasia causing Cushing's syndrome
    Herve Lefebvre
    European Institute for Peptide Research, Department of Endocrinology and Metabolic Diseases, INSERM, U 413, 76031 Rouen, France
    J Clin Endocrinol Metab 88:3035-42. 2003
    ..The term ACTH-independent used to designate primary adrenal Cushing's syndrome may therefore be inappropriate in some cases of bilateral macronodular adrenal hyperplasia with hypercortisolism and undetectable plasma ACTH levels...
  39. doi Insulin-like factor 3 levels in amniotic fluid of human male fetuses
    Ravinder Anand-Ivell
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, 5005 SA, Australia
    Hum Reprod 23:1180-6. 2008
    ....