Marcus Fändrich

Summary

Affiliation: Institute of Molecular Biotechnology
Country: Germany

Publications

  1. pmc The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation
    Peter Hortschansky
    Institut für Molekulare Biotechnologie IMB, Jena, Germany
    Protein Sci 14:1753-9. 2005
  2. pmc The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation
    Marcus Fändrich
    Oxford Centre for Molecular Sciences, Central Chemistry Laboratory, University of Oxford, South Parks Road, UK
    EMBO J 21:5682-90. 2002
  3. ncbi request reprint Apomyoglobin reveals a random-nucleation mechanism in amyloid protofibril formation
    Marcus Fändrich
    Institut für Molekulare Biotechnologie IMB, Beutenbergstrasse 11, Postfach 100 813, D 07708 Jena, Germany
    Acta Histochem 108:215-9. 2006
  4. pmc Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments
    Marcus Fändrich
    Institut fur Molekulare Biotechnologie, Beutenbergstrasse 11, D 07745 Jena, Germany
    Proc Natl Acad Sci U S A 100:15463-8. 2003
  5. ncbi request reprint Structure and formation of amyloid fibrils
    Marcus Fändrich
    Institute of Molecular Biotechnology, Jena, Germany
    Acta Histochem 105:379. 2003
  6. pmc Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides
    Jessica Meinhardt
    Leibniz Institut für Altersforschung, Fritz Lipmann Institut, D 07745 Jena, Germany
    Protein Sci 16:1214-22. 2007
  7. pmc Mutagenic exploration of the cross-seeding and fibrillation propensity of Alzheimer's beta-amyloid peptide variants
    Alexander Peim
    Leibniz Institut für Altersforschung, Jena, Germany
    Protein Sci 15:1801-5. 2006
  8. pmc Thermodynamic analysis of the aggregation propensity of oxidized Alzheimer's beta-amyloid variants
    Peter Hortschansky
    Leibniz Institut für Naturstoff Forschung une Infektionsbiologie, Hans Knöll Institut, D 07745 Jena, Germany
    Protein Sci 14:2915-8. 2005
  9. ncbi request reprint Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatin
    Gerald P Gellermann
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 360:251-7. 2006
  10. ncbi request reprint Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils
    Karolin Klement
    Leibniz Institut für Altersforschung, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 373:1321-33. 2007

Collaborators

Detail Information

Publications16

  1. pmc The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation
    Peter Hortschansky
    Institut für Molekulare Biotechnologie IMB, Jena, Germany
    Protein Sci 14:1753-9. 2005
    ..These data imply that the nucleation event is under influence of a stochastic factor that can manifest itself in profound macroscopic differences in the aggregation kinetics of otherwise indistinguishable samples...
  2. pmc The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation
    Marcus Fändrich
    Oxford Centre for Molecular Sciences, Central Chemistry Laboratory, University of Oxford, South Parks Road, UK
    EMBO J 21:5682-90. 2002
    ....
  3. ncbi request reprint Apomyoglobin reveals a random-nucleation mechanism in amyloid protofibril formation
    Marcus Fändrich
    Institut für Molekulare Biotechnologie IMB, Beutenbergstrasse 11, Postfach 100 813, D 07708 Jena, Germany
    Acta Histochem 108:215-9. 2006
    ..Once the appropriate structural characteristics are acquired, PFs are formed by addition of further polypeptide chains...
  4. pmc Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments
    Marcus Fändrich
    Institut fur Molekulare Biotechnologie, Beutenbergstrasse 11, D 07745 Jena, Germany
    Proc Natl Acad Sci U S A 100:15463-8. 2003
    ..However, it is inevitable that such conditions often stabilize protein folding intermediates...
  5. ncbi request reprint Structure and formation of amyloid fibrils
    Marcus Fändrich
    Institute of Molecular Biotechnology, Jena, Germany
    Acta Histochem 105:379. 2003
  6. pmc Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides
    Jessica Meinhardt
    Leibniz Institut für Altersforschung, Fritz Lipmann Institut, D 07745 Jena, Germany
    Protein Sci 16:1214-22. 2007
    ....
  7. pmc Mutagenic exploration of the cross-seeding and fibrillation propensity of Alzheimer's beta-amyloid peptide variants
    Alexander Peim
    Leibniz Institut für Altersforschung, Jena, Germany
    Protein Sci 15:1801-5. 2006
    ..Hence, the nucleus acts in this case as a catalyst that promotes the fibrillation of different polypeptide chains according to their intrinsic structural predilection...
  8. pmc Thermodynamic analysis of the aggregation propensity of oxidized Alzheimer's beta-amyloid variants
    Peter Hortschansky
    Leibniz Institut für Naturstoff Forschung une Infektionsbiologie, Hans Knöll Institut, D 07745 Jena, Germany
    Protein Sci 14:2915-8. 2005
    ....
  9. ncbi request reprint Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatin
    Gerald P Gellermann
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 360:251-7. 2006
    ....
  10. ncbi request reprint Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils
    Karolin Klement
    Leibniz Institut für Altersforschung, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 373:1321-33. 2007
    ..These observations are important for understanding and predicting aggregation on the basis of simple physico-chemical properties...
  11. pmc FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils
    Giorgia Zandomeneghi
    Institut für Molekulare Biotechnologie IMB, D 07745 Jena, Germany
    Protein Sci 13:3314-21. 2004
    ..These data imply that amyloid fibril formation from native beta-sheet proteins can involve a substantial structural reorganization...
  12. ncbi request reprint Absolute correlation between lag time and growth rate in the spontaneous formation of several amyloid-like aggregates and fibrils
    Marcus Fändrich
    Leibniz Institut für Altersforschung, Fritz Lipmann Institut, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 365:1266-70. 2007
    ..These data suggest mechanistic similarities in the nucleation behaviour of different amyloid-like fibrils and aggregates...
  13. doi request reprint Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils
    Jessica Meinhardt
    Leibniz Institut für Altersforschung Fritz Lipmann Institut, Beutenbergstrabetae 11, D 07745 Jena, Germany
    J Mol Biol 386:869-77. 2009
    ..This property differs significantly from native, monomeric protein folding reactions that produce, for one protein sequence, only one ordered conformation and only one set of inter-residue interactions...
  14. pmc Raft lipids as common components of human extracellular amyloid fibrils
    Gerald P Gellermann
    Institut fur Molekulare Biotechnologie, Beutenbergstrasse 11, 07745 Jena, Germany
    Proc Natl Acad Sci U S A 102:6297-302. 2005
    ..These data suggest the existence of common cellular mechanisms in the generation of different types of clinical amyloid deposits...
  15. ncbi request reprint Identification of molecular compounds critical to Alzheimer's-like plaque formation
    Gerald P Gellermann
    Leibniz Institute for Age Research, Fritz Lipmann Institut, Jena, Germany
    J Neurosci Res 85:2037-44. 2007
    ..Altogether, our data demonstrate the utility of this cell model for investigating pathways and molecular interactions critical to amyloidogenesis...
  16. pmc Mutagenic analysis of the nucleation propensity of oxidized Alzheimer's beta-amyloid peptide
    Tony Christopeit
    Institut fur Molekulare Biotechnologie, D 07745 Jena, Germany
    Protein Sci 14:2125-31. 2005
    ..These data imply that the two reactions, nucleation and polymerization, are governed by very similar physicochemical principles and that they involve the formation of the same types of noncovalent interactions...