I Dikic

Summary

Affiliation: Institute of Biochemistry II
Country: Germany

Publications

  1. doi request reprint Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal
    Mirko H H Schmidt
    Institute of Biochemistry II, Johann Wolfgang Goethe University School of Medicine, Frankfurt am Main, Germany
    Nat Cell Biol 11:873-80. 2009
  2. pmc Generation and physiological roles of linear ubiquitin chains
    Henning Walczak
    Tumour Immunology Unit, Department of Medicine, Imperial College London, 10N5 Commonwealth Building, Du Cane Road, London W12 0NN, UK
    BMC Biol 10:23. 2012
  3. pmc An ultrasensitive sorting mechanism for EGF receptor endocytosis
    Hannah Schmidt-Glenewinkel
    Division Theoretical Bioinformatics, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    BMC Syst Biol 2:32. 2008
  4. ncbi request reprint Targeting ubiquitin in cancers
    Ivan Dikic
    Institute of Biochemistry II, Goethe University Hospital, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Eur J Cancer 42:3095-102. 2006
  5. ncbi request reprint Cbl signaling networks in the regulation of cell function
    I Dikic
    Institute of Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cell Mol Life Sci 60:1805-27. 2003
  6. ncbi request reprint Negative receptor signalling
    Ivan Dikic
    Ludwig Institute for Cancer Research, Husargatan 3, SE 75 124 Uppsala, Sweden
    Curr Opin Cell Biol 15:128-35. 2003
  7. doi request reprint Ubiquitin-binding domains - from structures to functions
    Ivan Dikic
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University Frankfurt, Germany
    Nat Rev Mol Cell Biol 10:659-71. 2009
  8. doi request reprint Selective autophagy in cancer development and therapy
    Ivan Dikic
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University, Frankfurt, Main, Germany
    Cancer Res 70:3431-4. 2010
  9. doi request reprint Notch: Implications of endogenous inhibitors for therapy
    Ivan Dikic
    Frankfurt Institute for Molecular Life Sciences FMLS and Institute of Biochemistry II, Johann Wolfgang Goethe University School of Medicine, Frankfurt am Main, Germany
    Bioessays 32:481-7. 2010
  10. ncbi request reprint Mechanisms controlling EGF receptor endocytosis and degradation
    I Dikic
    Institute of Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Biochem Soc Trans 31:1178-81. 2003

Collaborators

Detail Information

Publications84

  1. doi request reprint Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal
    Mirko H H Schmidt
    Institute of Biochemistry II, Johann Wolfgang Goethe University School of Medicine, Frankfurt am Main, Germany
    Nat Cell Biol 11:873-80. 2009
    ..We identified neurons as a source of EGFL7 in the brain, suggesting that brain-derived EGFL7 acts as an endogenous antagonist of Notch signalling that regulates proliferation and differentiation of subventricular zone-derived adult NSCs...
  2. pmc Generation and physiological roles of linear ubiquitin chains
    Henning Walczak
    Tumour Immunology Unit, Department of Medicine, Imperial College London, 10N5 Commonwealth Building, Du Cane Road, London W12 0NN, UK
    BMC Biol 10:23. 2012
    ..We focus here on linear ubiquitin chains, how they are assembled, and how three different avenues of research have indicated physiological roles for linear ubiquitination in innate and adaptive immunity and suppression of inflammation...
  3. pmc An ultrasensitive sorting mechanism for EGF receptor endocytosis
    Hannah Schmidt-Glenewinkel
    Division Theoretical Bioinformatics, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    BMC Syst Biol 2:32. 2008
    ..Several mechanisms to generate this behaviour have been described theoretically, the underlying assumptions of which, however, have not been experimentally demonstrated for the EGF receptor internalization network...
  4. ncbi request reprint Targeting ubiquitin in cancers
    Ivan Dikic
    Institute of Biochemistry II, Goethe University Hospital, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Eur J Cancer 42:3095-102. 2006
    ..Here we discuss how oncogenic alterations in the Ub system can be targeted by anti-cancer therapies...
  5. ncbi request reprint Cbl signaling networks in the regulation of cell function
    I Dikic
    Institute of Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cell Mol Life Sci 60:1805-27. 2003
    ....
  6. ncbi request reprint Negative receptor signalling
    Ivan Dikic
    Ludwig Institute for Cancer Research, Husargatan 3, SE 75 124 Uppsala, Sweden
    Curr Opin Cell Biol 15:128-35. 2003
    ..e. Sprouty), cytoplasmic kinases (i.e. activated Cdc42-associated kinase) and phosphoinositol metabolites. These inhibitory signals are essential for normal cell functioning, and their deregulation often results in human diseases...
  7. doi request reprint Ubiquitin-binding domains - from structures to functions
    Ivan Dikic
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University Frankfurt, Germany
    Nat Rev Mol Cell Biol 10:659-71. 2009
    ..These new structure-based insights provide strategies for controlling cellular processes by targeting ubiquitin-UBD interfaces...
  8. doi request reprint Selective autophagy in cancer development and therapy
    Ivan Dikic
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University, Frankfurt, Main, Germany
    Cancer Res 70:3431-4. 2010
    ..We discuss the emerging principles of selective autophagy in cancer pathogenesis and treatment...
  9. doi request reprint Notch: Implications of endogenous inhibitors for therapy
    Ivan Dikic
    Frankfurt Institute for Molecular Life Sciences FMLS and Institute of Biochemistry II, Johann Wolfgang Goethe University School of Medicine, Frankfurt am Main, Germany
    Bioessays 32:481-7. 2010
    ..We present frequently used methods to decrease Notch signalling, and we discuss how soluble Notch inhibitors may be used to treat diseases...
  10. ncbi request reprint Mechanisms controlling EGF receptor endocytosis and degradation
    I Dikic
    Institute of Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Biochem Soc Trans 31:1178-81. 2003
    ..The emerging importance of the ubiquitin ligase Cbl and the adaptor molecule CIN85 (Cbl-interacting protein of 85 kDa) in the regulation of these pathways is discussed in detail...
  11. ncbi request reprint ALIX-ing phospholipids with endosome biogenesis
    Ivan Dikic
    Institute of Biochemistry II, Goethe University Medical School, 60590 Frankfurt, Germany
    Bioessays 26:604-7. 2004
    ..In vivo, LBPA functions are controlled by the adaptor protein Alix and depend on pH gradients along the endosomal compartments...
  12. ncbi request reprint Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix
    M H H Schmidt
    Institute of Biochemistry II, University Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Oncogene 25:3071-8. 2006
    ..Such a relationship provides a mechanism to fine-tune the kinetics of RTK endocytosis and degradation depending on the pool of active Cdc42 and the duration of EGFR signaling...
  13. ncbi request reprint Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins
    I Ivankovic-Dikic
    Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S 75124, Sweden
    Nat Cell Biol 2:574-81. 2000
    ..Thus, Pyk2/FAK have important functions in signal integration proximal to integrin/growth-factor receptor complexes in neurons...
  14. ncbi request reprint Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling
    I Dikic
    Ludwig Institute for Cancer Research, Uppsala, S 75124, Sweden
    J Biol Chem 273:14301-8. 1998
    ..Specific expression of Pyk2-H and its activation by antigens or chemokines in hematopoietic cells may contribute toward the generation of cell type-specific signals involved in host immune responses...
  15. ncbi request reprint Regulation of ubiquitin-binding proteins by monoubiquitination
    Daniela Hoeller
    Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Nat Cell Biol 8:163-9. 2006
    ..We propose that monoubiquitination of ubiquitin-binding proteins inhibits their capacity to bind to and control the functions of ubiquitinated targets in vivo...
  16. ncbi request reprint Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
    Marzena Bienko
    Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Science 310:1821-4. 2005
    ..Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS...
  17. ncbi request reprint Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases
    Katarzyna Kowanetz
    Institute of Biochemistry II, Goethe University Medical School, 60590 Frankfurt, Germany
    J Biol Chem 279:32786-95. 2004
    ..We suggest that Sts-1 and Sts-2 represent a novel class of Ub-binding proteins that regulate RTK endocytosis and control growth factor-induced cellular functions...
  18. ncbi request reprint CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases
    Iwona Szymkiewicz
    Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S 75124, Sweden
    J Biol Chem 277:39666-72. 2002
    ..Our data reveal a common pathway utilized by Cbl and Cbl-b that may have an important and redundant function in negative regulation of ligand-activated as well as oncogenically activated RTKs in vivo...
  19. ncbi request reprint G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals
    A Blaukat
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Mol Cell Biol 20:6837-48. 2000
    ..Cooperative signaling by multiple G proteins thus might represent a novel concept implicated in the regulation of cellular responses by GPCRs...
  20. doi request reprint Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins
    S Wagner
    Institute for Biochemistry II, Goethe University Medical School, Frankfurt, Germany
    Oncogene 27:3739-45. 2008
    ..Taken together, these data illustrate an important role for ubiquitin binding in the negative regulation of NF-kappaB signaling by ABINs and identify UBAN as a novel UBD...
  21. ncbi request reprint Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
    Kaisa Haglund
    Ludwig Institute for Cancer Research, Husargatan 3, SE 75 124 Uppsala, Sweden
    Nat Cell Biol 5:461-6. 2003
    ..Thus, monoubiquitination is the principal signal responsible for the movement of RTKs from the plasma membrane to the lysosome...
  22. ncbi request reprint Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors
    Philippe Soubeyran
    Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S 75124, Sweden
    Nature 416:183-7. 2002
    ..Thus, the evolutionary divergent C terminus of Cbl uses a mechanism that is functionally separable from the ubiquitin ligase activity of Cbl to mediate ligand-dependent downregulation of receptor tyrosine kinases...
  23. ncbi request reprint Role of ubiquitin- and Ubl-binding proteins in cell signaling
    Vladimir Kirkin
    Institute of Biochemistry II, Goethe University Hospital, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Curr Opin Cell Biol 19:199-205. 2007
    ....
  24. pmc Ubiquitylation and cell signaling
    Kaisa Haglund
    Institute for Biochemistry II, University Hospital of Goethe University, Frankfurt am Main, Germany
    EMBO J 24:3353-9. 2005
    ..Here, we highlight several recent examples on how Ub regulates signaling and how signaling regulates ubiquitylation during physiological and pathological cellular processes...
  25. ncbi request reprint Ubiquitin and NEDD8: brothers in arms
    Mirko H H Schmidt
    Institute of Biochemistry II, Johann Wolfgang Goethe University School of Medicine, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Sci STKE 2006:pe50. 2006
    ..This unexpected redundancy introduces additional complexity to the current view of Ub signaling pathways...
  26. ncbi request reprint Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
    Daniela Hoeller
    Institute of Biochemistry II, Goethe University School of Medicine, University Hospital, Building 75, Theodour Stern Kai 7, D 60590 Frankfurt, Germany
    Nat Rev Cancer 6:776-88. 2006
    ..Here we summarize the common principles and specific features of ubiquitin and Ubls in the regulation of cancer-relevant pathways, and discuss new strategies to target ubiquitin signalling in drug discovery...
  27. pmc Cargo- and compartment-selective endocytic scaffold proteins
    Iwona Szymkiewicz
    Institute of Biochemistry II, Goethe University Medical School, 60590 Frankfurt, Germany
    Biochem J 383:1-11. 2004
    ..In the present review we summarize present knowledge on endocytic scaffold molecules and discuss their functions...
  28. doi request reprint Inhibitors of apoptosis catch ubiquitin
    Krishnaraj Rajalingam
    Emmy Noether Group of the DFG, Goethe University Medical School, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Biochem J 417:e1-3. 2009
    ..These novel observations establish IAPs as ubiquitin-interacting proteins and opens up new lines of investigation...
  29. pmc Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner
    Nicola Crosetto
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Main, Germany
    J Biol Chem 283:35173-85. 2008
    ..Our study is the first to reveal the composite and regulated topography of Wrnip1 in the human nucleus, highlighting its potential role in replication and other nuclear transactions...
  30. ncbi request reprint Distinct monoubiquitin signals in receptor endocytosis
    Kaisa Haglund
    Institute of Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Trends Biochem Sci 28:598-603. 2003
    ....
  31. ncbi request reprint Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain
    Noriaki Shimokawa
    Molecular Signaling Group, Ludwig Institute for Cancer Research, Uppsala, S 75124, Sweden
    J Neurosci 22:9160-5. 2002
    ..Together, our results indicate that Past-A is a brain-specific glucose transporter that may represent an adaptation mechanism regulating sugar homeostasis in neuronal cells after hypercapnia...
  32. pmc Ubiquitination and selective autophagy
    S Shaid
    Institute of Biochemistry II, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cell Death Differ 20:21-30. 2013
    ..In this review, we focus on the special role of ubiquitin signals and selective autophagy receptors in sorting a variety of autophagic cargos...
  33. ncbi request reprint Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades
    A Blaukat
    Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala S 75124, Sweden
    J Biol Chem 274:14893-901. 1999
    ..Taken together, our data reveal specific pathways that couple Pyk2 with MAP kinases: the Grb2/Sos complex connects Pyk2 to the activation of ERK, whereas adaptor proteins p130Cas and Crk link Pyk2 with the JNK pathway...
  34. ncbi request reprint Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function
    A Blaukat
    Ludwig Institute for Cancer Research, Box 595, S 75124 Uppsala, Sweden
    J Biol Chem 276:40431-40. 2001
    ..The differential usage of clustered phosphoacceptor sites points to distinct roles of multiple kinases in controlling G protein-coupled receptor function...
  35. ncbi request reprint CYLD in ubiquitin signaling and tumor pathogenesis
    Fumiyo Ikeda
    Institute for Biochemistry II, Goethe University Medical School, Frankfurt 60590, Germany
    Cell 125:643-5. 2006
    ....
  36. doi request reprint A role for ubiquitin in selective autophagy
    Vladimir Kirkin
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Mol Cell 34:259-69. 2009
    ..This review explores the hypothesis that ubiquitin represents a selective degradation signal suitable for targeting various types of cargo, ranging from protein aggregates to membrane-bound organelles and microbes...
  37. doi request reprint A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
    Vladimir Kirkin
    Institute of Biochemistry II, Goethe University, Frankfurt Main, Germany
    Mol Cell 33:505-16. 2009
    ..We propose that NBR1 and p62 act as receptors for selective autophagosomal degradation of ubiquitinated targets...
  38. ncbi request reprint Ubiquitin hubs in oncogenic networks
    Nicola Crosetto
    Institute of Biochemistry II, Goethe University Hospital, Frankfort on the Main, Germany
    Mol Cancer Res 4:899-904. 2006
    ..Here, we define such proteins as key-nodes regulated by ubiquitin, discuss examples of their oncogenic aberrations, and indicate how pharmacologic manipulation of such molecular hubs might improve anticancer therapy...
  39. pmc Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series
    Fumiyo Ikeda
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    EMBO Rep 9:536-42. 2008
    ..Here, we describe recent progress in the understanding of atypical Ub chain assembly and their recognition by Ub-binding domains, and we discuss further their functional roles in vivo...
  40. pmc Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes
    Fumiyo Ikeda
    Institute of Biochemistry II, Goethe University Medical School, Frankfurt, Germany
    EMBO J 26:3451-62. 2007
    ..We propose that the ULD is a regulatory component of the TBK1/IKK-i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways...
  41. doi request reprint What determines the specificity and outcomes of ubiquitin signaling?
    Fumiyo Ikeda
    Frankfurt Institute for Molecular Life Sciences, Goethe University School of Medicine, Main, Germany
    Cell 143:677-81. 2010
    ....
  42. ncbi request reprint E3-independent monoubiquitination of ubiquitin-binding proteins
    Daniela Hoeller
    Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Mol Cell 26:891-8. 2007
    ..This modification is mechanistically and functionally distinct from E3-mediated and growth factor-dependent monoubiquitination...
  43. ncbi request reprint Oncogenic breakdowns in endocytic adaptor proteins
    Nicola Crosetto
    Institute of Biochemistry II, Goethe University Hospital, Theodor Stern Kai 7, D 60590, Frankfurt Main, Germany
    FEBS Lett 579:3231-8. 2005
    ..We discuss how breakdowns in the function of endocytic adaptors might facilitate impairment of tissue homeostasis and consequent tumor development...
  44. pmc Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors
    Kaisa Haglund
    Ludwig Institute for Cancer Research, Box 595, Husargatan 3, S 75124 Uppsala, Sweden
    Proc Natl Acad Sci U S A 99:12191-6. 2002
    ..Thus, our data demonstrate that Cbl/Cbl-b can mediate polyubiquitination of cargo as well as monoubiquitination of CIN85 to control endosomal sorting and degradation of receptor tyrosine kinases...
  45. pmc Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation
    Kaisa Haglund
    Institute for Biochemistry II, Building 75, Goethe University Medical School, Theodor Stern Kai 7, 605 90 Frankfurt am Main, Germany
    EMBO Rep 6:635-41. 2005
    ..Sprouty2 therefore acts as an inducible inhibitor of EGFR downregulation by targeting both the Cbl and CIN85 pathways...
  46. pmc Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl
    Philippe Soubeyran
    Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S 75124, Sweden
    Biochem J 370:29-34. 2003
    ..Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2...
  47. ncbi request reprint Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors
    Katarzyna Kowanetz
    Institute of Biochemistry II, University of Frankfurt Medical School, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Biol Chem 278:39735-46. 2003
    ..Thus, specific interactions of CIN85 SH3 domains with the PXXXPR motif in Cbl play multiple roles in down-regulation of receptor tyrosine kinases...
  48. ncbi request reprint Dab2 links CIN85 with clathrin-mediated receptor internalization
    Katarzyna Kowanetz
    Ludwig Institute for Cancer Research, Husargatan 3, Uppsala 75124, Sweden
    FEBS Lett 554:81-7. 2003
    ..Taken together, our data indicate a dynamic interplay between CIN85 and its effectors during endocytosis of receptor tyrosine kinases...
  49. ncbi request reprint CIN85/CMS family of adaptor molecules
    Ivan Dikic
    Ludwig Institute for Cancer Research, Husargatan 3, SE 75 124, Uppsala, Sweden
    FEBS Lett 529:110-5. 2002
    ..These interactions enable CIN85/CMS to function within a network of signaling pathways that co-ordinate critical steps involved in downregulation and degradation of RTKs...
  50. ncbi request reprint Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells
    Frank Eckerdt
    Department of Gynecology and Obstetrics, J W Goethe University, Theodor Stern Kai 7, Frankfurt D 60590, Germany
    J Biol Chem 280:36575-83. 2005
    ..Since previous reports suggested that Plk1 is a substrate of Pin1, our work adds a new dimension to this interaction of two important mitotic regulators...
  51. ncbi request reprint Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites
    Kaisa Haglund
    Institute for Biochemistry II, Building 75, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Cell Sci 117:2557-68. 2004
    ..Our results indicate that recruitment of Pyk2/Cbl complexes to lipid rafts participates in growth factor-induced regulation of the actin cytoskeleton in growing neurites...
  52. ncbi request reprint Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases
    Josipa Raguz
    Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    FEBS Lett 581:4767-72. 2007
    ..As a consequence, Sts-1-containing receptor complexes are inactive, whereas Sts-2-containing complexes are signalling competent...
  53. pmc Spatial organization of transmembrane receptor signalling
    Ioanna Bethani
    Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University, Frankfurt am Main, Germany
    EMBO J 29:2677-88. 2010
    ..We review the current knowledge about the functions of clustering of transmembrane receptors and lipid-protein interactions important for the spatial organization of signalling at the membrane...
  54. pmc Proteasome subunit Rpn13 is a novel ubiquitin receptor
    Koraljka Husnjak
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Nature 453:481-8. 2008
    ..Because Rpn13 is also the proteasomal receptor for Uch37, a deubiquitinating enzyme, our findings suggest a coupling of chain recognition and disassembly at the proteasome...
  55. ncbi request reprint SH3P2 in complex with Cbl and Src
    Iwona Szymkiewicz
    Institute of Biochemistry II, Goethe University Medical School, Frankfurt, Germany
    FEBS Lett 565:33-8. 2004
    ..Our data implicate that SH3P2, a novel component of adhesion sites, is involved in Cbl and Src-mediated pathways...
  56. ncbi request reprint Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport
    Ivan Dikic
    Institute of Biochemistry II, Goethe University School of Medicine, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Eur J Cell Biol 86:505-12. 2007
    ..This review intends to give an overview on the mechanisms of Cbl-mediated cell transformation in light of the dysregulated intracellular trafficking of RTKs...
  57. pmc CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors
    Katarzyna Kowanetz
    Institute of Biochemistry II, Goethe University Medical School, 60590 Frankfurt, Germany
    Mol Biol Cell 15:3155-66. 2004
    ..We propose that CIN85 functions as a scaffold molecule that binds to numerous endocytic accessory proteins, thus controlling distinct steps in trafficking of EGF receptors along the endocytic and recycling pathways...
  58. ncbi request reprint Receptor endocytosis via ubiquitin-dependent and -independent pathways
    Daniela Höller
    Institute of Biochemistry II, Goethe University Medical School, 60590 Frankfurt, Germany
    Biochem Pharmacol 67:1013-7. 2004
    ..Here, we discuss the current view on the role of Ub-dependent and -independent pathways in receptor internalization and endocytosis in mammalian cells...
  59. doi request reprint Caspase-8 is involved in neovascularization-promoting progenitor cell functions
    Dörte Scharner
    Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 29:571-8. 2009
    ..Caspases mediate apoptosis but are also involved in other critical biological processes. Therefore, we aimed to address the role of caspases in proangiogenic cells...
  60. ncbi request reprint NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets
    Vladimir Kirkin
    Institute of Biochemistry II, Goethe University, Frankfurt Main, Germany
    Autophagy 5:732-3. 2009
    ..We propose that NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited...
  61. pmc CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
    Noriaki Shimokawa
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt Main, Germany
    EMBO J 29:2421-32. 2010
    ..These findings indicate an important function of CIN85 in the regulation of dopamine receptor functions and provide a molecular explanation for the hyperactive behaviour of CIN85(Deltaex2) mice...
  62. pmc Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
    Patrick Schreiner
    Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, D 85747 Garching, Germany
    Nature 453:548-52. 2008
    ..Finally, we provide a model structure of Rpn13 complexed to diubiquitin, which provides insights into how Rpn13 as a ubiquitin receptor is coupled to substrate deubiquitination by Uch37...
  63. pmc Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex
    Mirko H H Schmidt
    William and Karen Davidson Laboratory of Brain Tumor Biology, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Mol Cell Biol 24:8981-93. 2004
    ..We propose that Alix inhibits EGFR internalization by attenuating the interaction between Cbl and SETA/CIN85 and by inhibiting Cbl-mediated ubiquitination of the EGFR...
  64. pmc Signal processing by its coil zipper domain activates IKK gamma
    Stuart Bloor
    Division of Protein and Nucleic Acid Chemistry, Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 105:1279-84. 2008
    ..We propose that this signal processing may involve homophilic CoZi interactions as suggested by the enhanced affinity of CoZi domains from constitutively active IKKgamma...
  65. ncbi request reprint CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function
    Rosa Molfetta
    Department of Experimental Medicine and Pathology, Institute Pasteur Fondazione Cenci Bolognetti, University La Sapienza, Rome, Italy
    J Immunol 175:4208-16. 2005
    ..This role of CIN85 could be extended to include other multimeric immune receptors, such as the T and B cell receptors, providing a more general molecular mechanism for attenuating immune responses...
  66. ncbi request reprint Assays to monitor degradation of the EGF receptor
    Mirko H H Schmidt
    Institute for Biochemistry II, Goethe University School of Medicine, Germany
    Methods Mol Biol 327:131-8. 2006
    ..Finally, protocols to quantitatively measure degradation of the EGFR by pulse chase experiments or using radiolabeled ligands such as 125I-EGF are presented...
  67. ncbi request reprint Cbl promotes clustering of endocytic adaptor proteins
    Daniela Jozic
    Division of Protein Structure, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Nat Struct Mol Biol 12:972-9. 2005
    ..These results provide molecular explanations for a novel mechanism by which Cbl controls receptor downregulation...
  68. doi request reprint Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking
    David Nonis
    Department of Neurology, J W Goethe University Medical School, Frankfurt M, Germany
    Cell Signal 20:1725-39. 2008
    ..Functional studies demonstrated that ataxin-2 affects endocytic trafficking of the epidermal growth factor receptor (EGFR). Taken together, these data implicate ataxin-2 to play a role in endocytic receptor cycling...
  69. ncbi request reprint Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance
    Caixia Guo
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    J Biol Chem 283:4658-64. 2008
    ..However, the ubiquitin-binding motifs do not affect Polkappa half-life. Finally, we have examined levels of Polkappa expression following the exposure of mouse cells to benzo[a]pyrene-dihydrodiol epoxide or UVB radiation...
  70. pmc Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities
    Mirko H H Schmidt
    William and Karen Davidson Laboratory of Brain Tumor Biology, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Biol Chem 280:3414-25. 2005
    ..We propose a model whereby Src antagonizes the effects of Alix by phosphorylation of its C terminus, leading to the disruption of interactions with target proteins...
  71. ncbi request reprint EGFR trafficking: parkin' in a jam
    Koraljka Husnjak
    Nat Cell Biol 8:787-8. 2006
  72. ncbi request reprint Proline-rich tyrosine kinase 2 regulates proliferation and differentiation of prostate cells
    Antonietta Picascia
    Dipartimento di Biologia e Patologia Molecolare e Cellulare Luigi Califano, Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Universita Degli Studi Di Napoli, Federico II Via Pansini 5, 80131, Naples, Italy
    Mol Cell Endocrinol 186:81-7. 2002
    ..Taken together our results suggest that Pyk2 plays a role in the regulation of prostate cell proliferation and, more interestingly, its expression may represents a sensitive marker of prostate state of differentiation...
  73. ncbi request reprint Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells
    Albrecht Piiper
    Department of Internal Medicine and Institute for Biochemistry II, Johann Wolfgang Goethe University, D 60590 Frankfurt, Germany
    J Biol Chem 277:43623-30. 2002
    ....
  74. ncbi request reprint A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro
    Masa Katic
    Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, HR 10000 Zagreb, Croatia
    Front Biosci 11:1722-32. 2006
    ..Together, data presented here demonstrate that clinoptilolite affects cellular microenvironment through mechanisms that are dependent on adsorptive and ion-exchange characteristics of this material...
  75. ncbi request reprint Reading protein modifications with interaction domains
    Bruce T Seet
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nat Rev Mol Cell Biol 7:473-83. 2006
    ..We also identify common strategies through which modification-dependent interactions synergize to regulate cell behaviour...
  76. ncbi request reprint Protein kinase A mediates cAMP-induced tyrosine phosphorylation of the epidermal growth factor receptor
    Albrecht Piiper
    Department of Internal Medicine, University of Saarland, D 66421, Homburg Saar, Germany
    Biochem Biophys Res Commun 301:848-54. 2003
    ..While PKA may directly phosphorylate the EGFR on serine residues, PKA-induced tyrosine phosphorylation of the EGFR occurs by an indirect mechanism...
  77. pmc Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage
    Caixia Guo
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Mol Cell Biol 26:8892-900. 2006
    ..In cells exposed to UV radiation, the association of REV1 with replication foci is dependent on functional UBMs. The UBMs of REV1 are shown to contribute to DNA damage tolerance and damage-induced mutagenesis in vivo...
  78. ncbi request reprint The Cbl interactome and its functions
    Mirko H H Schmidt
    Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Nat Rev Mol Cell Biol 6:907-18. 2005
    ..Dysregulation of spatial or temporal constraints in the Cbl interactome results in the development of human pathologies such as immune diseases, diabetes and cancer...
  79. ncbi request reprint CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes
    Irini Tossidou
    Division of Nephrology, Department of Medicine, and Division of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biol Chem 282:7457-64. 2007
    ..Because repression of CIN85 protein leads to a restored RTK signaling response, our results support an important role of CD2AP/CIN85 protein balance in the normal signaling response of podocytes...
  80. pmc Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae
    Joanne L Parker
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, United Kingdom
    Nucleic Acids Res 35:881-9. 2007
    ..Like its mammalian homolog, budding yeast Polymerase eta itself is ubiquitylated in a manner dependent on its ubiquitin-binding domain...
  81. ncbi request reprint Flt3-dependent transformation by inactivating c-Cbl mutations in AML
    Bülent Sargin
    Department of Medicine, Hematology and Oncology, and Interdisciplinary Center for Clinical Research, University Hospital Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Blood 110:1004-12. 2007
    ..Our results indicate an important role of Cbl proteins in Flt3 signal modulation. Also, the data suggest a novel mechanism of leukemic transformation in AML by mutational inactivation of negative RTK regulators...
  82. ncbi request reprint Molecular responses to acidosis of central chemosensitive neurons in brain
    Noriaki Shimokawa
    Department of Integrative Physiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi shi 371 8511, Japan
    Cell Signal 17:799-808. 2005
    ..This review discusses current knowledge on the signalling mechanisms and molecular basis of neuronal adaptation during acidosis...
  83. ncbi request reprint Compartmentalization of growth factor receptor signalling
    Daniela Hoeller
    Institute for Biochemistry II, University Hospital of Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Curr Opin Cell Biol 17:107-11. 2005
    ....
  84. doi request reprint Novel markers of normal and neoplastic human plasmacytoid dendritic cells
    Teresa Marafioti
    Leukaemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
    Blood 111:3778-92. 2008
    ....