Research Topics
Genomes and Genes | T N DearSummaryAffiliation: Ingenium Pharmaceuticals Country: Germany Publications
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Detail Information
Publications
Identification and characterization of two novel calpain large subunit genesT N Dear
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Gene 274:245-52. 2001..The 13 human large subunit genes and the single small subunit gene are located in eight syntenic groups on chromosomes 1, 2, 3, 6, 11, 15, 19 and X...- Gene structure, chromosomal localization, and expression pattern of Capn12, a new member of the calpain large subunit gene familyT N Dear
Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, D 79108, Germany
Genomics 68:152-60. 2000..4 cM. Refined mapping of Capn5, also previously localized to chromosome 7, indicated that it was not closely linked to Capn12, mapping tightly linked to a marker positioned at 48.5 cM... - CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6T N Dear
Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, D 79108, Germany
Genomics 59:243-7. 1999..The discovery of this new calpain emphasizes the complexity of the calpain family, with members being distinguished on the basis of protease activity, calcium dependence, and tissue expression... - Hox11 acts cell autonomously in spleen development and its absence results in altered cell fate of mesenchymal spleen precursorsB Kanzler
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, 79108, Germany
Dev Biol 234:231-43. 2001..The formation of the spleen primordium before the entry of haematopoietic cells does not require the activity of Hox11. However, subsequent differentiation of spleen precursor cells is dependent on the Hox11 gene... - Cloning, structure, expression analysis, and assignment to mouse chromosome 7 of the gene Zfp296 encoding a zinc finger proteinT N Dear
Department of Developmental Immunology, Max-Planck Institute for Immunobiology, Freiburg, Germany
Mamm Genome 11:1037-9. 2000 - Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during developmentT N Dear
Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
Mech Dev 89:201-9. 1999..Capn11 mRNA is restricted exclusively to spermatocytes and only during the later stages of meiosis... - Capn7: a highly divergent vertebrate calpain with a novel C-terminal domainT Franz
Max-Planck Institute for Immunobiology, Stuebeweg 51, D-79108 Freiburg, Germany
Mamm Genome 10:318-21. 1999 - Hox11 is required to maintain normal Wt1 mRNA levels in the developing spleenK Koehler
Max Planck Institute for Immunobiology, Freiburg, Germany
Dev Dyn 218:201-6. 2000..As Wt1-null embryos have recently been reported to be asplenic, these findings suggest that Wt1 and Hox11 may be components common to a genetic hierarchy that is required for spleen development... - A novel serine protease overexpressed in the hair follicles of nude miceN Meier
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, D 79108, Germany
Biochem Biophys Res Commun 258:374-8. 1999..Thus, BSSP is the first serine protease known to be expressed in the sebaceous gland. In nude mouse skin, this gene is overexpressed... - A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genesT N Dear
MRC Laboratory of Molecular Biology, Cambridge, UK
Gene 141:225-9. 1994..Gene 311 exhibits a similar temporal pattern of expression to the NK genes in this cluster. Therefore, 311 may constitute part of a homeobox cluster in which the genes are both co-ordinately regulated and functionally related... - Characterization of mouse and human nude genesM Schorpp
Deutsches Krebsforschungszentrum, Heidelberg, Germany
Immunogenetics 46:509-15. 1997.... 
The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genesT N Dear
Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom
Proc Natl Acad Sci U S A 90:4431-5. 1993..These all contain a threonine residue in place of the more common isoleucine or valine in helix 3 of the homeodomain. HOX11 therefore appears to belong to a family of DNA-binding transactivators of transcription...- The Hox11 gene is essential for cell survival during spleen developmentT N Dear
MRC Laboratory of Molecular Biology, Cambridge, UK
Development 121:2909-15. 1995..This function for hox11 suggests that enhanced cell survival may result from the t(10;14) which activates HOX11 in T cell leukaemias, further strengthening the association between oncogene-induced cell survival and tumorigenesis... - The WDNM1 gene product is a novel member of the 'four-disulphide core' family of proteinsT N Dear
Department of Medicine, University of Sydney, Westmead Hospital, NSW, Australia
Biochem Biophys Res Commun 176:247-54. 1991..Possible modulation in the level of this protein product could be related to overall proteinase activity of specific tumour cells which, in turn, could influence the invasive and metastatic potential of such cell populations... - Molecular cloning of putative odorant-binding and odorant-metabolizing proteinsT N Dear
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Biochemistry 30:10376-82. 1991..Its expression appears to be localized to the Bowman's glands, the site of several previously identified olfactory-specific biotransformation enzymes... - Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosaT N Dear
MRC Laboratory of Molecular Biology, Cambridge, UK
EMBO J 10:2813-9. 1991..Therefore, the olfactory mucosa may possess diverse, functionally-distinct odorant-binding proteins which recognize and bind separate classes of odorants...