Zoya Ignatova

Summary

Country: Germany

Publications

  1. ncbi Aggregation of a slow-folding mutant of a beta-clam protein proceeds through a monomeric nucleus
    Zoya Ignatova
    Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Biochemistry 44:7266-74. 2005
  2. ncbi Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein
    Zoya Ignatova
    Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 281:12959-67. 2006
  3. ncbi Effects of osmolytes on protein folding and aggregation in cells
    Zoya Ignatova
    Max Planck Institute for Biochemistry, Martinsried, Germany
    Methods Enzymol 428:355-72. 2007
  4. pmc Computational genes: a tool for molecular diagnosis and therapy of aberrant mutational phenotype
    Israel M Martinez-Perez
    Institute of Computer Technology, Hamburg University of Technology, Hamburg 21073, Germany
    BMC Bioinformatics 8:365. 2007
  5. pmc In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence
    Zoya Ignatova
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried 82152, Germany
    J Biol Chem 282:36736-43. 2007
  6. pmc FANSe: an accurate algorithm for quantitative mapping of large scale sequencing reads
    Gong Zhang
    Biochemistry, Institute of Biochemistry and Biology, University of Potsdam, Karl Liebknecht Str 24 25, 14467 Potsdam, Germany
    Nucleic Acids Res 40:e83. 2012
  7. doi Transient ribosomal attenuation coordinates protein synthesis and co-translational folding
    Gong Zhang
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nat Struct Mol Biol 16:274-80. 2009
  8. pmc Orthogonal cross-seeding: an approach to explore protein aggregates in living cells
    Justyna Hinz
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Biochemistry 47:4196-200. 2008
  9. pmc Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant
    Zoya Ignatova
    Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Proc Natl Acad Sci U S A 103:13357-61. 2006
  10. pmc From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein
    Zoya Ignatova
    Max Planck Institute for Biochemistry, Martinsreid, Germany
    Biopolymers 88:157-63. 2007

Collaborators

  • Angelo Valleriani
  • Gong Zhang
  • Justyna Hinz
  • Israel M Martinez-Perez
  • Volker Kasche
  • Chuanle Xiao
  • Ivan Fedyunin
  • Sebastian Kirchner
  • Magdalena Hubalewska
  • Lila M Gierasch
  • Karl Heinz Zimmermann
  • Boris Galunsky

Detail Information

Publications13

  1. ncbi Aggregation of a slow-folding mutant of a beta-clam protein proceeds through a monomeric nucleus
    Zoya Ignatova
    Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Biochemistry 44:7266-74. 2005
    ..03 A spacing between adjacent beta-sheets...
  2. ncbi Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein
    Zoya Ignatova
    Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 281:12959-67. 2006
    ....
  3. ncbi Effects of osmolytes on protein folding and aggregation in cells
    Zoya Ignatova
    Max Planck Institute for Biochemistry, Martinsried, Germany
    Methods Enzymol 428:355-72. 2007
    ..Having in vivo methods to analyze how osmolytes affect folding and aggregation enhances our ability to further these goals greatly...
  4. pmc Computational genes: a tool for molecular diagnosis and therapy of aberrant mutational phenotype
    Israel M Martinez-Perez
    Institute of Computer Technology, Hamburg University of Technology, Hamburg 21073, Germany
    BMC Bioinformatics 8:365. 2007
    ..A finite state machine manipulating information-carrying DNA strands can be used to perform autonomous molecular-scale computations at the cellular level...
  5. pmc In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence
    Zoya Ignatova
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried 82152, Germany
    J Biol Chem 282:36736-43. 2007
    ..These results point to an evolution of the dominant sequences in intracellular aggregates and may provide molecular insight into origins of toxic prefibrillar aggregates...
  6. pmc FANSe: an accurate algorithm for quantitative mapping of large scale sequencing reads
    Gong Zhang
    Biochemistry, Institute of Biochemistry and Biology, University of Potsdam, Karl Liebknecht Str 24 25, 14467 Potsdam, Germany
    Nucleic Acids Res 40:e83. 2012
    ..It shows a remarkable coverage of low-abundance mRNAs which is important for quantitative processing of RNA-Seq datasets...
  7. doi Transient ribosomal attenuation coordinates protein synthesis and co-translational folding
    Gong Zhang
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nat Struct Mol Biol 16:274-80. 2009
    ..We propose that local discontinuous translation temporally separates the translation of segments of the peptide chain and actively coordinates their co-translational folding...
  8. pmc Orthogonal cross-seeding: an approach to explore protein aggregates in living cells
    Justyna Hinz
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Biochemistry 47:4196-200. 2008
    ..In its simplicity, the approach is also potentially amenable to screen also for compounds that can reshape the aggregate core and induce the formation of alternative nonamyloidogenic species...
  9. pmc Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant
    Zoya Ignatova
    Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Proc Natl Acad Sci U S A 103:13357-61. 2006
    ..In addition, these results should be of practical importance because they may enable protein expression at higher efficiency under conditions where aggregation competes with proper folding...
  10. pmc From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein
    Zoya Ignatova
    Max Planck Institute for Biochemistry, Martinsreid, Germany
    Biopolymers 88:157-63. 2007
    ....
  11. ncbi Pro-sequence and Ca2+-binding: implications for folding and maturation of Ntn-hydrolase penicillin amidase from E. coli
    Zoya Ignatova
    Institute of Biotechnology II, Technical University Hamburg Harburg, Denickestr 15, 21073 Hamburg, Germany
    J Mol Biol 348:999-1014. 2005
    ..The cation shifts the equilibrium towards the native state and facilitates the autocatalytic processing of the pro-peptide...
  12. ncbi Fragments of pro-peptide activate mature penicillin amidase of Alcaligenes faecalis
    Volker Kasche
    Institute of Biotechnology II, Technical University Hamburg Harburg, Hamburg, Germany
    Eur J Biochem 270:4721-8. 2003
    ..These extensions of the A-chain raised the activity up to 2.3-fold and increased the specificity constants for benzylpenicillin hydrolysis mainly by an increase of the turnover number (kcat)...
  13. ncbi Unusual signal peptide directs penicillin amidase from Escherichia coli to the Tat translocation machinery
    Zoya Ignatova
    Institut für Biotecnologie II, Technische Universitat Hamburg Harburg, Denickestrasse 15, Hamburg, 21073, Germany
    Biochem Biophys Res Commun 291:146-9. 2002
    ....