Markus Huss

Summary

Country: Germany

Publications

  1. ncbi Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c
    Markus Huss
    , Fachbereich Biologie/Chemie, Abteilung Tierphysiologie, , Germany
    J Biol Chem 277:40544-8. 2002
  2. ncbi Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase
    Svenja Bockelmann
    Universitat Osnabruck, Fachbereich Biologie chemie, Abteilung Tierphysiologie, Barbarastrasse 11, 49069 Osnabruck, Germany
    J Biol Chem 285:38304-14. 2010
  3. ncbi Vacuolar H(+)-ATPases: intra- and intermolecular interactions
    Markus Huss
    University of Osnabruck, Faculty of Biology and Chemistry, Department of Animal Physiology, Barbarastrasse 11, 49076 Osnabruck, Germany
    Eur J Cell Biol 90:688-95. 2011
  4. ncbi Archazolid and apicularen: novel specific V-ATPase inhibitors
    Markus Huss
    Universitat Osnabruck, Fachbereich Biologie chemie, Abteilung Tierphysiologie, 49069 Osnabruck, Germany
    BMC Biochem 6:13. 2005
  5. ncbi Inhibitors of V-ATPases: old and new players
    Markus Huss
    Department of Biology Chemistry, University of Osnabruck, 49069 Osnabruck, Germany
    J Exp Biol 212:341-6. 2009
  6. ncbi Influence of ATP and ADP on dissociation of the V-ATPase into its V(1) and V(O) complexes
    Markus Huss
    Fachbereich Biologie chemie, Abteilung Tierphysiologie, Universitat Osnabruck, 49069, Osnabruck, Germany
    FEBS Lett 581:5566-72. 2007
  7. ncbi The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid
    Christin Osteresch
    Fachbereich Biologie chemie, Abteilung Tierphysiologie, Universitat Osnabruck, Barbarastrasse 11, 49069 Osnabruck, German
    J Biol Chem 287:31866-76. 2012
  8. ncbi Vacuolar-type proton pumps in insect epithelia
    Helmut Wieczorek
    Department of Biology Chemistry, University of Osnabruck, 49069 Osnabruck, Germany
    J Exp Biol 212:1611-9. 2009
  9. ncbi The insect plasma membrane H+ V-ATPase: intra-, inter-, and supramolecular aspects
    Helmut Wieczorek
    Department of Biology Chemistry, University of Osnabruck, 49069 Osnabruck, Germany
    J Bioenerg Biomembr 35:359-66. 2003
  10. ncbi Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases
    Brigitte Kunze
    Arbeitsgruppe Mikrobielle Kommunikation, Helmholtz Zentrum für Infektionsforschung, 38124 Braunschweig, Germany
    FEBS Lett 581:3523-7. 2007

Collaborators

Detail Information

Publications14

  1. ncbi Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c
    Markus Huss
    , Fachbereich Biologie/Chemie, Abteilung Tierphysiologie, , Germany
    J Biol Chem 277:40544-8. 2002
    ..Binding was also prevented by the plecomacrolides bafilomycin A(1) and B(1), respectively, but not by the benzolactone enamide salicylihalamide, a member of a novel class of V-ATPase inhibitors...
  2. ncbi Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase
    Svenja Bockelmann
    Universitat Osnabruck, Fachbereich Biologie chemie, Abteilung Tierphysiologie, Barbarastrasse 11, 49069 Osnabruck, Germany
    J Biol Chem 285:38304-14. 2010
    ..This hypothesis was supported by an additional subset of mutations within helix 4 that revealed that leucine 144 plays a role in archazolid binding...
  3. ncbi Vacuolar H(+)-ATPases: intra- and intermolecular interactions
    Markus Huss
    University of Osnabruck, Faculty of Biology and Chemistry, Department of Animal Physiology, Barbarastrasse 11, 49076 Osnabruck, Germany
    Eur J Cell Biol 90:688-95. 2011
    ..Both features require distinct intramolecular as well as intermolecular interactions. Here we will summarize our own results together with newer developments in both of these research areas...
  4. ncbi Archazolid and apicularen: novel specific V-ATPase inhibitors
    Markus Huss
    Universitat Osnabruck, Fachbereich Biologie chemie, Abteilung Tierphysiologie, 49069 Osnabruck, Germany
    BMC Biochem 6:13. 2005
    ..Since their malfunction is correlated with various diseases in humans, the elucidation of the properties of this enzyme for the development of selective inhibitors and drugs is one of the challenges in V-ATPase research...
  5. ncbi Inhibitors of V-ATPases: old and new players
    Markus Huss
    Department of Biology Chemistry, University of Osnabruck, 49069 Osnabruck, Germany
    J Exp Biol 212:341-6. 2009
    ....
  6. ncbi Influence of ATP and ADP on dissociation of the V-ATPase into its V(1) and V(O) complexes
    Markus Huss
    Fachbereich Biologie chemie, Abteilung Tierphysiologie, Universitat Osnabruck, 49069, Osnabruck, Germany
    FEBS Lett 581:5566-72. 2007
    ..Incubation of the V(1)V(O) holoenzyme with various adenine nucleotides revealed that ATP hydrolysis, leading to a state containing tightly bound ADP is necessary for its dissociation...
  7. ncbi The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid
    Christin Osteresch
    Fachbereich Biologie chemie, Abteilung Tierphysiologie, Universitat Osnabruck, Barbarastrasse 11, 49069 Osnabruck, German
    J Biol Chem 287:31866-76. 2012
    ..Therefore, the binding site of benzolactone enamides cannot be formed exclusively by subunit c. Apparently, subunit a substantially contributes to the binding of the benzolactone enamides...
  8. ncbi Vacuolar-type proton pumps in insect epithelia
    Helmut Wieczorek
    Department of Biology Chemistry, University of Osnabruck, 49069 Osnabruck, Germany
    J Exp Biol 212:1611-9. 2009
    ..Finally we review an integrated physiological approach in Malpighian tubules of the yellow fever mosquito Aedes aegypti which shows that the V-ATPase delivers the energy for both transcellular and paracellular ion transport...
  9. ncbi The insect plasma membrane H+ V-ATPase: intra-, inter-, and supramolecular aspects
    Helmut Wieczorek
    Department of Biology Chemistry, University of Osnabruck, 49069 Osnabruck, Germany
    J Bioenerg Biomembr 35:359-66. 2003
    ....
  10. ncbi Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases
    Brigitte Kunze
    Arbeitsgruppe Mikrobielle Kommunikation, Helmholtz Zentrum für Infektionsforschung, 38124 Braunschweig, Germany
    FEBS Lett 581:3523-7. 2007
    ..Since mitochondrial ATPases play a crucial role in the pathophysiology of several human disorders including cancer, cruentaren or synthetic derivatives thereof could form the basis of future therapeutic strategies...
  11. ncbi The first hydroxylated archazolid from the myxobacterium Cystobacter violaceus: isolation, structural elucidation and V-ATPase inhibition
    Dirk Menche
    Helmholtz Zentrum für Infektionsforschung GmbH, Medicinal Chemistry and Chemical Biology, Braunschweig, Germany
    J Antibiot (Tokyo) 60:328-31. 2007
    ..This novel metabolite was evaluated for growth inhibition of murine connective tissue cells and V-ATPase inhibition in comparison to other known archazolids...
  12. ncbi Design, synthesis, and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor
    Dirk Menche
    Helmholtz Zentrum für Infektionsforschung GmbH, Medizinische Chemie, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Bioorg Med Chem Lett 17:1732-5. 2007
    ....
  13. ncbi Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (myxobacteria) with inhibitory effect on mitochondrial ATPase activity. Fermentation and biological properties
    Brigitte Kunze
    Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
    J Antibiot (Tokyo) 59:664-8. 2006
    ..Cruentaren A inhibited F0F1 mitochondrial ATP-hydrolysis in submitochondrial particles of yeasts and beef heart...
  14. ncbi The V-type H(+)-ATPase in Malpighian tubules of Aedes aegypti: localization and activity
    Xing-He Weng
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    J Exp Biol 206:2211-9. 2003
    ..Measures of transepithelial Na(+) and K(+) secretion and estimates of the H(+) flux mediated by the V-type H(+)-ATPase suggest a 1:1 stoichiometry for Na(+)/H(+) and K(+)/H(+) exchange transport across the apical membrane...