Rene Hurlemann

Summary

Country: Germany

Publications

  1. ncbi Intact hippocampal gray matter in schizophrenia as revealed by automatized image analysis postmortem
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anat Embryol (Berl) 210:513-7. 2005
  2. ncbi Segregating intra-amygdalar responses to dynamic facial emotion with cytoarchitectonic maximum probability maps
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci Methods 172:13-20. 2008
  3. ncbi Interrelated neuropsychological and anatomical evidence of hippocampal pathology in the at-risk mental state
    R Hurlemann
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Psychol Med 38:843-51. 2008
  4. ncbi Noradrenergic control of emotion-induced amnesia and hypermnesia
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Rev Neurosci 17:525-32. 2006
  5. ncbi Noradrenergic-glucocorticoid mechanisms in emotion-induced amnesia: from adaptation to disease
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Psychopharmacology (Berl) 197:13-23. 2008
  6. ncbi 5-HT2A receptor density is decreased in the at-risk mental state
    Rene Hurlemann
    Brain Imaging Center West, Research Center Juelich, 52425, Juelich, Germany
    Psychopharmacology (Berl) 195:579-90. 2008
  7. ncbi Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Psychopharmacology (Berl) 194:261-9. 2007
  8. ncbi Noradrenergic modulation of emotion-induced forgetting and remembering
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci 25:6343-9. 2005
  9. ncbi Reduced 5-HT(2A) receptor signaling following selective bilateral amygdala damage
    Rene Hurlemann
    Brain Imaging Center West, Research Center Juelich, Juelich, Germany
    Soc Cogn Affect Neurosci 4:79-84. 2009
  10. ncbi Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anat Embryol (Berl) 210:519-23. 2005

Collaborators

Detail Information

Publications29

  1. ncbi Intact hippocampal gray matter in schizophrenia as revealed by automatized image analysis postmortem
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anat Embryol (Berl) 210:513-7. 2005
    ..Results showed no significant differences between diagnostic groups with respect to the dependent variables, supporting the view that there is no primary alteration of hippocampal gray matter in schizophrenia...
  2. ncbi Segregating intra-amygdalar responses to dynamic facial emotion with cytoarchitectonic maximum probability maps
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci Methods 172:13-20. 2008
    ..Our findings extend current models of facial emotion perception in humans by suggesting an intrinsic functional differentiation within the amygdala related to the extraction of value from facial expressions...
  3. ncbi Interrelated neuropsychological and anatomical evidence of hippocampal pathology in the at-risk mental state
    R Hurlemann
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Psychol Med 38:843-51. 2008
    ..A crucial question is the extent to which interrelated structural-functional deficits of the hippocampus reflect a vulnerability to schizophrenia, as opposed to the disorder per se...
  4. ncbi Noradrenergic control of emotion-induced amnesia and hypermnesia
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Rev Neurosci 17:525-32. 2006
    ..This filter mechanism may originnate in amygdala-hippocampal interactions that are modulated by both ascending locus coeruleus and descending prefrontal cortex inputs...
  5. ncbi Noradrenergic-glucocorticoid mechanisms in emotion-induced amnesia: from adaptation to disease
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Psychopharmacology (Berl) 197:13-23. 2008
    ..CONCLUSIONS: Immediate pharmacological blockade of noradrenergic-glucocorticoid signaling might prove effective in the secondary prevention of PTA and PTSD...
  6. ncbi 5-HT2A receptor density is decreased in the at-risk mental state
    Rene Hurlemann
    Brain Imaging Center West, Research Center Juelich, 52425, Juelich, Germany
    Psychopharmacology (Berl) 195:579-90. 2008
    ..Current perspectives on the pathophysiology of schizophrenia direct attention to serotonergic (serotonin, 5-HT) dysregulation in the prodrome or at-risk mental state (ARMS)...
  7. ncbi Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Psychopharmacology (Berl) 194:261-9. 2007
    ..This peri-emotional amnesia is amygdala-dependent and varies as a function of norepinephrine activity. However, less is known about the amnesiogenic potential of cortisol...
  8. ncbi Noradrenergic modulation of emotion-induced forgetting and remembering
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci 25:6343-9. 2005
    ..We conclude that a differential processing of emotional arousal and valence influences how the brain remembers and forgets...
  9. ncbi Reduced 5-HT(2A) receptor signaling following selective bilateral amygdala damage
    Rene Hurlemann
    Brain Imaging Center West, Research Center Juelich, Juelich, Germany
    Soc Cogn Affect Neurosci 4:79-84. 2009
    ..Our findings provide important insights into the molecular architecture of human anxiety behaviors and suggest the 5-HT(2A) receptor as a promising pharmacological target to control pathological anxiety...
  10. ncbi Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anat Embryol (Berl) 210:519-23. 2005
    ....
  11. ncbi Noradrenergic enhancement of amygdala responses to fear
    Oezguer A Onur
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Soc Cogn Affect Neurosci 4:119-26. 2009
    ....
  12. ncbi Amygdala control of emotion-induced forgetting and remembering: evidence from Urbach-Wiethe disease
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Neuropsychologia 45:877-84. 2007
    ..Our findings implicate the amygdala in a neural circuitry that orchestrates rapid retrograde and anterograde regulation of episodic memory access upon criteria of behavioral significance...
  13. ncbi Fear processing and social networking in the absence of a functional amygdala
    Benjamin Becker
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 72:70-7. 2012
    ....
  14. ncbi Analysis of neuroreceptor PET-data based on cytoarchitectonic maximum probability maps: a feasibility study
    Rene Hurlemann
    Brain Imaging Center West, Institute of Medicine, Research Center Julich, Julich, Germany
    Anat Embryol (Berl) 210:447-53. 2005
    ..47 for forward and backward procedure, respectively) suggest that the implementation of cytoarchitectonic maximum probability maps is a promising method for an accurate and observer-independent analysis of neuroreceptor PET data...
  15. ncbi Overnight deprivation from smoking disrupts amygdala responses to fear
    Oezguer A Onur
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Hum Brain Mapp 33:1407-16. 2012
    ..We suggest that aberrant amygdala reactivity in overnight-deprived smokers may reflect a pre-existing vulnerability to smoking and/or increase the risk of smoking relapse after a cessation attempt...
  16. ncbi Oxytocin modulates social distance between males and females
    Dirk Scheele
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci 32:16074-9. 2012
    ..In this way, OXT may help to promote fidelity within monogamous human relationships...
  17. ncbi Neuropsychological safety of nucleus accumbens deep brain stimulation for major depression: effects of 12-month stimulation
    Christiane Grubert
    Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
    World J Biol Psychiatry 12:516-27. 2011
    ..However, limited information exists regarding the impact of NAcc-DBS on cognitive functioning. The aim of this study was to examine whether NAcc-DBS in patients with TRD has any cognitive effects...
  18. ncbi Facilitation of learning by social-emotional feedback in humans is beta-noradrenergic-dependent
    Yoan Mihov
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Neuropsychologia 48:3168-72. 2010
    ..Propranolol had no effect on learning during the nonsocial feedback condition. Our findings suggest that a facilitation of declarative learning by social-emotional feedback critically involves signaling via beta-noradrenergic receptors...
  19. ncbi Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci 30:4999-5007. 2010
    ..Overall these findings provide the first demonstration that OT can facilitate amygdala-dependent, socially reinforced learning and emotional empathy in men...
  20. ncbi The N-methyl-D-aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans
    Oezguer A Onur
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 67:1205-11. 2010
    ..An important unresolved question though is whether the use of DCS can also facilitate hippocampus-dependent declarative learning in healthy people as opposed to being restricted to the fear memory domain...
  21. ncbi Enhanced emotion-induced amnesia in borderline personality disorder
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Psychol Med 37:971-81. 2007
    ..These changes are amygdala dependent and vary as a function of emotional arousal and valence...
  22. ncbi Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression
    Bettina H Bewernick
    Department of Psychiatry and Psychotherapy, University Hospital, 53105 Bonn, Germany
    Biol Psychiatry 67:110-6. 2010
    ..Since anhedonia is a feature of depression and there is evidence of dysfunction of the reward system, DBS to the nucleus accumbens (NAcc) might be promising...
  23. ncbi Oxytocin facilitates protective responses to aversive social stimuli in males
    Nadine Striepens
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Proc Natl Acad Sci U S A 109:18144-9. 2012
    ..Our results therefore show that OXT can potentiate the protective and mnemonic impact of aversive social information despite reducing amygdala activity, and suggest that the insula may play a role in emotional modulation of memory...
  24. ncbi Altered amygdala function in nicotine addiction: insights from human neuroimaging studies
    Yoan Mihov
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neuropsychologia 50:1719-29. 2012
    ..In light of this empirical evidence, we propose that impaired amygdala-guided harm avoidance and executive functions may be instrumental in maintaining nicotine addiction despite serious health consequences...
  25. ncbi From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia
    Wolfgang Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, der Universität Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:40-3. 2008
    ....
  26. ncbi Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
    Nadine Striepens
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Front Neuroendocrinol 32:426-50. 2011
    ....
  27. ncbi Modulating amygdala responses to emotion: evidence from pharmacological fMRI
    Alexandra Patin
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neuropsychologia 49:706-17. 2011
    ....
  28. ncbi Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 54:36-44. 2013
    ..Recent behavioral research indicates that personality traits may predispose to these side effects. To assess the genetic basis of the adverse psychotropic profile of LEV, a candidate gene-based two-stage association study was conducted...
  29. ncbi Acute S-ketamine application does not alter cerebral [18F]altanserin binding: a pilot PET study in humans
    A Matusch
    Institute of Medicine and Brain Imaging Center West, Research Center Juelich, Juelich, Germany
    J Neural Transm 114:1433-42. 2007
    ..Advantageously, the stability of [(18)F]altanserin PET towards acute influences is a prerequisite for its future use to detect sub-acute and chronic effects of ketamine...