Ana Claudia Zenclussen

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Murine abortion is associated with enhanced interleukin-6 levels at the feto-maternal interface
    Ana Claudia Zenclussen
    IDEHU Instituto de Estudios de Inmunidad Humoral, CONICET, Universidad de Buenos Aires, Argentina
    Cytokine 24:150-60. 2003
  2. ncbi request reprint Immunology of pregnancy: cellular mechanisms allowing fetal survival within the maternal uterus
    Ana Claudia Zenclussen
    AG Reproduktionsimmunologie, Institut fur Medizinische Immunologie, Charite, Medizinische Universität zu Berlin, Germany
    Expert Rev Mol Med 9:1-14. 2007
  3. ncbi request reprint Regulatory T cells in pregnancy
    Ana Claudia Zenclussen
    Institute of Medical Immunology, Charite, Medical University Berlin, Berlin, Germany
    Springer Semin Immunopathol 28:31-9. 2006
  4. ncbi request reprint Heme oxygenase as a therapeutic target in immunological pregnancy complications
    Ana Claudia Zenclussen
    Institute of Medical Immunology, Charite, Medical University Berlin, Room 2 0534, Augustenburger Platz 1, 13353 Berlin, Germany
    Int Immunopharmacol 5:41-51. 2005
  5. pmc Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model
    Ana Claudia Zenclussen
    Institut fur Medizinische Immunologie, Biomedizinisches Forschungszentrum, Raum 2 0534, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353, Berlin, Germany
    Am J Pathol 166:811-22. 2005
  6. ncbi request reprint Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface
    Ana C Zenclussen
    Institute of Medical Immunology, Charite, Medical University Berlin, Berlin, Germany
    Eur J Immunol 36:82-94. 2006
  7. ncbi request reprint The use of gene therapy tools in reproductive immunology research
    Ana Claudia Zenclussen
    Institute of Medical Immunology, Charite, Medicine University, Berlin, Germany
    Curr Gene Ther 5:459-66. 2005
  8. ncbi request reprint Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion
    Maria Laura Zenclussen
    Institute of Medical Immunology, BMFZ, Charite, Medicine University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Reprod Immunol 69:35-52. 2006
  9. ncbi request reprint Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface
    Andre Sollwedel
    Reproductive Immunology Group, Institute of Medical Immunology, Biomedizinisches Forschungszentrum BMFZ, Charité Medical University of Berlin, Germany
    J Immunol 175:4875-85. 2005
  10. ncbi request reprint Anti-P- and E-selectin therapy prevents abortion in the CBA/J x DBA/2J combination by blocking the migration of Th1 lymphocytes into the foetal-maternal interface
    Annarosa Zambon Bertoja
    Institute of Medical Immunology, Charite, Medical University of Berlin, Berlin, Germany
    Cell Immunol 238:97-102. 2005

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Murine abortion is associated with enhanced interleukin-6 levels at the feto-maternal interface
    Ana Claudia Zenclussen
    IDEHU Instituto de Estudios de Inmunidad Humoral, CONICET, Universidad de Buenos Aires, Argentina
    Cytokine 24:150-60. 2003
    ..Our results suggest that IL-6 produced not only by immunocompetent cells such as macrophages and mast cells, but also by trophoblasts and decidua cells, is directly involved in the pathology of abortion...
  2. ncbi request reprint Immunology of pregnancy: cellular mechanisms allowing fetal survival within the maternal uterus
    Ana Claudia Zenclussen
    AG Reproduktionsimmunologie, Institut fur Medizinische Immunologie, Charite, Medizinische Universität zu Berlin, Germany
    Expert Rev Mol Med 9:1-14. 2007
    ....
  3. ncbi request reprint Regulatory T cells in pregnancy
    Ana Claudia Zenclussen
    Institute of Medical Immunology, Charite, Medical University Berlin, Berlin, Germany
    Springer Semin Immunopathol 28:31-9. 2006
    ..Downregulated levels of Treg were accordingly also reported during human miscarriage. Furthermore, we have evidence suggesting that, to be protective, Treg need to be activated by male antigens during pregnancy...
  4. ncbi request reprint Heme oxygenase as a therapeutic target in immunological pregnancy complications
    Ana Claudia Zenclussen
    Institute of Medical Immunology, Charite, Medical University Berlin, Room 2 0534, Augustenburger Platz 1, 13353 Berlin, Germany
    Int Immunopharmacol 5:41-51. 2005
    ..Up-regulation of HO-1 or HO-2 would favour the Th2-cytokine production, which could avoid abortion onset...
  5. pmc Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model
    Ana Claudia Zenclussen
    Institut fur Medizinische Immunologie, Biomedizinisches Forschungszentrum, Raum 2 0534, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353, Berlin, Germany
    Am J Pathol 166:811-22. 2005
    ..Our data suggest that pregnancy-induced Treg cells play a vital role in maternal tolerance to the allogeneic fetus...
  6. ncbi request reprint Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface
    Ana C Zenclussen
    Institute of Medical Immunology, Charite, Medical University Berlin, Berlin, Germany
    Eur J Immunol 36:82-94. 2006
    ....
  7. ncbi request reprint The use of gene therapy tools in reproductive immunology research
    Ana Claudia Zenclussen
    Institute of Medical Immunology, Charite, Medicine University, Berlin, Germany
    Curr Gene Ther 5:459-66. 2005
    ..Since the sole application of a control vector did not provoke deleterious effects in pregnancy outcome, we propose the use of experimental gene therapy for unveiling molecular and cellular pathways leading to pregnancy success...
  8. ncbi request reprint Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion
    Maria Laura Zenclussen
    Institute of Medical Immunology, BMFZ, Charite, Medicine University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Reprod Immunol 69:35-52. 2006
    ..Thus, we propose HO-1 as a key regulator of pregnancy success. HO-1 would exert its action by locally up-regulating the Th2/Th1 cytokine ratio and by further protecting tissues from apoptosis...
  9. ncbi request reprint Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface
    Andre Sollwedel
    Reproductive Immunology Group, Institute of Medical Immunology, Biomedizinisches Forschungszentrum BMFZ, Charité Medical University of Berlin, Germany
    J Immunol 175:4875-85. 2005
    ..e., Bag-1, and by activating T regulatory cells rather than by changing the local cytokine profile...
  10. ncbi request reprint Anti-P- and E-selectin therapy prevents abortion in the CBA/J x DBA/2J combination by blocking the migration of Th1 lymphocytes into the foetal-maternal interface
    Annarosa Zambon Bertoja
    Institute of Medical Immunology, Charite, Medical University of Berlin, Berlin, Germany
    Cell Immunol 238:97-102. 2005
    ..Our data first confirm the important role of P-selectin in mediating the extravasation of abortive cells, while opening new therapeutic opportunities...
  11. doi request reprint The persistence of paternal antigens in the maternal body is involved in regulatory T-cell expansion and fetal-maternal tolerance in murine pregnancy
    Maria Laura Zenclussen
    Reproductive Immunology Group, Institute of Medical Immunology, Charite, Universitatsmedizin, Berlin, Germany
    Am J Reprod Immunol 63:200-8. 2010
    ..Knowing that Treg act in an antigen-specific way during pregnancy, we hypothesized that they are generated after maternal immune cells encounter paternal antigens...
  12. ncbi request reprint Kinetics of regulatory T cells during murine pregnancy
    Catharina Thuere
    Institute of Medical Immunology, Charite, Universitatsmedizin, Berlin, Germany
    Am J Reprod Immunol 58:514-23. 2007
    ..We aimed to determine the kinetics of Treg during murine gestation and investigate whether changes in Treg levels respond to hormonal variations during pregnancy or generated changes in the local indolamine dioxygenase (IDO) expression...
  13. doi request reprint PD-1 but not CTLA-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model
    Paul Ojiambo Wafula
    Institute of Medical Immunology, Charite Universitatsmedizin, Berlin, Germany
    Am J Reprod Immunol 62:283-92. 2009
    ..Cytotoxic T lymphocyte antigen-4 (CTLA-4) and Programmed cell death 1 (PD-1) are some of known Treg-associated molecules; however, their role in Treg-mediated fetal protection in murine model has not been investigated...
  14. ncbi request reprint Mechanisms behind flare of renal lupus during murine pregnancy
    Ana Claudia Zenclussen
    Institute of Medical Immunology, Charite, Medical University of Berlin, Germany
    Reprod Biomed Online 17:114-26. 2008
    ..Albeit obtained with an experimental animal model, their data are potentially of importance for lupus patients of reproductive age...
  15. ncbi request reprint Supporting the hypothesis of pregnancy as a tumor: survivin is upregulated in normal pregnant mice and participates in human trophoblast proliferation
    Stefan Fest
    Department of Paediatrics, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Reprod Immunol 59:75-83. 2008
    ..Here, we analyzed its expression during normal and pathological murine pregnancy and investigated its participation in human first trimester trophoblast cell survival and proliferation...
  16. ncbi request reprint Mechanisms of action of regulatory T cells specific for paternal antigens during pregnancy
    Anne Schumacher
    Institute of Medical Immunology, Charite, Universitatsmedizin, Berlin, Germany
    Obstet Gynecol 110:1137-45. 2007
    ..To investigate whether pregnancy-induced regulatory T cells are generated specifically for paternal antigens or expanded by hormonal changes and to study regulatory T cell-related mechanisms during pregnancy...
  17. doi request reprint Pregnancy: tolerance and suppression of immune responses
    Anne Leber
    Department for Neurosurgery, Charite, Medical University of Berlin, Berlin, Germany
    Methods Mol Biol 677:397-417. 2011
    ..However, during pregnancy, the semiallogeneic fetus is allowed to grow within the maternal uterus due to multiple mechanisms of immune tolerance, which are discussed in this chapter...
  18. ncbi request reprint A novel mouse model for preeclampsia by transferring activated th1 cells into normal pregnant mice
    Ana Claudia Zenclussen
    Reproductive Immunology Group, Institute of Medical Immunology, Charite, Medical University of Berlin, Germany
    Methods Mol Med 122:401-12. 2006
    ..This chapter describes the methods employed to develop the model as well as additional experiments developed to analyze cellular and molecular mechanisms involved...
  19. ncbi request reprint The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response
    Ricarda Joachim
    Charite, Department of Internal Medicine, Biomedizinisches Forschungszentrum, Humboldt University of Berlin, Campus Virchow, Raum 2 0549, Augustenburger Platz 1, 13353 Berlin, Germany
    Steroids 68:931-40. 2003
    ..Our data suggest that dydrogesterone abrogates stress-triggered abortion by inducing a Th2 biased local immune response...
  20. ncbi request reprint CD4(+)CD25+ T regulatory cells in murine pregnancy
    Ana Claudia Zenclussen
    Institute of Medical Immunology, Medical University Berlin, Biomedizinisches Forschungszentrum, Raum 2 0534, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Reprod Immunol 65:101-10. 2005
    ..Accordingly, down-regulated levels of Treg were also reported during human miscarriage. The putative mechanisms involved in Treg-induced tolerance in mice and humans are discussed in this review...
  21. ncbi request reprint Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood
    Steffen Paeschke
    Institute of Medical Immunology, Charite, Medical University of Berlin, Germany
    Am J Reprod Immunol 54:384-9. 2005
    ..The major aim of the present work was to investigate if pre-eclampsia, a late immunological complication of pregnancy, is characterized by similar hallmarks...
  22. ncbi request reprint Intratumoral infusion of interleukin-1beta and interferon-gamma induces tumor invasion with macrophages and lymphocytes in a rat glioma model
    Sandra Frewert
    Klinik für Neurochirurgie, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353, Germany
    Neurosci Lett 364:145-8. 2004
    ..Our results demonstrate that intratumoral cytokine infusion using CED leads to a strong tumor invasion with macrophages and lymphocytes suggesting a tumor specific immune response...
  23. ncbi request reprint Asymmetric antibodies (AAb) in the female reproductive tract
    Sandra Blois
    Faculty of Pharmacy and Biochemistry, IDEHU Instituto de Estudios de Inmunidad Humoral, CONICET, University of Buenos Aires, Junin 956 4 degrees Piso, 1113 Buenos Aires, Argentina
    J Reprod Immunol 64:31-43. 2004
    ..Additionally, we observed that the levels of AAbs decrease when susceptibility to infection in mice occurs at proestrus/estrus, further suggesting a protective role for AAbs...