Chuanbing Zang

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor alpha/gamma, in human breast cancer cells
    Chuanbing Zang
    Division of Oncology Hematology, Department of Hematology and Oncology, University Medicine Charité, Berlin, Germany
    Mol Cancer Ther 8:2296-307. 2009
  2. ncbi request reprint Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma
    Jan Eucker
    Department of Oncology and Hematology, University Hospital Charite, Berlin, Germany
    Anticancer Drugs 17:763-9. 2006
  3. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia
    Chuanbing Zang
    Division of Oncology Hematology, School of Medicine Charite, Humboldt University, Schumannstr 20 21, 10117 Berlin, Germany
    Leuk Res 28:387-97. 2004
  4. ncbi request reprint Dual PPARalpha/gamma ligand TZD18 either alone or in combination with imatinib inhibits proliferation and induces apoptosis of human CML cell lines
    Chuanbing Zang
    Division of Oncology Hematology, Universitatsmedizin Berlin, Charite Campus Mitte, Berlin, Germany
    Cell Cycle 5:2237-43. 2006
  5. ncbi request reprint Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma
    Jan Eucker
    Department of Oncology and Hematology, University Hospital Charite, Berlin, Germany
    Anticancer Drugs 15:955-60. 2004
  6. doi request reprint Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer
    Hongyu Liu
    Department of Oncology and Hematology, University Hospital Charite, Humboldt University of Berlin, Berlin, Germany
    Eur J Pharmacol 591:43-51. 2008
  7. doi request reprint Concurrent inhibition of PI3-kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1
    Chuanbing Zang
    Charite Universitatsmedizin Berlin, Department of Oncology and Hematology, Berlin, Germany
    Cancer Lett 339:288-97. 2013
  8. ncbi request reprint Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro
    Hongyu Liu
    Department of Oncology and Hematology, University Hospital of Berlin, Berlin, Germany
    Anticancer Res 32:1627-37. 2012
  9. ncbi request reprint Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas
    Chuanbing Zang
    Division of Oncology Hematology, School of Medicine Charite, Humboldt University, Berlin, Germany
    J Neurooncol 65:107-18. 2003
  10. doi request reprint Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma
    Anja Muller
    Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, Campus Berlin Buch, Humboldt University, Berlin, Germany
    Int J Cancer 133:1813-24. 2013

Collaborators

Detail Information

Publications12

  1. doi request reprint Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor alpha/gamma, in human breast cancer cells
    Chuanbing Zang
    Division of Oncology Hematology, Department of Hematology and Oncology, University Medicine Charité, Berlin, Germany
    Mol Cancer Ther 8:2296-307. 2009
    ..In summary, TZD18-treatment leads to the activation of endoplasmic reticulum stress response and, subsequently, growth arrest and apoptosis in breast cancer cells...
  2. ncbi request reprint Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma
    Jan Eucker
    Department of Oncology and Hematology, University Hospital Charite, Berlin, Germany
    Anticancer Drugs 17:763-9. 2006
    ..Thiazolidinediones comprise anti-lymphoma activity in vitro and should be further explored for the treatment of mantle cell lymphoma...
  3. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia
    Chuanbing Zang
    Division of Oncology Hematology, School of Medicine Charite, Humboldt University, Schumannstr 20 21, 10117 Berlin, Germany
    Leuk Res 28:387-97. 2004
    ..This effect was partially caspase-dependent because a pan-caspase inhibitor partially reversed this effect. In conclusion, our results suggest that PPARgamma ligands may offer a new therapeutic approach to aid in the treatment of ALL...
  4. ncbi request reprint Dual PPARalpha/gamma ligand TZD18 either alone or in combination with imatinib inhibits proliferation and induces apoptosis of human CML cell lines
    Chuanbing Zang
    Division of Oncology Hematology, Universitatsmedizin Berlin, Charite Campus Mitte, Berlin, Germany
    Cell Cycle 5:2237-43. 2006
    ..Overall, our findings strongly suggest that either TZD18, either alone or in combination with imatinib may be beneficial for the treatment of CML in myeloid blast crisis...
  5. ncbi request reprint Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma
    Jan Eucker
    Department of Oncology and Hematology, University Hospital Charite, Berlin, Germany
    Anticancer Drugs 15:955-60. 2004
    ..Furthermore, induction of apoptosis in sorted bone marrow plasma cells from myeloma patients was detected. Thiazolidinediones comprise anti-myeloma activity in vitro and should be explored further for the treatment of multiple myeloma...
  6. doi request reprint Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer
    Hongyu Liu
    Department of Oncology and Hematology, University Hospital Charite, Humboldt University of Berlin, Berlin, Germany
    Eur J Pharmacol 591:43-51. 2008
    ..In conclusion, honokiol, either alone or in combination with other therapeutics, could serve as a new, promising approach for breast cancer treatment...
  7. doi request reprint Concurrent inhibition of PI3-kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1
    Chuanbing Zang
    Charite Universitatsmedizin Berlin, Department of Oncology and Hematology, Berlin, Germany
    Cancer Lett 339:288-97. 2013
    ..In ABC cell lines, this suppression is possibly compensated by NF-κB- or Pim kinase-mediated signaling...
  8. ncbi request reprint Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro
    Hongyu Liu
    Department of Oncology and Hematology, University Hospital of Berlin, Berlin, Germany
    Anticancer Res 32:1627-37. 2012
    ..The aim of this study was to evaluate the anticancer effect of metformin alone and in combination with chemotherapeutic drugs and the mTOR inhibitor RAD001...
  9. ncbi request reprint Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas
    Chuanbing Zang
    Division of Oncology Hematology, School of Medicine Charite, Humboldt University, Berlin, Germany
    J Neurooncol 65:107-18. 2003
    ..Therefore, we conclude that these ligands may possess adjuvant therapeutic potential for patients with glioblastoma...
  10. doi request reprint Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma
    Anja Muller
    Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, Campus Berlin Buch, Humboldt University, Berlin, Germany
    Int J Cancer 133:1813-24. 2013
    ..Our findings may help to lay the foundation for further improvements in the treatment of MCL...
  11. doi request reprint The proteasome inhibitor bortezomib stimulates osteoblastic differentiation of human osteoblast precursors via upregulation of vitamin D receptor signalling
    Martin F Kaiser
    Department of Haematology and Oncology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Haematol 90:263-72. 2013
    ..The data suggest that supplementation of vitamin D in patients with myeloma treated with bortezomib is crucial for optimal bone formation...
  12. ncbi request reprint The mTOR inhibitor RAD001 sensitizes tumor cells to the cytotoxic effect of carboplatin in breast cancer in vitro
    Hongyu Liu
    Division of Oncology and Hematology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany and
    Anticancer Res 31:2713-22. 2011
    ..We hypothesized that targeting this signaling by the mTOR inhibitor RAD001 may potentiate the cytotoxicity of a conventional chemotherapeutic drug, carboplatin, and enhance the treatment efficacy for breast cancer...