P Wust

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi Magnetic nanoparticles for interstitial thermotherapy--feasibility, tolerance and achieved temperatures
    Peter Wust
    Clinic for Radiotherapy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Hyperthermia 22:673-85. 2006
  2. ncbi Appropriate patient instructions can reduce prostate motion
    Reinhold Graf
    Department of Radiation Oncology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Radiat Oncol 7:125. 2012
  3. ncbi Magnetic resonance imaging, computed tomography, and 68Ga-DOTATOC positron emission tomography for imaging skull base meningiomas with infracranial extension treated with stereotactic radiotherapy--a case series
    Reinhold Graf
    Department of Radiation Oncology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Head Face Med 8:1. 2012
  4. ncbi In vivo assessment of catheter positioning accuracy and prolonged irradiation time on liver tolerance dose after single-fraction 192Ir high-dose-rate brachytherapy
    Lutz Ludemann
    Department of Radiation Therapy, Charite Medical Center, Berlin, Germany
    Radiat Oncol 6:107. 2011
  5. ncbi Quantitative in vivo assessment of radiation injury of the liver using Gd-EOB-DTPA enhanced MRI: tolerance dose of small liver volumes
    Max Seidensticker
    Klinik fur Radiologie und Nuklearmedizin, Universitatsklinikum Magdeburg, Otto von Guericke Universitat Magdeburg, Germany
    Radiat Oncol 6:40. 2011
  6. ncbi Potentials of on-line repositioning based on implanted fiducial markers and electronic portal imaging in prostate cancer radiotherapy
    Reinhold Graf
    Charite Universitatsmedizin Berlin, Department of Radiotherapy, Germany
    Radiat Oncol 4:13. 2009
  7. ncbi Safety margin in irradiation of colorectal liver metastases: assessment of the control dose of micrometastases
    Max Seidensticker
    Klinik fur Radiologie und Nuklearmedizin, Universitatsklinikum Magdeburg, Otto von Guericke Universitat Magdeburg, Germany
    Radiat Oncol 5:24. 2010
  8. ncbi Radiobiological restrictions and tolerance doses of repeated single-fraction hdr-irradiation of intersecting small liver volumes for recurrent hepatic metastases
    Ricarda Ruhl
    Universitatsklinikum Magdeburg, Klinik fur Radiologie und Nuklearmedizin, Otto von Guericke Universitat Magdeburg, Germany
    Radiat Oncol 5:44. 2010
  9. ncbi A non-randomised, single-centre comparison of induction chemotherapy followed by radiochemotherapy versus concomitant chemotherapy with hyperfractionated radiotherapy in inoperable head and neck carcinomas
    Reinhold Graf
    Clinic for Radiation Medicine, Charite Medical School, Campus Virchow Klinikum, Augustenburger Platz, 113353 Berlin, Germany
    BMC Cancer 6:30. 2006
  10. ncbi Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy
    Isrid Sturm
    University Medical Center Charite, Campus Virchow Klinikum, Department of Hematology and Oncology, 13353 Berlin, Germany
    BMC Cancer 6:124. 2006

Detail Information

Publications116 found, 100 shown here

  1. ncbi Magnetic nanoparticles for interstitial thermotherapy--feasibility, tolerance and achieved temperatures
    Peter Wust
    Clinic for Radiotherapy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Hyperthermia 22:673-85. 2006
    ..The potential to estimate (by post-implantation analyses) and to achieve (by improving the technique) a satisfactory temperature distribution was evaluated in dependency on the implantation technique...
  2. ncbi Appropriate patient instructions can reduce prostate motion
    Reinhold Graf
    Department of Radiation Oncology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Radiat Oncol 7:125. 2012
    ..Interfraction prostate motion must be compensated by increased safety margins. If filling status of rectum and bladder is constant, motion should be reduced. We attempted to reduce interfraction motion errors by proper patient instruction...
  3. ncbi Magnetic resonance imaging, computed tomography, and 68Ga-DOTATOC positron emission tomography for imaging skull base meningiomas with infracranial extension treated with stereotactic radiotherapy--a case series
    Reinhold Graf
    Department of Radiation Oncology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Head Face Med 8:1. 2012
    ....
  4. ncbi In vivo assessment of catheter positioning accuracy and prolonged irradiation time on liver tolerance dose after single-fraction 192Ir high-dose-rate brachytherapy
    Lutz Ludemann
    Department of Radiation Therapy, Charite Medical Center, Berlin, Germany
    Radiat Oncol 6:107. 2011
    ..To assess brachytherapy catheter positioning accuracy and to evaluate the effects of prolonged irradiation time on the tolerance dose of normal liver parenchyma following single-fraction irradiation with 192Ir...
  5. ncbi Quantitative in vivo assessment of radiation injury of the liver using Gd-EOB-DTPA enhanced MRI: tolerance dose of small liver volumes
    Max Seidensticker
    Klinik fur Radiologie und Nuklearmedizin, Universitatsklinikum Magdeburg, Otto von Guericke Universitat Magdeburg, Germany
    Radiat Oncol 6:40. 2011
    ..In this study we sought to determine the hepatic tolerance dose to small volume single fraction high dose rate irradiation...
  6. ncbi Potentials of on-line repositioning based on implanted fiducial markers and electronic portal imaging in prostate cancer radiotherapy
    Reinhold Graf
    Charite Universitatsmedizin Berlin, Department of Radiotherapy, Germany
    Radiat Oncol 4:13. 2009
    ..To estimate the error reduction (and the corresponding margin reduction) by reducing the total error to 3 mm once a week, three times per week or every treatment day...
  7. ncbi Safety margin in irradiation of colorectal liver metastases: assessment of the control dose of micrometastases
    Max Seidensticker
    Klinik fur Radiologie und Nuklearmedizin, Universitatsklinikum Magdeburg, Otto von Guericke Universitat Magdeburg, Germany
    Radiat Oncol 5:24. 2010
    ..In this study we sought to determine the threshold dose for local control of occult micrometastases in patients undergoing CT (computed tomography)-guided brachytherapy of colorectal liver metastases...
  8. ncbi Radiobiological restrictions and tolerance doses of repeated single-fraction hdr-irradiation of intersecting small liver volumes for recurrent hepatic metastases
    Ricarda Ruhl
    Universitatsklinikum Magdeburg, Klinik fur Radiologie und Nuklearmedizin, Otto von Guericke Universitat Magdeburg, Germany
    Radiat Oncol 5:44. 2010
    ..To assess radiobiological restrictions and tolerance doses as well as other toxic effects derived from repeated applications of single-fraction high dose rate irradiation of small liver volumes in clinical practice...
  9. ncbi A non-randomised, single-centre comparison of induction chemotherapy followed by radiochemotherapy versus concomitant chemotherapy with hyperfractionated radiotherapy in inoperable head and neck carcinomas
    Reinhold Graf
    Clinic for Radiation Medicine, Charite Medical School, Campus Virchow Klinikum, Augustenburger Platz, 113353 Berlin, Germany
    BMC Cancer 6:30. 2006
    ..The aim of this study was to compare the results of concomitant application of radiochemotherapy for treating locally advanced head-and-neck carcinoma in comparison with the former standard of sequential radiochemotherapy...
  10. ncbi Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy
    Isrid Sturm
    University Medical Center Charite, Campus Virchow Klinikum, Department of Hematology and Oncology, 13353 Berlin, Germany
    BMC Cancer 6:124. 2006
    ..e. 5-fluorouracil (5-FU), ionising gamma-radiation (IR) and heat shock/hyperthermia...
  11. ncbi Implications of clinical RF hyperthermia on protection limits in the RF range
    Peter Wust
    Department of Radiation Oncology, Charite Universitatsmedizin Berlin, Germany
    Health Phys 92:565-73. 2007
    ..Even higher is the potential to compensate in smaller volumes. Here the perfusion in muscle can be increased from the basal value of 2-4 mL/100 g/min more than 5-10-fold...
  12. ncbi [Hyperthermia: current status and therapeutic results]
    P Wust
    , , Berlin
    Dtsch Med Wochenschr 128:2023-9. 2003
  13. ncbi [Part-body hyperthermia with a radiofrequency multiantenna applicator under online control in a 1.5 T MR-tomograph]
    P Wust
    Charite, Klinik fur Strahlenheilkunde, Berlin
    Rofo 176:363-74. 2004
    ..The -hybrid approach renders development of part body hyperthermia possible as an MR-controlled intervention in radiology...
  14. ncbi Evaluation of segmentation algorithms for generation of patient models in radiofrequency hyperthermia
    P Wust
    Strahlenklinik und Poliklinik, Charite, Campus Virchow Klinikum, Medizinische Fakultat der Humboldt Universitat zu Berlin, Germany
    Phys Med Biol 43:3295-307. 1998
    ..After all, the practicality and feasibility of every segmentation method critically depend on various details of the user software as pointed out in this article...
  15. ncbi Hyperthermia in combined treatment of cancer
    P Wust
    Department of Radiation Oncology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Lancet Oncol 3:487-97. 2002
    ..However, for every particular temperature-dependent interaction exploited for clinical purposes, sophisticated control of temperature, spatially as well as temporally, in deep body regions will further improve the potential...
  16. ncbi Visualization and registration of three-dimensional E-field distributions in annual-phased-array applicators
    P Wust
    Clinic for Radiation Medicine, Charite, Medical School of Humboldt University at Berlin, Germany
    Med Phys 26:653-9. 1999
    ..The measuring system is particularly suitable for a fast comparison of APA applicators applied for a homogeneous medium. Implications for heterogeneous structures (like in patients) are then possible via modeling calculations...
  17. ncbi Feasibility and analysis of thermal parameters for the whole-body-hyperthermia system IRATHERM-2000
    P Wust
    Department of Radiation Medicine, Charite Medical Center, Berlin, Germany
    Int J Hyperthermia 16:325-39. 2000
    ..In the authors' opinion, improved understanding of the mechanisms and crucial parameters underlying whole body hyperthermia, will enable a controllable and tolerable therapy through proficient contribution to equipment and methods...
  18. ncbi Influence of patient models and numerical methods on predicted power deposition patterns
    P Wust
    Center of Radiation Medicine, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Int J Hyperthermia 15:519-40. 1999
    ..A hyperthermia planning system has been developed for generating patient and applicator models as well as calculating and visualizing E-field and temperature distributions. Significant dependencies on models and algorithms have been found...
  19. ncbi Thermal monitoring: invasive, minimal-invasive and non-invasive approaches
    Peter Wust
    Clinic for Radiation Medicine, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Int J Hyperthermia 22:255-62. 2006
    ..Invasive intra-tumoural thermometry was established as a standard method several years ago. However, in deep heating, invasive techniques have disadvantages. Therefore, alternatives have been suggested and are under development...
  20. ncbi Electric field distributions in a phased-array applicator with 12 channels: measurements and numerical simulations
    P Wust
    Centre of Radiation Medicine, Charite Medical School, Medical Faculty of Humboldt University at Berlin, Germany
    Med Phys 27:2565-79. 2000
    ..The origin of these problems is mainly attributed to cross-talk phenomena and other characteristics of the transforming network, which need to be scrutinized further for a full understanding...
  21. ncbi Postimplantation analysis enables improvement of dose-volume histograms and reduction of toxicity for permanent seed implantation
    Peter Wust
    Department of Radiation Oncology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Radiat Oncol Biol Phys 71:28-35. 2008
    ..To demonstrate how postimplantation analysis is useful for improving permanent seed implantation and reducing toxicity...
  22. ncbi Whole-body hyperthermia in the scope of von Ardenne's systemic cancer multistep therapy (sCMT) combined with chemotherapy in patients with metastatic colorectal cancer: a phase I/II study
    B Hildebrandt
    Medizinische Klinik für Hämatologie und Onkologie, Universitätklinikum Charité, Berlin, Germany
    Int J Hyperthermia 20:317-33. 2004
    ..The fact that three patients who did not respond to initial chemotherapy achieved a PR after additional sCMT suggests that sCMT may enhance the effect of chemotherapy in patients with colorectal cancer...
  23. ncbi Influence of neoadjuvant radiochemotherapy combined with hyperthermia on the quality of life in rectum cancer patients
    T Schulze
    Department of Surgery and Surgical Oncology, , Charit, Campus Buch, , Berlin, Germany
    Int J Hyperthermia 22:301-18. 2006
    ..The addition of hyperthermia during the neoadjuvant therapy with the potentially associated inconveniences has no negative effects on QoL...
  24. ncbi Clinical evaluation and verification of the hyperthermia treatment planning system hyperplan
    J Gellermann
    Center of Radiation Medicine, Charite Medical School, Campus Virchow Klinikum, Humboldt University at Berlin, Berlin, Germany
    Int J Radiat Oncol Biol Phys 47:1145-56. 2000
    ..A prototype of the hyperthermia treatment planning system (HTPS) HyperPlan for the SIGMA-60 applicator (BSD Medical Corp., Salt Lake City, Utah, USA) has been evaluated with respect to clinical practicability and correctness...
  25. ncbi Rationale for using invasive thermometry for regional hyperthermia of pelvic tumors
    P Wust
    Clinic for Radiation Medicine, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Int J Radiat Oncol Biol Phys 41:1129-37. 1998
    ..We tried to estimate the benefit/cost ratio of invasive thermometry in regional hyperthermia using the radiofrequency system BSD-2000...
  26. ncbi 123I-IMT SPECT for evaluation of the response to radiation therapy in high grade gliomas: a feasibility study
    D Kuczer
    Department of Radiology, Nuclear Medicine and Radiooncology, Campus Virchow Klinikum, Berlin, Germany
    Br J Radiol 80:274-8. 2007
    ..973). Serial IMT SPECT measurements allow detection of changes in amino acid accumulation in high-grade gliomas under radiation therapy. However, these changes seem to possess no prognostic value in respect to survival prediction...
  27. ncbi Regional hyperthermia of the abdomen in conjunction with chemotherapy for peritoneal carcinomatosis: evaluation of two annular-phased-array applicators
    C H Cho
    Charite Universitatsmedizin Berlin, Clinic for Radiotherapy, Berlin, Germany
    Int J Hyperthermia 24:399-408. 2008
    ..In this phase I/II study, we evaluated regional hyperthermia of the pelvis and abdomen using the annular-phased-array technique as an adjunct to chemotherapy...
  28. ncbi Comparison of four magnetic resonance methods for mapping small temperature changes
    W Wlodarczyk
    Clinic for Radiation Medicine, Charité Medical School Campus Virchow Klinikum, Berlin, Germany
    Phys Med Biol 44:607-24. 1999
    ..Therefore, at present the water PRF method appears to be most suitable for MR monitoring of small temperature changes during hyperthermia treatment...
  29. ncbi Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: is there a benefit in using functional imaging?
    T Denecke
    Klinik für Strahlenheilkunde und PET Zentrum Berlin Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany
    Eur Radiol 15:1658-66. 2005
    ..002, CT P=0.197, MRI P=0.500). These results suggest that FDG-PET is superior to CT and MRI in predicting response to preoperative multimodal treatment of locally advanced primary rectal cancer...
  30. ncbi Regional pelvic hyperthermia as an adjunct to chemotherapy (oxaliplatin, folinic acid, 5-fluorouracil) in pre-irradiated patients with locally recurrent rectal cancer: a pilot study
    B Hildebrandt
    Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Int J Hyperthermia 20:359-69. 2004
    ..Overall toxicity was moderate, although hyperthermia may add side-effects to this approach. Results, moreover, suggest a relevant palliative effect in patients with pre-irradiated pelvic recurrence of rectal cancer...
  31. ncbi Methods and potentials of magnetic resonance imaging for monitoring radiofrequency hyperthermia in a hybrid system
    J Gellermann
    Department of Radiation Medicine, Charite Medical School, Berlin, Germany
    Int J Hyperthermia 21:497-513. 2005
    ..A hybridization of an MRI scanner with a hyperthermia system is necessary for a real-time NIT. The selection of the best thermographic method is difficult, because many parameters and attributes have to be considered...
  32. ncbi Anaesthesiological experiences with whole body hyperthermia
    T Kerner
    Department of Anaesthesiology and Critical Care Medicine, Charite Medical Center, Virchow Hospital, Humboldt University, D 13344 Berlin, Germany
    Int J Hyperthermia 19:1-12. 2003
    ....
  33. ncbi Antenna arrays in the SIGMA-eye applicator: interactions and transforming networks
    P Wust
    Center of Radiation Medicine, , Humboldt University at Berlin, Germany
    Med Phys 28:1793-805. 2001
    ..There is a linear but variable relationship between selected (amplifiers) and actually given (feed points) parameters. This linear mapping (described by a matrix) and its characteristics need further investigation...
  34. ncbi Temperature data and specific absorption rates in pelvic tumours: predictive factors and correlations
    W Tilly
    Clinic of Radiation Medicine, Charité Medical School of Humboldt University, Berlin, Germany
    Int J Hyperthermia 17:172-88. 2001
    ..Individual limitations of regional hyperthermia caused by anatomical, biological and clinical factors are liable to be difficult to overcome with the rather restricted potentials of the BSD 2000 system to control the SAR distribution...
  35. ncbi Treatment of locally recurrent rectal cancer with special focus on regional pelvic hyperthermia
    B Hildebrandt
    Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Onkologie 27:506-11. 2004
    ..Here we give a short overview on the options available for the treatment of pelvic recurrence of rectal cancer, with special focus on adjunctive regional pelvic radiofrequency hyperthermia...
  36. ncbi Recurrent rectal cancer within the pelvis. A multicenter analysis of 123 patients and recommendations for adjuvant radiotherapy
    Stefan Hocht
    Department of Radiation Oncology and Radiotherapy, Charite Campus Benjamin Franklin, Berlin, Germany
    Strahlenther Onkol 180:15-20. 2004
    ..To evaluate whether changes in surgical technique have influenced this pattern of recurrence, a multicenter retrospective analysis was carried out on a patient population treated recently...
  37. ncbi Value of combined PET/CT for radiation planning in CT-guided percutaneous interstitial high-dose-rate single-fraction brachytherapy for colorectal liver metastases
    Ingo G Steffen
    Klinik fur Strahlenheilkunde, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Radiat Oncol Biol Phys 77:1178-85. 2010
    ..To determine the additional value of fluorodeoxyglucose-positron emission tomography (PET) for clinical target volume definition in the planning of computed tomography (CT)-guided interstitial brachytherapy for liver metastases...
  38. ncbi Corrections of arterial input function for dynamic H215O PET to assess perfusion of pelvic tumours: arterial blood sampling versus image extraction
    L Ludemann
    Department of Radiology, Nuclear Medicine and Radiooncology, Charite Medical Center, Berlin, Germany
    Phys Med Biol 51:2883-900. 2006
    ..0%) and lower partition coefficients (-31.6 +/- 24.2%). The perfusion values and partition coefficients determined with the VOI technique have to be corrected in order to compare the results with those of studies using a blood AIF...
  39. ncbi Fast spectroscopic imaging for non-invasive thermometry using the Pr[MOE-DO3A] complex
    M Hentschel
    Department of Radiology, Charite, Medical School of the Humboldt University, Berlin, Germany
    Phys Med Biol 44:2397-408. 1999
    ..2 degrees C. Furthermore, 3D EPSI experiments with a 16 x 16 x 16 matrix size yielded temperature measurements within 17 s from voxels of size 3 x 3 x 3 mm3...
  40. ncbi Monitoring arterial blood pressure during whole body hyperthermia
    T Kerner
    Department of Anesthesiology and Critical Care Medicine, Charite Medical Center, Virchow Hospital, Humboldt University, Berlin
    Acta Anaesthesiol Scand 46:561-6. 2002
    ..This investigation was performed to evaluate the agreement of invasive measurements at various sites, and to compare invasive and non-invasive methods of ABP monitoring under conditions of a heat-induced extreme vasodilation...
  41. ncbi Morbidity and quality of life during thermotherapy using magnetic nanoparticles in locally recurrent prostate cancer: results of a prospective phase I trial
    M Johannsen
    Department of Urology, Charite Universitatsmedizin, Berlin, Germany
    Int J Hyperthermia 23:315-23. 2007
    ..To investigate the treatment-related morbidity and quality of life (QoL) during thermotherapy using superparamagnetic nanoparticles in patients with locally recurrent prostate cancer...
  42. ncbi Impact of overall treatment time on local control of anal cancer treated with radiochemotherapy
    R Graf
    Center of Radiation Medicine, Campus Virchow Clinic, , Humboldt University, Berlin, Germany
    Oncology 65:14-22. 2003
    ....
  43. ncbi Noninvasive magnetic resonance thermography of recurrent rectal carcinoma in a 1.5 Tesla hybrid system
    Johanna Gellermann
    Clinic for Radiation Medicine, , Berlin, Germany
    Cancer Res 65:5872-80. 2005
    ..Feasibility of noninvasive MR thermography for regional hyperthermia has been shown and should be further investigated...
  44. ncbi CT-guided interstitial brachytherapy in the local treatment of extrahepatic, extrapulmonary secondary malignancies
    Gero Wieners
    , Charit, Campus Virchow Klinikum, , Augustenburger Platz 1, 13353, Berlin, Germany
    Eur Radiol 16:2586-93. 2006
    ..5% after 6 months and progression-free survival 47% after 6 months. Minimally invasive CT-guided HDR brachytherapy is safe and effective in the palliative treatment of extrahepatic, extrapulmonary secondary malignancies...
  45. ncbi Current status of radiant whole-body hyperthermia at temperatures >41.5 degrees C and practical guidelines for the treatment of adults. The German 'Interdisciplinary Working Group on Hyperthermia'
    B Hildebrandt
    Medizinische Klink für Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Int J Hyperthermia 21:169-83. 2005
    ..These recommendations may be helpful to ensure the quality of WBH performed at different institutions...
  46. ncbi Intracranial thermotherapy using magnetic nanoparticles combined with external beam radiotherapy: results of a feasibility study on patients with glioblastoma multiforme
    Klaus Maier-Hauff
    Department of Neurosurgery, Bundeswehrkrankenhaus, Berlin, Germany
    J Neurooncol 81:53-60. 2007
    ..6 degrees C (42.4-49.5 degrees C) were measured and signs of local tumor control were observed. In conclusion, deep cranial thermotherapy using magnetic nanoparticles can be safely applied on glioblastoma multiforme patients...
  47. ncbi Regional hyperthermia in conjunction with definitive radiotherapy against recurrent or locally advanced prostate cancer T3 pN0 M0
    Wolfgang Tilly
    Department of Radiation Medicine, , Berlin, Germany
    Strahlenther Onkol 181:35-41. 2005
    ..CONCLUSION: Regional hyperthermia might be a low-toxicity approach to increase PSA control of common treatment schedules. Further evaluation, in particular employing improved hyperthermia technology, is worthwhile...
  48. ncbi Interactions between hyperthermia and cytotoxic drugs
    B Hildebrandt
    Charité Centrum Tumormedizin, Charite Universitatsmedizin Berlin, Germany
    Cancer Treat Res 134:185-93. 2007
    ....
  49. ncbi Is absolute noninvasive temperature measurement by the Pr[MOE-DO3A] complex feasible
    M Hentschel
    Strahlenklinik und Poliklinik, Charite, Medizinische Fakultät der Humboldt Universität, Berlin, Germany
    MAGMA 10:52-9. 2000
    ..It can be concluded that the results obtained indicate the feasibility of the 1H spectroscopy method in conjunction with the Pr[MOE-DO3A] probe for absolute temperature measurements, with a maximum accuracy of +/- 0.2 degrees C...
  50. ncbi Clinical use of the hyperthermia treatment planning system HyperPlan to predict effectiveness and toxicity
    Geetha Sreenivasa
    Department of Radiation Medicine, , Berlin, Germany
    Int J Radiat Oncol Biol Phys 55:407-19. 2003
    ..Even at its present state of development, hyperthermia planning for regional hyperthermia delivers valuable information, not only for clinical practice, but also for further technologic improvements...
  51. ncbi [Influence of preoperative (hyperthermic) radiochemotherapy on manometric anal sphincter function in locally advanced rectal cancer]
    Johannes Fritzmann
    , , , , Berlin, Germany
    Strahlenther Onkol 180:281-8. 2004
    ..CONCLUSION: Preoperative RCT impairs sphincter function especially in patients with distal tumors. In addition, RCT could have a negative influence on the continence of patients who received sphincter-preserving surgery...
  52. ncbi Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy
    Beate Rau
    Charite Medical School, Campus Berlin Buch, Humboldt University, Department of Surgery and Surgical Oncology, Robert Roessle Klinik, Lindenberger Weg 80, 13125 Berlin, Germany
    J Clin Oncol 21:3391-401. 2003
    ..The focus of this study was on the dynamics of these genetic markers in a longitudinal study-that is, before and after radiochemotherapy...
  53. ncbi Noninvasive magnetic resonance thermography of soft tissue sarcomas during regional hyperthermia: correlation with response and direct thermometry
    Johanna Gellermann
    Clinic for Radiation Medicine, University Hospital Charite, Campus Virchow Klinikum, Berlin, Germany
    Cancer 107:1373-82. 2006
    ..96). CONCLUSIONS: Noninvasive MR thermography of soft tissue sarcoma was feasible and suitable for validating the quality of heating during RHT...
  54. ncbi Radiation exposure to patient and staff in hepatic chemoembolization: risk estimation of cancer and deterministic effects
    Nico Hidajat
    Department of Radiology, Charite Campus Virchow Klinikum, Humboldt University of Berlin, Berlin, Germany
    Cardiovasc Intervent Radiol 29:791-6. 2006
    ..For the radiologist and assistant, risk of fatal cancer and genetic defect and lens opacity might arise when they perform interventions such as TACE intensively...
  55. ncbi Radiation risks for the radiologist performing transjugular intrahepatic portosystemic shunt (TIPS)
    N Hidajat
    Department of Radiology, , University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Br J Radiol 79:483-6. 2006
    ..If the interventionist performs a large number of TIPS procedures in a year, the risk of fatal cancer and developing cataracts becomes relatively high...
  56. ncbi The biologic rationale of hyperthermia
    B Hildebrandt
    Charité Centrum Tumormedizin, Charite Universitatsmedizin Berlin, Germany
    Cancer Treat Res 134:171-84. 2007
    ....
  57. ncbi Clinical hyperthermia of prostate cancer using magnetic nanoparticles: presentation of a new interstitial technique
    M Johannsen
    Department of Urology, Charite Campus Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Int J Hyperthermia 21:637-47. 2005
    ..To the authors' knowledge, this is the first report on clinical application of interstitial hyperthermia using magnetic nanoparticles in the treatment of human cancer...
  58. ncbi Use of H(2) (15)O-PET for investigating perfusion changes in pelvic tumors due to regional hyperthermia
    L Ludemann
    Department of Radiation Therapy, CVK, Charite Universititatsmedizin Berlin, 13353 Berlin, Germany
    Int J Hyperthermia 25:299-308. 2009
    ..An increase in tumor oxygenation and perfusion due to hyperthermia has been reported for experimental tumors. The present study was performed to investigate this hypothesis in patients who underwent regional hyperthermia...
  59. ncbi [CT-guided interstitial brachytherapy of lung malignancies. Technique and first results]
    J Ricke
    Klinik fur Strahlenheilkunde, Charité Virchow Klinikum Berlin
    Radiologe 44:684-6. 2004
    ..Initially, this technique has been developed for the treatment of liver malignancies. In the following we describe this novel technique as well as initial results for the treatment of lung malignancies...
  60. ncbi Pre-operative staging of cervical cancer: comparison of magnetic resonance imaging (MRI) and computed tomography (CT) with histologic results
    J J Oellinger
    Strahlenklinik und Poliklinik Virchow Klinikum, Medizinische Fakultät Humboldt Universität Berlin
    Zentralbl Gynakol 122:82-91. 2000
    ..If MRI were used more widely it would contribute to simplification and shortening of the preoperative diagnostic procedure in patients with cervical carcinoma...
  61. ncbi Combined treatment of inoperable carcinomas of the uterine cervix with radiotherapy and regional hyperthermia. Results of a phase II trial
    S Dinges
    Klinik fur Strahlentherapie, Universitatsklinikum Rudolf Virchow, Berlin
    Strahlenther Onkol 174:517-21. 1998
    ..The purpose of this phase II study was to investigate the toxicity and effectiveness of a combined approach with radiotherapy and regional hyperthermia...
  62. ncbi Residual translational and rotational errors after kV X-ray image-guided correction of prostate location using implanted fiducials
    Reinhold Graf
    Department of Radiation Oncology, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    Strahlenther Onkol 186:544-50. 2010
    ..To evaluate the residual errors and required safety margins after stereoscopic kilovoltage (kV) X-ray target localization of the prostate in image-guided radiotherapy (IGRT) using internal fiducials...
  63. ncbi Thermotherapy of prostate cancer using magnetic nanoparticles: feasibility, imaging, and three-dimensional temperature distribution
    Manfred Johannsen
    Department of Urology, Campus Mitte, Charite Universitatsmedizin, Berlin, Germany
    Eur Urol 52:1653-61. 2007
    ....
  64. ncbi Magnetic nanoparticle hyperthermia for prostate cancer
    Manfred Johannsen
    Department of Urology, Charite Universitatsmedizin, Berlin, Germany
    Int J Hyperthermia 26:790-5. 2010
    ..Until these limitations are overcome and thermoablation can safely be applied as a monotherapy, this treatment modality is being evaluated in combination with irradiation in patients with localised prostate cancer...
  65. ncbi Differential gene expression in peripheral blood lymphocytes of cancer patients treated with whole body hyperthermia and chemotherapy: a pilot study
    Bert Hildebrandt
    Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin der Humboldt Universität, Berlin, Germany
    Int J Hyperthermia 22:625-35. 2006
    ..The aim of this study was to identify genes that become upregulated in peripheral blood lymphocytes (PBLs) of cancer patients during a combined treatment with WBH and chemotherapy by generating complex arrays of cDNA...
  66. ncbi Evaluation of MR-induced hot spots for different temporal SAR modes using a time-dependent finite difference method with explicit temperature gradient treatment
    Jacek Nadobny
    Clinic for Radiation Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin 13353, Germany
    IEEE Trans Biomed Eng 54:1837-50. 2007
    ..It is shown that this FD scheme significantly reduces the staircase errors at thermal boundaries that are locally sloped or curved with respect to the cubical grid elements...
  67. ncbi [Thermal therapy of prostate cancer using magnetic nanoparticles]
    Manfred Johannsen
    Department of Urology, Campus Mitte, Charite Universitatsmedizin Berlin, Alemania
    Actas Urol Esp 31:660-7. 2007
    ..Until these limitations will be overcome and thermal ablation can safely be applied as a monotherapy, this treatment modality is being evaluated in combination with irradiation in patients with localized prostate cancer...
  68. ncbi Quantification of fMRI BOLD signal and volume applied to the somatosensory cortex
    Lutz Ludemann
    Universitatsklinikum Charite, CVK, Klinik für Radiologie, Nuklearmedizin und Strahlenheilkunde
    Z Med Phys 17:108-17. 2007
    ..On the other hand, the statistical methods did not yield any significant difference in activation between both hemispheres. The VOI-based method presented here is an additional tool to study the extent and amplitude of the BOLD signal...
  69. ncbi Adaptation of antenna profiles for control of MR guided hyperthermia (HT) in a hybrid MR-HT system
    Mirko Weihrauch
    Clinic for Radiation Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Med Phys 34:4717-25. 2007
    ..It is shown that only few comparison steps are necessary for obtaining a dramatic improvement of the general predictability and quality of the specific absorption rate (SAR) inside the MR-HT hybrid system...
  70. ncbi Perfusion measurement using DCE-MRI: implications for hyperthermia
    Lutz Ludemann
    Department of Radiotherapy, Charite, CVK, Berlin, Germany
    Int J Hyperthermia 24:91-6. 2008
    ..Hyperthermia modifies the contrast agent bolus in that a shorter and more highly concentrated bolus appears earlier in the tissue...
  71. ncbi Brain tumor perfusion: comparison of dynamic contrast enhanced magnetic resonance imaging using T1, T2, and T2* contrast, pulsed arterial spin labeling, and H2(15)O positron emission tomography
    Lutz Ludemann
    Department of Radiation Medicine, Universitatsklinikum Charite, Campus Virchow Klinikum, Berlin, Germany
    Eur J Radiol 70:465-74. 2009
    ..Different techniques for measuring of perfusion are clinically available, but these are usually applied to healthy brain tissue...
  72. ncbi Changes in hepatic blood flow during whole body hyperthermia
    Maria Deja
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Germany
    Int J Hyperthermia 26:95-100. 2010
    ..The aim of this clinical study was to determine changes in hepatic blood flow during WBH for the treatment of metastatic cancer...
  73. ncbi Regional abdominal hyperthermia combined with systemic chemotherapy for the treatment of patients with ovarian cancer relapse: Results of a pilot study
    Christina Fotopoulou
    Department of Gynaecology, University Hospital, Berlin, Germany
    Int J Hyperthermia 26:118-26. 2010
    ..We performed a prospective phase I/II-study of regional abdominal hyperthermia (RHT) combined with systemic chemotherapy in OCR patients in order to evaluate outcome, efficacy and tolerance...
  74. ncbi Non-invasive magnetic resonance thermography during regional hyperthermia
    Lutz Ludemann
    Department of Radiation Therapy, CVK, Charite Universititatsmedizin Berlin, Berlin, Germany
    Int J Hyperthermia 26:273-82. 2010
    ..TmDOTMA(-) appears to be the most promising lanthanide complex because it showed a temperature imaging accuracy of <0.3 degrees C...
  75. ncbi Simulation of different applicator positions for treatment of a presacral tumour
    Johanna Gellermann
    Clinic for Radiation Medicine, Charite Medical School, Campus Berlin Buch, Lindenberger Weg 80, 13125 Berlin, Germany
    Int J Hyperthermia 23:37-47. 2007
    ..This study is to clarify whether a change of position of the Sigma-Eye applicator in this region can improve the heating...
  76. ncbi The cellular and molecular basis of hyperthermia
    Bert Hildebrandt
    Medical Clinic, Department of Hematology and Oncology, Charite Medical School, Humboldt University, Campus Virchow Clinic, D 13344 Berlin, Germany
    Crit Rev Oncol Hematol 43:33-56. 2002
    ....
  77. ncbi Value of 123I-IMT SPECT for diagnosis of recurrent non-astrocytic intracranial tumours
    Michail Plotkin
    Department of Radiology, Nuclear Medicine and Radio oncology, Klinik fur Strahlenheilkunde, Campus Virchow Klinikum, Charite Universitatsmedizin, 13353 Berlin, Germany
    Neuroradiology 47:18-26. 2005
    ..The limitation of the IMT-SPECT is its low sensitivity for the detection of small lesions...
  78. ncbi 18F-FET PET for planning of thermotherapy using magnetic nanoparticles in recurrent glioblastoma
    Michail Plotkin
    Department of Radiology, Nuclear Medicine and Radiooncology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Int J Hyperthermia 22:319-25. 2006
    ..The aim of this study was to evaluate the usefulness of PET with a recently introduced amino acid tracer O-(2-[18F]fluoroethyl)-]L-tyrosine (FET) for targeting the nanoparticles implantation...
  79. ncbi 123I-IMT SPECT and 1H MR-spectroscopy at 3.0 T in the differential diagnosis of recurrent or residual gliomas: a comparative study
    Michail Plotkin
    Klinik fur Strahlenheilkunde, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin, Germany
    J Neurooncol 70:49-58. 2004
    ....
  80. ncbi Development and evaluation of a three-dimensional hyperthermia applicator with Water-COated Antennas (WACOA)
    Jacek Nadobny
    Center of Radiation Medicine, Campus Virchow Klinikum, Charite Medical Center, Humboldt University at Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Med Phys 30:2052-64. 2003
    ..Experimental and numerical evaluations demonstrate a good stability of impedance matching, a low inter-channel coupling of less than -20 dB, and a good ability of field pattern steering...
  81. ncbi Description and characterization of the novel hyperthermia- and thermoablation-system MFH 300F for clinical magnetic fluid hyperthermia
    Uwe Gneveckow
    Department of Radiation Medicine, Charite Medical School Berlin, Campus Virchow Klinikum, Center of Biomedical Nanotechnology, Spandauer Damm 130, 14050 Berlin, Germany
    Med Phys 31:1444-51. 2004
    ..01 g/l Fe in the MRI. The system has proved its capability and practicability for heat treatment in deep regions of the human body...
  82. ncbi [Standards and perspectives in locoregional hyperthermia]
    Bert Hildebrandt
    Medizinische Klinik für Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Deutschland
    Wien Med Wochenschr 154:148-58. 2004
    ..We here give a critical update on the proven indications of the different locoregional hyperthermia approaches and on the current clinical and technological progress in this field...
  83. ncbi [CT-Guided brachytherapy. A novel percutaneous technique for interstitial ablation of liver metastases]
    Jens Ricke
    Klinik fur Strahlenheilkunde, Charite Virchow Klinikum, Humboldt Universitat zu Berlin, Berlin, Germany
    Strahlenther Onkol 180:274-80. 2004
    ..To assess safety and efficacy of CT-guided brachytherapy of liver malignancies...
  84. ncbi CT-guided interstitial brachytherapy of liver malignancies alone or in combination with thermal ablation: phase I-II results of a novel technique
    Jens Ricke
    Klinik fur Strahlenheilkunde, Charité Virchow Klinikum Medical Faculty of the Humboldt University Berlin, Berlin, Germany
    Int J Radiat Oncol Biol Phys 58:1496-505. 2004
    ..To assess the safety and efficacy of CT-guided brachytherapy alone or in combination with laser-induced thermotherapy (LITT) in patients with liver malignancies...
  85. ncbi Response prediction by FDG-PET after neoadjuvant radiochemotherapy and combined regional hyperthermia of rectal cancer: correlation with endorectal ultrasound and histopathology
    Holger Amthauer
    Klinik fur Strahlenheilkunde und PET Zentrum Berlin, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Nucl Med Mol Imaging 31:811-9. 2004
    ..FDG-PET results were statistically significant (P<0.001, CI=95%). FDG-PET has great potential in the assessment of tumour response to neoadjuvant RCT in combination with RHT and is superior to EUS for this purpose...
  86. ncbi Whole body hyperthermia induces apoptosis in subpopulations of blood lymphocytes
    Annette Dieing
    Medical Clinic, Department of Hematology and Oncology, Charite Medical School, Humboldt University, Campus Mitte, Berlin, Germany
    Immunobiology 207:265-73. 2003
    ..Our results suggest, that apoptosis is one reason for the previously described decrease of T-cells during WBH and of NK-cells after WBH, and that the hyperthermia-related apoptosis-inducing mechanism is different in T-cells and NK-cells...
  87. ncbi Experimental and numerical investigation of feed-point parameters in a 3-D hyperthermia applicator using different FDTD models of feed networks
    Jacek Nadobny
    Charité Campus Virchow Klinikum Klinik für Strahlenheilkunde, Augustenburger Platz 1, 13353 Berlin, Germany
    IEEE Trans Biomed Eng 49:1348-59. 2002
    ..The measured data correlate best with the latter FDTD model, resulting in an improvement of more than 20% and 20 degrees (average difference in amplitudes and phases) when compared with the two simpler FDTD models...
  88. ncbi Restaging of locally advanced carcinoma of the rectum with MR imaging after preoperative radio-chemotherapy plus regional hyperthermia
    Karl Titus Hoffmann
    Department of Radiology and Radiation Oncology, Campus Virchow Klinikum, Charite
    Strahlenther Onkol 178:386-92. 2002
    ....
  89. ncbi Liver malignancies: CT-guided interstitial brachytherapy in patients with unfavorable lesions for thermal ablation
    Jens Ricke
    Klinik fur Strahlenheilkunde, Charite Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    J Vasc Interv Radiol 15:1279-86. 2004
    ..To evaluate computed tomography (CT)-guided brachytherapy in patients with very large liver malignancies or with liver tumors located adjacent to the liver hilum...
  90. ncbi Hyperfractionated accelerated chemoradiation with concurrent fluorouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer: final results of the radiotherapy coo
    Volker Budach
    Department of Radiation Oncology, University Hospitals Charité, Berlin, Germany
    J Clin Oncol 23:1125-35. 2005
    ..6 Gy) to hyperfractionated accelerated radiation therapy alone (HART; 77.6 Gy)...
  91. ncbi A clinical water-coated antenna applicator for MR-controlled deep-body hyperthermia: a comparison of calculated and measured 3-D temperature data sets
    Jacek Nadobny
    Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Klinik fur Strahlenheilkunde, Augustenburger Platz 1, 13353 Berlin, Germany
    IEEE Trans Biomed Eng 52:505-19. 2005
    ..The calculation and optimization of temperature patterns was obtained using the finite element method (FEM). For MR temperature measurements the proton resonance frequency (PRF) method was used...
  92. ncbi The effect of induced hyperthermia on the immune system
    Annette Dieing
    Department of Oncology and Hematology, Charite Campus Mitte, University Medicine Berlin, Germany, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Prog Brain Res 162:137-52. 2007
    ..In this chapter, we review the most relevant data known about the effect of hyperthermia on the immune system with special focus on alterations induced by therapeutical whole-body hyperthermia (WBH) in cancer patients...
  93. ncbi Quantitative measurement of leakage volume and permeability in gliomas, meningiomas and brain metastases with dynamic contrast-enhanced MRI
    Lutz Ludemann
    Department of Neuroradiology and Radiology, Universitatsklinikum Charite, 10117 Berlin, Germany
    Magn Reson Imaging 23:833-41. 2005
    ..Perfusion was shown to increase linearly with blood volume for volumes of up to 20%, flattening out thereafter. The scatter plots of extravascular extracellular volume and blood volume were shown to differ among the tumor entities...
  94. ncbi Adjuvant chemotherapy with folinic acid and 5-fluorouracil in patients with locally advanced rectal cancer previously treated by preoperative radiochemotherapy and curative tumor resection
    Bert Hildebrandt
    Medizinische Klinik für Hämatologie und Onkologie, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Int J Colorectal Dis 21:582-9. 2006
    ..The role of postoperative adjuvant chemotherapy in patients with rectal cancer pretreated by preoperative radiochemotherapy (RCT) and curative surgery is still poorly investigated...
  95. ncbi Diagnostic value of 123I-IMT SPECT in the follow-up of head and neck cancer
    Michail Plotkin
    Department of Radiology, Nuclear Medicine and Radiooncology, Campus Virchow, Berlin, Germany
    Onkologie 29:147-52. 2006
    ..In the current study, we assess the value of single-photon emission tomography (SPECT) using the amino acid tracer L-3-[123I]iodine-alpha-methyl-tyrosine (IMT) for the detection of recurrent head and neck cancer...
  96. ncbi Stress induced changes in lymphocyte subpopulations and associated cytokines during whole body hyperthermia of 41.8-42.2 degrees C
    Olaf Ahlers
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, 13344, Berlin, Germany
    Eur J Appl Physiol 95:298-306. 2005
    ..Further studies are necessary to examine the pathophysiological details and to evaluate the meaning of these transient immunological changes for patient's outcome...
  97. ncbi CT-guided interstitial single-fraction brachytherapy of lung tumors: phase I results of a novel technique
    Jens Ricke
    Klinik fur Strahlenheilkunde, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Chest 127:2237-42. 2005
    ..To assess the safety of CT-guided brachytherapy of lung malignancies and to evaluate the initial therapeutic response...
  98. ncbi In vivo assessment of the tolerance dose of small liver volumes after single-fraction HDR irradiation
    Jens Ricke
    Klinik fur Strahlenheilkunde, Charite, Campus Virchow Klinikum, Humboldt University Medical School, Berlin, Germany
    Int J Radiat Oncol Biol Phys 62:776-84. 2005
    ..To prospectively assess a dose-response relationship for small volumes of liver parenchyma after single-fraction irradiation...
  99. ncbi Dose-escalated conformal radiotherapy of glioblastomas -- results of a retrospective comparison applying radiation doses of 60 and 70 Gy
    Reinhold Graf
    Centre of Radiation Medicine, Humboldt University, Berlin, Germany
    Onkologie 28:325-30. 2005
    ..Dose escalated three-dimensional conformal radiotherapy with 70 Gy against glioblastomas was compared retrospectively with the standard scheme of 60 Gy using 2-D-planning...
  100. ncbi In vivo assessment of the gastric mucosal tolerance dose after single fraction, small volume irradiation of liver malignancies by computed tomography-guided, high-dose-rate brachytherapy
    Florian Streitparth
    Department of Radiology, , Campus Virchow Clinic, Humboldt University, Berlin, Germany
    Int J Radiat Oncol Biol Phys 65:1479-86. 2006
    ..5 Gy for the clinical endpoint ulceration of the gastric mucosa. This in vivo assessment is in accordance with previously published tolerance data...
  101. ncbi Goal-directed therapy of cardiac preload in induced whole-body hyperthermia
    Maria Deja
    Department of Anesthesiology and Critical Care Medicine, Charite Medical Center, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Chest 128:580-6. 2005
    ..To optimize volume therapy during induced whole-body hyperthermia (WBH) < or = 42.2 degrees C, pulmonary capillary wedge pressure (PCWP) and intrathoracic blood volume index (ITBVI) were compared as goal parameters...