Andreas Wunder

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Optical imaging of vascular pathophysiology
    Andreas Wunder
    Molecular Imaging Group, Dept of Experimental Neurology, Center for Stroke Research Berlin CSB, Charite University Medicine Berlin, Chariteplatz 1, 10098, Berlin, Germany
    Basic Res Cardiol 103:182-90. 2008
  2. doi request reprint Imaging blood-brain barrier dysfunction in animal disease models
    Andreas Wunder
    Department of Experimental Neurology, Center for Stroke Research Berlin, Charite University Medicine Berlin, Berlin, Germany
    Epilepsia 53:14-21. 2012
  3. ncbi request reprint Noninvasive fluorescence imaging in animal models of stroke
    N Stemmer
    Center for Stroke Research Berlin, Small Animal Imaging Center, Department of Experimental Neurology, Charite University Medicine Berlin, Germany
    Curr Med Chem 19:4786-93. 2012
  4. doi request reprint Non-invasive visualization of CNS inflammation with nuclear and optical imaging
    A Wunder
    Center for Stroke Research Berlin CSB, Department of Experimental Neurology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Neuroscience 158:1161-73. 2009
  5. ncbi request reprint Molecular imaging: novel tools in visualizing rheumatoid arthritis
    A Wunder
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine I, University of Regensburg, Germany
    Rheumatology (Oxford) 44:1341-9. 2005
  6. doi request reprint Near-infrared fluorescence imaging with fluorescently labeled albumin: a novel method for non-invasive optical imaging of blood-brain barrier impairment after focal cerebral ischemia in mice
    Jan Klohs
    Department of Experimental Neurology, Charite University Medicine Berlin, Germany
    J Neurosci Methods 180:126-32. 2009
  7. pmc Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining
    Peyman Bahmani
    Department of Experimental Neurology, Center for Stroke Research Berlin, Small Animal Imaging Center, Charite University Medicine Berlin, Chariteplatz 1, Berlin, Germany
    J Cereb Blood Flow Metab 31:1311-20. 2011
  8. doi request reprint Fluorescence tomography technique optimized for noninvasive imaging of the mouse brain
    Riad Bourayou
    Berlin NeuroImaging Center, Chariteplatz 1, 10098 Berlin, Germany
    J Biomed Opt 13:041311. 2008
  9. pmc Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke
    Denise Harhausen
    Department of Experimental Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 8:e69529. 2013
  10. pmc Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives
    Marietta Zille
    Department of Experimental Neurology, Center for Stroke Research Berlin, Charite University Medicine Berlin, Berlin, Germany
    J Cereb Blood Flow Metab 32:213-31. 2012

Collaborators

Detail Information

Publications22

  1. doi request reprint Optical imaging of vascular pathophysiology
    Andreas Wunder
    Molecular Imaging Group, Dept of Experimental Neurology, Center for Stroke Research Berlin CSB, Charite University Medicine Berlin, Chariteplatz 1, 10098, Berlin, Germany
    Basic Res Cardiol 103:182-90. 2008
    ..This article comprises a brief overview of optical imaging techniques, such as fluorescence imaging and bioluminescence imaging for the visualization of vascular pathophysiology...
  2. doi request reprint Imaging blood-brain barrier dysfunction in animal disease models
    Andreas Wunder
    Department of Experimental Neurology, Center for Stroke Research Berlin, Charite University Medicine Berlin, Berlin, Germany
    Epilepsia 53:14-21. 2012
    ..This review outlines key recent advances in imaging techniques that have contributed to the understanding of BBB dysfunction in disease and discusses major obstacles and opportunities to advance these techniques into the clinical realm...
  3. ncbi request reprint Noninvasive fluorescence imaging in animal models of stroke
    N Stemmer
    Center for Stroke Research Berlin, Small Animal Imaging Center, Department of Experimental Neurology, Charite University Medicine Berlin, Germany
    Curr Med Chem 19:4786-93. 2012
    ..Second, a short introduction to animal models of stroke is provided. Third, examples for NFI in animal models of stroke are given. Finally, the use of NFI in human stroke is critically discussed...
  4. doi request reprint Non-invasive visualization of CNS inflammation with nuclear and optical imaging
    A Wunder
    Center for Stroke Research Berlin CSB, Department of Experimental Neurology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Neuroscience 158:1161-73. 2009
    ....
  5. ncbi request reprint Molecular imaging: novel tools in visualizing rheumatoid arthritis
    A Wunder
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine I, University of Regensburg, Germany
    Rheumatology (Oxford) 44:1341-9. 2005
    ..With regard to their applicability in rheumatic diseases, we discuss potential molecular targets, current experimental approaches and the future prospects for molecular imaging in rheumatoid arthritis...
  6. doi request reprint Near-infrared fluorescence imaging with fluorescently labeled albumin: a novel method for non-invasive optical imaging of blood-brain barrier impairment after focal cerebral ischemia in mice
    Jan Klohs
    Department of Experimental Neurology, Charite University Medicine Berlin, Germany
    J Neurosci Methods 180:126-32. 2009
    ..In conclusion, NIRF-BSA is a suitable marker of plasma albumin extravasation in the mouse brain. Non-invasive NIRF imaging with NIRF-BSA is a useful tool to study BBB integrity in preclinical models of central nervous system pathology...
  7. pmc Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining
    Peyman Bahmani
    Department of Experimental Neurology, Center for Stroke Research Berlin, Small Animal Imaging Center, Charite University Medicine Berlin, Chariteplatz 1, Berlin, Germany
    J Cereb Blood Flow Metab 31:1311-20. 2011
    ..It provides important information on the experimental and potential clinical applications of annexin A5-based imaging agents in stroke...
  8. doi request reprint Fluorescence tomography technique optimized for noninvasive imaging of the mouse brain
    Riad Bourayou
    Berlin NeuroImaging Center, Chariteplatz 1, 10098 Berlin, Germany
    J Biomed Opt 13:041311. 2008
    ..iii) Finally, on an animal model with a fluorescent inclusion in the brain, the target position was reconstructed with an accuracy of 1.6 mm...
  9. pmc Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke
    Denise Harhausen
    Department of Experimental Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 8:e69529. 2013
    ..We provide further strong evidence that DPA-714 is a specific ligand to image activated microglia/macrophages in experimental models of brain inflammation. ..
  10. pmc Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives
    Marietta Zille
    Department of Experimental Neurology, Center for Stroke Research Berlin, Charite University Medicine Berlin, Berlin, Germany
    J Cereb Blood Flow Metab 32:213-31. 2012
    ..As there is much interest in the visualization of stroke using noninvasive imaging strategies, we also specifically discuss how these techniques can be interpreted within the context of cell death...
  11. doi request reprint Near-infrared fluorescent probes for imaging vascular pathophysiology
    Jan Klohs
    Dept of Experimental Neurology, Center for Stroke Research Berlin CSB, Charite University Medicine, Chariteplatz 1, 10117, Berlin, Germany
    Basic Res Cardiol 103:144-51. 2008
    ..The publications reviewed herein discuss the characteristics of cyanine dyes and their conjugates and present examples for the application of these probes for imaging vascular pathophysiology...
  12. ncbi request reprint In vivo near-infrared fluorescence imaging of matrix metalloproteinase activity after cerebral ischemia
    Jan Klohs
    Department of Experimental Neurology, Center for Stroke Research Berlin, Charite University Medicine Berlin, Chariteplatz 1, Berlin 10117, Germany
    J Cereb Blood Flow Metab 29:1284-92. 2009
    ..Our study shows that MMP activity after cerebral ischemia can be imaged noninvasively with NIRF using an MMP-activatable probe, which might be a useful tool to study MMP activity in the pathophysiology of the disease...
  13. ncbi request reprint Noninvasive near-infrared imaging of fluorochromes within the brain of live mice: an in vivo phantom study
    Jan Klohs
    Experimental Neurology, Charite Universitaetsmedizin Berlin, Germany
    Mol Imaging 5:180-7. 2006
    ..This encourages the application of NIRF for molecular imaging in the mouse brain using NIRF reporters...
  14. doi request reprint Towards noninvasive molecular fluorescence imaging of the human brain
    J Steinbrink
    Clinic of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurodegener Dis 5:296-303. 2008
    ..We argue that due to its high sensitivity, optical molecular imaging of the brain is feasible, which - together with its bedside applicability - makes it a promising technique for use in patients...
  15. pmc Single-cell resolution mapping of neuronal damage in acute focal cerebral ischemia using thallium autometallography
    Franziska Stöber
    1 Department of Experimental Neurology, Center for Stroke Research Berlin CSB, Charite University Medicine Berlin, Berlin, Germany 2 Department of Auditory Learning and Speech, Leibniz Institute for Neurobiology, Magdeburg, Germany
    J Cereb Blood Flow Metab 34:144-52. 2014
    ....
  16. doi request reprint Optical imaging
    Jochen Müller
    Department of Experimental Neurology, Charite University Medicine, Berlin, Germany
    Recent Results Cancer Res 187:221-46. 2013
    ....
  17. doi request reprint In vivo imaging of the inflammatory receptor CD40 after cerebral ischemia using a fluorescent antibody
    Jan Klohs
    Department Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Stroke 39:2845-52. 2008
    ..5 (cy5.5-cd40mab)...
  18. doi request reprint Brain perfusion SPECT in the mouse: normal pattern according to gender and age
    Ivayla Apostolova
    Department of Nuclear Medicine, Charite Universitatsmedizin Berlin, Germany
    Neuroimage 63:1807-17. 2012
    ..ECD is not suitable as tracer for brain SPECT in the mouse because of its fast clearance from tissue indicating an interspecies difference in esterase activity between mice and humans...
  19. ncbi request reprint Albumin-coupled methotrexate (MTX-HSA) is a new anti-arthritic drug which acts synergistically to MTX
    C Fiehn
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Rheumatology (Oxford) 43:1097-105. 2004
    ..To evaluate the anti-arthritic effects of the new inflammation-targeted drug MTX-HSA and to investigate whether peripheral blood mononuclear cells (PBMC) are potential target cells for albumin-mediated drug delivery...
  20. ncbi request reprint [Current state of molecular imaging research]
    J Grimm
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Rofo 177:326-37. 2005
    ..This article comprises a review of current technologies of molecular imaging, describes the development of contrast agents and various imaging modalities, new applications in specific disease models, and potential future developments...
  21. pmc Methotrexate (MTX) and albumin coupled with MTX (MTX-HSA) suppress synovial fibroblast invasion and cartilage degradation in vivo
    C Fiehn
    Department of Haematology, Oncology and Rheumatology, Clinic of Internal Medicine V, University of Heidelberg, Germany
    Ann Rheum Dis 63:884-6. 2004
    ..To investigate the effect of methotrexate (MTX) and albumin coupled with methotrexate (MTX-HSA) on cartilage invasion and induction of perichondrocytic degradation by rheumatoid arthritis synovial fibroblasts (RA SF) in vivo...
  22. ncbi request reprint [Molecular imaging in rheumatoid arthritis]
    A Wunder
    Center for Molecular Imaging Research Massachusetts, General Hospital Havard Medical School, Charlestown, MA 02129, USA
    Z Rheumatol 62:II33-6. 2003
    ..Therefore, the choice of the imaging modality for molecular imaging depends on the questions that need to be answered. This review discusses the potential of imaging modalities for molecular imaging in rheumatoid arthritis (RA)...