Margitta Worm

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Novel unconventional therapeutic approaches to atopic eczema
    M Worm
    Department of Dermatology and Allergy, Charite, Humboldt University, Berlin, Germany
    Dermatology 201:191-5. 2000
  2. ncbi request reprint Food allergy and non-allergic food hypersensitivity in children and adolescents
    C C Roehr
    Department of Pediatric Pneumology and Immunology, University Hospital Charite, Humboldt University, Berlin, Germany
    Clin Exp Allergy 34:1534-41. 2004
  3. ncbi request reprint Patch testing in children--recommendations of the German Contact Dermatitis Research Group (DKG)
    Margitta Worm
    Department of Dermatology and Allergy, Charite, Berlin, Germany
    J Dtsch Dermatol Ges 5:107-9. 2007
  4. pmc Implementation of anaphylaxis management guidelines: a register-based study
    Linus Grabenhenrich
    Institute of Social Medicine, Epidemiology and Health Economics, Charité University Medical Centre Berlin, Berlin, Germany
    PLoS ONE 7:e35778. 2012
  5. pmc Treatment of atopic dermatitis with pimecrolimus - impact on quality of life
    Hae Hyuk Lee
    Allergy Center Charité CCM, Department of Dermatology and Allergy, Charité Universitätsmedizin Berlin Germany
    Ther Clin Risk Manag 3:1021-6. 2007
  6. doi request reprint Cat peptide antigen desensitisation for treating cat allergic rhinoconjunctivitis
    Margitta Worm
    Charite, Allergy Centre Charité, Department of Dermatology and Allergology, Chariteplatz 1, 10117 Berlin, Germany 0049 30 450518105 0049 30 450518931
    Expert Opin Investig Drugs 22:1347-57. 2013
  7. pmc The epidemiology of anaphylaxis in Europe: protocol for a systematic review
    Sukhmeet S Panesar
    Centre for Population Health Sciences, The University of Edinburgh Medical School, Doorway 3, Teviot Place, Edinburgh, EH8 9AG, UK
    Clin Transl Allergy 3:9. 2013
  8. pmc The acute and long-term management of anaphylaxis: protocol for a systematic review
    Sangeeta Dhami
    Medical School, Doorway 3, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Clin Transl Allergy 3:14. 2013
  9. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  10. doi request reprint Prevalence and treatment profile of patients with grass pollen and house dust mite allergy
    Margitta Worm
    Allergy Center Charité, Department of Dermatology and Allergology, Charite Universitatsmedizin Berlin, Germany
    J Dtsch Dermatol Ges 11:653-61. 2013

Detail Information

Publications136 found, 100 shown here

  1. ncbi request reprint Novel unconventional therapeutic approaches to atopic eczema
    M Worm
    Department of Dermatology and Allergy, Charite, Humboldt University, Berlin, Germany
    Dermatology 201:191-5. 2000
    ..Any new type of unconventional therapy should thus be thoroughly evaluated and shown to be equal or superior to conventional treatments with regard to both efficacy and tolerability before it is recommended for use in clinical practice...
  2. ncbi request reprint Food allergy and non-allergic food hypersensitivity in children and adolescents
    C C Roehr
    Department of Pediatric Pneumology and Immunology, University Hospital Charite, Humboldt University, Berlin, Germany
    Clin Exp Allergy 34:1534-41. 2004
    ..Little information is available on the prevalence of food hypersensitivity in unselected paediatric populations. No data were available for German children...
  3. ncbi request reprint Patch testing in children--recommendations of the German Contact Dermatitis Research Group (DKG)
    Margitta Worm
    Department of Dermatology and Allergy, Charite, Berlin, Germany
    J Dtsch Dermatol Ges 5:107-9. 2007
    ..Standardized patch testing makes it possible to systematically investigate allergic contact dermatitis and identify relevant allergens in children...
  4. pmc Implementation of anaphylaxis management guidelines: a register-based study
    Linus Grabenhenrich
    Institute of Social Medicine, Epidemiology and Health Economics, Charité University Medical Centre Berlin, Berlin, Germany
    PLoS ONE 7:e35778. 2012
    ..Gaps between recommendations and their implementation have been reported, but only in confined settings. Hence, we analysed nation-wide data on the management of anaphylaxis, evaluating the implementation of guidelines...
  5. pmc Treatment of atopic dermatitis with pimecrolimus - impact on quality of life
    Hae Hyuk Lee
    Allergy Center Charité CCM, Department of Dermatology and Allergy, Charité Universitätsmedizin Berlin Germany
    Ther Clin Risk Manag 3:1021-6. 2007
    ..In this article we discuss data which has assessed the impact of AD on the patient's quality of life, and the consequent role of topical anti-inflammatory therapy for long-term AD treatment...
  6. doi request reprint Cat peptide antigen desensitisation for treating cat allergic rhinoconjunctivitis
    Margitta Worm
    Charite, Allergy Centre Charité, Department of Dermatology and Allergology, Chariteplatz 1, 10117 Berlin, Germany 0049 30 450518105 0049 30 450518931
    Expert Opin Investig Drugs 22:1347-57. 2013
    ..Allergic rhinoconjunctivitis is an increasingly common source of morbidity with sensitivity to cats accounting for 10-15% of the disease burden. Allergy to cats is a major risk factor for the development of asthma...
  7. pmc The epidemiology of anaphylaxis in Europe: protocol for a systematic review
    Sukhmeet S Panesar
    Centre for Population Health Sciences, The University of Edinburgh Medical School, Doorway 3, Teviot Place, Edinburgh, EH8 9AG, UK
    Clin Transl Allergy 3:9. 2013
    ..The aims of this systematic review will be to understand and describe the epidemiology of anaphylaxis, i.e. frequency, risk factors and outcomes of anaphylaxis, and describe how these characteristics vary by person, place and time...
  8. pmc The acute and long-term management of anaphylaxis: protocol for a systematic review
    Sangeeta Dhami
    Medical School, Doorway 3, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Clin Transl Allergy 3:14. 2013
    ..The aims of this systematic review will be to assess the effectiveness of interventions for the acute management of anaphylaxis, and pharmacological and non-pharmacological approaches for the long-term management of anaphylaxis...
  9. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  10. doi request reprint Prevalence and treatment profile of patients with grass pollen and house dust mite allergy
    Margitta Worm
    Allergy Center Charité, Department of Dermatology and Allergology, Charite Universitatsmedizin Berlin, Germany
    J Dtsch Dermatol Ges 11:653-61. 2013
    ....
  11. doi request reprint Causes and risk factors for anaphylaxis
    Margitta Worm
    Allergy Center Charité, Department of Dermatology, Venereology and Allergology, Berlin, Germany
    J Dtsch Dermatol Ges 11:44-50. 2013
    ..Furthermore the mechanisms of co-factors and identification of biomarkers for risk assessment are important research areas for the future...
  12. doi request reprint [Epidemiology of anaphylaxis]
    M Worm
    Klinik fur Dermatologie, Venerologie und Allergologie, Allergie Centrum Charité, Charite Universitatsmedizin Berlin
    Hautarzt 64:88-92. 2013
    ..The anaphylaxis registry within the German-speaking area achieved to provide data of the most frequent elicitors, risk factors and the medical treatment from affected individuals to optimize the management of patients with anaphylaxis...
  13. pmc Frequency of disease-associated and other nuclear autoantibodies in patients of the German Network for Systemic Scleroderma: correlation with characteristic clinical features
    Rudolf Mierau
    Laboratory at Rheumaklinik Aachen, Hauptstrasse 21, Aachen, D 52066, Germany
    Arthritis Res Ther 13:R172. 2011
    ..In the present study, we analysed in detail nuclear autoantibodies and their associations in systemic sclerosis (SSc) patients included in the German Network for Systemic Scleroderma Registry...
  14. ncbi request reprint Symptom profile and risk factors of anaphylaxis in Central Europe
    M Worm
    Department of Dermatology and Allergy, University Hospital Charite, Berlin, Germany
    Allergy 67:691-8. 2012
    ..Standardized acquired clinical data from large cohorts of well-defined cases are not available. The aim of this study was to analyse the symptom profile and risk factors of anaphylaxis in a large Central European cohort...
  15. doi request reprint [The registry for severe allergic reactions in German-speaking countries. Recent data and perspectives]
    M Worm
    Allergie Centrum Charité, Klinik für Dermatologie und Allergologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55:380-4. 2012
    ..The registry is an important clinical epidemiological tool which allows to generate research but also disease management-related questions...
  16. doi request reprint [Allergic skin reactions. Current survey]
    M Worm
    Klinik fur Dermatologie, Venerologie und Allergologie, Allergie Centrum Charité, Charité Campus Mitte Universitätsmedizin Berlin
    Dtsch Med Wochenschr 133:S63-6. 2008
  17. doi request reprint Impact of native, heat-processed and encapsulated hazelnuts on the allergic response in hazelnut-allergic patients
    M Worm
    Department of Dermatology and Allergy, Allergy Centrum Charité Campus Mitte, Universitaetsmedizin Berlin, Germany
    Clin Exp Allergy 39:159-66. 2009
    ..Pollen-associated food allergy is common. However, systemic reactions or even life-threatening anaphylaxis are rare...
  18. ncbi request reprint [Periorbital contact eczema]
    M Worm
    Klinik für Dermatologie und Allergologie, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin
    Klin Monbl Augenheilkd 222:853-5. 2005
    ..Until now the short-term use of corticosteroids are is employed for the treatment of allergic contact eczema. Modern substances with an optimal therapeutic index should rather be used...
  19. ncbi request reprint Epidemiology of anaphylaxis
    Margitta Worm
    Allergie Centrum Charité, Klinik für Dermatologie und Allergologie, Berlin, Germany
    Chem Immunol Allergy 95:12-21. 2010
    ..Risk factors for anaphylaxis include age, the presence of other allergic or cardiovascular comorbidities - and gender. More data throughout different countries are needed to monitor the elicitating factors and identify patients at risk...
  20. ncbi request reprint Frequency of atopic dermatitis and relevance of food allergy in adults in Germany
    Margitta Worm
    Allergy Centre Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, D 10117 Berlin, Germany
    Acta Derm Venereol 86:119-22. 2006
    ..A non-selected AD patient cohort does not frequently suffer from clinically relevant pollen-associated food allergy...
  21. doi request reprint Exogenous histamine aggravates eczema in a subgroup of patients with atopic dermatitis
    Margitta Worm
    Department of Dermatology and Allergology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Acta Derm Venereol 89:52-6. 2009
    ..Plasma histamine and diamine oxidase activity were not associated with the clinical response to histamine...
  22. ncbi request reprint Differential immunomodulating effects of inactivated probiotic bacteria on the allergic immune response
    Claudia Rasche
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Acta Derm Venereol 87:305-11. 2007
    ..Regarding cytokine production, the data suggest a differential response to both bacteria depending on the atopic state, but a clear promotion of T-helper1-dominated response in allergic donors...
  23. ncbi request reprint Effects of retinoids on in vitro and in vivo IgE production
    M Worm
    Department of Dermatology, Charite Virchow Klinikum, Humboldt Universitat Berlin, Germany
    Int Arch Allergy Immunol 124:233-6. 2001
    ..The aim of the present study was to extend these findings regarding the potential use of retinoids for the treatment of allergic diseases...
  24. ncbi request reprint Increased leukotriene production by food additives in patients with atopic dermatitis and proven food intolerance
    M Worm
    Humboldt University, Department of Dermatology and Allergy, Charite Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    Clin Exp Allergy 31:265-73. 2001
    ..These findings indicate that single food additives as aggravating factors in AD patients may trigger the disease through increased sLT production as a pathophysiological mechanism...
  25. ncbi request reprint Novel therapies for atopic eczema
    Margitta Worm
    Universitätsklinikum Charité Klinik for Dermatologie, Venerologie und Allergologie, Schumannstr 20 21, 10117 Berlin, Germany
    Curr Opin Investig Drugs 3:1596-603. 2002
    ..Finally, recently patented, experimental compounds are presented, which interfere with several pathways involved in the immune response of AD...
  26. ncbi request reprint Nevoid bag-like soft fibromas
    M Worm
    Department of Dermatology, Charite, Humboldt University, Berlin, Germany
    Dermatology 199:167-8. 1999
    ..We suggest that these nevoid bag-like soft fibromas represent a new malformation in the heterogenous group of nevoid tumors...
  27. ncbi request reprint [Patch testing with the DKG standard series 2001-2004. Results from the IVDK]
    M Worm
    Klinik für Dermatologie und Allergologie, Charite Campus Mitte, Universitatsmedizin Berlin
    Hautarzt 56:1114-24. 2005
    ..Information on the most common contact allergens is updated...
  28. doi request reprint Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice
    Christin Weise
    Allergy Center Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 24:361-7. 2013
    ..Such food components are fatty acids or carbohydrates. Nevertheless, little is known about the impact of oral administration of polyunsaturated fatty acids (PUFA) and non-digestible oligosaccharides on allergen-induced dermatitis...
  29. doi request reprint Tolerability and clinical outcome of coseasonal treatment with Escherichia coli strain Nissle 1917 in grass pollen-allergic subjects
    Sabine Dölle
    Allergy Center Charité, Department of Dermatology and Allergology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int Arch Allergy Immunol 163:29-35. 2014
    ..Herein, we investigated the efficacy and tolerability of EcN in subjects with grass pollen-dependent allergic rhinoconjunctivitis...
  30. ncbi request reprint Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge
    Elke O Luger
    DRFZ, German Rheumatism Research Center, Berlin, Germany
    J Allergy Clin Immunol 124:819-26.e4. 2009
    ..Seasonal allergen exposure triggers clinical symptoms and enhances allergen-specific IgE. Whether allergen-specific plasma cells originating from seasonal allergen exposures can survive and become long-lived is so far unclear...
  31. doi request reprint Tomato allergy: impact of genotype and environmental factors on the biological response
    Sabine Dölle
    Department of Dermatology and Allergology, Allergy Centre Charité, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Sci Food Agric 91:2234-40. 2011
    ..A new approach is to develop hypoallergenic food products. This study characterises the allergenic potential of tomatoes, considering cultivation conditions, developmental stages and genotypes, in order to identify hypoallergenic fruits...
  32. ncbi request reprint Inhibition of IgE production by the imidazoquinoline resiquimod in nonallergic and allergic donors
    Birgit Frotscher
    Department of Dermatology and Allergy, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Germany
    J Invest Dermatol 119:1059-64. 2002
    ..Taken together our results show that resiquimod is a potent modulator of IgE production in vitro in normal but also in allergic donors...
  33. ncbi request reprint Immunophenotypic characterization of peripheral B cells. During short-term immunotherapy with tree pollen allergoid and the immunoadjuvant monophosphoryl lipid A
    Anne C Röver
    Department of Dermatology and Allergy, Charite, Humboldt University, Berlin
    J Investig Allergol Clin Immunol 12:227-34. 2002
    ..Whether these effects are a result of direct allergen action on the B cells or whether they are mediated by T cells and their clinical relevance remains to be elucidated...
  34. doi request reprint Allergy for a lifetime?
    Elke O Luger
    Deutsches Rheuma ForschungsZentrum Berlin, Wissenschaftsgemeinschaft Leibniz, Berlin, Germany
    Allergol Int 59:1-8. 2010
    ..Current concepts target plasma cells for depletion, e.g. the proteasome inhibitor bortezomib, BAFF and APRIL antagonists and autologous hematopoietic stem cell transplantation...
  35. ncbi request reprint Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts
    Guido Heine
    Allergie Centrum Charité, CCM, Klinik fur Dermatologie, Venerologie und Allergologie, Charité Universitäts medizin Berlin, Berlin, Germany Cell Biology Group, Deutsches Rheuma Forschungszentrum Berlin DRFZ, Berlin, Germany
    Eur J Immunol 44:1615-21. 2014
    ....
  36. ncbi request reprint Frequency of contact allergy in German children and adolescents patch tested between 1995 and 2002: results from the Information Network of Departments of Dermatology and the German Contact Dermatitis Research Group
    Guido Heine
    Klinik fur Dermatologie, Venerologie und Allergologie, Campus Charite Mitte, Universitatsmedizin, Berlin, Germany
    Contact Dermatitis 51:111-7. 2004
    ..Atopy-related diseases were more common in children compared to adults. On the basis of the data of this study, the relationship between atopy and the risk of development of ACD, at least in children, needs further investigation...
  37. doi request reprint Interleukin-17A promotes IgE production in human B cells
    Milena Milovanovic
    Department of Dermatology and Allergy, Allergy Center Charité, CCM, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Invest Dermatol 130:2621-8. 2010
    ..Therefore, IL-17A might be a target for the treatment of IgE-dependent diseases, including atopic dermatitis...
  38. doi request reprint Vitamin D receptor activation improves allergen-triggered eczema in mice
    Björn Hartmann
    Allergie Centrum Charité, CCM, Klinik für Dermatologie und Allergologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Invest Dermatol 132:330-6. 2012
    ..Thus, our study provides evidence that systemic VDR agonist treatment may improve allergen-triggered eczema in vivo...
  39. ncbi request reprint Systemic PPARgamma ligation inhibits allergic immune response in the skin
    Anja Dahten
    Department of Dermatology and Allergy, Allergy Center Charité Campus Mitte Universitätsmedizin Berlin, Berlin, Germany
    J Invest Dermatol 128:2211-8. 2008
    ..Our findings point to therapeutic strategies, including a PPARgamma-ligand-based treatment...
  40. doi request reprint Liver X receptors control IgE expression in B cells
    Guido Heine
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Immunol 182:5276-82. 2009
    ..Thus, our data indicates that LXRs are involved in the control of IgE secretion by differentiating B cells...
  41. ncbi request reprint Recommendation: dermatologist's procedure. Recommendations for quality assurance of the German Society of Dermatology (DDG) and the Task Force on Occupational and Environmental Dermatology (ABD)
    Swen Malte John
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Germany
    J Dtsch Dermatol Ges 5:1146-8. 2007
  42. doi request reprint Vitamin D receptor binds to the ε germline gene promoter and exhibits transrepressive activity
    Milena Milovanovic
    Allergy Center Charité, CCM, Department of Dermatology and Allergy, Charite Universitatsmedizin, Berlin, Germany
    J Allergy Clin Immunol 126:1016-23, 1023.e1-4. 2010
    ..We demonstrated previously that calcitriol, the active form of vitamin D, inhibits ε germline transcription, a prerequisite for IgE production. However, the underlying mechanisms remain unexplored...
  43. doi request reprint Late reactions to patch test preparations with reduced concentrations of p-phenylenediamine: a multicentre investigation of the German Contact Dermatitis Research Group
    Uwe Hillen
    Department of Dermatology, University Hospital Essen, University of Duisburg Essen, Hufelandstrasse 55, Essen, Germany
    Contact Dermatitis 64:196-202. 2011
    ..p-Phenylenediamine (PPD) 1% in petrolatum has been shown in a prospective study to elicit late reactions in 1.5% of routine patch tests, which may be indicative of patch test sensitization...
  44. doi request reprint Oral administration of Escherichia coli Nissle 1917 prevents allergen-induced dermatitis in mice
    Christin Weise
    Allergy Center Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Dermatol 20:805-9. 2011
    ..Probiotics, such as Escherichia coli Nissle 1917 (EcN), have been shown to be beneficial for prevention and treatment of several chronic inflammatory diseases...
  45. pmc Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis
    Cilla Söderhäll
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    PLoS Biol 5:e242. 2007
    ..Lack of COL29A1 expression in the outer epidermis of AD patients points to a role of collagen XXIX in epidermal integrity and function, the breakdown of which is a clinical hallmark of AD...
  46. doi request reprint 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells
    Guido Heine
    Allergy Center Charité, CCM, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Immunol 38:2210-8. 2008
    ....
  47. pmc Triggers and treatment of anaphylaxis: an analysis of 4,000 cases from Germany, Austria and Switzerland
    Margitta Worm
    Allergy Center Charité, Department of Dermatology, Venerology and Allergology, Charite Universitatsmedizin Berlin, ADAC Air Rescue Service Senftenberg, Department of Dermatology and Venereology, Medical University of Graz, Austria, Department of Pediatrics, Pneumonology and Immunology, Charite Universitatsmedizin Berlin, Allergy Clinic, Department of Dermatology, SALK, Paracelsus Medical University, Salzburg, Austria, Pediatric Allergology, University Children s Hospital Zurich, Zurich, Switzerland, Department of Dermatology, University Hospital Erlangen Nürnberg, Department of Pediatric Pneumology and Allergology at the KID Center, Dresden Friedrichstadt, Department of Dermatology, Venerology and Allergy at the Saarland University, Homburg Saar, Department of Allergology, Johanniter Krankenhaus im Fläming Treuenbrietzen GmbH, Treuenbrietzen, Department of Internal Medicine I Pneumology and Allergology Immunology, Friedrich Schiller University Jena, Department of Pediatric Pulmonology and Allergology, Children s Hospital of the University of Cologne, Allergy Unit, Department of Dermatology, University Hospital Basel, Basel, Schweiz, Department of Dermatology, Venereology and Allergology, University of Leipzig, Department of Dermatology and Allergology
    Dtsch Arztebl Int 111:367-75. 2014
    ..Anaphylaxis is the most severe manifestation of a mast cell-dependent immediate reaction and may be fatal. According to data from the Berlin region, its incidence is 2-3 cases per 100 000 persons per year...
  48. doi request reprint Provoking allergens and treatment of anaphylaxis in children and adolescents--data from the anaphylaxis registry of German-speaking countries
    Stephanie Hompes
    Department of Dermatology and Allergy, University Hospital Charite Berlin, Germany
    Pediatr Allergy Immunol 22:568-74. 2011
    ..The under-represented usage of adrenaline indicates the need of educational measures for patients and their physicians...
  49. doi request reprint Identification of IgE binding to Api g 1-derived peptides
    Elvira Ruppel
    Allergie Centrum Charité, Klinik für Dermatologie und Allergologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Chembiochem 11:2283-93. 2010
    ..Our improved assay strategy allows us to distinguish between celery-allergic and healthy individuals, but needs to be explored in a larger cohort of well-defined patients...
  50. ncbi request reprint Topical therapy of hand eczema - analysis of the prescription profile from dermatologists in private practice
    Stephanie Soost
    Department of Dermatology, Venereology and Allergology, Charite Universitatsmedizin Berlin, Germany IMS Health GmbH and Co OHG, Frankfurt, Germany
    J Dtsch Dermatol Ges 10:180-4. 2012
    ..Nowadays, it is recommended that treatment be adapted to the severity of the disease. According to the guidelines on the management of hand eczema, topical corticosteroids are the first-line therapy for hand eczema...
  51. ncbi request reprint Sublingual immunotherapy
    Lucie Heinzerling
    Department of Dermatology and Allergy, Allergy Center Charité, Berlin, Germany
    J Dtsch Dermatol Ges 4:428-33; quiz 434-5. 2006
  52. doi request reprint 1,25-dihydroxyvitamin D3 impairs NF-κB activation in human naïve B cells
    Kerstin Geldmeyer-Hilt
    Allergie Centrum Charité, CCM, Klinik für Dermatologie und Allergologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Biochem Biophys Res Commun 407:699-702. 2011
    ..Thus, the vitamin D receptor inhibits costimulatory signal transduction in naïve B cells, namely by reducing CD40 signaling...
  53. doi request reprint Isolation and phenotypic characterization of mucosal nasal lymphocytes by direct ex vivo analysis
    Christin Wolfram
    Department of Dermatology and Allergy, Allergy Center Charité, Medical University Berlin, Campus Charite Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Eur Arch Otorhinolaryngol 266:677-83. 2009
    ..In our study, we show that direct ex vivo isolation of lymphocytes is practicable method and offers a new technique to examine the local nasal allergic immune response using a multiparametric phenotypical analysis...
  54. ncbi request reprint Retinoic acid inhibits CD40 + interleukin-4-mediated IgE production in vitro
    M Worm
    Department of Dermatology, Charite Virchow Klinikum, Humboldt Universität and Deutsches Rheuma Forschungszentrum, Berlin, Germany
    Blood 92:1713-20. 1998
    ..Taken together, this study shows that RA inhibits IgE production of anti-CD40 + IL-4-stimulated B cells in vitro...
  55. ncbi request reprint Tamoxifen counteracts the allergic immune response and improves allergen-induced dermatitis in mice
    M Babina
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Exp Allergy 40:1256-65. 2010
    ..We hypothesized that TX might inhibit type I allergic reactions, which are also characterized by deviations in humoral immunity...
  56. ncbi request reprint Type-IV sensitization profile of individuals with atopic eczema: results from the Information Network of Departments of Dermatology (IVDK) and the German Contact Dermatitis Research Group (DKG)
    G Heine
    Klinik fur Dermatologie, Venerologie und Allergologie, Allergie Centrum Charité Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 61:611-6. 2006
    ..2%) and hand dermatitis (6.6%) was more common, and leg dermatitis (4.0%) less common. Analysis of occupation, suspected allergen source, and accompanying factors revealed no major differences between the both groups...
  57. ncbi request reprint Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production
    F Scheffel
    Department of Dermatology and Allergy, Charite Medical School Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Inflamm Res 54:113-8. 2005
    ..All-trans retinoic acid (ATRA) inhibits IgE synthesis from anti-CD40 plus IL-4 stimulated human B lymphocytes...
  58. ncbi request reprint Ethanol as a cause of hypersensitivity reactions to alcoholic beverages
    I Ehlers
    Department of Dermatology and Allergy, Charite, Hamboldt University, Berlin, Germany
    Clin Exp Allergy 32:1231-5. 2002
    ..By contrast pure ethanol has rarely been reported as a cause of hypersensitivity reactions and its mechanism has not been clarified yet...
  59. ncbi request reprint Efficacy and safety of sublingual tablets of house dust mite allergen extracts in adults with allergic rhinitis
    Karl Christian Bergmann
    Allergy Centre Charité, Charite Universitatsmedizin Berlin, Berlin, Germany Electronic address
    J Allergy Clin Immunol 133:1608-14.e6. 2014
    ..Preliminary studies have suggested the efficacy of sublingual tablets of house dust mite (HDM) extracts in adults with allergic rhinitis...
  60. doi request reprint Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy
    Margitta Worm
    Department of Dermatology, Venerology and Allergology, Charite Universitatsmedizin, Berlin, Germany
    J Allergy Clin Immunol 127:89-97, 97.e1-14. 2011
    ..Immunotherapy targeting allergen-specific T cells, with synthetic peptides representing T-cell epitopes, might improve safety and reduce the duration of treatment...
  61. doi request reprint Atopic dermatitis and allergic rhinitis--do co-effects in therapy exist?
    Karsten Weller
    Allergy Center Charité, Department of Dermatology, Venereology and Allergology, Charite University Medicine, Chariteplatz 1, Berlin, Germany
    J Dtsch Dermatol Ges 10:221-36; quiz 238-9. 2012
    ..In addition, a better understanding of the pathophysiology should have a positive impact on the treatment of atopic manifestations such as atopic dermatitis and allergic rhinitis...
  62. ncbi request reprint Role of adverse reactions to food in urticaria and exercise-induced anaphylaxis
    Sie Uen Chong
    Department of Dermatology and Allergy, Charite, Humboldt University Berlin, Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Int Arch Allergy Immunol 129:19-26. 2002
    ..In specific FDEIA, an IgE-mediated food allergy causes symptoms only in combination with exercise. In the latter group, wheat is an important allergen...
  63. doi request reprint Evidence for novel tomato seed allergens: IgE-reactive legumin and vicilin proteins identified by multidimensional protein fractionation-mass spectrometry and in silico epitope modeling
    Olivia Y Bässler
    Max Planck Institute of Molecular Plant Physiology, D 14467 Potsdam, Germany, Universitat Potsdam GoFORSYS, D 14467 Potsdam, Germany
    J Proteome Res 8:1111-22. 2009
    ..Individual patient sera exhibited varying IgE-sensitivity against the purified proteins. In silico structural modeling indicates high homology between epitopes of known walnut allergens and the detected IgE-crossreactive tomato proteins...
  64. ncbi request reprint Increased sensitivity of patch testing by standardized tape stripping beforehand: a multicentre diagnostic accuracy study
    Heinrich Dickel
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Contact Dermatitis 62:294-302. 2010
    ..As a modification of patch testing, the strip patch test was established to obtain more sensitive and reliable test results. Comparative data on diagnostic accuracy for both tests are missing...
  65. ncbi request reprint Colophony-induced contact dermatitis due to ECG electrodes in an infant
    Elsbeth Oestmann
    Allergie Centrum Charité, Klinik fur Dermatologie, Venerologie und Allergologie, Charite Universitatsmedizin, Berlin, Germany
    Contact Dermatitis 56:177-8. 2007
  66. doi request reprint Inhibition of IgE production by docosahexaenoic acid is mediated by direct interference with STAT6 and NFκB pathway in human B cells
    Christin Weise
    Allergy Center Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    J Nutr Biochem 22:269-75. 2011
    ..Taken together, DHA inhibits IgE production of human B cells by direct interference with both the CD40 and the IL-4 signaling pathway. The data provide one explanation for the anti-allergic role of DHA at the molecular level...
  67. ncbi request reprint Quantitative repeated open application testing with a rinse-off product in methyldibromo glutaronitrile-sensitive patients: results of the IVDK
    Annice Heratizadeh
    Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hanover, Germany
    Contact Dermatitis 62:330-7. 2010
    ..While the use of methyldibromo glutaronitrile (MDBGN) in leave-on products is clearly associated with high sensitization or elicitation risk, such a clear-cut relation could be questioned with regard to rinse-off products...
  68. ncbi request reprint Aromatic components of food as novel eliciting factors of pseudoallergic reactions in chronic urticaria
    Torsten Zuberbier
    Department of Dermatology and Allergy, Charite, Humboldt University, Germany
    J Allergy Clin Immunol 109:343-8. 2002
    ..Pseudoallergic reactions (PARs) against both additives and natural foods have been reported to elicit chronic urticaria, but in natural food the responsible ingredients are largely unknown...
  69. ncbi request reprint Wasp venom rush immunotherapy induces transient downregulation of B cell surface molecule expression
    Anne C Roever
    Department of Dermatology and Allergy, Charite Campus Mitte, Humboldt University, Berlin, Germany
    Int Arch Allergy Immunol 127:226-33. 2002
    ..To elucidate changes in the B cell phenotype during this process, we examined the expression of several surface molecules on peripheral B cells before and during VIT...
  70. ncbi request reprint 1alpha,25-dihydroxyvitamin D3 inhibits anti-CD40 plus IL-4-mediated IgE production in vitro
    Guido Heine
    Department of Dermatology and Allergy, Charite, Humboldt University, Berlin, Germany
    Eur J Immunol 32:3395-404. 2002
    ..The involved mechanism includes epsilon germ-line transcription, NF-kappaB activation and switch recombination suggesting that complex mechanisms of VD action in anti-CD40+IL-4-stimulated B cells are responsible...
  71. ncbi request reprint The German Multicentre Study on Multiple Chemical Sensitivity (MCS)
    Dieter Eis
    Robert Koch Institute RKI, Berlin, Germany
    Int J Hyg Environ Health 211:658-81. 2008
    ..In contrast, numerous indicators for the relevance of behavioural accentuations, psychic alterations or psychosomatic impairments were found in the group of EM-outpatients with subjective "environmental illness"...
  72. doi request reprint 10 years quality assurance of the dermatologist's procedure. ABD review board part II: 2003-2009
    Heike Voss
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Germany
    J Dtsch Dermatol Ges 9:42-6. 2011
    ..Consequently, the Task Force on Occupational and Environmental Dermatology (ABD) of the German Society of Dermatology set up a review board in May 1999...
  73. pmc Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy
    Manuel Hitzler
    German Federal Institute for Risk Assessment BfR, Department of Product Safety, Berlin, Germany
    PLoS ONE 7:e46776. 2012
    ..Our findings suggest that PD-L1 on LCs plays a crucial role in type IV allergic reactions and in response to bacterial stimuli by controlling the nature of inflammatory Th cell responses...
  74. ncbi request reprint [Topical immunomodulators for treatment of eczema]
    Guido Heine
    Klinik fur Dermatologie, Venerologie und Allergologie, Campus Charite Mitte, Universitätsklinikum der Humboldt Universität zu Berlin, Deutschland
    Wien Med Wochenschr 153:522-5. 2003
    ..The diversity of these interactions is extensive, and clinical studies will prove their clinical efficacy...
  75. doi request reprint Whole blood flow cytometric measurement of NFATc1 and IL-2 expression to analyze cyclosporine A-mediated effects in T cells
    Claudia Brandt
    Deutsches Rheuma Forschungszentrum DRFZ, Berlin, Germany
    Cytometry A 77:607-13. 2010
    ..Further experiments have to demonstrate whether the parallel cytometric measurement of NFATc1 and IL-2 in whole blood is a good predictor of individual CsA efficacy and toxicity in CsA-treated patients...
  76. doi request reprint Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen-induced dermatitis in mice
    Christin Weise
    Allergy Center Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Germany
    Pediatr Allergy Immunol 22:497-504. 2011
    ..In this study, we investigated the impact of dietary docosahexaenoic (DHA) and arachidonic acid (AA) on development and severity of allergen-induced dermatitis...
  77. ncbi request reprint A cold-response index for the assessment of Raynaud's phenomenon
    John Foerster
    Klinik fur Dermatologie, Charite, Chariteplatz 1, 10117 Berlin, Germany
    J Dermatol Sci 45:113-20. 2007
    ..We have previously described the time elapsed before 63% of pre-cooling temperature is reached as a RP activity index...
  78. ncbi request reprint Infrared-monitored cold response in the assessment of Raynaud's phenomenon
    J Foerster
    Clinic for Dermatology, Charite, Berlin, Germany
    Clin Exp Dermatol 31:6-12. 2006
    ..We have previously shown that fingertip re-warming after cold challenge follows a first-order transient response curve that can be described by a single variable, designated tau...
  79. doi request reprint GA² LEN/EAACI pocket guide for allergen-specific immunotherapy for allergic rhinitis and asthma
    T Zuberbier
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 65:1525-30. 2010
    ..The recommendations cover patient selection, allergen extract to be used, route of administration of SIT (in particular, sublingual and subcutaneous immunotherapy), and necessary precautions to be followed in using SIT...
  80. doi request reprint Risk factors of adverse reactions to food in German adults
    S Soost
    Department of Dermatology and Allergy, Allergy Center Charité, Universitatsmedizin Berlin, Germany
    Clin Exp Allergy 39:1036-44. 2009
    ..Allergic diseases have been increasing during the last decades. Previous studies suggest an impact of a variety of risk factors on the prevalence of food hypersensitivity...
  81. ncbi request reprint Allergen-mediated modulation of CD23 expression is interferon-gamma and interleukin-10 dependent in allergic and non-allergic individuals
    A C Roever
    Department of Dermatology and Allergy, Charite Campus Mitte, Humboldt University, Berlin, Germany
    Clin Exp Allergy 33:1568-75. 2003
    ..In the present study, we investigated in detail the effects of complete birch pollen allergen extract (BPA) on CD23 expression of peripheral blood mononuclear cells (PBMCs) in vitro...
  82. doi request reprint Epidemiology of urticaria: a representative cross-sectional population survey
    T Zuberbier
    Department of Dermatology and Allergy, Allergie Centrum Charité, Charite Universitatsmedizin Berlin, Germany
    Clin Exp Dermatol 35:869-73. 2010
    ..To investigate the prevalence of urticaria with a focus on chronic urticaria (CU) in a general German population...
  83. ncbi request reprint Mast cells as initiators of immunity and host defense
    B M Henz
    Department of Dermatology, Humboldt University, Berlin, Germany
    Exp Dermatol 10:1-10. 2001
    ..While these data require further clarification, the basic ability of mast cells to initiate innate and acquired immune reactions can no longer be questioned...
  84. ncbi request reprint Neutrophil respiratory burst is decreased in scleroderma and normalized by near-infrared mediated hyperthermia
    J Foerster
    Department of Dermatology, Charite Hospital, Berlin, Germany
    Clin Exp Dermatol 31:799-806. 2006
    ..The production of reactive oxygen species (ROS) by fibroblasts has been suggested to contribute to scleroderma pathogenesis. Infrared-mediated hyperthermia has recently been shown to be of benefit in scleroderma...
  85. ncbi request reprint Prospective safety analysis of an ultrarush specific immunotherapy in adults with wasp venom allergy
    H Lee
    Klinik fur Dermatologie, Venerologie und Allergologie Allergie Centrum Charité CCM Charité Universitätsmedizin Berlin Charitéplatz, 10117 Berlin Germany
    Allergy 61:1237-8. 2006
  86. doi request reprint Cabbage Allergy: A Rare Cause of Food-induced Anaphylaxis
    Sabine Dölle
    Department of Dermatology and Allergology, Charite Universitatsmedizin Berlin, DE 10117 Berlin, Germany
    Acta Derm Venereol 93:485-6. 2013
    ..Abstract is missing (Letter). ..
  87. doi request reprint Isolation of human B cell populations
    Guido Heine
    Klinik fur Dermatologie, Venerologie und Allergologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Curr Protoc Immunol . 2011
    ..Here we describe in detail four methods for isolating B cells from human blood or mononuclear cells, and discuss how these techniques can be combined with fluorescent cell sorting for the characterization of specific B cell populations...
  88. doi request reprint Docosahexaenoic acid (DHA) supplementation in atopic eczema: a randomized, double-blind, controlled trial
    C Koch
    Allergy Center Charité, Department of Dermatology and Allergology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Br J Dermatol 158:786-92. 2008
    ..The increasing prevalence of atopic eczema has been linked to the alteration of the Western diet, namely the reduced consumption of omega-3 (n-3) polyunsaturated fatty acids (PUFA) and an increased omega-6 (n-6) PUFA intake...
  89. ncbi request reprint Modulation of lymphocyte phenotype and function by immunoglobulins
    J Kirschbaum
    Allergy Center Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Schumannstr, 20 21, 10117 Berlin, Germany
    Br J Dermatol 154:225-30. 2006
    ..Immunoglobulins have immune-modulating capacities and are used for the treatment of different dermatological diseases. They have also been reported for the treatment of severe atopic dermatitis (AD)...
  90. ncbi request reprint A combination of wheat flour, ethanol and food additives inducing FDEIA
    E M Fiedler
    Department of Dermatology and Allergy, University Clinic Charite, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Allergy 57:1090-1. 2002
  91. ncbi request reprint Prevalence of adverse reactions to food in Germany - a population study
    T Zuberbier
    Department of Dermatology and Allergy, University Hospital Charite, Humboldt University, Germany
    Allergy 59:338-45. 2004
    ..A population study was performed to identify the prevalence of all kinds of adverse reactions to food...
  92. ncbi request reprint Gastrointestinal nematode infection interferes with experimental allergic airway inflammation but not atopic dermatitis
    S Hartmann
    Department of Molecular Parasitology, Humboldt University Berlin, Berlin, Germany
    Clin Exp Allergy 39:1585-96. 2009
    ....
  93. ncbi request reprint Cytokine and Ig-production by CG-containing sequences with phosphorodiester backbone and dumbbell-shape
    M Schmidt
    Mologen AG, Berlin, Germany
    Allergy 61:56-63. 2006
    ..Immunostimulatory oligodeoxynucleotides (CpG-ODN) usually contain phosphorothioate (PS) backbones for nucleotide protection, which may result in some nonspecific side-effects like prolongation of coagulation time...
  94. ncbi request reprint Association of the toll-like receptor 2 A-16934T promoter polymorphism with severe atopic dermatitis
    D Y Oh
    Institut für Mikrobiologie und Hygiene, Allergie Centrum Charité, CCM, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 64:1608-15. 2009
    ..A genetically determined defective function of pattern recognition receptors such as toll-like receptors (TLRs) has been proposed as a candidate mechanism in the pathogenesis of AD...
  95. doi request reprint Comparison of patients with and without digital ulcers in systemic sclerosis: detection of possible risk factors
    C Sunderkotter
    Department of Dermatology, University of Munster, Von Esmarch Str 58, 48149 Munster, Germany
    Br J Dermatol 160:835-43. 2009
    ..For optimal management it would be useful to identify the risk factors for DU. Such statistical analyses have been rare because they require a high number of patients...
  96. ncbi request reprint Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
    Marco Frentsch
    Clinical Immunology Group, Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Nat Med 11:1118-24. 2005
    ....
  97. ncbi request reprint A 7-step consultation plan for health care workers and hairdressers
    Stephanie Soost
    Department of Dermatology, Venerology and Allergy, Charite University Hospital, Berlin, Germany
    J Dtsch Dermatol Ges 5:756-60. 2007
    ..Optimal prevention methods make it possible for more individuals to remain active in their profession. We devised a 7-step consultation plan which was employed in a standard fashion and then evaluated...
  98. ncbi request reprint [Efficacy of tracrolimus 0.1% ointment in prurigo]
    Hae Hyuk Lee
    Klinik fur Dermatologie, Venerologie und Allergologie, Charite Universitatsmedizin Berlin
    J Dtsch Dermatol Ges 3:690-4. 2005
    ..Potent topical corticosteroids are used the intense pruritus in prurigo diseases. Their long-term application leads to local side effects such as atrophy and telangiectasia...
  99. ncbi request reprint Introducing genetic testing for adult-type hypolactasia
    Carsten Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Humboldt University of Berlin, Berlin, Germany
    Digestion 71:245-50. 2005
    ..To evaluate genotyping for two DNA variants (c.1993+327C>T and c.1438+117G>A), recently found to be associated with adult-type hypolactasia, in the diagnosis of lactose intolerance...