H Witt

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis
    H Witt
    Institute of Laboratory Medicine and Pathobiochemistry, Charite Virchow Hospital, Humboldt University, Berlin, Germany
    Gastroenterology 117:7-10. 1999
  2. ncbi Prenatal diagnosis of Alagille syndrome
    H Witt
    Department of Paediatrics, , Berlin, Germany
    J Pediatr Gastroenterol Nutr 38:105-6. 2004
  3. ncbi Chronic pancreatitis and cystic fibrosis
    H Witt
    Kinderklinik, Charite Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Gut 52:ii31-41. 2003
  4. ncbi A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
    Heiko Witt
    Department of Hepatology and Gastroenterology, Charite University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
    Nat Genet 38:668-73. 2006
  5. ncbi Gene mutations in children with chronic pancreatitis
    H Witt
    Department of Paediatrics, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Pancreatology 1:432-8. 2001
  6. ncbi The SPINK in chronic pancreatitis: similar finds, different minds
    H Witt
    Kinderklinik, , , Augustenburger Platz 1, D-13353 Berlin, Germany
    Gut 50:590-1. 2002
  7. ncbi Alpha1-antitrypsin genotypes in patients with chronic pancreatitis
    H Witt
    Dept of Paediatrics and Institute of Laboratory Medicine and Pathobiochemistry, Charite, Humboldt University, Berlin, Germany
    Scand J Gastroenterol 37:356-9. 2002
  8. ncbi Genetics of chronic pancreatitis
    Heiko Witt
    Department of Paediatrics, Charit, Campus Virchow-Klinikum, Humboldt University, Berlin, Germany
    J Pediatr Gastroenterol Nutr 34:125-36. 2002
  9. ncbi Rapid detection of the Wilson's disease H1069Q mutation by melting curve analysis with the LightCycler
    H Witt
    Department of Paediatrics, Charite, Humboldt University, Berlin, Germany
    Clin Chem Lab Med 39:953-5. 2001
  10. ncbi Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
    H Witt
    Department of Pediatrics, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Nat Genet 25:213-6. 2000

Detail Information

Publications49

  1. ncbi A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis
    H Witt
    Institute of Laboratory Medicine and Pathobiochemistry, Charite Virchow Hospital, Humboldt University, Berlin, Germany
    Gastroenterology 117:7-10. 1999
    ..This study was conducted to determine the spectrum and frequency of cationic trypsinogen mutations in unrelated patients with idiopathic or hereditary chronic pancreatitis (CP)...
  2. ncbi Prenatal diagnosis of Alagille syndrome
    H Witt
    Department of Paediatrics, , Berlin, Germany
    J Pediatr Gastroenterol Nutr 38:105-6. 2004
  3. ncbi Chronic pancreatitis and cystic fibrosis
    H Witt
    Kinderklinik, Charite Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Gut 52:ii31-41. 2003
    ..The identification of further disease modifying genetic factors will increase the pathophysiological understanding and may help to identify new therapeutic targets...
  4. ncbi A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
    Heiko Witt
    Department of Hepatology and Gastroenterology, Charite University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
    Nat Genet 38:668-73. 2006
    ..In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis...
  5. ncbi Gene mutations in children with chronic pancreatitis
    H Witt
    Department of Paediatrics, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Pancreatology 1:432-8. 2001
    ..Therefore, we propose to classify CP as either 'primary CP' (with or without a family history) or 'secondary CP' caused by toxic, metabolic or other factors...
  6. ncbi The SPINK in chronic pancreatitis: similar finds, different minds
    H Witt
    Kinderklinik, , , Augustenburger Platz 1, D-13353 Berlin, Germany
    Gut 50:590-1. 2002
  7. ncbi Alpha1-antitrypsin genotypes in patients with chronic pancreatitis
    H Witt
    Dept of Paediatrics and Institute of Laboratory Medicine and Pathobiochemistry, Charite, Humboldt University, Berlin, Germany
    Scand J Gastroenterol 37:356-9. 2002
    ..The aim of this study was to investigate the relationship between alpha1-antitrypsin deficiency and CP by genetic analysis...
  8. ncbi Genetics of chronic pancreatitis
    Heiko Witt
    Department of Paediatrics, Charit, Campus Virchow-Klinikum, Humboldt University, Berlin, Germany
    J Pediatr Gastroenterol Nutr 34:125-36. 2002
  9. ncbi Rapid detection of the Wilson's disease H1069Q mutation by melting curve analysis with the LightCycler
    H Witt
    Department of Paediatrics, Charite, Humboldt University, Berlin, Germany
    Clin Chem Lab Med 39:953-5. 2001
    ..The protocol allows genotyping of 30 samples in less than 1 hour without a need for restriction enzyme digestion or gel electrophoresis...
  10. ncbi Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
    H Witt
    Department of Pediatrics, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Nat Genet 25:213-6. 2000
    ..In 18 patients, 6 of whom were homozygous, we detected a missense mutation of codon 34 (N34S). We also found four other sequence variants. Our results indicate that mutations in SPINK1 are associated with chronic pancreatitis...
  11. ncbi Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy
    E Schott
    Department of Hepatology and Gastroenterology, CVK, Charite Universitatsmedizin, Berlin, Germany
    J Viral Hepat 15:71-8. 2008
    ..Our results suggest that variations of TLR7 impair the immune response to HCV and imply a gender-specific effect of this X-chromosomal variation...
  12. ncbi MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort
    Sebastian Müller
    Department of Pediatric Pneumology and Immunology, Charité Universitäts medizin, Berlin, Germany
    Pediatr Allergy Immunol 18:665-70. 2007
    ..Our data suggest that MBL deficiency does not represent a pre-disposing factor for respiratory infections or atopic disorders in infants and children...
  13. ncbi Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease
    Thomas von Hahn
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Scand J Gastroenterol 43:584-92. 2008
    ..Our objective was to analyze these two variations...
  14. ncbi Evaluation of complement factor 5 variants as genetic risk factors for the development of advanced fibrosis in chronic hepatitis C infection
    Juliane Halangk
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    J Hepatol 49:339-45. 2008
    ..In 277 patients with hepatitis C, two C5 SNPs, rs17611 and rs2300929, have been associated with advanced fibrosis...
  15. ncbi Keratin 8 Y54H and G62C mutations are not associated with inflammatory bowel disease
    C Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Universitatsmedizin Berlin, Charite, Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Dig Liver Dis 36:388-91. 2004
    ..Keratin 8 deficient mice display signs of colitis and diarrhoea characteristic for inflammatory bowel disease. Very recently, two keratin 8 mutations, Y54H and G62C, were identified...
  16. ncbi Molecular signatures and new candidates to target the pathogenesis of rheumatoid arthritis
    U Ungethuem
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, CharitéUniversitätsmedizin Berlin, Germany
    Physiol Genomics 42:267-82. 2010
    ....
  17. ncbi DLG5 variants in inflammatory bowel disease
    Carsten Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Universitatsmedizin Berlin, Berlin, Germany
    Am J Gastroenterol 101:786-92. 2006
    ..Furthermore, we evaluated whether DLG5 variants alter gastrointestinal permeability in Crohn's disease (CD)...
  18. ncbi The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease
    Daniel C Baumgart
    Division of Gastroenterology and Hepatology, Department of Medicine, Charite Medical School, Humboldt University of Berlin, Berlin, Germany
    Digestion 76:196-202. 2007
    ..Therefore, the study of candidate genes involved in host pathogen interactions is of key interest...
  19. ncbi Smads as intracellular mediators of airway inflammation
    David A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Exp Lung Res 30:223-50. 2004
    ....
  20. ncbi No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: a study in 3 independent European cohorts
    Carsten Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Universitatsmedizin Berlin, Germany
    Inflamm Bowel Dis 14:332-7. 2008
    ..The aim of this study was to analyze the frequency of p.C10X in 3 independent European (IBD) cohorts from Germany, Hungary, and the Netherlands...
  21. ncbi ICOS-gene variants are not associated with atopic disease susceptibility in European children
    Katja C Beier
    Department of Paediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Pediatr Allergy Immunol 20:242-5. 2009
    ..Our data suggest that these ICOS variants do not play a major role in the development of atopy in European children...
  22. ncbi Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer
    Matthias Treiber
    Department of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    J Mol Med (Berl) 84:1015-22. 2006
    ..6%) control subjects of African descent. Our data suggest that the KRT8 alterations, Y54H and G62C, do not predispose patients to the development of pancreatitis or pancreatic cancer...
  23. ncbi Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease
    Eckart Schott
    Department of Hepatology and Gastroenterology, Charite University Hospital Berlin, Berlin, Germany
    Eur J Gastroenterol Hepatol 19:947-51. 2007
    ..In reverse form, CTLA4 variations are associated with chronic infections such as chronic hepatitis B...
  24. ncbi Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis
    Helen Beranek
    Medizinische Klinik und Poliklinik II, , Leipzig, Kinderklinik, , Berlin, Germany
    Eur J Gastroenterol Hepatol 15:1223-7. 2003
    ..The variant TNF-238A, however, might be a relevant risk factor for disease manifestation in families with hereditary pancreatitis...
  25. ncbi A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection
    Eckart Schott
    Department of Hepatology and Gastroenterology, CVK, Charite Universitatsmedizin Berlin, Germany
    J Hepatol 47:203-11. 2007
    ..Since HCV is an RNA virus, a role for TLR7 in the immune response against HCV is likely. No systematic analysis of TLR7 single nucleotide polymorphisms (SNPs) has been published...
  26. ncbi Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis
    C Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Universitatsmedizin Berlin, Berlin, Germany
    Aliment Pharmacol Ther 26:1025-33. 2007
    ..A recent study reported that a non-synonymous single nucleotide polymorphism (rs11209026, p.Arg381Gln) located in the IL23R gene is a protective marker for inflammatory bowel disease...
  27. ncbi Evaluation of angiotensinogen c.1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver diseases of various etiologies
    Juliane Halangk
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Genet Test Mol Biomarkers 13:407-14. 2009
    ..A functional genetic alteration in the human AGT promoter (c.1-44G>A) has been linked to accelerated progression of fibrosis in hepatitis C virus infection...
  28. ncbi Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection
    Andreas Mas Marques
    Robert Koch Institut, Berlin, Germany
    Infect Genet Evol 9:847-52. 2009
    ..1413G>A heterozygosity (33.0% vs. 46.1%, p=0.023). The data indicate that LDLR alterations are correlated with response to interferon-based combination therapy and with self-limitation of HCV 1 infection...
  29. ncbi The role of epoxide hydrolase Y113H gene variant in pancreatic diseases
    Johann Ockenga
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Germany
    Pancreas 38:e97-e101. 2009
    ..We studied the role of the EPHX1 c.337T>C (p.Y113H) variant, whichleads to altered enzyme activity, in pancreatic diseases...
  30. ncbi Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets
    F Wittchen
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    J Mol Med (Berl) 85:257-71. 2007
    ....
  31. ncbi IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis
    Simona Eva Zitnik
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 20:551-5. 2009
    ..These findings suggest that IL13 variants play a major role not only in non-cognate but also in allergen specific IgE synthesis...
  32. ncbi Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection
    Tobias Mueller
    Charite, Campus Virchow Klinikum, Medizinische Klinik mit Schwerpunkt, Hepatologie und Gastroenterologie, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Hepatol 41:652-8. 2004
    ..We investigated whether the IL12B polymorphisms within the promoter region (4 bp insertion/deletion) and the 3'-UTR (1188-A/C), which have been reported to influence IL-12 synthesis, are associated with the outcome of HCV infection...
  33. ncbi Evaluation of the -26G>A CC16 polymorphism in acute respiratory distress syndrome
    Ilka Frerking
    Department of Anesthesiology, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Crit Care Med 33:2404-6. 2005
    ..Furthermore, CC16 potently inhibits phospholipase A2, which plays a major role in ARDS pathophysiology. A functional polymorphism (-26G>A) was previously identified and related to decreased CC16 levels, asthma, and asthma severity...
  34. ncbi Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy
    Heiko Witt
    Department of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Gastroenterology 132:1557-73. 2007
    ..Surgical and endoscopic interventions are reserved for complications such as pseudocysts, abscess, and malignancy...
  35. ncbi Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection
    Eckart Schott
    Department of Hepatology and Gastroenterology, CVK, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Hepatol 46:372-80. 2007
    ..We investigated whether CTLA4 single nucleotide polymorphisms are associated with the resolution of infection or with the course of disease...
  36. ncbi Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis
    Heiko Witt
    Department of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Pancreas 39:188-92. 2010
    ..Genetic alterations of different pancreatic zymogens or their inhibitors have been associated with chronic pancreatitis (CP)...
  37. ncbi The course of genetically determined chronic pancreatitis
    Volker Keim
    Medizinische Klinik II, Universitatsklinikum Leipzig, Germany
    JOP 4:146-54. 2003
    ..The clinical course of chronic pancreatitis in patients with mutations of cationic trypsinogen and the trypsin inhibitor SPINK1 has not yet been characterized...
  38. ncbi N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Deutschland
    Pancreatology 3:67-8. 2003
    ..The SPINK1 mutation N34S is associated to chronic pancreatitis of idiopathic, alcoholic and tropic origin. Our aim was to evaluate its prevalence in patients with sporadic pancreatic cancer...
  39. ncbi Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis
    Kaspar Truninger
    Department of Medicine II, University of Freiburg, Germany
    Am J Gastroenterol 97:1133-7. 2002
    ..In addition, we investigated the impact of this mutation on the long-term course of CP...
  40. ncbi The SPINK1 N34S variant is associated with acute pancreatitis
    Derek A O'Reilly
    Department of Surgery, Derriford Hospital, University of Plymouth, Plymouth, UK
    Eur J Gastroenterol Hepatol 20:726-31. 2008
    ..The aim of this study was to investigate the prevalence of genetic variants of the trypsin inhibitor, SPINK1, in acute pancreatitis...
  41. ncbi Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations
    Eesh Bhatia
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Gastroenterology 123:1020-5. 2002
    ..In the present study we report on mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene in north Indian patients with TCP...
  42. ncbi A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis
    Sundaresan Santhosh
    Pancreas 36:317-20. 2008
  43. ncbi Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis
    Orsolya Kiraly
    Department of Molecular and Cell Biology, Boston University, Goldman School of Dental Medicine, Boston, Massachusetts, USA
    Hum Mutat 28:469-76. 2007
    ..Therefore, these variants should be classified as severe and regarded as disease-causing rather than disease-modifiers...
  44. ncbi HFE genotypes in patients with chronic pancreatitis and pancreatic adenocarcinoma
    Tomas Hucl
    Department of Medicine II, University of Heidelberg, Mannheim, Germany
    Genet Med 9:479-83. 2007
    ..C282Y and p.H63D may increase susceptibility to chronic liver and pancreatic disease. This study determines the frequencies of p.C282Y and p.H63D alterations in patients with chronic pancreatitis and pancreatic adenocarcinoma...
  45. ncbi Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1
    Tobias Mueller
    Hepatology 38:1592; author reply 1592-3. 2003
  46. ncbi Pancreatic disorders and cystic fibrosis: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Jaime Belkind-Gerson
    J Pediatr Gastroenterol Nutr 39:S688-94. 2004
  47. ncbi Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
    Jonas Rosendahl
    Department of Gastroenterology and Hepatology, University of Leipzig, Philipp Rosenthal Strasse 27, 04103 Leipzig, Germany
    Nat Genet 40:78-82. 2008
    ..The results indicate that loss-of-function alterations in CTRC predispose to pancreatitis by diminishing its protective trypsin-degrading activity...
  48. ncbi The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis
    Thomas Muller
    Department of Pediatrics, University of Innsbruck, Innsbruck, Austria
    J Hepatol 38:164-8. 2003
    ..We recently cloned the gene causing copper toxicosis in Bedlington terriers, MURR1, as well as the orthologous human gene on chromosome 2p13-p16...
  49. ncbi Genetic aspects of tropical calcific pancreatitis
    Heiko Witt
    Klinik und Poliklinik für Kinder und Jugendmedizin des Klinikums rechts der Isar, Technische Universitat Munchen, Kolner Platz 1, 80804 Munich, Germany
    Rev Endocr Metab Disord 9:213-26. 2008
    ..The current review focuses on the recent developments in the understanding of the genetic basis of inherited pancreatitis, with special emphasis on TCP...