Susanna Wiegand

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants
    Anna Lena Volckmar
    Department of Child and Adolescent Psychiatry, University Duisburg Essen, Virchowstr, 171, D 45147, Essen, Germany
    BMC Med Genomics 5:65. 2012
  2. doi request reprint [Therapeutic approaches for obesity and comorbidities in young immigrants]
    S Wiegand
    Interdisziplinäres Sozialpädiatrisches Zentrum der Charité Kinderklinik, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:543-50. 2013
  3. doi request reprint Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study
    Susanna Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Eur J Endocrinol 163:585-92. 2010
  4. doi request reprint Gamma-glutamyl transferase is strongly associated with degree of overweight and sex
    Susanna Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Universitatsmedizin Berlin, Germany
    J Pediatr Gastroenterol Nutr 52:635-8. 2011
  5. doi request reprint Daily insulin requirement of children and adolescents with type 1 diabetes: effect of age, gender, body mass index and mode of therapy
    Susanna Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 158:543-9. 2008
  6. ncbi request reprint [Gender and obesity--what does "being fat" mean to boys and girls?]
    Susanna Wiegand
    Charité Kinderklinik, Universitatsmedizin Berlin, Interdisziplinäres SPZ, Bereich Adipositas, Endokrinologie, Diabetes, Berlin
    Ther Umsch 64:319-24. 2007
  7. doi request reprint [Dietary interventions and social care for treating obesity in children]
    S Wiegand
    Interdisziplinäres Sozialpädiatrisches Zentrum der Charité Kinderklinik, Universitatsmedizin Berlin, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54:533-40. 2011
  8. ncbi request reprint [Who needs what? New approaches to multidisciplinary diagnostics and therapy for adipose children and youths in a multiethnic city]
    S Wiegand
    Interdisziplinäres Sozialpädiatrisches Zentrum und Institut für pädiatrische Endokrinologie und Diabetologie, CCV, Universitatsmedizin, Berlin
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 48:307-14. 2005
  9. ncbi request reprint Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity -- a problem that is no longer restricted to minority groups
    Susanna Wiegand
    Paediatric Endocrinology, Charite Children s Hospital, Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 151:199-206. 2004
  10. doi request reprint Obese boys at increased risk for nonalcoholic liver disease: evaluation of 16,390 overweight or obese children and adolescents
    S Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Germany
    Int J Obes (Lond) 34:1468-74. 2010

Detail Information

Publications25

  1. pmc Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants
    Anna Lena Volckmar
    Department of Child and Adolescent Psychiatry, University Duisburg Essen, Virchowstr, 171, D 45147, Essen, Germany
    BMC Med Genomics 5:65. 2012
    ..Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance for human body weight regulation...
  2. doi request reprint [Therapeutic approaches for obesity and comorbidities in young immigrants]
    S Wiegand
    Interdisziplinäres Sozialpädiatrisches Zentrum der Charité Kinderklinik, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:543-50. 2013
    ..Such offers have to be (further) developed in accordance with family background, with youth culture and adolescent stage of development...
  3. doi request reprint Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study
    Susanna Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Eur J Endocrinol 163:585-92. 2010
    ..To study whether metformin reduces obesity, homeostasis model assessment for insulin resistance index (HOMA-IR), and the metabolic syndrome (MtS) in obese European adolescents in addition to previous unsuccessful lifestyle intervention...
  4. doi request reprint Gamma-glutamyl transferase is strongly associated with degree of overweight and sex
    Susanna Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Universitatsmedizin Berlin, Germany
    J Pediatr Gastroenterol Nutr 52:635-8. 2011
    ..13, 95% confidence interval 15.07-48.85) and male sex (odds ratio 2.60, 95% confidence interval 2.03-3.31). GGT seems to be of clinical relevance and may be marketable as a surrogate in risk profiling for children with obesity...
  5. doi request reprint Daily insulin requirement of children and adolescents with type 1 diabetes: effect of age, gender, body mass index and mode of therapy
    Susanna Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 158:543-9. 2008
    ..The purpose of this study was to generate insulin dose (ID) percentiles for children and adolescents with type 1 diabetes mellitus (DM1) having the opportunity to assess this important parameter in relation to age and sex...
  6. ncbi request reprint [Gender and obesity--what does "being fat" mean to boys and girls?]
    Susanna Wiegand
    Charité Kinderklinik, Universitatsmedizin Berlin, Interdisziplinäres SPZ, Bereich Adipositas, Endokrinologie, Diabetes, Berlin
    Ther Umsch 64:319-24. 2007
    ..Obese girls are also four times more likely to become a victim of peer aggression compared to obese boys or non-obese girls. Obese boys on the other hand are more likely to become media dependent...
  7. doi request reprint [Dietary interventions and social care for treating obesity in children]
    S Wiegand
    Interdisziplinäres Sozialpädiatrisches Zentrum der Charité Kinderklinik, Universitatsmedizin Berlin, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54:533-40. 2011
    ..The high-risk groups for pediatric obesity, i.e., families with migration background and/or low socioeconomic status, have been poorly reached by established programs...
  8. ncbi request reprint [Who needs what? New approaches to multidisciplinary diagnostics and therapy for adipose children and youths in a multiethnic city]
    S Wiegand
    Interdisziplinäres Sozialpädiatrisches Zentrum und Institut für pädiatrische Endokrinologie und Diabetologie, CCV, Universitatsmedizin, Berlin
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 48:307-14. 2005
    ..Therefore, a substantial societal effort is needed to facilitate prevention for all children, and effective therapies have to be tailored depending on biological and psychosocial risk factors...
  9. ncbi request reprint Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity -- a problem that is no longer restricted to minority groups
    Susanna Wiegand
    Paediatric Endocrinology, Charite Children s Hospital, Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 151:199-206. 2004
    ..The incidence of childhood obesity and type 2 diabetes is an increasing problem in Europe. We determined the prevalence of impaired glucose regulation in a predominantly Caucasian cohort of 491 children and adolescents with obesity...
  10. doi request reprint Obese boys at increased risk for nonalcoholic liver disease: evaluation of 16,390 overweight or obese children and adolescents
    S Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Germany
    Int J Obes (Lond) 34:1468-74. 2010
    ..Therefore, the prevalence of elevated liver enzymes and their relationship to biological parameters were studied in a large pediatric obesity cohort...
  11. doi request reprint Proinsulin and the proinsulin/insulin ratio in overweight and obese children and adolescents: relation to clinical parameters, insulin resistance, and impaired glucose regulation
    Carlotta von Berghes
    Department of Pediatric Endocrinology and Diabetology, Charite Universitatsmedizin Berlin, Germany
    Pediatr Diabetes 12:242-9. 2011
    ..In adults with impaired glucose regulation (IGR) or type 2 diabetes mellitus (T2DM), proinsulin (PI) and its ratio to insulin (ins; PI/I ratio) are frequently elevated...
  12. doi request reprint Do common variants separate between obese melanocortin-4 receptor gene mutation carriers and non-carriers? The impact of cryptic relatedness
    Jessica Mühlhaus
    Institute of Experimental Pediatric Endocrinology, Charite Campus Virchow Klinikum, Berlin, Germany
    Horm Res Paediatr 77:358-68. 2012
    ..We genotyped 28 SNPs, covering MC4R, and searched for haplotypes discriminating between obese mutation carriers and non-carriers...
  13. ncbi request reprint Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin
    Jeannine Sauber
    Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Endocrinol 163:259-64. 2010
    ..In this study, we screened the GIPR gene for mutations and examined the association between three single-nucleotide polymorphisms (SNPs; rs8111428, rs2302382, rs1800437) and childhood obesity, as well as impaired glucose homeostasis...
  14. doi request reprint Differences in taste sensitivity between obese and non-obese children and adolescents
    Johanna Overberg
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Arch Dis Child 97:1048-52. 2012
    ..However, data are partly contradictory and insufficient. Therefore, in this study taste sensitivity of obese and non-obese children/adolescents was analysed...
  15. doi request reprint Rescue of melanocortin 4 receptor (MC4R) nonsense mutations by aminoglycoside-mediated read-through
    Harald Brumm
    Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Obesity (Silver Spring) 20:1074-81. 2012
    ..Restoration of full-length proteins by PTC124 could not be confirmed. Future pharmaceutical applications must consider the potency of aminoglycosides to restore receptor function as well as the ability to pass the blood-brain barrier...
  16. doi request reprint Is there a further acceleration in the age at onset of menarche? A cross-sectional study in 1840 school children focusing on age and bodyweight at the onset of menarche
    A M Bau
    Institute for Experimental Pediatric Endocrinology, Charite University Medicine Berlin, Berlin, Germany
    Eur J Endocrinol 160:107-13. 2009
    ..More than 30 years ago Frisch and Revelle proposed a body weight threshold for the onset of menarche. Based on this hypothesis, a further acceleration of age at menarche can be expected in times of childhood obesity...
  17. ncbi request reprint [Gene, fast food and no motion. Causes of childhood obesity]
    A Gruters
    Otto Heubner Centrum für Kinderheilkunde und Jugendmedizin, Universitatsklinikum Charite, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin
    MMW Fortschr Med 144:34-6. 2002
    ..In the case of extremely overweight children, a genetic investigation would be worthwhile...
  18. ncbi request reprint Expression of immediate early genes in sensory ganglia
    D A Groneberg
    Division of Allergy Research, Biomedical Research Center, Charite Medical School, Humboldt University of Berlin, Germany
    Neurochem Res 26:1113-7. 2001
    ....
  19. ncbi request reprint [Psychological aspects of obesity in children and adolescents in integrated health care]
    A M Bau
    Universitatsmedizin Berlin, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50:1145-51. 2007
  20. pmc An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity
    Peter Kuehnen
    Institut für Experimentelle Pädiatrische Endokrinologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS Genet 8:e1002543. 2012
    ..Exon 3 hypermethylation in the POMC locus represents the first identified DNA methylation variant that is associated with the individual risk for obesity...
  21. ncbi request reprint Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys
    Susanna Wiegand
    Paediatric Endocrinology, Campus Virchow, Charite University Medicine Berlin, 13353, Berlin, Germany
    Eur J Endocrinol 157:319-24. 2007
    ..Altered 11beta-HSD1 may cause tissue-specific Cushing's syndrome with central obesity and impaired glucose homeostasis...
  22. ncbi request reprint Impaired glucose tolerance and type 2 diabetes mellitus: a new field for pediatrics in Europe
    S Wiegand
    Paediatric Endocrinology, Charite Children s Hospital, Humboldt University, Berlin, Germany
    Int J Obes (Lond) 29:S136-42. 2005
    ..The most sensitive measurement for detecting changes in glucose metabolism in obese children seems to be an oral glucose tolerance test (OGGT) which is not practical for all daily outpatient clinics...
  23. ncbi request reprint Type 2 diabetes in children and adolescents in a 2-year follow-up: insufficient adherence to diabetes centers
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Horm Res 69:107-13. 2008
    ..To study the 2-year course of children and adolescents with type 2 diabetes mellitus (T2DM) in general practice to present (1) the treatment modalities, (2) patient adherence, and (3) the occurrence of comorbidities...
  24. ncbi request reprint Medical care of obese children and adolescents. APV: a standardised multicentre documentation derived to study initial presentation and cardiovascular risk factors in patients transferred to specialised treatment institutions
    Thomas Reinehr
    Vest Youth Hospital, University of Witten Herdecke, Dr Friedrich Steiner Strasse 5, 45711 Datteln, Germany
    Eur J Pediatr 163:308-12. 2004
    ....
  25. doi request reprint Cardiovascular risk in 26,008 European overweight children as established by a multicenter database
    Dagmar I'Allemand
    Children s Hospital of Eastern Switzerland, St Gallen, Switzerland
    Obesity (Silver Spring) 16:1672-9. 2008
    ..Therefore, weight-related risk factors, their interrelationship, and association with biological parameters were assessed in a large group of overweight (OW) children, documented by an electronic database...