Research Topics
Genomes and Genes
| Thomas WaltherSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptideThomas Walther
Department of Cardiology, Medical Center Benjamin Franklin, Free University of Berlin, D 12200 Berlin, Germany
Biol Chem 385:179-84. 2004..Moreover, the NEP-independent BNP degradation provides an effective means for achieving a beneficial BNP increase in cardiovascular pathology by inhibiting the assumed novel NP-degrading peptidase(s)...- Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart diseaseThomas Walther
Charite Universitatsmedizin, Campus Benjamin Franklin, Department of Cardiology and Pneumonology, Hindenburgdamm 30, 12200 Berlin, Germany
Circulation 115:333-44. 2007..An adequate exchange of ATP and ADP over the inner mitochondrial membrane by the adenine nucleotide translocase (ANT) is thereby essential to guarantee the cellular energy supply... - Agonist autoantibodies against the angiotensin AT1 receptor in renal and hypertensive disordersThomas Walther
Charite, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, Berlin, Germany
Curr Hypertens Rep 9:128-32. 2007..This review summarizes current knowledge about the generation, function, and clinical importance of AT1-AA... - Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculatureThomas Walther
Department of Cardiology and Pneumology, Charite Campus Benjamin Franklin, Berlin, Germany
Hypertension 46:1275-9. 2005..The generation of this antibody seems to be associated with distinct types of pregnancy disorders resulting from impaired placental development. The AT1 autoantibody may thus be causative for pathological uteroplacental perfusion... 
Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathyDirk Westermann
Department of Cardiology and Pneumology, Charité Universitä tsmedizinBerlin, Campus Benjamin Franklin, Berlin, Germany
Diabetes 58:1373-81. 2009..The underlying pathology of this disease is still under discussion. We studied the role of the kinin B1 receptor on the development of experimental diabetic cardiomyopathy...- Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarctionMatthias Koch
Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
Eur J Pharmacol 550:143-8. 2006..Further studies have to show whether these results can be caused by other therapeutically options. Long acting bradykinin receptor agonists might be an alternative option to improve ischemic heart disease... - Central angiotensin II controls alcohol consumption via its AT1 receptorBjörn Maul
Institute of Molecular Pharmacology, Berlin, Germany
FASEB J 19:1474-81. 2005..Our results indicate that a distinct drug-mediated control of the central RAS could be a promising therapy for alcohol disease... - Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathyCarsten Tschope
Department of Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
FASEB J 19:2057-9. 2005..These insights might have therapeutic implications also for human diabetic cardiomyopathy... 
Myocardial overexpression of adenine nucleotide translocase 1 ameliorates diabetic cardiomyopathy in miceYong Wang
Department of Cardiology, Charite Universitatsmedizin Berlin, Germany
Exp Physiol 94:220-7. 2009..Cardiomyocyte-restricted overexpression of ANT1 prevents the development of diabetic cardiomyopathy; therefore, accelerated ADP/ATP exchange could be a new promising target to treat diabetic cardiomyopathy...- Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in miceYong Wang
Department Cardiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
Eur J Heart Fail 9:548-57. 2007..Our study aimed to investigate the effect of cardiomyocyte-specific CNP over-expression on I/R injury and MI in transgenic mice... - The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic ratsLinda Ebermann
Department of Cardiology, Charite, Campus Benjamin Franklin, Berlin, Germany
Eur J Pharmacol 590:276-80. 2008.... - Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptorsFlorian Gembardt
Department of Cardiology, Charite Berlin, Campus Benjamin Franklin, Berlin, Germany
FASEB J 22:3068-77. 2008.... - Excessive hypertension and end-organ damage in a transgenic mouse line carrying the rat angiotensinogen genePing Xu
Department of Cardiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
J Cardiovasc Pharmacol 53:38-43. 2009..Thus, this line TGM(rAOGEN)102 provides a new model to study hypertension-mediated end-organ damage and to evaluate new antihypertensive or cardioprotective drugs... - Improvement of defective sarcoplasmic reticulum Ca2+ transport in diabetic heart of transgenic rats expressing the human kallikrein-1 geneCarsten Tschope
Department of Cardiology and Pneumology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
FASEB J 18:1967-9. 2004..An increased phosphorylation of the SERCA2 regulatory protein phospholamban at threonine17 via a B2 receptor-mediated mechanism is thereby involved... - Does the C-type natriuretic peptide have prognostic value in chagas disease and other dilated cardiomyopathies?Silvia Heringer-Walther
Department of Cardiology and Pneumology, CUM, Campus Benjamin Franklin CBF, Berlin, Germany
J Cardiovasc Pharmacol 48:293-8. 2006..Our data are the first to demonstrate the raised levels of the third natriuretic peptide CNP in CD and other DCM. Whereas ANP and BNP have a high predictive value for mortality in both diseases, CNP is without any predictive potency... - Angiotensin AT2 receptor deficiency after myocardial infarction: its effects on cardiac function and fibrosis depend on the stimulusCarsten Tschope
Department of Cardiology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Cell Biochem Biophys 43:45-52. 2005..Thus, hypertension-induced fibrosis is probably triggered by other control mechanisms than fibrosis induced by MI... - Fibrosis rather than blood pressure determines cardiac BNP expression in miceThomas Walther
Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12200, Berlin, Germany
Regul Pept 116:95-100. 2003.... - Angiotensin deficiency in mice leads to dilated cardiomyopathyThomas Walther
Department Cardiology, Campus Benjamin Franklin, Charite Berlin, Hindenburgdamm, Germany
Eur J Pharmacol 493:161-5. 2004.... - Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein geneCarsten Tschope
Department of Cardiology and Pneumonology, Campus Benjamin Franklin, Charite University Medicine, Free University of Berlin, Germany
FASEB J 18:828-35. 2004..Transgenic expression of hKLK1 counteracts the progression of LV contractile dysfunction and extracellular matrix remodeling in STZ-induced diabetic cardiomyopathy via a BK B2 receptor-dependent pathway... - Relation of ANP and BNP to their N-terminal fragments in fetal circulation: evidence for enhanced neutral endopeptidase activity and resistance of BNP to neutral endopeptidase in the fetusThomas Walther
Department of Cardiology, Benjamin Franklin Medical Center, Free University of Berlin, Berlin, Germany
BJOG 111:452-5. 2004..These findings point to a BNP degradation that is not dependent on neutral endopeptidase... - Elevated NT-ProBNP levels in patients with increased left ventricular filling pressure during exercise despite preserved systolic functionCarsten Tschope
Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Germany
J Card Fail 11:S28-33. 2005..We therefore investigated the plasma levels of the N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with heart failure symptoms during exercise, despite preserved systolic cardiac function... - The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarctionCarsten Tschope
Department of Cardiology and Pneumology, Charite University Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
Cardiovasc Res 61:559-69. 2004..In addition, we treated wild-type rats with IRB and/or the B1R antagonist, B9958, and determined the left ventricular (LV) function... - AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in ratsThomas Walther
Department of Cardiology and Pneumology, Free University of Berlin, Berlin, Germany
FASEB J 16:1237-41. 2002..Our data suggest that NEP is more decisive than ACE in mediating BK degradation and may indicate BK involvement in the cardioprotective effects of AT1 antagonists... - A combined technique for predicting pre-eclampsia: concurrent measurement of uterine perfusion and analysis of heart rate and blood pressure variabilityThomas Walther
Department of Cardiology, Charit, Campus Benjamin Franklin (CBF, Berlin, Germany
J Hypertens 24:747-50. 2006..4%. CONCLUSIONS: This technique of incorporating one-stop clinical assessment of uterine perfusion and variability parameters in the second trimester produces the most effective prediction of pre-eclampsia to date... - The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout miceVirginia S Lemos
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil, and Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University, Berlin, Germany
J Cardiovasc Pharmacol 46:274-9. 2005..Our results show that Ang(1-7) and AVE 0991 produced an NO-dependent vasodilator effect in the mouse aorta that is mediated by the G protein-coupled receptor Mas... - Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodentsFlorian Gembardt
Department of Cardiology, Charite, Campus Benjamin Franklin, Germany
Peptides 26:1270-7. 2005..Contrary to mRNA, we found weak activity in the lung of both species. Our data demonstrate a tissue- and species-specific pattern for ACE2 under physiological conditions... - Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathyFrank Spillmann
Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12220 Berlin, Germany
Int Immunopharmacol 2:1823-32. 2002.... - Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient miceBjörn Maul
Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
J Mol Med (Berl) 86:563-71. 2008..These findings suggest a crucial role of AT2 in normal brain function and that dysfunction of the receptor has impact on brain development and ultrastructural morphology with distinct consequences on learning and memory... - Longitudinal analysis of heart rate variability in chronic hypertensive pregnancyThomas Walther
Department of Cardiology, Charite, Campus Benjamin Franklin, Berlin, Germany
Hypertens Res 28:113-8. 2005..Thus, our data indicate that patients with long-term hypertension are still able to respond to the physiological changes occurring during pregnancy... - Natriuretic peptide system in fetal heart and circulationThomas Walther
Department of Cardiology and Pneumology, Free University of Berlin, Germany
J Hypertens 20:785-91. 2002..In comparison with data on the relevance of natriuretic peptides in adults, those summarized here indicate a functional maturation of the natriuretic peptide system during ontogeny in mammals... - New function for an old enzyme: NEP deficient mice develop late-onset obesityMatthias Becker
Department for Biochemical Neurobiology, Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
PLoS ONE 5:. 2010..Typically, human obesity has a polygenetic causation. Neutral endopeptidase (NEP), also known as neprilysin, is considered to be one of the key enzymes in the metabolism of many active peptide hormones... - Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced alcohol consumption in miceBjörn Maul
Department for Biochemical Neurobiology, Leibnizinstitut für Molekulare Pharmakologie, Berlin, Germany
PLoS ONE 7:e50187. 2012..Therefore, targeting NEP activity might be a very attractive approach for the treatment of alcohol abuse in a society with increasing social and financial stress... - Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidaseThomas Walther
Department of Cardiology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
PLoS ONE 4:e4590. 2009..The aim of our study was to explore the impact of NEP deficiency on the initial development of dementia-like symptoms in mice... - Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery diseaseEphraim B Beck
Heart Center, Department of Cardiology, University of Leipzig, Struempellstrasse 39, Leipzig, Germany
Eur J Prev Cardiol 19:412-8. 2012..The aim of the present study was to determine the impact of 4 weeks of exercise training on circulating growth factors and to elucidate their involvement in the training-induced changes in vasomotion in patients with CAD... - Angiotensin metabolites can stimulate receptors of the Mas-related genes familyFlorian Gembardt
Department of Cardiology, Charite Berlin, Campus Benjamin Franklin, Berlin, Germany
Mol Cell Biochem 319:115-23. 2008..Furthermore, we describe first an AT(1)-independent direct Ang IV signaling and show that Ang II and Ang III mediate signaling independent of their specific receptors AT(1) and AT(2), whereby the receptor specificity differs... - Valve-in-valve implantation of Medtronic CoreValve prosthesis in patients with failing bioprosthetic aortic valvesAxel Linke
Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
Circ Cardiovasc Interv 5:689-97. 2012..Transcatheter aortic valve implantation (TAVI) using the Medtronic CoreValve (MCV) system might represent an alternative to conventional redo surgery in older high-risk patients with a failing aortic valve bioprosthesis... - Fetal, neonatal cord, and maternal plasma concentrations of angiotensin-converting enzyme (ACE)Thomas Walther
Department of Cardiology and Pneumology, Free University of Berlin, Berlin, Germany
Prenat Diagn 22:111-3. 2002..It was the aim of the present study to measure ACE activity in human fetal blood and to determine its changes with advancing gestational age... - Multiple interactions between the renin-angiotensin and the kallikrein-kinin systems: role of ACE inhibition and AT1 receptor blockadeCarsten Tschope
Department of Cardiology and Pneomology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12220 Berlin, Germany
J Cardiovasc Pharmacol 39:478-87. 2002..This review discusses multiple possibilities of cross-talks between the RAS and KKS in vascular and cardiac physiology and pathology after ACE inhibition and AT1 receptor blockade... - Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repairYasuharu Matsumoto
Department of Cardiology, Heart Center Leipzig, University of Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
Eur Heart J 30:346-55. 2009..This study investigated whether degenerative AV stenosis (AS) is associated with the presence of valvular endothelial senescence and a reduction in the number and function of endothelial progenitor cells (EPCs)... - Cell type-specific expression of the Mas proto-oncogene in testisNatalia Alenina
Department of Cardiology, University Hospital Benjamin Franklin, Berlin Buch, Germany
J Histochem Cytochem 50:691-6. 2002..The strong ontogenetically controlled and cell type-specific expression of this membrane-bound receptor in testis implicates a role for the Mas proto-oncogene in testis maturation and function... - Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptideKristin Pankow
Fachbereich Biologie, Chemie, Pharmazie, Freie Universitat Berlin, Germany
Circ Res 101:875-82. 2007..Thus, the cooperative, successive action of the 2 transmembranal peptidases meprin A and NEP is crucial for rapid renal BNP inactivation. Therefore, the inhibition of meprin A could be a potent tool for increasing circulating BNP levels... - Prognostic value of natriuretic peptides in Chagas' disease: a 3-year follow-up investigationMaria da Consolacao V Moreira
Department of Internal Medicine, Felicio Rocho Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Cardiology 110:217-25. 2008..To determine the diagnostic and prognostic value of natriuretic peptides in patients with CD, we measured atrial (ANP) and brain natriuretic peptide (BNP), and compared the findings with other dilated cardiomyopathies (DCM)... - Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesisNingling Kang
Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin Buch, Germany
J Mol Med (Berl) 80:359-66. 2002..Our results support an important role of local AOGEN expression in hypertension-induced end-organ damage but not in the development of the kidney... - Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidaseChristine Maric
Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
Nephron Physiol 103:p149-56. 2006..Neutral endopeptidase (NEP) inhibition attenuates renal damage in the diabetic kidney, but little is known about the mechanisms of this renoprotective effect... - Is parvovirus B19 the cause for autoimmunity against the angiotensin II type receptor?Holger Stepan
Department of Obstetrics and Gynecology, University of Leipzig, Germany
J Reprod Immunol 73:130-4. 2007..We find parvovirus IgG-positive pregnant women in all subgroups without relation to AT1-AA presence. This favors AT1-AA generation to be independent of epitope mimicry between parvovirus B19 capsid proteins and the AT1 receptor... - New insights into the biology of preeclampsiaHolger Stepan
Department of Obstetrics and Gynecology, University of Leipzig, 04103 Leipzig, Germany
Biol Reprod 74:772-6. 2006..This review focuses on the most recent and relevant insights into the biology of preeclampsia and develops hypotheses regarding possible links between the reported aspects of preeclampsia... - Five-year results of 219 consecutive patients treated with extracorporeal membrane oxygenation for refractory postoperative cardiogenic shockNicolas Doll
Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
Ann Thorac Surg 77:151-7; discussion 157. 2004..Postcardiotomy cardiogenic shock occurs in approximately 1% of patients. We prospectively evaluated the early and long-term outcome as well as predictors of survival when using temporary extracorporeal membrane oxygenation (ECMO) support... - Differential regulation of in vivo angiogenesis by angiotensin II receptorsThomas Walther
Research Laboratories of Schering AG, Experimental Oncology, 13342 Berlin, Germany
FASEB J 17:2061-7. 2003.... - Imprinting of the murine MAS protooncogene is restricted to its antisense RNANatalia Alenina
Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
Biochem Biophys Res Commun 290:1072-8. 2002..Our results strongly suggest that Mas is not imprinted in mice but that an antisense RNA probably starting in the neighboring Igf2r gene is maternally imprinted in both embryos and adult organs... - Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor MasRobson A S Santos
Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
Proc Natl Acad Sci U S A 100:8258-63. 2003..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide... - Brain natriuretic peptide as a predictor of cardiomyopathy in Chagas' diseaseThomas Walther
Lancet 361:1567. 2003 - Transgenic rat model of Huntington's diseaseStephan von Horsten
Department of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
Hum Mol Genet 12:617-24. 2003..This model allows longitudinal in vivo imaging studies and is therefore ideally suited for the evaluation of novel therapeutic approaches such as neurotransplantation... - [Arterial revascularization of coronary vessels]Volkmar Falk
Klinik fur Herzchirurgie, Herzzentrum Leipzig
Herz 27:426-34. 2002..Recent studies have also demonstrated a survival benefit of double over single ITA graft use. Especially in younger patients bilateral ITA grafting is recommended... - Ischemic injury in experimental stroke depends on angiotensin IIThomas Walther
Max Planck Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany
FASEB J 16:169-76. 2002..Our data, therefore, demonstrate a direct correlation between brain angiotensin II and the severity of ischemic injury in experimental stroke... - Expression of C-type natriuretic peptide in human placenta and myometrium in normal pregnancies and pregnancies complicated by intrauterine growth retardation. Preliminary resultsHolger Stepan
Department of Obstetrics and Gynecology, University of Leipzig, Germany
Fetal Diagn Ther 17:37-41. 2002..Since CNP shows antimitogenic and vasodilatative properties, it was the aim of the study to investigate whether CNP expression is altered in placenta and myometrium from pregnancies complicated by intrauterine growth retardation... - Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidneySergio Veloso Brant Pinheiro
Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
Hypertension 44:490-6. 2004..Our data also suggest the involvement of AT2/AT1-related mechanisms, including functional antagonism, oligomerization or cross-talk, in the renal responses to AVE... - Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-beta peptidesXiaoou Sun
Leibniz Institut fur Molekulare Pharmakologie FMP, D 13125 Berlin, Germany
Eur J Pharmacol 588:18-25. 2008..Our results show that ACE besides its typical function as a dipeptidyl-carboxypeptidase has also unequivocal endopeptidolytic activities... - Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient miceFranziska Faber
Faculty of Biology, Martin Luther University, Weinbergweg 10, D 06120, Germany
Regul Pept 136:130-7. 2006..These differences induced by an altered AngII/AngIII ratio oppose the hypothesis that central AngII and AngIII act in a congruent pattern... - Emergency coronary artery bypass graft surgery for acute coronary syndrome: beating heart versus conventional cardioplegic cardiac arrest strategiesArdawan Julian Rastan
Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
Circulation 114:I477-85. 2006..Aim of this study was to compare the outcome of beating heart versus conventional coronary artery bypass graft (CABG) strategies in acute coronary syndromes for emergency indications... - Quattro valve trial at mid-term: December 1996 to November 2004Robert W M Frater
Montefiore Medical Center, Bronx, NY, USA
J Heart Valve Dis 15:230-7; discussion 237. 2006..A prospective trial was started in December 1996; herein are reported the results of the three centers that performed the surgery and followed up patients in the majority of cases. Young patients were deliberately included in the trial... - Questionable role of the angiotensin II receptor subtype 1 autoantibody in the pathogenesis of preeclampsiaHolger Stepan
Hypertension 50:e3; author reply e4. 2007 - Percutaneous aortic valve replacement for severe aortic stenosis in high-risk patients using the second- and current third-generation self-expanding CoreValve prosthesis: device success and 30-day clinical outcomeEberhard Grube
HELIOS Heart Center Siegburg, Siegburg, Germany
J Am Coll Cardiol 50:69-76. 2007..We sought to determine both the procedural performance and safety of percutaneous implantation of the second (21-French [F])- and third (18-F)-generation CoreValve aortic valve prosthesis (CoreValve Inc., Irvine, California)... - Autonomic cardiovascular control in pregnancies with abnormal uterine perfusionAndreas Voss
Department of Medical Engineering, University of Applied Sciences, Jena, Germany
Am J Hypertens 19:306-12. 2006..based on blood pressure variability (BPV), baroreflex sensitivity (BRS), and heart rate variability (HRV) analyses... - [Coronary artery bypass grafting on the beating heart in high-risk patients]Ardawan Julian Rastan
Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum Leipzig, Struempellstrasse 39, 04289, Leipzig, Germany
Herz 32:483-90. 2007..In conclusion, beating-heart coronary artery bypass grafting seems to be advantageous in various risk populations and should be considered for patients with more than average risks for cardiopulmonary bypass and cardioplegic arrest... - Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertensionMariam H M Yousif
Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait
Cell Biochem Funct 26:256-63. 2008..We conclude that inhibition of CaMKII-mediated signalling could be an effective way to antagonize the elevated activities of injury-promoting factors in diabetic patients with hypertension... - On-pump beating heart versus off-pump coronary artery bypass surgery-evidence of pump-induced myocardial injuryArdawan Julian Rastan
Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, Struempellstr 39, 04289 Leipzig, Germany
Eur J Cardiothorac Surg 27:1057-64. 2005.... - G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptorEvi Kostenis
7TM Pharma, Hoersholm, Denmark
Circulation 111:1806-13. 2005..We therefore tested whether this could be mediated indirectly through an interaction with the angiotensin II type 1 receptor, AT1... - Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial functionConcepcion Peiro
Department Pharmacology, Facultad de Medicina, Universidad Autonoma, Madrid, Spain
J Hypertens 25:2421-5. 2007....