Thomas Walther

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptide
    Thomas Walther
    Department of Cardiology, Medical Center Benjamin Franklin, Free University of Berlin, D 12200 Berlin, Germany
    Biol Chem 385:179-84. 2004
  2. ncbi request reprint Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease
    Thomas Walther
    Charite Universitatsmedizin, Campus Benjamin Franklin, Department of Cardiology and Pneumonology, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 115:333-44. 2007
  3. ncbi request reprint Agonist autoantibodies against the angiotensin AT1 receptor in renal and hypertensive disorders
    Thomas Walther
    Charite, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, Berlin, Germany
    Curr Hypertens Rep 9:128-32. 2007
  4. ncbi request reprint Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature
    Thomas Walther
    Department of Cardiology and Pneumology, Charite Campus Benjamin Franklin, Berlin, Germany
    Hypertension 46:1275-9. 2005
  5. pmc Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy
    Dirk Westermann
    Department of Cardiology and Pneumology, Charité Universitä tsmedizinBerlin, Campus Benjamin Franklin, Berlin, Germany
    Diabetes 58:1373-81. 2009
  6. ncbi request reprint Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarction
    Matthias Koch
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
    Eur J Pharmacol 550:143-8. 2006
  7. ncbi request reprint Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy
    Carsten Tschope
    Department of Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 19:2057-9. 2005
  8. ncbi request reprint Central angiotensin II controls alcohol consumption via its AT1 receptor
    Björn Maul
    Institute of Molecular Pharmacology, Berlin, Germany
    FASEB J 19:1474-81. 2005
  9. doi request reprint Myocardial overexpression of adenine nucleotide translocase 1 ameliorates diabetic cardiomyopathy in mice
    Yong Wang
    Department of Cardiology, Charite Universitatsmedizin Berlin, Germany
    Exp Physiol 94:220-7. 2009
  10. ncbi request reprint The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats
    Linda Ebermann
    Department of Cardiology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Eur J Pharmacol 590:276-80. 2008

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptide
    Thomas Walther
    Department of Cardiology, Medical Center Benjamin Franklin, Free University of Berlin, D 12200 Berlin, Germany
    Biol Chem 385:179-84. 2004
    ..Moreover, the NEP-independent BNP degradation provides an effective means for achieving a beneficial BNP increase in cardiovascular pathology by inhibiting the assumed novel NP-degrading peptidase(s)...
  2. ncbi request reprint Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease
    Thomas Walther
    Charite Universitatsmedizin, Campus Benjamin Franklin, Department of Cardiology and Pneumonology, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 115:333-44. 2007
    ..An adequate exchange of ATP and ADP over the inner mitochondrial membrane by the adenine nucleotide translocase (ANT) is thereby essential to guarantee the cellular energy supply...
  3. ncbi request reprint Agonist autoantibodies against the angiotensin AT1 receptor in renal and hypertensive disorders
    Thomas Walther
    Charite, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, Berlin, Germany
    Curr Hypertens Rep 9:128-32. 2007
    ..This review summarizes current knowledge about the generation, function, and clinical importance of AT1-AA...
  4. ncbi request reprint Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature
    Thomas Walther
    Department of Cardiology and Pneumology, Charite Campus Benjamin Franklin, Berlin, Germany
    Hypertension 46:1275-9. 2005
    ..The generation of this antibody seems to be associated with distinct types of pregnancy disorders resulting from impaired placental development. The AT1 autoantibody may thus be causative for pathological uteroplacental perfusion...
  5. pmc Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy
    Dirk Westermann
    Department of Cardiology and Pneumology, Charité Universitä tsmedizinBerlin, Campus Benjamin Franklin, Berlin, Germany
    Diabetes 58:1373-81. 2009
    ..The underlying pathology of this disease is still under discussion. We studied the role of the kinin B1 receptor on the development of experimental diabetic cardiomyopathy...
  6. ncbi request reprint Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarction
    Matthias Koch
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
    Eur J Pharmacol 550:143-8. 2006
    ..Further studies have to show whether these results can be caused by other therapeutically options. Long acting bradykinin receptor agonists might be an alternative option to improve ischemic heart disease...
  7. ncbi request reprint Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy
    Carsten Tschope
    Department of Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 19:2057-9. 2005
    ..These insights might have therapeutic implications also for human diabetic cardiomyopathy...
  8. ncbi request reprint Central angiotensin II controls alcohol consumption via its AT1 receptor
    Björn Maul
    Institute of Molecular Pharmacology, Berlin, Germany
    FASEB J 19:1474-81. 2005
    ..Our results indicate that a distinct drug-mediated control of the central RAS could be a promising therapy for alcohol disease...
  9. doi request reprint Myocardial overexpression of adenine nucleotide translocase 1 ameliorates diabetic cardiomyopathy in mice
    Yong Wang
    Department of Cardiology, Charite Universitatsmedizin Berlin, Germany
    Exp Physiol 94:220-7. 2009
    ..Cardiomyocyte-restricted overexpression of ANT1 prevents the development of diabetic cardiomyopathy; therefore, accelerated ADP/ATP exchange could be a new promising target to treat diabetic cardiomyopathy...
  10. ncbi request reprint The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats
    Linda Ebermann
    Department of Cardiology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Eur J Pharmacol 590:276-80. 2008
    ....
  11. ncbi request reprint Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice
    Yong Wang
    Department Cardiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Eur J Heart Fail 9:548-57. 2007
    ..Our study aimed to investigate the effect of cardiomyocyte-specific CNP over-expression on I/R injury and MI in transgenic mice...
  12. doi request reprint Excessive hypertension and end-organ damage in a transgenic mouse line carrying the rat angiotensinogen gene
    Ping Xu
    Department of Cardiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Cardiovasc Pharmacol 53:38-43. 2009
    ..Thus, this line TGM(rAOGEN)102 provides a new model to study hypertension-mediated end-organ damage and to evaluate new antihypertensive or cardioprotective drugs...
  13. ncbi request reprint Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors
    Florian Gembardt
    Department of Cardiology, Charite Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 22:3068-77. 2008
    ....
  14. ncbi request reprint Improvement of defective sarcoplasmic reticulum Ca2+ transport in diabetic heart of transgenic rats expressing the human kallikrein-1 gene
    Carsten Tschope
    Department of Cardiology and Pneumology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
    FASEB J 18:1967-9. 2004
    ..An increased phosphorylation of the SERCA2 regulatory protein phospholamban at threonine17 via a B2 receptor-mediated mechanism is thereby involved...
  15. ncbi request reprint Angiotensin AT2 receptor deficiency after myocardial infarction: its effects on cardiac function and fibrosis depend on the stimulus
    Carsten Tschope
    Department of Cardiology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Cell Biochem Biophys 43:45-52. 2005
    ..Thus, hypertension-induced fibrosis is probably triggered by other control mechanisms than fibrosis induced by MI...
  16. ncbi request reprint Does the C-type natriuretic peptide have prognostic value in chagas disease and other dilated cardiomyopathies?
    Silvia Heringer-Walther
    Department of Cardiology and Pneumology, CUM, Campus Benjamin Franklin CBF, Berlin, Germany
    J Cardiovasc Pharmacol 48:293-8. 2006
    ..Our data are the first to demonstrate the raised levels of the third natriuretic peptide CNP in CD and other DCM. Whereas ANP and BNP have a high predictive value for mortality in both diseases, CNP is without any predictive potency...
  17. doi request reprint Door-to-implantation time of extracorporeal life support systems predicts mortality in patients with out-of-hospital cardiac arrest
    Jürgen Leick
    Department of Cardiology, Kerckhoff Heart and Thorax Centre, Benekestrasse 2 8, 61231 Bad Nauheim, Germany
    Clin Res Cardiol 102:661-9. 2013
    ..This study aimed to identify predictors of mortality in patients with out-of-hospital cardiac arrest (OHCA) undergoing in-hospital extracorporeal life support system (ECLS) treatment...
  18. ncbi request reprint Fibrosis rather than blood pressure determines cardiac BNP expression in mice
    Thomas Walther
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12200, Berlin, Germany
    Regul Pept 116:95-100. 2003
    ....
  19. pmc Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced alcohol consumption in mice
    Björn Maul
    Department for Biochemical Neurobiology, Leibnizinstitut für Molekulare Pharmakologie, Berlin, Germany
    PLoS ONE 7:e50187. 2012
    ..Therefore, targeting NEP activity might be a very attractive approach for the treatment of alcohol abuse in a society with increasing social and financial stress...
  20. ncbi request reprint Relation of ANP and BNP to their N-terminal fragments in fetal circulation: evidence for enhanced neutral endopeptidase activity and resistance of BNP to neutral endopeptidase in the fetus
    Thomas Walther
    Department of Cardiology, Benjamin Franklin Medical Center, Free University of Berlin, Berlin, Germany
    BJOG 111:452-5. 2004
    ..To investigate the role of neutral endopeptidase in the turnover of atrial (ANP) and brain (BNP) natriuretic peptides and their N-terminal fragments in human fetal circulation...
  21. ncbi request reprint Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene
    Carsten Tschope
    Department of Cardiology and Pneumonology, Campus Benjamin Franklin, Charite University Medicine, Free University of Berlin, Germany
    FASEB J 18:828-35. 2004
    ..Transgenic expression of hKLK1 counteracts the progression of LV contractile dysfunction and extracellular matrix remodeling in STZ-induced diabetic cardiomyopathy via a BK B2 receptor-dependent pathway...
  22. ncbi request reprint Angiotensin deficiency in mice leads to dilated cardiomyopathy
    Thomas Walther
    Department Cardiology, Campus Benjamin Franklin, Charite Berlin, Hindenburgdamm, Germany
    Eur J Pharmacol 493:161-5. 2004
    ....
  23. ncbi request reprint The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice
    Virginia S Lemos
    Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil, and Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University, Berlin, Germany
    J Cardiovasc Pharmacol 46:274-9. 2005
    ..Our results show that Ang(1-7) and AVE 0991 produced an NO-dependent vasodilator effect in the mouse aorta that is mediated by the G protein-coupled receptor Mas...
  24. ncbi request reprint A combined technique for predicting pre-eclampsia: concurrent measurement of uterine perfusion and analysis of heart rate and blood pressure variability
    Thomas Walther
    Department of Cardiology, Charite, Campus Benjamin Franklin CBF, Berlin, Germany
    J Hypertens 24:747-50. 2006
    ..Although most pre-eclamptic patients have pathological uterine perfusion in the second trimester, perfusion disturbance has a positive predictive accuracy (PPA) only of approximately 30%...
  25. ncbi request reprint Elevated NT-ProBNP levels in patients with increased left ventricular filling pressure during exercise despite preserved systolic function
    Carsten Tschope
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Germany
    J Card Fail 11:S28-33. 2005
    ..We therefore investigated the plasma levels of the N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with heart failure symptoms during exercise, despite preserved systolic cardiac function...
  26. ncbi request reprint The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarction
    Carsten Tschope
    Department of Cardiology and Pneumology, Charite University Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, D 12220 Berlin, Germany
    Cardiovasc Res 61:559-69. 2004
    ..In addition, we treated wild-type rats with IRB and/or the B1R antagonist, B9958, and determined the left ventricular (LV) function...
  27. ncbi request reprint Detection of Myocardial Injury by CMR After Transcatheter Aortic Valve Replacement
    Won Keun Kim
    Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany Department of Cardiac Surgery, Kerckhoff Heart Center, Bad Nauheim, Germany
    J Am Coll Cardiol 64:349-57. 2014
    ..Myocardial injury after transcatheter aortic valve replacement (TAVR) is common, but its cause and relationship to the extent of myocardial tissue loss remain unclear...
  28. ncbi request reprint Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents
    Florian Gembardt
    Department of Cardiology, Charite, Campus Benjamin Franklin, Germany
    Peptides 26:1270-7. 2005
    ..Contrary to mRNA, we found weak activity in the lung of both species. Our data demonstrate a tissue- and species-specific pattern for ACE2 under physiological conditions...
  29. ncbi request reprint AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats
    Thomas Walther
    Department of Cardiology and Pneumology, Free University of Berlin, Berlin, Germany
    FASEB J 16:1237-41. 2002
    ..Our data suggest that NEP is more decisive than ACE in mediating BK degradation and may indicate BK involvement in the cardioprotective effects of AT1 antagonists...
  30. ncbi request reprint Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy
    Frank Spillmann
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12220 Berlin, Germany
    Int Immunopharmacol 2:1823-32. 2002
    ....
  31. ncbi request reprint Longitudinal analysis of heart rate variability in chronic hypertensive pregnancy
    Thomas Walther
    Department of Cardiology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Hypertens Res 28:113-8. 2005
    ..Thus, our data indicate that patients with long-term hypertension are still able to respond to the physiological changes occurring during pregnancy...
  32. ncbi request reprint Transapical access and closure devices: rationale and current status
    Johannes Blumenstein
    Department of Cardiology, Heart Center, Kerckhoff Klinik, Benekestrasse 2 8, 61231, Bad Nauheim, Germany
    Expert Rev Cardiovasc Ther 11:1613-7. 2013
    ..To further ease the transapical access first apical closure devices have been developed and entered first clinical trials...
  33. doi request reprint Neutrophil gelatinase-associated lipocalin (NGAL) for the early detection of cardiac surgery associated acute kidney injury
    Christoph Liebetrau
    Department of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany
    Scand J Clin Lab Invest 73:392-9. 2013
    ..We investigated whether increased urinary NGAL concentrations were predictive of AKI within 4 days after surgery and of mortality within 9 months...
  34. ncbi request reprint Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice
    Björn Maul
    Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
    J Mol Med (Berl) 86:563-71. 2008
    ..These findings suggest a crucial role of AT2 in normal brain function and that dysfunction of the receptor has impact on brain development and ultrastructural morphology with distinct consequences on learning and memory...
  35. ncbi request reprint Natriuretic peptide system in fetal heart and circulation
    Thomas Walther
    Department of Cardiology and Pneumology, Free University of Berlin, Germany
    J Hypertens 20:785-91. 2002
    ..In comparison with data on the relevance of natriuretic peptides in adults, those summarized here indicate a functional maturation of the natriuretic peptide system during ontogeny in mammals...
  36. pmc New function for an old enzyme: NEP deficient mice develop late-onset obesity
    Matthias Becker
    Department for Biochemical Neurobiology, Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
    PLoS ONE 5:. 2010
    ..Typically, human obesity has a polygenetic causation. Neutral endopeptidase (NEP), also known as neprilysin, is considered to be one of the key enzymes in the metabolism of many active peptide hormones...
  37. pmc Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase
    Thomas Walther
    Department of Cardiology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    PLoS ONE 4:e4590. 2009
    ..The aim of our study was to explore the impact of NEP deficiency on the initial development of dementia-like symptoms in mice...
  38. doi request reprint Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease
    Ephraim B Beck
    Heart Center, Department of Cardiology, University of Leipzig, Struempellstrasse 39, Leipzig, Germany
    Eur J Prev Cardiol 19:412-8. 2012
    ..The aim of the present study was to determine the impact of 4 weeks of exercise training on circulating growth factors and to elucidate their involvement in the training-induced changes in vasomotion in patients with CAD...
  39. ncbi request reprint Angiotensin metabolites can stimulate receptors of the Mas-related genes family
    Florian Gembardt
    Department of Cardiology, Charite Berlin, Campus Benjamin Franklin, Berlin, Germany
    Mol Cell Biochem 319:115-23. 2008
    ..Furthermore, we describe first an AT(1)-independent direct Ang IV signaling and show that Ang II and Ang III mediate signaling independent of their specific receptors AT(1) and AT(2), whereby the receptor specificity differs...
  40. ncbi request reprint Classification of cardiovascular time series based on different coupling structures using recurrence networks analysis
    Gonzalo Marcelo Ramírez Ávila
    Institut fur Physik, Humboldt Universitat zu Berlin, Berlin, Germany
    Philos Trans A Math Phys Eng Sci 371:20110623. 2013
    ..This allows us to predict PE with a sensitivity of 91.7 per cent and a specificity of 68.1 per cent, thus validating the use of this method for classifying healthy and preeclamptic patients. ..
  41. doi request reprint Valve-in-valve implantation of Medtronic CoreValve prosthesis in patients with failing bioprosthetic aortic valves
    Axel Linke
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Cardiovasc Interv 5:689-97. 2012
    ..Transcatheter aortic valve implantation (TAVI) using the Medtronic CoreValve (MCV) system might represent an alternative to conventional redo surgery in older high-risk patients with a failing aortic valve bioprosthesis...
  42. doi request reprint Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair
    Yasuharu Matsumoto
    Department of Cardiology, Heart Center Leipzig, University of Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur Heart J 30:346-55. 2009
    ..This study investigated whether degenerative AV stenosis (AS) is associated with the presence of valvular endothelial senescence and a reduction in the number and function of endothelial progenitor cells (EPCs)...
  43. ncbi request reprint Mobile left ventricular thrombus in left ventricular dysfunction: case report and review of literature
    Jürgen Leick
    Department of Cardiology, Kerckhoff Heart and Thorax Center, Benekestr 2 8, 61231 Bad Nauheim, Germany
    Clin Res Cardiol 102:479-84. 2013
    ..Therapeutic recommendations like treatment with low molecular heparin and intravenous unfractionated heparin (UFH), thrombolysis or surgical thrombectomy have failed to reach a consensus...
  44. ncbi request reprint Multiple interactions between the renin-angiotensin and the kallikrein-kinin systems: role of ACE inhibition and AT1 receptor blockade
    Carsten Tschope
    Department of Cardiology and Pneomology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12220 Berlin, Germany
    J Cardiovasc Pharmacol 39:478-87. 2002
    ..This review discusses multiple possibilities of cross-talks between the RAS and KKS in vascular and cardiac physiology and pathology after ACE inhibition and AT1 receptor blockade...
  45. ncbi request reprint Fetal, neonatal cord, and maternal plasma concentrations of angiotensin-converting enzyme (ACE)
    Thomas Walther
    Department of Cardiology and Pneumology, Free University of Berlin, Berlin, Germany
    Prenat Diagn 22:111-3. 2002
    ..It was the aim of the present study to measure ACE activity in human fetal blood and to determine its changes with advancing gestational age...
  46. pmc The German Aortic Valve Registry (GARY): in-hospital outcome
    Christian W Hamm
    Department of Cardiology, Medical Clinic I, Kerckhoff Heart and Thorax Center, University of Giessen, Benekestrasse 2 8, Bad Nauheim 61231, Germany
    Eur Heart J 35:1588-98. 2014
    ..The German Aortic Valve Registry (GARY) provides data on conventional and catheter-based aortic procedures on an all-comers basis...
  47. ncbi request reprint Cell type-specific expression of the Mas proto-oncogene in testis
    Natalia Alenina
    Department of Cardiology, University Hospital Benjamin Franklin, Berlin Buch, Germany
    J Histochem Cytochem 50:691-6. 2002
    ..The strong ontogenetically controlled and cell type-specific expression of this membrane-bound receptor in testis implicates a role for the Mas proto-oncogene in testis maturation and function...
  48. ncbi request reprint Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis
    Ningling Kang
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin Buch, Germany
    J Mol Med (Berl) 80:359-66. 2002
    ..Our results support an important role of local AOGEN expression in hypertension-induced end-organ damage but not in the development of the kidney...
  49. ncbi request reprint Prognostic value of natriuretic peptides in Chagas' disease: a 3-year follow-up investigation
    Maria da Consolacao V Moreira
    Department of Internal Medicine, Felicio Rocho Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Cardiology 110:217-25. 2008
    ..To determine the diagnostic and prognostic value of natriuretic peptides in patients with CD, we measured atrial (ANP) and brain natriuretic peptide (BNP), and compared the findings with other dilated cardiomyopathies (DCM)...
  50. ncbi request reprint Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide
    Kristin Pankow
    Fachbereich Biologie, Chemie, Pharmazie, Freie Universitat Berlin, Germany
    Circ Res 101:875-82. 2007
    ..Thus, the cooperative, successive action of the 2 transmembranal peptidases meprin A and NEP is crucial for rapid renal BNP inactivation. Therefore, the inhibition of meprin A could be a potent tool for increasing circulating BNP levels...
  51. ncbi request reprint Is parvovirus B19 the cause for autoimmunity against the angiotensin II type receptor?
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Reprod Immunol 73:130-4. 2007
    ..We find parvovirus IgG-positive pregnant women in all subgroups without relation to AT1-AA presence. This favors AT1-AA generation to be independent of epitope mimicry between parvovirus B19 capsid proteins and the AT1 receptor...
  52. ncbi request reprint Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidase
    Christine Maric
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Nephron Physiol 103:p149-56. 2006
    ..Neutral endopeptidase (NEP) inhibition attenuates renal damage in the diabetic kidney, but little is known about the mechanisms of this renoprotective effect...
  53. ncbi request reprint [Coronary artery bypass grafting on the beating heart in high-risk patients]
    Ardawan Julian Rastan
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum Leipzig, Struempellstrasse 39, 04289, Leipzig, Germany
    Herz 32:483-90. 2007
    ..In conclusion, beating-heart coronary artery bypass grafting seems to be advantageous in various risk populations and should be considered for patients with more than average risks for cardiopulmonary bypass and cardioplegic arrest...
  54. ncbi request reprint [Arterial revascularization of coronary vessels]
    Volkmar Falk
    Klinik fur Herzchirurgie, Herzzentrum Leipzig
    Herz 27:426-34. 2002
    ..Recent studies have also demonstrated a survival benefit of double over single ITA graft use. Especially in younger patients bilateral ITA grafting is recommended...
  55. ncbi request reprint Five-year results of 219 consecutive patients treated with extracorporeal membrane oxygenation for refractory postoperative cardiogenic shock
    Nicolas Doll
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 77:151-7; discussion 157. 2004
    ..Postcardiotomy cardiogenic shock occurs in approximately 1% of patients. We prospectively evaluated the early and long-term outcome as well as predictors of survival when using temporary extracorporeal membrane oxygenation (ECMO) support...
  56. ncbi request reprint Ischemic injury in experimental stroke depends on angiotensin II
    Thomas Walther
    Max Planck Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany
    FASEB J 16:169-76. 2002
    ..Our data, therefore, demonstrate a direct correlation between brain angiotensin II and the severity of ischemic injury in experimental stroke...
  57. ncbi request reprint Autonomic cardiovascular control in pregnancies with abnormal uterine perfusion
    Andreas Voss
    Department of Medical Engineering, University of Applied Sciences, Jena, Germany
    Am J Hypertens 19:306-12. 2006
    ..based on blood pressure variability (BPV), baroreflex sensitivity (BRS), and heart rate variability (HRV) analyses...
  58. ncbi request reprint Imprinting of the murine MAS protooncogene is restricted to its antisense RNA
    Natalia Alenina
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    Biochem Biophys Res Commun 290:1072-8. 2002
    ..Our results strongly suggest that Mas is not imprinted in mice but that an antisense RNA probably starting in the neighboring Igf2r gene is maternally imprinted in both embryos and adult organs...
  59. ncbi request reprint New insights into the biology of preeclampsia
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, 04103 Leipzig, Germany
    Biol Reprod 74:772-6. 2006
    ..This review focuses on the most recent and relevant insights into the biology of preeclampsia and develops hypotheses regarding possible links between the reported aspects of preeclampsia...
  60. ncbi request reprint Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney
    Sergio Veloso Brant Pinheiro
    Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
    Hypertension 44:490-6. 2004
    ..Our data also suggest the involvement of AT2/AT1-related mechanisms, including functional antagonism, oligomerization or cross-talk, in the renal responses to AVE...
  61. ncbi request reprint G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor
    Evi Kostenis
    7TM Pharma, Hoersholm, Denmark
    Circulation 111:1806-13. 2005
    ..We therefore tested whether this could be mediated indirectly through an interaction with the angiotensin II type 1 receptor, AT1...
  62. ncbi request reprint On-pump beating heart versus off-pump coronary artery bypass surgery-evidence of pump-induced myocardial injury
    Ardawan Julian Rastan
    Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 27:1057-64. 2005
    ....
  63. ncbi request reprint Quattro valve trial at mid-term: December 1996 to November 2004
    Robert W M Frater
    Montefiore Medical Center, Bronx, NY, USA
    J Heart Valve Dis 15:230-7; discussion 237. 2006
    ..A prospective trial was started in December 1996; herein are reported the results of the three centers that performed the surgery and followed up patients in the majority of cases. Young patients were deliberately included in the trial...
  64. ncbi request reprint Emergency coronary artery bypass graft surgery for acute coronary syndrome: beating heart versus conventional cardioplegic cardiac arrest strategies
    Ardawan Julian Rastan
    Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Circulation 114:I477-85. 2006
    ..Aim of this study was to compare the outcome of beating heart versus conventional coronary artery bypass graft (CABG) strategies in acute coronary syndromes for emergency indications...
  65. ncbi request reprint Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice
    Franziska Faber
    Faculty of Biology, Martin Luther University, Weinbergweg 10, D 06120, Germany
    Regul Pept 136:130-7. 2006
    ..These differences induced by an altered AngII/AngIII ratio oppose the hypothesis that central AngII and AngIII act in a congruent pattern...
  66. ncbi request reprint Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function
    Concepcion Peiro
    Department Pharmacology, Facultad de Medicina, Universidad Autonoma, Madrid, Spain
    J Hypertens 25:2421-5. 2007
    ....
  67. ncbi request reprint Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension
    Mariam H M Yousif
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait
    Cell Biochem Funct 26:256-63. 2008
    ..We conclude that inhibition of CaMKII-mediated signalling could be an effective way to antagonize the elevated activities of injury-promoting factors in diabetic patients with hypertension...
  68. ncbi request reprint Questionable role of the angiotensin II receptor subtype 1 autoantibody in the pathogenesis of preeclampsia
    Holger Stepan
    Hypertension 50:e3; author reply e4. 2007
  69. ncbi request reprint Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-beta peptides
    Xiaoou Sun
    Leibniz Institut fur Molekulare Pharmakologie FMP, D 13125 Berlin, Germany
    Eur J Pharmacol 588:18-25. 2008
    ..Our results show that ACE besides its typical function as a dipeptidyl-carboxypeptidase has also unequivocal endopeptidolytic activities...
  70. ncbi request reprint Transgenic rat model of Huntington's disease
    Stephan von Horsten
    Department of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Hum Mol Genet 12:617-24. 2003
    ..This model allows longitudinal in vivo imaging studies and is therefore ideally suited for the evaluation of novel therapeutic approaches such as neurotransplantation...
  71. ncbi request reprint Brain natriuretic peptide as a predictor of cardiomyopathy in Chagas' disease
    Thomas Walther
    Lancet 361:1567. 2003
  72. ncbi request reprint Percutaneous aortic valve replacement for severe aortic stenosis in high-risk patients using the second- and current third-generation self-expanding CoreValve prosthesis: device success and 30-day clinical outcome
    Eberhard Grube
    HELIOS Heart Center Siegburg, Siegburg, Germany
    J Am Coll Cardiol 50:69-76. 2007
    ..We sought to determine both the procedural performance and safety of percutaneous implantation of the second (21-French [F])- and third (18-F)-generation CoreValve aortic valve prosthesis (CoreValve Inc., Irvine, California)...
  73. pmc Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    Robson A S Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
    Proc Natl Acad Sci U S A 100:8258-63. 2003
    ..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide...
  74. ncbi request reprint Differential regulation of in vivo angiogenesis by angiotensin II receptors
    Thomas Walther
    Research Laboratories of Schering AG, Experimental Oncology, 13342 Berlin, Germany
    FASEB J 17:2061-7. 2003
    ....
  75. ncbi request reprint Expression of C-type natriuretic peptide in human placenta and myometrium in normal pregnancies and pregnancies complicated by intrauterine growth retardation. Preliminary results
    Holger Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    Fetal Diagn Ther 17:37-41. 2002
    ..Since CNP shows antimitogenic and vasodilatative properties, it was the aim of the study to investigate whether CNP expression is altered in placenta and myometrium from pregnancies complicated by intrauterine growth retardation...