Ulrich Wahn

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Staff costs of hospital-based outpatient care of patients with cystic fibrosis
    Helge Hollmeyer
    Department of Pediatric Pneumonology and Immunology, Charite University Medicine Berlin, Germany
    Health Econ Rev 1:10. 2011
  2. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
  3. doi request reprint High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: a double-blind, placebo-controlled study
    Ulrich Wahn
    Department for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany
    J Allergy Clin Immunol 130:886-93.e5. 2012
  4. pmc Allergen-specific immunotherapy provides immediate, long-term and preventive clinical effects in children and adults: the effects of immunotherapy can be categorised by level of benefit -the centenary of allergen specific subcutaneous immunotherapy
    Lars Jacobsen
    Research Centre for Prevention and Health, Glostrup University Hospital, Copenhagen, Denmark
    Clin Transl Allergy 2:8. 2012
  5. pmc Does the viral subtype influence the biennial cycle of respiratory syncytial virus?
    Gordana Mlinaric-Galinovic
    Department of Virology, Croatian National Institute of Public Health and University Medical School of Zagreb, Zagreb, Croatia
    Virol J 6:133. 2009
  6. ncbi request reprint Prediction and early diagnosis
    Ulrich Wahn
    Department of Pediatric Pneumology and Immunology, University Children s Hospital, Charite, Berlin, Germany
    Chem Immunol Allergy 84:128-34. 2004
  7. doi request reprint Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis
    Ulrich Wahn
    Berlin Children s Hospital, Charite Campus Virchow Klinikum, Augustenburger Platz, Berlin, Germany
    J Allergy Clin Immunol 123:160-166.e3. 2009
  8. ncbi request reprint Strategies for atopy prevention
    H Ulrich Wahn
    Department of Pneumology and Immunology, Charite Berlin, Virchow Klinikum, 13353 Berlin, Germany
    J Nutr 138:1770S-1772S. 2008
  9. doi request reprint Infection and regulation of the immune response
    U Wahn
    Charite Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Immunol Lett 122:138-40. 2009
  10. doi request reprint Review of recent results of montelukast use as a monotherapy in children with mild asthma
    Ulrich Wahn
    Charite Universitatsmedizin, Department for Pediatric Pneumology and Immunology, Berlin, Germany
    Clin Ther 30:1026-35. 2008

Detail Information

Publications82

  1. pmc Staff costs of hospital-based outpatient care of patients with cystic fibrosis
    Helge Hollmeyer
    Department of Pediatric Pneumonology and Immunology, Charite University Medicine Berlin, Germany
    Health Econ Rev 1:10. 2011
    ..abstract:..
  2. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
    ....
  3. doi request reprint High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: a double-blind, placebo-controlled study
    Ulrich Wahn
    Department for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany
    J Allergy Clin Immunol 130:886-93.e5. 2012
    ..Sublingual allergen-specific immunotherapy is a viable alternative to subcutaneous immunotherapy particularly attractive for use in children...
  4. pmc Allergen-specific immunotherapy provides immediate, long-term and preventive clinical effects in children and adults: the effects of immunotherapy can be categorised by level of benefit -the centenary of allergen specific subcutaneous immunotherapy
    Lars Jacobsen
    Research Centre for Prevention and Health, Glostrup University Hospital, Copenhagen, Denmark
    Clin Transl Allergy 2:8. 2012
    ..SIT should not only be recognised as first-line therapeutic treatment for allergic rhinoconjunctivitis but also as secondary preventive treatment for respiratory allergic diseases...
  5. pmc Does the viral subtype influence the biennial cycle of respiratory syncytial virus?
    Gordana Mlinaric-Galinovic
    Department of Virology, Croatian National Institute of Public Health and University Medical School of Zagreb, Zagreb, Croatia
    Virol J 6:133. 2009
    ..In order to determine if these differences are accounted for by the circulation of different RSV subtypes, we studied the prevalence of RSV subtype A and B strains in Zagreb County from 1 January 2006 to 31 December 2007...
  6. ncbi request reprint Prediction and early diagnosis
    Ulrich Wahn
    Department of Pediatric Pneumology and Immunology, University Children s Hospital, Charite, Berlin, Germany
    Chem Immunol Allergy 84:128-34. 2004
  7. doi request reprint Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis
    Ulrich Wahn
    Berlin Children s Hospital, Charite Campus Virchow Klinikum, Augustenburger Platz, Berlin, Germany
    J Allergy Clin Immunol 123:160-166.e3. 2009
    ..The efficacy and safety of the 300-index of reactivity (IR) dose of 5-grass-pollen sublingual immunotherapy (SLIT) tablets (Stallergènes, Antony, France) have been demonstrated for the treatment of hay fever in adults...
  8. ncbi request reprint Strategies for atopy prevention
    H Ulrich Wahn
    Department of Pneumology and Immunology, Charite Berlin, Virchow Klinikum, 13353 Berlin, Germany
    J Nutr 138:1770S-1772S. 2008
    ..On the other hand, the evaluation of risk factors and determinants is a necessary prerequisite for any effective intervention...
  9. doi request reprint Infection and regulation of the immune response
    U Wahn
    Charite Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Immunol Lett 122:138-40. 2009
    ..It should be noted, however, that the association of allergy prevalence and a loss of allergy protective factors described above seems to be more pronounced regarding respiratory allergy than other phenotypes of the atopic syndrome...
  10. doi request reprint Review of recent results of montelukast use as a monotherapy in children with mild asthma
    Ulrich Wahn
    Charite Universitatsmedizin, Department for Pediatric Pneumology and Immunology, Berlin, Germany
    Clin Ther 30:1026-35. 2008
    ..Several asthma controllers are indicated for use in children. International guidelines recommend the use of inhaled corticosteroids as the preferred controller therapy in mild persistent asthma...
  11. ncbi request reprint Immunotherapy in children
    Ulrich Wahn
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Curr Opin Allergy Clin Immunol 2:557-60. 2002
    ..Specific allergen immunotherapy although being performed for almost 100 years, is still being addressed in clinical trials. In children the sublingual allergen application has gained considerable interest...
  12. ncbi request reprint Efficacy and safety of pimecrolimus cream in the long-term management of atopic dermatitis in children
    Ulrich Wahn
    Department of Pediatric Pneumology and Immunology, Charite, Humboldt University, Berlin, Germany
    Pediatrics 110:e2. 2002
    ..We assessed whether early treatment of AD signs/symptoms with pimecrolimus could influence long-term outcome by preventing disease flares...
  13. ncbi request reprint The development of atopic phenotypes: genetic and environmental determinants
    Ulrich Wahn
    Department of Pneumology, Charite Universitatsmedizin, Augustenburger Platz 1, DE 13353 Berlin, Germany
    Nestle Nutr Workshop Ser Pediatr Program 59:1-11; discussion 11-15. 2007
    ..Infantile diet, early exposure to environmental allergens and a variety of environmental and lifestyle factors may act as strong modulators of atopy during the first decade of life...
  14. doi request reprint The significance of environmental exposure on the progression of allergic diseases
    U Wahn
    Department for Paediatric Pneumology and Immunology, Charite, Berlin, Germany
    Allergy 66:7-9. 2011
    ..These factors include gastrointestinal or skin exposure to food allergens; respiratory exposure to indoor and outdoor allergens; presence of environmental pollutants such as tobacco smoke; and exposure to microbial compounds...
  15. ncbi request reprint MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort
    Sebastian Müller
    Department of Pediatric Pneumology and Immunology, Charité Universitäts medizin, Berlin, Germany
    Pediatr Allergy Immunol 18:665-70. 2007
    ..Our data suggest that MBL deficiency does not represent a pre-disposing factor for respiratory infections or atopic disorders in infants and children...
  16. doi request reprint IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis
    Simona Eva Zitnik
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 20:551-5. 2009
    ..These findings suggest that IL13 variants play a major role not only in non-cognate but also in allergen specific IgE synthesis...
  17. ncbi request reprint Association of Filaggrin loss-of-function-mutations with atopic dermatitis and asthma in the Early Treatment of the Atopic Child (ETAC) population
    Sebastian Müller
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 20:358-61. 2009
    ..0001). The replication and its statistical significance underlines the importance of the FLG polymorphisms and the importance of the skin barrier function in the development of AD and subsequent asthma...
  18. doi request reprint An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma
    Ingo Marenholz
    Max Delbrück Centrum MDC for Molecular Medicine, Berlin, Germany
    J Allergy Clin Immunol 123:911-6. 2009
    ..Asthma prediction in early infancy is essential for the development of new preventive strategies. Loss-of-function mutations in the filaggrin gene (FLG) were identified as risk factors for eczema and associated asthma...
  19. ncbi request reprint Messages from the German Multicentre Allergy Study
    Renate Nickel
    Department for Pediatric Pneumology and Immunology, Charite, Berlin, Germany
    Pediatr Allergy Immunol 13:7-10. 2002
    ..Furthermore, candidate gene studies of atopic dermatitis and increased total serum IgE levels on chromosomes 5q, 12q and 17q in MAS-children and their parents are outlined...
  20. ncbi request reprint Association study of Glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations
    Renate Nickel
    Department of Pediatric Pneumonology and Immunology, Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 16:539-41. 2005
    ..We conclude from our data that polymorphisms within GSTP1 do not play a major role in the development of bronchial asthma in German children...
  21. doi request reprint ICOS-gene variants are not associated with atopic disease susceptibility in European children
    Katja C Beier
    Department of Paediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Pediatr Allergy Immunol 20:242-5. 2009
    ..Our data suggest that these ICOS variants do not play a major role in the development of atopy in European children...
  22. ncbi request reprint Lipopolysaccharides modulate allergen-specific immune regulation in a murine model of mucosal tolerance induction
    Kerstin Gerhold
    Department of Pediatric Pneumology and Immunology, University Hospital Charite, Berlin, Germany
    Int Arch Allergy Immunol 147:25-34. 2008
    ..We delineated T-cell functions after induction of mucosal tolerance in the context of intranasally delivered organic dust compounds, lipopolysaccharides (LPS)...
  23. ncbi request reprint Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    Lancet 368:763-70. 2006
    ..Unknown factors between birth and school age determine the progressive loss of pulmonary function in children with persistent asthma. We investigated the role of allergic sensitisation and allergen exposure early in life...
  24. ncbi request reprint Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects
    Matthias Volkmar Kopp
    University Children s Hospital, Freiburg, Germany
    Pediatr Allergy Immunol 18:523-7. 2007
    ..These results strongly suggest that the observed effects of decreased SLT release after omalizumab treatment were attributable to the treatment with omalizumab, rather than to SIT therapy...
  25. ncbi request reprint The natural course of atopic dermatitis from birth to age 7 years and the association with asthma
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite, Dr von Haunersches Kinderspital, Lindwurmastrasse 4, 80337 Munich, Germany
    J Allergy Clin Immunol 113:925-31. 2004
    ..Atopic dermatitis (AD) is considered to be one of the first manifestations in the atopic march. However, few prospective studies on AD and its association with childhood asthma exist...
  26. ncbi request reprint The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS)
    Susanne Lau
    University Children s Hospital, Department of Pneumology and Immunology Berlin, Charite Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Paediatr Respir Rev 3:265-72. 2002
    ....
  27. doi request reprint History of respiratory infections in the first 12 yr among children from a birth cohort
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 19:505-12. 2008
    ..Episodes within these reference values per se should not cause unwarranted concern or intervention because of suspected immunodeficiency...
  28. ncbi request reprint A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema
    Florian Schulz
    Pediatric Pneumology and Immunology, Charite, Berlin, Germany
    J Allergy Clin Immunol 120:1097-102. 2007
    ..IL-31 is a novel cytokine that, when overexpressed in transgenic mice, induces severe itching dermatitis resembling human eczema...
  29. ncbi request reprint Treatment of infants with atopic eczema with pimecrolimus cream 1% improves parents' quality of life: a multicenter, randomized trial
    Doris Staab
    Charite Virchow Klinikum, Kinderklinik und Poliklinik, Berlin, Germany
    Pediatr Allergy Immunol 16:527-33. 2005
    ..05 for all five domains, despite the very short duration of the study. It is concluded that improvements in atopic eczema in infants achieved by treatment with pimecrolimus have a significant beneficial effect on the QoL of parents...
  30. pmc The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations
    Michaela Schedel
    University Children s Hospital, Ludwig Maximilian s University Munich, Germany
    Respir Res 7:91. 2006
    ..Thus, we tried to further elucidate the role of ADAM33 polymorphisms (SNPs) in a genetic analysis of German case control and longitudinal populations...
  31. ncbi request reprint No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations
    Philipp Deindl
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 16:40-2. 2005
    ..We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children...
  32. ncbi request reprint Transient suppression of atopy in early childhood is associated with high vaccination coverage
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Pediatrics 111:e282-8. 2003
    ..To analyze prevalences of allergic sensitization and atopic disease in relation to vaccination coverage...
  33. pmc Health-related quality of life in children with cystic fibrosis: validation of the German CFQ-R
    Anne Schmidt
    Department of Paediatric Pulmonology and Immunology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Health Qual Life Outcomes 7:97. 2009
    ..Self-Rating is combined with proxy-rating by parents in the use of the questionnaire...
  34. doi request reprint Can the use of HEPA cleaners in homes of asthmatic children and adolescents sensitized to cat and dog allergens decrease bronchial hyperresponsiveness and allergen contents in solid dust?
    Claudia Sulser
    Department of Pediatric Pneumology and Immunology, Charité Medical Centre, Berlin, Germany
    Int Arch Allergy Immunol 148:23-30. 2009
    ..Conflicting data have emerged regarding the potential benefit of air cleaners with respect to a reduction of indoor pet allergens and bronchial hyperresponsiveness (BHR)...
  35. ncbi request reprint The value of specific IgE to peanut and its component Ara h 2 in the diagnosis of peanut allergy
    Lucila C Lopes de Oliveira
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany Division of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil
    J Allergy Clin Immunol Pract 1:394-8. 2013
    ..To avoid unnecessary oral food challenges, which are time consuming, stressful, and risky, improved in vitro diagnostic methods for food allergy such as component resolved diagnostics are still under investigation...
  36. pmc Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis
    Cilla Söderhäll
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    PLoS Biol 5:e242. 2007
    ..Lack of COL29A1 expression in the outer epidermis of AD patients points to a role of collagen XXIX in epidermal integrity and function, the breakdown of which is a clinical hallmark of AD...
  37. ncbi request reprint Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children
    Claudia Sengler
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    J Allergy Clin Immunol 111:515-9. 2003
    ..CC16 is expressed in the bronchial epithelium and exhibits potent anti-inflammatory properties. A single-nucleotide polymorphism (SNP) in the CC16 gene (A38G) was previously associated with asthma...
  38. ncbi request reprint Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march
    Ingo Marenholz
    Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany
    J Allergy Clin Immunol 118:866-71. 2006
    ..Recently, 2 loss-of-function mutations in the gene encoding the epidermal barrier protein filaggrin were reported to be predisposing factors for eczema and concomitant asthma, suggesting a possible role in disease transition...
  39. doi request reprint Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever
    Laura Hatzler
    Department of Paediatric Pneumology and Immunology, Charité University Medical Centre, Berlin, Germany
    J Allergy Clin Immunol 130:894-901.e5. 2012
    ..IgE sensitization against grass pollen is a cause of seasonal allergic rhinitis...
  40. doi request reprint Oral application of bacterial lysate in infancy decreases the risk of atopic dermatitis in children with 1 atopic parent in a randomized, placebo-controlled trial
    Susanne Lau
    Department of Pediatric Pneumology and Immunology, Charité Medical University Berlin, Berlin, Germany
    J Allergy Clin Immunol 129:1040-7. 2012
    ..Lower prevalence of atopy was found in children with continuous exposure to livestock and thus to microbial compounds. In animal models exposure to endotoxin (LPS) decreases allergic sensitization and airway inflammation...
  41. doi request reprint Walnut allergy in peanut-allergic patients: significance of sequential epitopes of walnut homologous to linear epitopes of Ara h 1, 2 and 3 in relation to clinical reactivity
    Leonard Rosenfeld
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Berlin, Germany
    Int Arch Allergy Immunol 157:238-45. 2012
    ..Therefore, we analyzed the binding of specific IgE antibodies to sequential epitopes of peanut and walnut in peanut-allergic patients with and without walnut allergy...
  42. ncbi request reprint The role of anti-IgE therapy in combination with allergen specific immunotherapy for seasonal allergic rhinitis
    Philippe Stock
    Department of Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany
    BioDrugs 21:403-10. 2007
    ..These data show that the combination of anti-IgE plus SIT may be beneficial for the treatment of allergic diseases, offering improved efficacy, limited adverse effects, and potential immune-modifying effects...
  43. doi request reprint Oral peanut immunotherapy in children with peanut anaphylaxis
    Katharina Blumchen
    Department of Pediatric Pneumology and Immunology, University Hospital Charite, Berlin, Germany
    J Allergy Clin Immunol 126:83-91.e1. 2010
    ..The only treatment option for peanut allergy is strict avoidance...
  44. doi request reprint Environmental noise and asthma in children: sex-specific differences
    Angelina Bockelbrink
    Institute for Social Medicine, Epidemiology, and Health Economics, Charite University Medical Center, Berlin, Germany
    J Asthma 45:770-3. 2008
    ..The aim of this study was to compare subjectively reported noise annoyance in 12-year-old asthmatic and non-asthmatic children with special regard to sex-specific differences...
  45. ncbi request reprint The costs of atopy and asthma in children: assessment of direct costs and their determinants in a birth cohort
    Stefan Weinmann
    Department of Pediatric Pneumology and Immunology, Children s Hospital, Berlin, Germany
    Pediatr Allergy Immunol 14:18-26. 2003
    ..Moreover, the importance of considering cost-driving factors and using cohort or longitudinal designs in cost-of-illness approaches is emphasized...
  46. ncbi request reprint Prenatal stress enhances susceptibility of murine adult offspring toward airway inflammation
    Maike K Pincus-Knackstedt
    Department of Pediatrics, Division of Pneumology and Immunology, Charite, University Medicine Berlin, Germany
    J Immunol 177:8484-92. 2006
    ..This will foster the substantiation of disease-prevention strategies, such as asthma, during the prenatal period...
  47. doi request reprint Oral immunotherapy for food allergy in children
    Kirsten Beyer
    Children s Hospital Charité, Humboldt University, Berlin, Germany
    Curr Opin Allergy Clin Immunol 8:553-6. 2008
    ..Within the last several years, the usefulness of oral immunotherapy has been investigated in food allergic patients. This review covers the most recent findings...
  48. ncbi request reprint Parental hay fever reinforces IgE to pollen as pre-clinical biomarker of hay fever in childhood
    Laura Hatzler
    Department of Paediatric Pneumology and Immunology, Charité University Medical Centre, Berlin, Germany
    Pediatr Allergy Immunol 25:366-73. 2014
    ..An early IgE response to grass or birch pollen can anticipate seasonal allergic rhinitis to pollen later in life or remain clinically silent...
  49. pmc Polymorphisms and haplotypes of acid mammalian chitinase are associated with bronchial asthma
    Sibylle Bierbaum
    University Children s Hospital, University of Freiburg, Germany
    Am J Respir Crit Care Med 172:1505-9. 2005
    ..It acts downstream of interleukin-13; inhibition of AMCase leads to an abrogated T-helper cell 2 inflammation, less bronchial hyperreactivity, and fewer eosinophils...
  50. doi request reprint Use of Phadiatop Infant in diagnosis of specific sensitization in young children with wheeze or eczema
    Susanne Lau
    Charité Medical University, Department of Pediatric Pneumology and Immunology, Berlin, Germany
    Pediatr Allergy Immunol 19:337-41. 2008
    ..The test thus provides an opportunity for early correct diagnosis and identification of subjects at risk for whom intervention may be necessary...
  51. ncbi request reprint Is there a role for anti-IgE in combination with specific allergen immunotherapy?
    Eckard Hamelmann
    Department of Pediatric Pneumology, Charite, Humboldt University, Berlin, Germany
    Curr Opin Allergy Clin Immunol 3:501-10. 2003
    ..In the present review, state-of-the-art treatment of allergic diseases with anti-IgE and allergen-specific immunotherapy is summarized, and the potential of combination therapy with both treatment options is discussed...
  52. ncbi request reprint Anti-IgE therapy in allergic asthma
    Claudia Rolinck-Werninghaus
    Department of Paediatric Pneumology and Immunology, Charite, Campus Virchow, University Children s Hospital, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Curr Drug Targets Inflamm Allergy 4:551-64. 2005
    ....
  53. pmc Age related, structured educational programmes for the management of atopic dermatitis in children and adolescents: multicentre, randomised controlled trial
    Doris Staab
    Department of Paediatric Pulmonology and Immunology, Charite, Humboldt University, Berlin
    BMJ 332:933-8. 2006
    ..To determine the effects of age related, structured educational programmes on the management of moderate to severe atopic dermatitis in childhood and adolescence...
  54. ncbi request reprint How should a birth cohort study be organised? Experience from the German MAS cohort study
    Renate Nickel
    University Children s Hospital, Department of Pneumology and Immunology, Charite Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Paediatr Respir Rev 3:169-76. 2002
    ....
  55. pmc Granulysin-expressing CD4+ T cells as candidate immune marker for tuberculosis during childhood and adolescence
    Henrik Mueller
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS ONE 6:e29367. 2011
    ..Granulysin produced by cytolytic T cells directly contributes to immune defense against tuberculosis (TB). We investigated granulysin as a candidate immune marker for childhood and adolescent TB...
  56. ncbi request reprint Effect of oral cyclosporin A in children with Staphylococcus aureus-colonized vs S aureus-infected severe atopic dermatitis
    Rita Bunikowski
    Department of Pediatric Pneumology and Immunology, Humboldt University of Berlin, Germany
    Pediatr Allergy Immunol 14:55-9. 2003
    ..However, anti-infective treatment administered before immunomodulatory therapy is likely to be decisive for the long-term therapeutic effect...
  57. doi request reprint Dopamine D2 receptor mRNA expression is increased in the jugular-nodose ganglia of rats with nitrogen dioxide-induced chronic bronchitis
    Christian Peiser
    Department of Pediatric Pneumology and Immunology, Charite Campus Virchow, Medical University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurosci Lett 465:143-6. 2009
    ....
  58. ncbi request reprint Body image in cystic fibrosis--development of a brief diagnostic scale
    Kerstin Wenninger
    Department for Paediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    J Behav Med 26:81-94. 2003
    ..In summary, our results provide preliminary evidence for the reliability and construct, concurrent, and clinical validity of the instrument...
  59. ncbi request reprint The atopy patch test in the diagnostic workup of suspected food-related symptoms in children
    Anne Mehl
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Berlin, Germany
    J Allergy Clin Immunol 118:923-9. 2006
    ..There is an increasing need to develop test instruments that make oral food challenges superfluous...
  60. doi request reprint Differential diagnosis of food-induced symptoms
    Birgit Ahrens
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 19:92-6. 2008
    ....
  61. ncbi request reprint The effect of hydrotherapy on the incidence of common cold episodes in children: a randomised clinical trial
    Christoph Gruber
    Department of Paediatric Pneumology and Immunology, Charite Children s Hospital, Humboldt University, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Pediatr 162:168-76. 2003
    ..In the study period, there were no significant differences in the incidence of colds (control vs. experimental group, mean +/- SD, 4.8+/-3.5 vs. 4.1+/-3.3 episodes) or the average duration of episodes (7.7+/-3.5 vs. 7.6+/-3.8 days)...
  62. doi request reprint Isoniazid pharmacokinetic studies of the 1960s: considering a higher isoniazid dose in childhood tuberculosis
    Stephanie Thee
    Department of Paediatric Pneumology and Immunology, Charite, Universitatsmedizin Berlin, Germany
    Scand J Infect Dis 42:294-8. 2010
    ..In children, it appears to be more appropriate to calculate the INH dose on the basis of body surface area rather than bodyweight...
  63. ncbi request reprint Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis
    Joachim Kuehr
    University Children s Hospital, Freiburg, Germany
    J Allergy Clin Immunol 109:274-80. 2002
    ..Specific immunotherapy (SIT) and treatment with monoclonal anti-IgE antibody have complementary modes of action...
  64. doi request reprint Interferon-gamma inducible protein 10 as a biomarker for active tuberculosis and latent tuberculosis infection in children: a case-control study
    Neele Alsleben
    Department of Paediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Scand J Infect Dis 44:256-62. 2012
    ..We also assessed test agreement between IP-10 and the QuantiFERON(®)-TB Gold In-Tube (QFT-IT) test results, and investigated whether IP-10 release upon mitogen stimulation is associated with age...
  65. doi request reprint Serum retinoic acid and atopy among children of different ethnic origin living in Germany
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Pediatr Gastroenterol Nutr 54:558-60. 2012
    ..They did not differ significantly between atopic and nonatopic individuals. Serum levels of ATRA are related to those of provitamin A carotenoids but are not directly related to atopy in the present study...
  66. ncbi request reprint Anti-IgE therapy
    Ulrich Wahn
    University Hospital Charité Virchow, Berlin, Germany
    Clin Allergy Immunol 18:625-40. 2004
  67. ncbi request reprint Beta-defensins and LL-37 in bronchoalveolar lavage fluid of patients with cystic fibrosis
    Christiane I U Chen
    Department of Pediatric Pneumology and Immunology, Charite, Humboldt University, Berlin, Germany
    J Cyst Fibros 3:45-50. 2004
    ..The aim of this study was to determine the concentrations of these peptides in airway surface fluid of CF patients with mild lung disease...
  68. pmc Interactions between genes and environmental factors in asthma and atopy: new developments
    Claudia Sengler
    Department of Pediatric Pneumology and Immunology, Charite, Humboldt University Berlin, Berlin, Germany
    Respir Res 3:7. 2002
    ....
  69. doi request reprint Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Allergy Clin Immunol 126:791-7. 2010
    ..Most infants developing atopic dermatitis have a low risk for atopy. Primary prevention of atopic dermatitis is difficult...
  70. ncbi request reprint The 12-min walk test as an assessment criterion for lung transplantation in subjects with cystic fibrosis
    Kristina Rüter
    Department of Pediatric Pneumology and Immunology, Charite, Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Cyst Fibros 2:8-13. 2003
    ..This study demonstrates that in CF patients with end-stage lung disease, walking distance during a 12-min walk test is more informative with respect to survival than single parameters such as SaO(2,) pCO(2), FEV(1) or BMI...
  71. ncbi request reprint The revised German Cystic Fibrosis Questionnaire: validation of a disease-specific health-related quality of life instrument
    Kerstin Wenninger
    Department for Paediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Qual Life Res 12:77-85. 2003
    ..Translations are currently being validated in four different countries. The aim of the present study was to validate the German adaptation of the CFQ-14+...
  72. ncbi request reprint X-linked agammaglobulinaemia and Pneumocystis carinii pneumonia--an unusual coincidence?
    Anna Maria Dittrich
    Department of Paediatric Pneumology and Immunology, Charite Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Pediatr 162:432-3. 2003
  73. ncbi request reprint Minimal inflammation, acute phase response and avoidance of misclassification of vitamin A and iron status in infants--importance of a high-sensitivity C-reactive protein (CRP) assay
    Klaus Abraham
    Department of Pediatric Pneumology and Immunology, University Clinic Charite, Humboldt University Berlin, Berlin, Germany
    Int J Vitam Nutr Res 73:423-30. 2003
    ..A high-sensitivity CRP assay is necessary to detect this low level, and in the case of iron or vitamin A, it can help to avoid misclassification of the nutritional status...
  74. doi request reprint Subcutaneous immunotherapy and pharmacotherapy in seasonal allergic rhinitis: a comparison based on meta-analyses
    Paolo Maria Matricardi
    Pediatric Pneumology and Immunology Department, Charité Medical University, Berlin, Germany
    J Allergy Clin Immunol 128:791-799.e6. 2011
    ..Allergen-specific subcutaneous immunotherapy (SCIT) of seasonal allergic rhinitis (SAR) is usually considered a "second-line," slow-acting, disease-modifying treatment...
  75. ncbi request reprint Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis
    Ulrich Wahn
    Department of Pediatric Pneumology and Immunology, University Children s Hospital, Berlin, Germany
    J Allergy Clin Immunol 111:763-9. 2003
    ..This is the first prospective, randomized, double-blind, placebo-controlled study showing statistical improvement of an H(1)-antihistamine in children with seasonal allergic rhinitis in all symptoms throughout the entire treatment period...
  76. ncbi request reprint Evaluation of a parental training program for the management of childhood atopic dermatitis
    Doris Staab
    Department for Pediatric Pneumology and Immunology, Children s Hospital Charité Campus Virchow, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 13:84-90. 2002
    ..Finally, significant reduction of treatment costs was achieved. We conclude that structured training programs for parents of children with AD is a helpful adjunct to dermatological treatment...
  77. ncbi request reprint Placebo-controlled study of the mite allergen-reducing effect of tannic acid plus benzyl benzoate on carpets in homes of children with house dust mite sensitization and asthma
    Susanne Lau
    University Children s Hospital Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 13:31-6. 2002
    ....
  78. ncbi request reprint Primary ciliary dyskinesia associated with normal axoneme ultrastructure is caused by DNAH11 mutations
    Georg C Schwabe
    Department for General Pediatrics, Charite University Hospital, Campus Virchow, Berlin, Germany
    Hum Mutat 29:289-98. 2008
    ....
  79. ncbi request reprint Is early BCG vaccination associated with less atopic disease? An epidemiological study in German preschool children with different ethnic backgrounds
    Christoph Gruber
    University Children s Hospital, Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 13:177-81. 2002
    ..This study demonstrated a weak protective effect of BCG vaccination against asthma but a much stronger protective effect of non-German ethnicity against atopic manifestations among preschool children from Germany...
  80. ncbi request reprint Small toys contained in chocolate eggs--good or bad surprise?
    Rainer Kehrt
    Department of Paediatric Pneumology and Immunology, Virchow Klinikum, Humboldt University, Berlin, Germany
    Respir Med 96:955-6. 2002
  81. ncbi request reprint Endotoxins prevent murine IgE production, T(H)2 immune responses, and development of airway eosinophilia but not airway hyperreactivity
    Kerstin Gerhold
    Department of Pediatric Pneumology and Immunology, University Hospital Charite, Berlin, Germany
    J Allergy Clin Immunol 110:110-6. 2002
    ..Contact with immunomodulatory factors, such as LPS, in early infancy is associated with decreased allergen sensitization...
  82. ncbi request reprint Effect of treatment with dornase alpha on airway inflammation in patients with cystic fibrosis
    Karl Paul
    Department of Pediatric Pneumology and Immunology, Charite, Germany
    Am J Respir Crit Care Med 169:719-25. 2004
    ..We conclude that in patients with CF, an increase in neutrophilic airway inflammation is found that is positively influenced by rhDNase treatment...