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Species | Chris E TalsnessSummaryAffiliation: Humboldt University Country: Germany Publications
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Publications
In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspringChris E Talsness
Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charité University Medical School Berlin, Berlin, Germany
Environ Health Perspect 116:308-14. 2008..Polybrominated diphenyl ethers (PBDEs) are capable of disrupting thyroid hormone homeostasis. PBDE-47 (2,2',4,4'-tetrabromodiphenyl ether) is one of the most abundant congeners found in human breast adipose tissue and maternal milk samples...- Components of plastic: experimental studies in animals and relevance for human healthChris E Talsness
Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Charité University Medical School Berlin, Berlin, Germany
Philos Trans R Soc Lond B Biol Sci 364:2079-96. 2009.... 
Overview of toxicological aspects of polybrominated diphenyl ethers: a flame-retardant additive in several consumer productsChris E Talsness
Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Charite Universitatsmedizin Berlin, Garystr 5, 14195 Berlin, Germany
Environ Res 108:158-67. 2008....- A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult female offspring ratsSimone W Grande
Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, 14195 Berlin, Germany
Toxicology 229:114-22. 2007..An increase in the number of ovarian atretic tertiary follicles was the only effect observed in adult female offspring exposed in utero and during lactation to DEHP... - A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult male offspring ratsAnderson J M Andrade
, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, Berlin, Germany
Toxicology 228:85-97. 2006..The lowest observed adverse effect levels (LOAELs) for these effects were 15 and 5 mg/kg/day, respectively. Therefore, the no observed adverse effect level (NOAEL) for this study can be set at 1.215 mg/kg/day... 
Sex differences in effects on sexual development in rat offspring after pre- and postnatal exposure to triphenyltin chlorideKonstanze Grote
Institute of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, Berlin, Germany
Toxicology 260:53-9. 2009..The results of the present study suggest that the sensitive window for the evaluated endpoints seems to be the period of prenatal development and that male offspring rats were more susceptible to treatment...- Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardantChris E Talsness
, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystr. 5, 14195 Berlin, Germany
Toxicol Lett 157:189-202. 2005..Exposure to PBDE-99 resulted in female reproductive tract changes in the F1 generation which were apparent at adulthood... - Effects of peripubertal exposure to triphenyltin on female sexual development of the ratKonstanze Grote
Inst. of Clinical Pharmacology and Toxicology, , Campus Benjamin Franklin, 14195 Berlin, Germany
Toxicology 222:17-24. 2006..We conclude that peripubertal exposure to 6 mg TPT/kg bw, and to a lesser extent to 2mg TPT/kg bw, affects female sexual development... - Effects of in utero and lactational exposure to triphenyltin chloride on pregnancy outcome and postnatal development in rat offspringKonstanze Grote
Inst of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany
Toxicology 238:177-85. 2007..These results were unexpected, as in two earlier studies with pubertal rats TPTCl at the same dose levels no signs of general toxicity were observed... - Sex-dependent aromatase activity in rat offspring after pre- and postnatal exposure to triphenyltin chlorideCarolin Hobler
Inst of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany
Toxicology 276:198-205. 2010..We conclude that TPT administered during the particularly vulnerable period of development can affect aromatase activity in rats... - A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): effects on androgenic status, developmental landmarks and testicular histology in male offspring ratsAnderson J M Andrade
, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, 14195 Berlin, Germany
Toxicology 225:64-74. 2006..The current results show that DEHP acts as an anti-androgen at a high dose exposure (405 mg/kg/day). However, these results also indicate that other subtle developmental effects occur at lower DEHP doses... - A dose-response study following in utero and lactational exposure to di(2-ethylhexyl)phthalate: effects on female rat reproductive developmentSimone Wichert Grande
Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, , 14195 Berlin, Germany
Toxicol Sci 91:247-54. 2006..Anogenital distance and nipple development were unaffected. Based on the results of delayed pubertal onset, the no observed adverse effect level for female reproductive development may be set at 5 mg DEHP/kg bw/day... - A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): non-monotonic dose-response and low dose effects on rat brain aromatase activityAnderson J M Andrade
, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, 14195 Berlin, Germany
Toxicology 227:185-92. 2006..To our knowledge, this is the first study to report biological effects of DEHP at doses that overlap with the estimated exposure of the general human population... - Developmental exposure to low-dose PBDE-99: tissue distribution and thyroid hormone levelsSergio Noboru Kuriyama
Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Charité University Medical School Berlin, Campus Benjamin Franklin, Berlin, Germany
Toxicology 242:80-90. 2007..In addition, we have previously reported permanent changes in the reproductive systems and locomotor activity of male and female offspring using these same dosages... - Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspringSergio N Kuriyama
Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, , Campus Benjamin Franklin, Berlin, Germany
Environ Health Perspect 113:149-54. 2005..This is the lowest dose of PBDE reported to date to have an in vivo toxic effect in rodents and supports the premise that low-dose studies should be encouraged for hazard identification of persistent environmental pollutants... - Effects of organotin compounds on pubertal male ratsKonstanze Grote
Institute of Clinical Pharmacology and Toxicology, , Campus Benjamin Franklin, 14195 Berlin, Germany
Toxicology 202:145-58. 2004..We conclude that peripubertal exposure to 15 mg TBT and 6 mg TPT/kg bw clearly affected male sexual development... - Embryotoxic potential of N-methyl-pyrrolidone (NMP) and three of its metabolites using the rat whole embryo culture systemBurkhard Flick
Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Garystrasse 5, 14195 Berlin, Germany
Toxicol Appl Pharmacol 237:154-67. 2009..Hereby, only NMP and 5-HNMP induced specific embryotoxic effects and were classified as weakly embryotoxic, whereas the other two metabolites, 2-HMSI and MSI, were determined to be non-embryotoxic... - Parent bisphenol A accumulation in the human maternal-fetal-placental unitGilbert Schönfelder
Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Benjamin Franklin Medical Center, Freie Universitat, Berlin, Berlin, Germany
Environ Health Perspect 110:A703-7. 2002..We suggest that the range of BPA concentrations we measured may be related to sex differences in metabolization of parent BPA or variable maternal use of consumer products leaching BPA... - Commentary on "Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses" by Edward J. CalabreseChris E Talsness
Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, , Berlin, Germany
Crit Rev Toxicol 35:599-601. 2005 - Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposureFrederick S vom Saal
Reprod Toxicol 24:131-8. 2007 - Effects of developmental exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in ratsHellmuth Lilienthal
Department of Neurobehavioral Toxicology, Medical Institute of Environmental Hygiene, Heinrich Heine University, , Germany
Environ Health Perspect 114:194-201. 2006..These results support the hypothesis that PBDEs are endocrine-active compounds and interfere with sexual development and sexually dimorphic behavior...