Chris E Talsness

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspring
    Chris E Talsness
    Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charité University Medical School Berlin, Berlin, Germany
    Environ Health Perspect 116:308-14. 2008
  2. pmc Components of plastic: experimental studies in animals and relevance for human health
    Chris E Talsness
    Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Charité University Medical School Berlin, Berlin, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2079-96. 2009
  3. ncbi request reprint Overview of toxicological aspects of polybrominated diphenyl ethers: a flame-retardant additive in several consumer products
    Chris E Talsness
    Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Charite Universitatsmedizin Berlin, Garystr 5, 14195 Berlin, Germany
    Environ Res 108:158-67. 2008
  4. ncbi request reprint A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult female offspring rats
    Simone W Grande
    Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, 14195 Berlin, Germany
    Toxicology 229:114-22. 2007
  5. ncbi request reprint A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult male offspring rats
    Anderson J M Andrade
    Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, Berlin, Germany
    Toxicology 228:85-97. 2006
  6. doi request reprint Sex differences in effects on sexual development in rat offspring after pre- and postnatal exposure to triphenyltin chloride
    Konstanze Grote
    Institute of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, Berlin, Germany
    Toxicology 260:53-9. 2009
  7. ncbi request reprint Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardant
    Chris E Talsness
    Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystr 5, 14195 Berlin, Germany
    Toxicol Lett 157:189-202. 2005
  8. ncbi request reprint Effects of peripubertal exposure to triphenyltin on female sexual development of the rat
    Konstanze Grote
    Inst of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany
    Toxicology 222:17-24. 2006
  9. ncbi request reprint Effects of in utero and lactational exposure to triphenyltin chloride on pregnancy outcome and postnatal development in rat offspring
    Konstanze Grote
    Inst of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany
    Toxicology 238:177-85. 2007
  10. doi request reprint Sex-dependent aromatase activity in rat offspring after pre- and postnatal exposure to triphenyltin chloride
    Carolin Hobler
    Inst of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany
    Toxicology 276:198-205. 2010

Collaborators

Detail Information

Publications21

  1. pmc In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspring
    Chris E Talsness
    Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charité University Medical School Berlin, Berlin, Germany
    Environ Health Perspect 116:308-14. 2008
    ..Polybrominated diphenyl ethers (PBDEs) are capable of disrupting thyroid hormone homeostasis. PBDE-47 (2,2',4,4'-tetrabromodiphenyl ether) is one of the most abundant congeners found in human breast adipose tissue and maternal milk samples...
  2. pmc Components of plastic: experimental studies in animals and relevance for human health
    Chris E Talsness
    Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Charité University Medical School Berlin, Berlin, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2079-96. 2009
    ....
  3. ncbi request reprint Overview of toxicological aspects of polybrominated diphenyl ethers: a flame-retardant additive in several consumer products
    Chris E Talsness
    Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Charite Universitatsmedizin Berlin, Garystr 5, 14195 Berlin, Germany
    Environ Res 108:158-67. 2008
    ....
  4. ncbi request reprint A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult female offspring rats
    Simone W Grande
    Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, 14195 Berlin, Germany
    Toxicology 229:114-22. 2007
    ..An increase in the number of ovarian atretic tertiary follicles was the only effect observed in adult female offspring exposed in utero and during lactation to DEHP...
  5. ncbi request reprint A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult male offspring rats
    Anderson J M Andrade
    Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, Berlin, Germany
    Toxicology 228:85-97. 2006
    ..The lowest observed adverse effect levels (LOAELs) for these effects were 15 and 5 mg/kg/day, respectively. Therefore, the no observed adverse effect level (NOAEL) for this study can be set at 1.215 mg/kg/day...
  6. doi request reprint Sex differences in effects on sexual development in rat offspring after pre- and postnatal exposure to triphenyltin chloride
    Konstanze Grote
    Institute of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, Berlin, Germany
    Toxicology 260:53-9. 2009
    ..The results of the present study suggest that the sensitive window for the evaluated endpoints seems to be the period of prenatal development and that male offspring rats were more susceptible to treatment...
  7. ncbi request reprint Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardant
    Chris E Talsness
    Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystr 5, 14195 Berlin, Germany
    Toxicol Lett 157:189-202. 2005
    ..Exposure to PBDE-99 resulted in female reproductive tract changes in the F1 generation which were apparent at adulthood...
  8. ncbi request reprint Effects of peripubertal exposure to triphenyltin on female sexual development of the rat
    Konstanze Grote
    Inst of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany
    Toxicology 222:17-24. 2006
    ..We conclude that peripubertal exposure to 6 mg TPT/kg bw, and to a lesser extent to 2mg TPT/kg bw, affects female sexual development...
  9. ncbi request reprint Effects of in utero and lactational exposure to triphenyltin chloride on pregnancy outcome and postnatal development in rat offspring
    Konstanze Grote
    Inst of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany
    Toxicology 238:177-85. 2007
    ..These results were unexpected, as in two earlier studies with pubertal rats TPTCl at the same dose levels no signs of general toxicity were observed...
  10. doi request reprint Sex-dependent aromatase activity in rat offspring after pre- and postnatal exposure to triphenyltin chloride
    Carolin Hobler
    Inst of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany
    Toxicology 276:198-205. 2010
    ..We conclude that TPT administered during the particularly vulnerable period of development can affect aromatase activity in rats...
  11. ncbi request reprint A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): effects on androgenic status, developmental landmarks and testicular histology in male offspring rats
    Anderson J M Andrade
    Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, 14195 Berlin, Germany
    Toxicology 225:64-74. 2006
    ..The current results show that DEHP acts as an anti-androgen at a high dose exposure (405 mg/kg/day). However, these results also indicate that other subtle developmental effects occur at lower DEHP doses...
  12. ncbi request reprint A dose-response study following in utero and lactational exposure to di(2-ethylhexyl)phthalate: effects on female rat reproductive development
    Simone Wichert Grande
    Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charité University Medical School Berlin, 14195 Berlin, Germany
    Toxicol Sci 91:247-54. 2006
    ..Anogenital distance and nipple development were unaffected. Based on the results of delayed pubertal onset, the no observed adverse effect level for female reproductive development may be set at 5 mg DEHP/kg bw/day...
  13. ncbi request reprint A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): non-monotonic dose-response and low dose effects on rat brain aromatase activity
    Anderson J M Andrade
    Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Garystrasse 5, 14195 Berlin, Germany
    Toxicology 227:185-92. 2006
    ..To our knowledge, this is the first study to report biological effects of DEHP at doses that overlap with the estimated exposure of the general human population...
  14. ncbi request reprint Developmental exposure to low-dose PBDE-99: tissue distribution and thyroid hormone levels
    Sergio Noboru Kuriyama
    Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Charité University Medical School Berlin, Campus Benjamin Franklin, Berlin, Germany
    Toxicology 242:80-90. 2007
    ..In addition, we have previously reported permanent changes in the reproductive systems and locomotor activity of male and female offspring using these same dosages...
  15. pmc Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspring
    Sergio N Kuriyama
    Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Charité University Medical School Berlin, Campus Benjamin Franklin, Berlin, Germany
    Environ Health Perspect 113:149-54. 2005
    ..This is the lowest dose of PBDE reported to date to have an in vivo toxic effect in rodents and supports the premise that low-dose studies should be encouraged for hazard identification of persistent environmental pollutants...
  16. ncbi request reprint Effects of organotin compounds on pubertal male rats
    Konstanze Grote
    Institute of Clinical Pharmacology and Toxicology, Charite University Medical School, Campus Benjamin Franklin, 14195 Berlin, Germany
    Toxicology 202:145-58. 2004
    ..We conclude that peripubertal exposure to 15 mg TBT and 6 mg TPT/kg bw clearly affected male sexual development...
  17. doi request reprint Embryotoxic potential of N-methyl-pyrrolidone (NMP) and three of its metabolites using the rat whole embryo culture system
    Burkhard Flick
    Charité University Medical School Berlin, Campus Benjamin Franklin, Institute of Clinical Pharmacology and Toxicology, Garystrasse 5, 14195 Berlin, Germany
    Toxicol Appl Pharmacol 237:154-67. 2009
    ..Hereby, only NMP and 5-HNMP induced specific embryotoxic effects and were classified as weakly embryotoxic, whereas the other two metabolites, 2-HMSI and MSI, were determined to be non-embryotoxic...
  18. pmc Parent bisphenol A accumulation in the human maternal-fetal-placental unit
    Gilbert Schönfelder
    Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Benjamin Franklin Medical Center, Freie Universitat, Berlin, Berlin, Germany
    Environ Health Perspect 110:A703-7. 2002
    ..We suggest that the range of BPA concentrations we measured may be related to sex differences in metabolization of parent BPA or variable maternal use of consumer products leaching BPA...
  19. ncbi request reprint Commentary on "Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses" by Edward J. Calabrese
    Chris E Talsness
    Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Charite University Medical School, Berlin, Germany
    Crit Rev Toxicol 35:599-601. 2005
  20. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  21. pmc Effects of developmental exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats
    Hellmuth Lilienthal
    Department of Neurobehavioral Toxicology, Medical Institute of Environmental Hygiene, Heinrich Heine University, Dusseldorf, Germany
    Environ Health Perspect 114:194-201. 2006
    ..These results support the hypothesis that PBDEs are endocrine-active compounds and interfere with sexual development and sexually dimorphic behavior...