A Swidsinski

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Altered intestinal function in patients with chronic heart failure
    Anja Sandek
    Department of Gastroenterology, Charite, Campus Mitte, Berlin, Germany
    J Am Coll Cardiol 50:1561-9. 2007
  2. ncbi request reprint Mucosal flora in inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, Berlin, Germany
    Gastroenterology 122:44-54. 2002
  3. ncbi request reprint Azathioprine and mesalazine-induced effects on the mucosal flora in patients with IBD colitis
    Alexander Swidsinski
    Humboldt University, Charite Hospital, CCM, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, 10098 Berlin, Germany
    Inflamm Bowel Dis 13:51-6. 2007
  4. doi request reprint Positive effects of local therapy with a vaginal lactic acid gel on dysuria and E.coli bacteriuria question our current views on recurrent cystitis
    Alexander Swidsinski
    Polymicrobial Infections and Bacterial Biofilms, Laboratory for Molecular Genetics, CCM, Charite Hospital, Charite Universitatsmedizin Berlin, Campus Mitte, 10098 Berlin, Germany
    Arch Gynecol Obstet 285:1619-25. 2012
  5. pmc Mucosal invasion by fusobacteria is a common feature of acute appendicitis in Germany, Russia, and China
    Alexander Swidsinski
    Department of Gastroenterology, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Charite Universitatsmedizin Berlin, Germany
    Saudi J Gastroenterol 18:55-8. 2012
  6. pmc Comparative study of the intestinal mucus barrier in normal and inflamed colon
    Alexander Swidsinski
    Humboldt University, Charite, CCM, 10098 Berlin, Germany
    Gut 56:343-50. 2007
  7. ncbi request reprint Mucosal flora in Crohn's disease and ulcerative colitis - an overview
    A Swidsinski
    Department of Gastroenterology, Hepatology and Endocrinology, Charite Hospital, Berlin, Germany
    J Physiol Pharmacol 60:61-71. 2009
  8. ncbi request reprint Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization of the intestinal microbiota
    Alexander Swidsinski
    Humboldt University, Charite Hospital, CCM, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Berlin, Germany
    Inflamm Bowel Dis 13:963-70. 2007
  9. doi request reprint Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum/necrophorum
    Alexander Swidsinski
    Humboldt University, Charite Hospital, CCM, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Berlin, Germany
    Gut 60:34-40. 2011
  10. doi request reprint Bacterial overgrowth and inflammation of small intestine after carboxymethylcellulose ingestion in genetically susceptible mice
    Alexander Swidsinski
    Humboldt University, Charite Hospital, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, 10098 Berlin, Germany
    Inflamm Bowel Dis 15:359-64. 2009

Detail Information

Publications32

  1. ncbi request reprint Altered intestinal function in patients with chronic heart failure
    Anja Sandek
    Department of Gastroenterology, Charite, Campus Mitte, Berlin, Germany
    J Am Coll Cardiol 50:1561-9. 2007
    ..We evaluated morphology and function of the gut in patients with chronic heart failure (CHF)...
  2. ncbi request reprint Mucosal flora in inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, Berlin, Germany
    Gastroenterology 122:44-54. 2002
    ..Microorganisms that directly interact with the intestinal mucosa are obscured by fecal flora and poorly characterized...
  3. ncbi request reprint Azathioprine and mesalazine-induced effects on the mucosal flora in patients with IBD colitis
    Alexander Swidsinski
    Humboldt University, Charite Hospital, CCM, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, 10098 Berlin, Germany
    Inflamm Bowel Dis 13:51-6. 2007
    ..The study investigated the influence of IBD treatment on the concentrations and spatial organization of mucosal bacteria using fluorescence in situ hybridization with 16s r-RNA targeting probes...
  4. doi request reprint Positive effects of local therapy with a vaginal lactic acid gel on dysuria and E.coli bacteriuria question our current views on recurrent cystitis
    Alexander Swidsinski
    Polymicrobial Infections and Bacterial Biofilms, Laboratory for Molecular Genetics, CCM, Charite Hospital, Charite Universitatsmedizin Berlin, Campus Mitte, 10098 Berlin, Germany
    Arch Gynecol Obstet 285:1619-25. 2012
    ..We tested the effect of vaginally applied lactic acid gel on symptoms and bacteriuria in acutely exacerbated recurrent Eschericia coli cystitis...
  5. pmc Mucosal invasion by fusobacteria is a common feature of acute appendicitis in Germany, Russia, and China
    Alexander Swidsinski
    Department of Gastroenterology, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Charite Universitatsmedizin Berlin, Germany
    Saudi J Gastroenterol 18:55-8. 2012
    ..To investigate the geographic occurrence of mucosa-invading Fusobacteria in acute appendicitis...
  6. pmc Comparative study of the intestinal mucus barrier in normal and inflamed colon
    Alexander Swidsinski
    Humboldt University, Charite, CCM, 10098 Berlin, Germany
    Gut 56:343-50. 2007
    ..To study the role of mucus in the spatial separation of intestinal bacteria from mucosa...
  7. ncbi request reprint Mucosal flora in Crohn's disease and ulcerative colitis - an overview
    A Swidsinski
    Department of Gastroenterology, Hepatology and Endocrinology, Charite Hospital, Berlin, Germany
    J Physiol Pharmacol 60:61-71. 2009
    ..The cleaning effect of these on the colonic mucus has to be investigated. The present contribution summarizes new data on the biostructure of the intestinal microbiota...
  8. ncbi request reprint Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization of the intestinal microbiota
    Alexander Swidsinski
    Humboldt University, Charite Hospital, CCM, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Berlin, Germany
    Inflamm Bowel Dis 13:963-70. 2007
    ..Migration is an important virulence factor for intestinal bacteria. However, the role of bacterial mobility in the penetration of viscous mucus and their spatial organization within the colon is relatively unknown...
  9. doi request reprint Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum/necrophorum
    Alexander Swidsinski
    Humboldt University, Charite Hospital, CCM, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Berlin, Germany
    Gut 60:34-40. 2011
    ..Acute appendicitis is a local intestinal inflammation with unclear origin. The aim was to test whether bacteria in appendicitis differ in composition to bacteria found in caecal biopsies from healthy and disease controls...
  10. doi request reprint Bacterial overgrowth and inflammation of small intestine after carboxymethylcellulose ingestion in genetically susceptible mice
    Alexander Swidsinski
    Humboldt University, Charite Hospital, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, 10098 Berlin, Germany
    Inflamm Bowel Dis 15:359-64. 2009
    ..We investigated the influence of 2% carboxymethylcellulose (CMC) on the biostructure of the intestinal microbiota in IL-10 gene-deficient mice...
  11. doi request reprint Biostructure of fecal microbiota in healthy subjects and patients with chronic idiopathic diarrhea
    Alexander Swidsinski
    Gastroenterology, Humboldt University, Berlin, Germany
    Gastroenterology 135:568-79. 2008
    ..Our aim was to quantitatively access the biostructure of fecal microbiota in healthy subjects and patients with chronic idiopathic diarrhea and evaluate the responses to Saccharomyces boulardii treatment...
  12. doi request reprint Bacterial biofilm suppression with antibiotics for ulcerative and indeterminate colitis: consequences of aggressive treatment
    Alexander Swidsinski
    Humboldt University, Charite Hospital, CCM, Laboratory for Molecular Genetics, Polymicrobial Infections and Biofilms, Berlin, Germany
    Arch Med Res 39:198-204. 2008
    ..Antibiotics are commonly used in inflammatory bowel disease (IBD). Little is known about their effect on the mucosal flora...
  13. doi request reprint Desquamated epithelial cells covered with a polymicrobial biofilm typical for bacterial vaginosis are present in randomly selected cryopreserved donor semen
    Alexander Swidsinski
    Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Humboldt University, Charite Hospital, CCM, Charite Universitatsmedizin Berlin, Berlin, Germany
    FEMS Immunol Med Microbiol 59:399-404. 2010
    ..Gardnerella biofilm, typical for BV, was found in the semen of three of the 20 donors. Donor semen might be a vector for BV...
  14. ncbi request reprint Active Crohn's disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora
    Alexander Swidsinski
    Humboldt University, Charite Hospital, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Berlin, Germany
    Inflamm Bowel Dis 14:147-61. 2008
    ..The intestinal microflora is important in the pathogenesis of inflammatory bowel disease (IBD). The impact of its spatial organization on health and disease is unknown...
  15. pmc Bacterial biofilm within diseased pancreatic and biliary tracts
    A Swidsinski
    Innere Klinik, Gastroenterologie, Charite, 10098 Berlin, Germany
    Gut 54:388-95. 2005
    ..Bacterial community structures in human pancreatic and biliary tracts were evaluated...
  16. ncbi request reprint Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, 10098 Berlin, Germany
    World J Gastroenterol 11:1131-40. 2005
    ..To study the role of intestinal flora in inflammatory bowel disease (IBD)...
  17. pmc Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, 10098 Berlin, Germany
    J Clin Microbiol 43:3380-9. 2005
    ..A Bacteroides fragilis biofilm is the main feature of IBD. This was not previously recognized due to a lack of appropriate tissue fixation. Both 5-ASA and antibiotics suppress but do not eliminate the adherent biofilm...
  18. ncbi request reprint Adherent biofilms in bacterial vaginosis
    Alexander Swidsinski
    Medizinische Klinik, Charite, CCM, Humboldt Universitat, 10098 Berlin, Germany
    Obstet Gynecol 106:1013-23. 2005
    ..Our aims were to study the bacterial community structure and the spatial organization of microbiota on the epithelial surfaces of vaginal biopsy specimens...
  19. doi request reprint [Functional biostructure of colonic microbiota (central fermenting area, germinal stock area and separating mucus layer) in healthy subjects and patients with diarrhea treated with Saccharomyces boulardii]
    A Swidsinski
    Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms and Department of Medicine, Section of Gastroenterology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Gastroenterol Clin Biol 34:S79-92. 2010
    ..Saccharomyces boulardii significantly improves the stool biostructure in patients with chronic idiopathic diarrhea and has no influence on the stool microbiota in healthy subjects...
  20. pmc Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis
    A Swidsinski
    Medizinische Klinik, Charité Humboldt Universität, CCM, Molekular genetisches Labor für polymikrobielle Infektionen und bakterielle Biofilme, Berlin, Germany
    J Clin Pathol 60:253-60. 2007
    ..The reasons for recurrent adenotonsillitis are poorly understood...
  21. doi request reprint Dissimilarity in the occurrence of Bifidobacteriaceae in vaginal and perianal microbiota in women with bacterial vaginosis
    Alexander Swidsinski
    Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, 10098 Berlin, Germany
    Anaerobe 16:478-82. 2010
    ..Only some species originating from the intestinal tract do display pronounced vaginotropism, like G. vaginalis, whereas many other species do not...
  22. ncbi request reprint The role of bacteria in gallstone pathogenesis
    A Swidsinski
    Innere Klinik, Gastroenterologie, , Germany
    Front Biosci 6:E93-103. 2001
    ....
  23. ncbi request reprint An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole
    Alexander Swidsinski
    Molekulargenetisches Labor für polymikrobielle Infektionen und bakterielle Biofilme, Berlin, Germany
    Am J Obstet Gynecol 198:97.e1-6. 2008
    ..The purpose of this study was to determine the efficacy of standard treatment with oral metronidazole in the eradication of the bacterial vaginosis biofilm...
  24. ncbi request reprint Effects of the angiotensin II type 1 receptor antagonist telmisartan on monocyte adhesion and activation in patients with essential hypertension
    Uta Syrbe
    Medical Clinic for Gastroenterology, Infectious Disease and Rheumatology, Charite, Medical Faculty, Humboldt University, Berlin, Germany
    Hypertens Res 30:521-8. 2007
    ..The mechanism of action remains to be elucidated, since reduction in monocyte adhesion was not attributable to changes in adhesion molecule expression...
  25. ncbi request reprint Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells
    Tonyia Eaves-Pyles
    Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1070, USA
    Int J Med Microbiol 298:397-409. 2008
    ..These findings demonstrate that E. coli O83:H1 possesses the characteristics of the AIEC LF82 strain that may contribute to the low-grade, chronic inflammation observed in Crohn's disease...
  26. ncbi request reprint High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
    Arlette Darfeuille-Michaud
    Pathogenie Bacterienne Intestinale, Laboratoire de Bacteriologie, Universite d Auvergne, Clermont Ferrand, France
    Gastroenterology 127:412-21. 2004
    ..This study was performed to assess the prevalence of AIEC associated with intestinal mucosa of patients with CD, ulcerative colitis (UC), and of controls...
  27. ncbi request reprint Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Inflamm Bowel Dis 11:1060-9. 2005
    ..These studies support the hypothesis that increased exposure of mucosal cells to intestinal bacteria may lead to development of intestinal inflammation in IL-10 or other genetically susceptible individuals...
  28. ncbi request reprint Bacteria associated with bacterial vaginosis
    Laura P Hale
    N Engl J Med 354:202-3; author reply 202-3. 2006
  29. ncbi request reprint Interactions of intestinal epithelial cells with bacteria and immune cells: methods to characterize microflora and functional consequences
    Geraldine Canny
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 341:17-35. 2006
    ....
  30. ncbi request reprint Standards for bacterial identification by fluorescence In situ hybridization within eukaryotic tissue using ribosomal rRNA-based probes
    Alexander Swidsinski
    Inflamm Bowel Dis 12:824-6; author reply 826-7. 2006
  31. ncbi request reprint Constipation as cause of acute abdominal pain in children
    Vera Loening-Baucke
    Division of General Pediatrics, University of Iowa, Iowa City, Iowa, USA
    J Pediatr 151:666-9. 2007
    ..To evaluate the causes of acute abdominal pain in a large academic pediatric primary care population...