Research Topics
Genomes and Genes | Andreas SturmSummaryAffiliation: Humboldt University Country: Germany Publications
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Publications
Critical role of caspases in the regulation of apoptosis and proliferation of mucosal T cellsAndreas Sturm
Division of Gastroenterology, Department of Medicine, University Hospital of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4952, USA
Gastroenterology 122:1334-45. 2002..This unique behavior may allow proper control of mucosal T-cell proliferation while still permitting elimination by apoptosis in the face of excessive antigenic pressure...
Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinomaUta Berndt
Department of Medicine, Division of Gastroenterology and Hepatology, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
Mol Cancer 9:177. 2010....- Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activationAndreas Sturm
Medizinische Klinik mit Sektion Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
J Immunol 173:3825-37. 2004.... - Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signalingAndreas Sturm
Department of Hepatology and Gastroenterology, Campus Virchow Clinic, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
Infect Immun 73:1452-65. 2005.... 
Galectin-2 and -4, but not galectin-1, promote intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanismDaniela Paclik
Medizinische Klinik m S Hepatologie and Gastroenterologie, Campus Virchow Klinikum, Charite, Universitatsmedizin Berlin, Berlin, Germany
Inflamm Bowel Dis 14:1366-72. 2008..Galectins are increasingly recognized as novel regulators of inflammation. Thus, we aimed to explore the effect of galectin-2 (Gal-2) and Gal-4 on epithelial cell function and wound healing...- Enteral and parenteral nutrition distinctively modulate intestinal permeability and T cell function in vitroClaudia Guzy
Department of Medicine, Division of Gastroenterology and Hepatology Charité, Universitatsmedizin Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353, Berlin, Germany
Eur J Nutr 48:12-21. 2009..Nutritional support is an established element of therapy for various indications. However, its impact on the mucosal barrier function is not well understood... - Galectins distinctively regulate central monocyte and macrophage functionDaniela Paclik
Department of Hepatology and Gastroenterology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
Cell Immunol 271:97-103. 2011..By inhibiting T-cell function via macrophage priming, we show that galectins link the innate and adaptive immune systems and provide new insights into the action of sugar-binding proteins... - Galectin-2 induces apoptosis of lamina propria T lymphocytes and ameliorates acute and chronic experimental colitis in miceDaniela Paclik
Medizinische Klinik m S Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin, Germany
J Mol Med (Berl) 86:1395-406. 2008..Furthermore, galectin-2 has no significant toxicity over a broad dose range, suggesting that it may serve as a new therapeutic agent in the treatment of inflammatory bowel disease... - Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycleDaniela Paclik
Medizinische Klinik m S Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
PLoS ONE 3:e2629. 2008.... - The probiotic Escherichia coli strain Nissle 1917 induces gammadelta T cell apoptosis via caspase- and FasL-dependent pathwaysClaudia Guzy
Department of Medicine, Division of Gastroenterology and Hepatology, Charite Universitatsmedizin Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
Int Immunol 20:829-40. 2008.... - Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancerUta Berndt
Department of Medicine, Division of Gastroenterology and Hepatology, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
Cancer Res 68:880-8. 2008..Thus, topological proteomic analysis may help to unravel the role of the adaptive immune system in colorectal cancer and aid the development of new antitumor immunotherapy approaches... - TNFα inhibitors restrict T cell activation and cycling via Notch-1 signalling in inflammatory bowel diseaseLael Werner
Department of Medicine, Division of Gastroenterology and Hepatology, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Berlin, Germany
Gut 61:1016-27. 2012..Despite the clinical success of TNFα inhibitors, their physiological mode of action is not fully understood. The aim of this study was to investigate the mode of action of anti-TNFα agents in IBD... - Increased small intestinal permeability in ulcerative colitis: rather genetic than environmental and a risk factor for extensive disease?Carsten Buning
Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Berlin, Germany
Inflamm Bowel Dis 18:1932-9. 2012..A disturbed epithelial barrier could play a pivotal role in ulcerative colitis (UC). We performed a family-based study analyzing in vivo gastrointestinal permeability in patients with UC, their healthy relatives, spouses, and controls... - Impact of pain on health-related quality of life in patients with inflammatory bowel diseaseAnja Schirbel
Division of Gastroenterology and Hepatology, Department of Medicine, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
World J Gastroenterol 16:3168-77. 2010..To evaluate intensity, localization and cofactors of pain in Crohn's disease and ulcerative colitis patients in connection with health-related quality of life (HRQOL) and disease activity... - Proteomic analysis of the inflamed intestinal mucosa reveals distinctive immune response profiles in Crohn's disease and ulcerative colitisUta Berndt
Division of Gastroenterology and Hepatology, Department of Medicine, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
J Immunol 179:295-304. 2007..Thus, topological proteomic analysis may help to unravel the pathogenesis of inflammatory bowel disease by defining distinct immunopathogenic profiles in CrD and UC... - Magnetic resonance enteroclysis in patients with Crohn's disease: fat saturated T2-weighted sequences for evaluation of inflammatory activityChristian Grieser
Klinik für Radiologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
J Crohns Colitis 6:294-301. 2012..To evaluate fat saturated (fs) T2-weighted (w) fast relaxation fast spin echo (FRFSE)-sequences compared to the standard protocol with contrast agent for the evaluation of inflammatory activity in patients with Crohn's Disease (CD)... - The intestinal epithelial barrier: does it become impaired with age?Johannes Meier
Medizinische Klinik m S Hepatologie, Gastroenterologie, Endokrinologie und Stoffwechsel, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, DE 13353 Berlin, Germany
Dig Dis 27:240-5. 2009..g. lipids, does seem to be impaired in the elderly. However, impaired blood flow, ischemic changes and the increased use of NSAIDs naturally contribute to an impaired epithelial barrier in elderly patients... - The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specificJulia Benckert
Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
J Clin Invest 121:1946-55. 2011.... - Mucosal T cell proliferation and apoptosis in inflammatory bowel diseaseAndreas Sturm
Department of Hepatology and Gastroenterology, Charite Universitatsmedizin Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
Curr Drug Targets 9:381-7. 2008.... - CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathwayAndreas Sturm
Department of Hepatology and Gastroenterology, Charite Universitatsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, D 13353 Berlin, Germany
Cytokine 29:42-8. 2005..As intestinal epithelial cells have been recently shown to produce CXCL8, the aim of this study was to identify functional activities of CXCL8 on intestinal epithelial cells... - Current treatment of ulcerative colitisJohannes Meier
Department of Hepatology and Gastroenterology, Charite Universitatsmedizin Berlin, Campus Virchow Clinic, 13353 Berlin, Germany
World J Gastroenterol 17:3204-12. 2011..Recommendations are based on published consensus guidelines derived from national and international guidelines on the treatment of ulcerative colitis... - The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of actionMatthias Prager
Department of Medicine, Division of Gastroenterology, Infectiology and Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin 10117, Germany
Int J Colorectal Dis 27:565-73. 2012..We hypothesized that variants in genes occurring in pathways such as autophagy and IL23 signalling might contribute to CD by altering intestinal permeability... - Concomitant use of immunomodulators with anti-TNF in Crohn's disease: yes or no?Johannes Meier
Med Klinik m S Hepatologie, Gastroenterologie, Endokrinologie und Stoffwechsel, Berlin, Germany
Curr Drug Targets 11:176-8. 2010..This article aims to interpret the available data on the efficiency, immunogenicity, and safety of concomitant therapy in patients under anti-TNF therapy... - Imaging in inflammatory bowel disease mucosal healing in ulcerative colitis: relevance for clinical outcomesAnja Schirbel
Medizinische Klinik m S Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Curr Drug Targets 13:1234-44. 2012.... - Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel diseaseStefania Vetrano
Division of Gastroenterology, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, University of Milan, Rozzano, Italy
Gastroenterology 135:173-84. 2008..Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored... - Dual function of the extracellular matrix: stimulatory for cell cycle progression of naive T cells and antiapoptotic for tissue-derived memory T cellsAndreas Sturm
Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, OH 44106, USA
J Immunol 173:3889-900. 2004..When naive PBT encounter Ag in the context of ECM, their progression through the cell cycle is enhanced, favoring clonal expansion; while tissue T cell longevity may be mediated by interactions with the ECM... - p53 negatively regulates intestinal immunity by delaying mucosal T cell cyclingAndreas Sturm
Division of Gastroenterology, Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4952, USA
J Clin Invest 109:1481-92. 2002..By slowing LPT cycling, p53 may act as a negative regulator of mucosal immunity, promoting immunological tolerance by preventing excessive T cell replication... - Epithelial restitution and wound healing in inflammatory bowel diseaseAndreas Sturm
Medizinische Klinik I, Markus Krankenhaus, Wilhelm Epstein Strasse 2, 60431 Frankfurt Main, Germany
World J Gastroenterol 14:348-53. 2008..Enhancement of intestinal repair mechanisms by regulatory peptides or other modulatory factors may provide future approaches for the treatment of diseases that are characterized by injuries of the epithelial surface... - Mesalamine promotes intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanismDaniel C Baumgart
Department of Medicine, Division of Hepatology and Gastroenterology, , Medical School of the Humboldt-University of Berlin, Germany
Scand J Gastroenterol 40:958-64. 2005.... - Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammationAlessandro Musso
Division of Gastroenterology, Ospedale San Giovanni Battista, University of Torino, Torino, Italy
Inflamm Bowel Dis 11:91-8. 2005.... - Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patientsSilvio Danese
Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Ohio 44106, USA
Gastroenterology 124:1249-64. 2003..CONCLUSIONS: These results show that platelets can actively contribute to mucosal inflammation and represent a previously unrecognized component of IBD pathogenesis...