Andreas Sturm

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi Critical role of caspases in the regulation of apoptosis and proliferation of mucosal T cells
    Andreas Sturm
    Division of Gastroenterology, Department of Medicine, University Hospital of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4952, USA
    Gastroenterology 122:1334-45. 2002
  2. pmc Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle
    Daniela Paclik
    Medizinische Klinik m S Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 3:e2629. 2008
  3. pmc Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma
    Uta Berndt
    Department of Medicine, Division of Gastroenterology and Hepatology, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
    Mol Cancer 9:177. 2010
  4. pmc Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling
    Andreas Sturm
    Department of Hepatology and Gastroenterology, Campus Virchow Clinic, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Infect Immun 73:1452-65. 2005
  5. ncbi Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation
    Andreas Sturm
    Medizinische Klinik mit Sektion Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Immunol 173:3825-37. 2004
  6. doi Galectin-2 and -4, but not galectin-1, promote intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism
    Daniela Paclik
    Medizinische Klinik m S Hepatologie and Gastroenterologie, Campus Virchow Klinikum, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Inflamm Bowel Dis 14:1366-72. 2008
  7. doi Increased small intestinal permeability in ulcerative colitis: rather genetic than environmental and a risk factor for extensive disease?
    Carsten Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Berlin, Germany
    Inflamm Bowel Dis 18:1932-9. 2012
  8. doi Enteral and parenteral nutrition distinctively modulate intestinal permeability and T cell function in vitro
    Claudia Guzy
    Department of Medicine, Division of Gastroenterology and Hepatology Charité, Universitatsmedizin Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353, Berlin, Germany
    Eur J Nutr 48:12-21. 2009
  9. doi The probiotic Escherichia coli strain Nissle 1917 induces gammadelta T cell apoptosis via caspase- and FasL-dependent pathways
    Claudia Guzy
    Department of Medicine, Division of Gastroenterology and Hepatology, Charite Universitatsmedizin Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Int Immunol 20:829-40. 2008
  10. doi Galectins distinctively regulate central monocyte and macrophage function
    Daniela Paclik
    Department of Hepatology and Gastroenterology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Cell Immunol 271:97-103. 2011

Collaborators

Detail Information

Publications33

  1. ncbi Critical role of caspases in the regulation of apoptosis and proliferation of mucosal T cells
    Andreas Sturm
    Division of Gastroenterology, Department of Medicine, University Hospital of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4952, USA
    Gastroenterology 122:1334-45. 2002
    ..Caspases are critical mediators of apoptosis and proliferation of peripheral blood T cells (PBT), but their role in lamina propria T cells (LPT), a cell population highly susceptible to apoptosis, has not been explored...
  2. pmc Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle
    Daniela Paclik
    Medizinische Klinik m S Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 3:e2629. 2008
    ....
  3. pmc Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma
    Uta Berndt
    Department of Medicine, Division of Gastroenterology and Hepatology, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
    Mol Cancer 9:177. 2010
    ....
  4. pmc Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling
    Andreas Sturm
    Department of Hepatology and Gastroenterology, Campus Virchow Clinic, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Infect Immun 73:1452-65. 2005
    ....
  5. ncbi Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation
    Andreas Sturm
    Medizinische Klinik mit Sektion Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Immunol 173:3825-37. 2004
    ....
  6. doi Galectin-2 and -4, but not galectin-1, promote intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism
    Daniela Paclik
    Medizinische Klinik m S Hepatologie and Gastroenterologie, Campus Virchow Klinikum, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Inflamm Bowel Dis 14:1366-72. 2008
    ..Galectins are increasingly recognized as novel regulators of inflammation. Thus, we aimed to explore the effect of galectin-2 (Gal-2) and Gal-4 on epithelial cell function and wound healing...
  7. doi Increased small intestinal permeability in ulcerative colitis: rather genetic than environmental and a risk factor for extensive disease?
    Carsten Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Berlin, Germany
    Inflamm Bowel Dis 18:1932-9. 2012
    ..A disturbed epithelial barrier could play a pivotal role in ulcerative colitis (UC). We performed a family-based study analyzing in vivo gastrointestinal permeability in patients with UC, their healthy relatives, spouses, and controls...
  8. doi Enteral and parenteral nutrition distinctively modulate intestinal permeability and T cell function in vitro
    Claudia Guzy
    Department of Medicine, Division of Gastroenterology and Hepatology Charité, Universitatsmedizin Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353, Berlin, Germany
    Eur J Nutr 48:12-21. 2009
    ..Nutritional support is an established element of therapy for various indications. However, its impact on the mucosal barrier function is not well understood...
  9. doi The probiotic Escherichia coli strain Nissle 1917 induces gammadelta T cell apoptosis via caspase- and FasL-dependent pathways
    Claudia Guzy
    Department of Medicine, Division of Gastroenterology and Hepatology, Charite Universitatsmedizin Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Int Immunol 20:829-40. 2008
    ....
  10. doi Galectins distinctively regulate central monocyte and macrophage function
    Daniela Paclik
    Department of Hepatology and Gastroenterology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Cell Immunol 271:97-103. 2011
    ..By inhibiting T-cell function via macrophage priming, we show that galectins link the innate and adaptive immune systems and provide new insights into the action of sugar-binding proteins...
  11. ncbi Galectin-2 induces apoptosis of lamina propria T lymphocytes and ameliorates acute and chronic experimental colitis in mice
    Daniela Paclik
    Medizinische Klinik m S Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin, Germany
    J Mol Med (Berl) 86:1395-406. 2008
    ..Furthermore, galectin-2 has no significant toxicity over a broad dose range, suggesting that it may serve as a new therapeutic agent in the treatment of inflammatory bowel disease...
  12. doi Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer
    Uta Berndt
    Department of Medicine, Division of Gastroenterology and Hepatology, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Cancer Res 68:880-8. 2008
    ..Thus, topological proteomic analysis may help to unravel the role of the adaptive immune system in colorectal cancer and aid the development of new antitumor immunotherapy approaches...
  13. doi TNFα inhibitors restrict T cell activation and cycling via Notch-1 signalling in inflammatory bowel disease
    Lael Werner
    Department of Medicine, Division of Gastroenterology and Hepatology, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Berlin, Germany
    Gut 61:1016-27. 2012
    ..Despite the clinical success of TNFα inhibitors, their physiological mode of action is not fully understood. The aim of this study was to investigate the mode of action of anti-TNFα agents in IBD...
  14. ncbi Proteomic analysis of the inflamed intestinal mucosa reveals distinctive immune response profiles in Crohn's disease and ulcerative colitis
    Uta Berndt
    Division of Gastroenterology and Hepatology, Department of Medicine, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Immunol 179:295-304. 2007
    ..Thus, topological proteomic analysis may help to unravel the pathogenesis of inflammatory bowel disease by defining distinct immunopathogenic profiles in CrD and UC...
  15. ncbi CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway
    Andreas Sturm
    Department of Hepatology and Gastroenterology, Charite Universitatsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, D 13353 Berlin, Germany
    Cytokine 29:42-8. 2005
    ..As intestinal epithelial cells have been recently shown to produce CXCL8, the aim of this study was to identify functional activities of CXCL8 on intestinal epithelial cells...
  16. doi The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action
    Matthias Prager
    Department of Medicine, Division of Gastroenterology, Infectiology and Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin 10117, Germany
    Int J Colorectal Dis 27:565-73. 2012
    ..We hypothesized that variants in genes occurring in pathways such as autophagy and IL23 signalling might contribute to CD by altering intestinal permeability...
  17. pmc Impact of pain on health-related quality of life in patients with inflammatory bowel disease
    Anja Schirbel
    Division of Gastroenterology and Hepatology, Department of Medicine, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    World J Gastroenterol 16:3168-77. 2010
    ..To evaluate intensity, localization and cofactors of pain in Crohn's disease and ulcerative colitis patients in connection with health-related quality of life (HRQOL) and disease activity...
  18. ncbi Imaging in inflammatory bowel disease mucosal healing in ulcerative colitis: relevance for clinical outcomes
    Anja Schirbel
    Medizinische Klinik m S Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Curr Drug Targets 13:1234-44. 2012
    ....
  19. doi Increased T-helper 2 cytokines in bile from patients with IgG4-related cholangitis disrupt the tight junction-associated biliary epithelial cell barrier
    Tobias Müller
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Gastroenterology 144:1116-28. 2013
    ..A T-helper (Th) 2 cell cytokine profile predominates in liver tissues from these patients. We investigated whether Th2 cytokines disrupt the barrier function of biliary epithelial cells (BECs) in patients with IgG4-related cholangitis...
  20. doi Magnetic resonance enteroclysis in patients with Crohn's disease: fat saturated T2-weighted sequences for evaluation of inflammatory activity
    Christian Grieser
    Klinik für Radiologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Crohns Colitis 6:294-301. 2012
    ..To evaluate fat saturated (fs) T2-weighted (w) fast relaxation fast spin echo (FRFSE)-sequences compared to the standard protocol with contrast agent for the evaluation of inflammatory activity in patients with Crohn's Disease (CD)...
  21. ncbi Mucosal T cell proliferation and apoptosis in inflammatory bowel disease
    Andreas Sturm
    Department of Hepatology and Gastroenterology, Charite Universitatsmedizin Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Drug Targets 9:381-7. 2008
    ....
  22. doi The intestinal epithelial barrier: does it become impaired with age?
    Johannes Meier
    Medizinische Klinik m S Hepatologie, Gastroenterologie, Endokrinologie und Stoffwechsel, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, DE 13353 Berlin, Germany
    Dig Dis 27:240-5. 2009
    ..g. lipids, does seem to be impaired in the elderly. However, impaired blood flow, ischemic changes and the increased use of NSAIDs naturally contribute to an impaired epithelial barrier in elderly patients...
  23. pmc The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific
    Julia Benckert
    Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Clin Invest 121:1946-55. 2011
    ....
  24. pmc Current treatment of ulcerative colitis
    Johannes Meier
    Department of Hepatology and Gastroenterology, Charite Universitatsmedizin Berlin, Campus Virchow Clinic, 13353 Berlin, Germany
    World J Gastroenterol 17:3204-12. 2011
    ..Recommendations are based on published consensus guidelines derived from national and international guidelines on the treatment of ulcerative colitis...
  25. ncbi Concomitant use of immunomodulators with anti-TNF in Crohn's disease: yes or no?
    Johannes Meier
    Med Klinik m S Hepatologie, Gastroenterologie, Endokrinologie und Stoffwechsel, Berlin, Germany
    Curr Drug Targets 11:176-8. 2010
    ..This article aims to interpret the available data on the efficiency, immunogenicity, and safety of concomitant therapy in patients under anti-TNF therapy...
  26. ncbi Lisofylline and lysophospholipids ameliorate experimental colitis in rats
    Andreas Sturm
    Department of Medicine, Divisions of Gastroenterology and Hepatology, Charite Campus Virchow Clinic, Berlin, Germany
    Digestion 66:23-9. 2002
    ..Therefore, we investigated the effects of lysophosphatidic acid and lysophosphatidylethanolamine, two natural occurring phospholipids and lisofylline, which decreases lipid peroxidation, in an in-vivo model of intestinal inflammation...
  27. pmc p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling
    Andreas Sturm
    Division of Gastroenterology, Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4952, USA
    J Clin Invest 109:1481-92. 2002
    ..By slowing LPT cycling, p53 may act as a negative regulator of mucosal immunity, promoting immunological tolerance by preventing excessive T cell replication...
  28. doi Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease
    Stefania Vetrano
    Division of Gastroenterology, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, University of Milan, Rozzano, Italy
    Gastroenterology 135:173-84. 2008
    ..Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored...
  29. ncbi Dual function of the extracellular matrix: stimulatory for cell cycle progression of naive T cells and antiapoptotic for tissue-derived memory T cells
    Andreas Sturm
    Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, OH 44106, USA
    J Immunol 173:3889-900. 2004
    ..When naive PBT encounter Ag in the context of ECM, their progression through the cell cycle is enhanced, favoring clonal expansion; while tissue T cell longevity may be mediated by interactions with the ECM...
  30. ncbi Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients
    Silvio Danese
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Ohio 44106, USA
    Gastroenterology 124:1249-64. 2003
    ..We investigated whether platelets from patients with IBD express enhanced levels of CD40L and induce human intestinal microvascular endothelial cells (HIMEC) to up-regulate cell adhesion molecule (CAM) expression and secrete chemokines...
  31. ncbi Mesalamine promotes intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism
    Daniel C Baumgart
    Department of Medicine, Division of Hepatology and Gastroenterology, Charite Medical Center Virchow Hospital, Medical School of the Humboldt University of Berlin, Germany
    Scand J Gastroenterol 40:958-64. 2005
    ..The aim of this study was to investigate whether 5-ASA also modulates intestinal epithelial wound repair in vitro...
  32. pmc Epithelial restitution and wound healing in inflammatory bowel disease
    Andreas Sturm
    Medizinische Klinik I, Markus Krankenhaus, Wilhelm Epstein Strasse 2, 60431 Frankfurt Main, Germany
    World J Gastroenterol 14:348-53. 2008
    ..Enhancement of intestinal repair mechanisms by regulatory peptides or other modulatory factors may provide future approaches for the treatment of diseases that are characterized by injuries of the epithelial surface...
  33. ncbi Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation
    Alessandro Musso
    Division of Gastroenterology, Ospedale San Giovanni Battista, University of Torino, Torino, Italy
    Inflamm Bowel Dis 11:91-8. 2005
    ....