Verena Stangl

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Effects of lycopene on the initial state of atherosclerosis in New Zealand White (NZW) rabbits
    Mario Lorenz
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e30808. 2012
  2. ncbi request reprint Homocysteine inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion via nuclear factor-kappaB dependent pathway
    V Stangl
    Medizinische Klinik und Poliklinik, Schwerpunkt Kardiologie, Angiologie and Pneumologie, Charité der Humboldt Universität, Campus Mitte, Berlin, Germany
    Biochem Biophys Res Commun 280:1093-100. 2001
  3. ncbi request reprint The role of tea and tea flavonoids in cardiovascular health
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie, Charite, Universitatsmedizin Berlin, Campus Mitte, Germany
    Mol Nutr Food Res 50:218-28. 2006
  4. ncbi request reprint Molecular targets of tea polyphenols in the cardiovascular system
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charité Universitätsmedizin Berlin, CCM, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Cardiovasc Res 73:348-58. 2007
  5. ncbi request reprint The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets
    Verena Stangl
    Medizinische Klinik und Poliklinik, Schwerpunkt Kardiologie, Angiologie, Pneumologie, Charité der Humboldt Universität, Campus Mitte, Berlin, Germany
    J Nutr 135:172-8. 2005
  6. doi request reprint Current diagnostic concepts to detect coronary artery disease in women
    Verena Stangl
    Med Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, D 10117 Berlin, Germany
    Eur Heart J 29:707-17. 2008
  7. doi request reprint Pregnancy outcome in patients with complex pulmonary atresia: case report and review of the literature
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, CCM, Chariteplatz 1, D 10117 Berlin, Germany
    Eur J Heart Fail 12:202-7. 2010
  8. doi request reprint Maternal heart disease and pregnancy outcome: a single-centre experience
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Chariteplatz 1, D 10117 Berlin, Germany
    Eur J Heart Fail 10:855-60. 2008
  9. ncbi request reprint Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie, Humboldt Universitat Berlin, Charite, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    FASEB J 18:272-9. 2004
  10. doi request reprint Lack of effects of tomato products on endothelial function in human subjects: results of a randomised, placebo-controlled cross-over study
    Verena Stangl
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin, Berlin, Germany
    Br J Nutr 105:263-7. 2011

Collaborators

Detail Information

Publications56

  1. pmc Effects of lycopene on the initial state of atherosclerosis in New Zealand White (NZW) rabbits
    Mario Lorenz
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e30808. 2012
    ..We therefore studied the effects of lycopene on diet-induced increase in serum lipid levels and the initiation of atherosclerosis in New Zealand White (NZW) rabbits...
  2. ncbi request reprint Homocysteine inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion via nuclear factor-kappaB dependent pathway
    V Stangl
    Medizinische Klinik und Poliklinik, Schwerpunkt Kardiologie, Angiologie and Pneumologie, Charité der Humboldt Universität, Campus Mitte, Berlin, Germany
    Biochem Biophys Res Commun 280:1093-100. 2001
    ....
  3. ncbi request reprint The role of tea and tea flavonoids in cardiovascular health
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie, Charite, Universitatsmedizin Berlin, Campus Mitte, Germany
    Mol Nutr Food Res 50:218-28. 2006
    ..A number of factors are discussed which may contribute to inconsistent data in humans. Overall, tea represents a promising tool for the prevention and treatment of cardiovascular disorders...
  4. ncbi request reprint Molecular targets of tea polyphenols in the cardiovascular system
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charité Universitätsmedizin Berlin, CCM, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Cardiovasc Res 73:348-58. 2007
    ..However, more detailed and profound analysis of molecular actions in different cells of the cardiovascular system is necessary before safe clinical use of tea polyphenols for treatment of cardiovascular diseases will become possible...
  5. ncbi request reprint The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets
    Verena Stangl
    Medizinische Klinik und Poliklinik, Schwerpunkt Kardiologie, Angiologie, Pneumologie, Charité der Humboldt Universität, Campus Mitte, Berlin, Germany
    J Nutr 135:172-8. 2005
    ..Thus phloretin may have beneficial effects in the onset and progression of cardiovascular diseases...
  6. doi request reprint Current diagnostic concepts to detect coronary artery disease in women
    Verena Stangl
    Med Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, D 10117 Berlin, Germany
    Eur Heart J 29:707-17. 2008
    ..The present review discusses the validity of classical diagnostic procedures for CAD in women, and addresses the relevance of newer techniques in the context of a female-specific diagnostic approach...
  7. doi request reprint Pregnancy outcome in patients with complex pulmonary atresia: case report and review of the literature
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, CCM, Chariteplatz 1, D 10117 Berlin, Germany
    Eur J Heart Fail 12:202-7. 2010
    ..We review the medical literature on pregnancy course as well as maternal and foetal outcome in cases involving this maternal congenital heart disease...
  8. doi request reprint Maternal heart disease and pregnancy outcome: a single-centre experience
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Chariteplatz 1, D 10117 Berlin, Germany
    Eur J Heart Fail 10:855-60. 2008
    ..Maternal and neonatal complication rates are increased in pregnant women with heart disease. Cardiac risk assessment may be improved by defining low and high-risk groups...
  9. ncbi request reprint Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie, Humboldt Universitat Berlin, Charite, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    FASEB J 18:272-9. 2004
    ..Our results indicate that low-dose proteasome inhibition enhances eNOS expression and activity, and improves endothelial function...
  10. doi request reprint Lack of effects of tomato products on endothelial function in human subjects: results of a randomised, placebo-controlled cross-over study
    Verena Stangl
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin, Berlin, Germany
    Br J Nutr 105:263-7. 2011
    ..In conclusion, consumption of tomato products associated with a significant increase in plasma lycopene levels had no effects on endothelial function in healthy postmenopausal women...
  11. ncbi request reprint [Cardiovascular risk factors in women]
    V Stangl
    Med Klinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie, Charité der Humboldt Universität, Campus Mitte, Berlin
    Dtsch Med Wochenschr 128:1659-64. 2003
  12. ncbi request reprint Negative inotropic mediators released from the heart after myocardial ischaemia-reperfusion
    Verena Stangl
    Medizinische Klinik, Kardiologie, Angiologie, Pneumologie, Charite, Campus Mitte, Humboldt Universitat zu Berlin, Schumannstr 20 21, D 10098 Berlin, Germany
    Cardiovasc Res 53:12-30. 2002
    ....
  13. ncbi request reprint [Pregnancy risks in acquired heart diseases]
    V Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie Charité der Humboldt Universität, Campus Mitte, Berlin Schumannstr 20 21 10117 Berlin
    Z Kardiol 90:16-29. 2001
    ..Close interdisciplinary collaboration and tightly networked support for patients are the prerequisite for successful management of high-risk pregnancies involving maternal heart disease...
  14. doi request reprint Potent anti-inflammatory effects of low-dose proteasome inhibition in the vascular system
    Antje Ludwig
    Klinik für Kardiologie und Angiologie, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Mol Med (Berl) 87:793-802. 2009
    ..This low-dose proteasome inhibition led to decreased hypertension-induced oxidative stress and reduced expression of vascular cell adhesion molecule 1 (VCAM-1) in the aortae...
  15. ncbi request reprint The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells
    Antje Ludwig
    Medizinische Klinik und Poliklinik, Schwerpunkt Kardiologie, Angiologie, Pneumologie Charité der Humboldt Universität, Campus Mitte, Berlin, Germany
    Biochem Biophys Res Commun 316:659-65. 2004
    ..Furthermore, EGCG reduced the TNF-alpha-induced adhesion of THP-1 cells to HUVECs. EGCG did not influence TNF-alpha-stimulated NF-kappaB activation...
  16. ncbi request reprint Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection
    Henryk Dreger
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Cardiovasc Res 83:354-61. 2009
    ..Here, we have addressed the question whether the induction of antioxidative enzymes contributes to cardioprotection by non-toxic proteasome inhibition...
  17. doi request reprint Attenuation of early atherogenesis in low-density lipoprotein receptor-deficient mice by proteasome inhibition
    Nicola Wilck
    Medizinische Klinik für Kardiologie und Angiologie, Charité Universitätsmedizin Berlin Campus Mitte, Chariteplatz 1, D 10117 Berlin, Germany
    Arterioscler Thromb Vasc Biol 32:1418-26. 2012
    ..The present study investigated the effect of low-dose proteasome inhibition on early lesion formation in low-density lipoprotein receptor-deficient mice fed a Western-type diet...
  18. doi request reprint Proteasome inhibition prevents experimentally-induced endothelial dysfunction
    Mario Lorenz
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin Berlin, Germany
    Life Sci 84:929-34. 2009
    ..As there are conflicting data about the effects of proteasome inhibition on endothelial function, we investigated whether proteasome inhibition could prevent experimentally-induced endothelial dysfunction...
  19. ncbi request reprint Suppression of cardiomyocyte hypertrophy by inhibition of the ubiquitin-proteasome system
    Silke Meiners
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitaetsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Hypertension 51:302-8. 2008
    ....
  20. doi request reprint Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells
    Kera Westphal
    Medizinische Klinik für Kardiologie und Angiologie, Charite Universitaetsmedizin Berlin, 10117 Berlin, Germany
    Free Radic Biol Med 47:1652-60. 2009
    ..As GPx-3 is secreted into the plasma, our data point toward a borderline defense mechanism of endothelial cell-derived GPx-3 to protect the vasculature from oxidative stress...
  21. ncbi request reprint The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea
    Nicoline Jochmann
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Br J Nutr 99:863-8. 2008
    ..black tea: 0.66 (95 % CI - 0.76, 2.09) %; P = 0.36). NMD did not vary between any of the groups. In conclusion, green and black tea are equally effective in improving endothelial function...
  22. ncbi request reprint Inhibition of the ubiquitin-proteasome pathway induces differential heat-shock protein response in cardiomyocytes and renders early cardiac protection
    Karl Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie, Angiologie, und Pneumologie, Institute of Biochemistry, Charite, Campus Mitte, Humboldt Universitat zu Berlin, Schumannstrasse 20 21, Berlin, D 10117, Germany
    Biochem Biophys Res Commun 291:542-9. 2002
    ..In these proof-of-principle experiments, we show that PI induces differential heat-shock response in cardiomyocytes, accompanied by enhanced cell survival and functional recovery after various forms of stress...
  23. doi request reprint Characteristics of catechin- and theaflavin-mediated cardioprotection
    Henryk Dreger
    Medizinische Klinik m S Kardiologie und Angiologie CCM, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Exp Biol Med (Maywood) 233:427-33. 2008
    ..In conclusion, activation of prosurvival signaling kinases and upregulation of antioxidative enzymes do not play a major role in tea polyphenol-mediated cardioprotection...
  24. doi request reprint Protection of vascular cells from oxidative stress by proteasome inhibition depends on Nrf2
    Henryk Dreger
    Medizinische Klinik für Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Cardiovasc Res 85:395-403. 2010
    ..Here, we elucidate the mechanisms of proteasome inhibitor-mediated upregulation of antioxidative enzymes and cytoprotection...
  25. ncbi request reprint Impact of gender on three-month outcome and left ventricular remodeling after transfemoral transcatheter aortic valve implantation
    Verena Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Campus Mitte, Universitatsmedizin Berlin, Germany
    Am J Cardiol 110:884-90. 2012
    ..In conclusion, women clinically benefit from TAVI to a degree similar to that of men. However, there are gender differences involving the recovery response of the left ventricle after TAVI...
  26. ncbi request reprint Nontoxic proteasome inhibition activates a protective antioxidant defense response in endothelial cells
    Silke Meiners
    Universitatsmedizin Berlin, Charite, Medizinische Klinik und Poliklinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Free Radic Biol Med 40:2232-41. 2006
    ..Our data thus suggest that nontoxic proteasome inhibition might offer a new therapeutic approach for the treatment of endothelial dysfunction in cardiovascular disorders...
  27. ncbi request reprint Addition of milk prevents vascular protective effects of tea
    Mario Lorenz
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, CCM, Chariteplatz 1, D 10117 Berlin, Germany
    Eur Heart J 28:219-23. 2007
    ..We studied the vascular effects of tea, with or without milk, in humans and elucidated the impact of individual milk proteins in cell culture experiments, with isolated rat aortic rings and by HPLC analysis...
  28. doi request reprint Positive inotropic effects of epigallocatechin-3-gallate (EGCG) involve activation of Na+/H+ and Na+/Ca2+ exchangers
    Mario Lorenz
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
    Eur J Heart Fail 10:439-45. 2008
    ..There is evidence that the tea catechin epigallocatechin-3-gallate (EGCG) modulates myocardial contractility. However, the underlying mechanisms remain to be determined...
  29. doi request reprint Short-term effects of transcatheter aortic valve implantation on left atrial mechanics and left ventricular diastolic function
    Sebastian Spethmann
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Am Soc Echocardiogr 26:64-71.e2. 2013
    ..The goal of this study was to evaluate the short-term effects of transcatheter aortic valve implantation (TAVI) on LA myocardial deformation as well as left ventricular (LV) diastolic function...
  30. doi request reprint Epigenetic regulation of cell adhesion and communication by enhancer of zeste homolog 2 in human endothelial cells
    Henryk Dreger
    Medizinische Klinik für Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Hypertension 60:1176-83. 2012
    ..Ezh2-dependent repression of genes involved in cell adhesion and communication contributes to the regulation of angiogenesis...
  31. doi request reprint Green and black tea are equally potent stimuli of NO production and vasodilation: new insights into tea ingredients involved
    Mario Lorenz
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charité, Universitatsmedizin Berlin, CCM, Chariteplatz 1, Berlin, Germany
    Basic Res Cardiol 104:100-10. 2009
    ..Theaflavins and thearubigins predominantly counterbalance the lack of catechins in black tea. The findings may underline the contribution of black tea consumption in prevention of cardiovascular diseases...
  32. ncbi request reprint Downregulation of matrix metalloproteinases and collagens and suppression of cardiac fibrosis by inhibition of the proteasome
    Silke Meiners
    Medizinische Klinik, Kardiologie and Center for Cardiovascular Research, Berlin, Germany
    Hypertension 44:471-7. 2004
    ....
  33. doi request reprint Recovery of left ventricular and left atrial mechanics in various entities of aortic stenosis 12 months after TAVI
    Sebastian Spethmann
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin D 10117, Germany
    Eur Heart J Cardiovasc Imaging 15:389-98. 2014
    ..This study evaluated the effects of TAVI on LA and LV mechanics in varying entities of AS 12 months after implantation...
  34. doi request reprint Doppler haemodynamics and effective orifice areas of Edwards SAPIEN and CoreValve transcatheter aortic valves
    Sebastian Spethmann
    Charite Campus Mitte, Universitatsmedizin, Chariteplatz 1, D 10117 Berlin, Germany
    Eur Heart J Cardiovasc Imaging 13:690-6. 2012
    ..So far, no reference values for the echocardiographic assessment of this new class of heart valves have been established. The aim of our study was to determine Doppler haemodynamics and the effective orifice area (EOA)...
  35. pmc Circulating angiogenic factors in patients with thromboangiitis obliterans
    Bernd Hewing
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e34717. 2012
    ..Recent attempts in therapeutic angiogenesis have been promising. Therefore, the aim of our study was to evaluate angiogenic processes and factors including circulating progenitor cells in TAO...
  36. pmc Smoking decreases the level of circulating CD34+ progenitor cells in young healthy women--a pilot study
    Antje Ludwig
    Med, Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitaetsmedizin Berlin, Campus Mitte, Berlin, Germany
    BMC Womens Health 10:20. 2010
    ....
  37. ncbi request reprint Chronic smoking prevents amelioration of endothelial function in the course of the menstrual cycle
    Nicoline Jochmann
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Circ J 73:568-72. 2009
    ..Smoking is the most important modifiable cardiovascular risk factor in young women. The aim of this study was to investigate whether tobacco use influences physiological changes in endothelial function during the menstrual cycle...
  38. doi request reprint Green tea and cardiovascular disease: from molecular targets towards human health
    Nicoline Jochmann
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Curr Opin Clin Nutr Metab Care 11:758-65. 2008
    ..To summarize current knowledge of the protective effects of green tea and green tea constituents, particularly catechins, on the cardiovascular system...
  39. ncbi request reprint Comprehensive proteomic and transcriptomic analysis reveals early induction of a protective anti-oxidative stress response by low-dose proteasome inhibition
    Sven Bieler
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Proteomics 9:3257-67. 2009
    ....
  40. doi request reprint Long-term Doppler hemodynamics and effective orifice areas of Edwards SAPIEN and medtronic CoreValve prostheses after TAVI
    Sebastian Spethmann
    Department of Cardiology and Angiology, Campus Charite Mitte, Charite University Medicine Berlin, Berlin, Germany Department of Internal Medicine, Bundeswehrkrankenhaus, Berlin, Germany
    Echocardiography 31:302-10. 2014
    ..As biological prostheses are at potential risk for early degeneration, the aim of our study was to compare Doppler hemodynamics and effective orifice area (EOA) directly after and at least 1 year after valve implantation...
  41. pmc Contrast-enhanced MR imaging of atherosclerosis using citrate-coated superparamagnetic iron oxide nanoparticles: calcifying microvesicles as imaging target for plaque characterization
    Susanne Wagner
    Department of Radiology, Section of Experimental Radiology, Charite Universitatsmedizin Berlin, Campus Charite Mitte, and Campus Benjamin Franklin, Berlin, Germany
    Int J Nanomedicine 8:767-79. 2013
    ..To evaluate the suitability of citrate-coated very small superparamagnetic iron oxide particles (VSOP) as a contrast agent for identifying inflammation in atherosclerotic lesions using magnetic resonance imaging (MRI)...
  42. ncbi request reprint Effect of statins on the proteasomal activity in mammalian endothelial and vascular smooth muscle cells
    Antje Ludwig
    Medizinische Klinik und Poliklinik, Schwerpunkt Kardiologie, Angiologie, Pneumologie Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
    Biochem Pharmacol 70:520-6. 2005
    ..We conclude that the similar biological effects of statins and proteasome inhibitors in vascular cells are not due to a common inhibitory mechanism of action on the proteasome...
  43. ncbi request reprint Proteasome inhibitors: poisons and remedies
    Silke Meiners
    Universitatsmedizin Berlin, Charite, Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Germany
    Med Res Rev 28:309-27. 2008
    ..According to this idea, we suggest that inhibition of the proteasome to a defined degree may offer a promising tool in achieving desired therapeutic effects in various diseases...
  44. ncbi request reprint A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation
    Mario Lorenz
    Medizinische Klinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie, Charite, Campus Mitte, Humboldt Universitat zu Berlin, Berlin D 10117, Germany
    J Biol Chem 279:6190-5. 2004
    ....
  45. ncbi request reprint Female-specific aspects in the pharmacotherapy of chronic cardiovascular diseases
    Nicoline Jochmann
    Medizinische Klinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie, Institut fur Klinische Pharmakologie, Universitatsmedizin Berlin, D 10117 Berlin, Germany
    Eur Heart J 26:1585-95. 2005
    ..On the whole, the study situation for women is appreciably less favourable than for men: owing to the fact that women are under-represented in most studies, and that few gender-specific analyses have been conducted...
  46. doi request reprint The ubiquitin-proteasome pathway and endothelial (dys)function
    Karl Stangl
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, Campus Mitte, D 10117 Berlin, Germany
    Cardiovasc Res 85:281-90. 2010
    ..This review discusses the potential implications of the UPS in endothelial dysfunction...
  47. doi request reprint Rapid binding of electrostatically stabilized iron oxide nanoparticles to THP-1 monocytic cells via interaction with glycosaminoglycans
    Antje Ludwig
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite, Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Basic Res Cardiol 108:328. 2013
    ..VSOP should be investigated further in appropriate in vivo experiments to characterize accumulation in unstable plaque...
  48. ncbi request reprint Alternative splicing in intron 13 of the human eNOS gene: a potential mechanism for regulating eNOS activity
    Mario Lorenz
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, CCM, Chariteplatz 1, D 10117 Berlin, Germany
    FASEB J 21:1556-64. 2007
    ..These data suggest a new mechanism for the regulation of eNOS activity and NO production in the cardiovascular system by truncated, dominant-negative splice variants of human eNOS...
  49. pmc Acute regional improvement of myocardial function after interventional transfemoral aortic valve replacement in aortic stenosis: a speckle tracking echocardiography study
    Sebastian Schattke
    Charite Universitatsmedizin Berlin, Medizinische Klinik m S Kardiologie und Angiologie, Charite Campus Mitte, Germany
    Cardiovasc Ultrasound 10:15. 2012
    ..The goal of this study was to describe the course of LV reverse remodelling immediately after TAVI in a broad spectrum of patients with symptomatic severe aortic valve stenosis...
  50. ncbi request reprint Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist
    Thomas Dschietzig
    Medizinische Klinik m S Kardiologie, Angiologie, Pulmologie, Charite Berlin, Berlin, Germany
    FASEB J 18:1536-8. 2004
    ..These findings may deepen our understanding of relaxin's abundant physiological actions, as well as our insights into general principles of hormone signaling...
  51. ncbi request reprint Interaction of CA repeat polymorphism of the endothelial nitric oxide synthase and hyperhomocysteinemia in acute coronary syndromes: evidence of gender-specific differences
    Michael Laule
    Medizinische Klinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie, Charite, Campus Mitte, Humboldt Universitat, Schumannstrasse 21 21, 10117 Berlin, Germany
    J Mol Med (Berl) 81:305-9. 2003
    ..32 at 38 CA repeats. This effect modification was not observed in men. These data suggest gender-specific gene-environment interaction between the CA repeat eNOS polymorphism and homocysteine in acute coronary syndromes...
  52. doi request reprint Successful treatment of thromboangiitis obliterans (Buerger's disease) with immunoadsorption: results of a pilot study
    Gert Baumann
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charité, Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Clin Res Cardiol 100:683-90. 2011
    ..Since abnormalities of the immune system appear to be involved in the pathogenesis, we investigated in this pilot study the efficiency of Ig immunoadsorption (IA) therapy...
  53. ncbi request reprint Renal sympathetic denervation: early impact on ambulatory resistant hypertension
    Marius Schwerg
    Department of Cardiology and Angiology, Campus Mitte Charité Universitätsmedizin, Berlin, Germany
    J Clin Hypertens (Greenwich) 16:406-11. 2014
    ..Only approximately half of patients with resistant hypertension responded to RDN. However, in these responders, a remarkable reduction of 24-hour BP occurred as early as 1 month after RDN. ..
  54. doi request reprint Local drug delivery - the early Berlin experience: single drug administration versus sustained release
    Ulrich Speck
    Department of Radiology, Experimental Radiology, Charite, University Hospital, Berlin, Germany
    EuroIntervention 7:K17-22. 2011
    ....
  55. ncbi request reprint [Antioxidants and atherosclerosis. What is certain in primary and secondary prevention?]
    Michael Laule
    Medizinische Klinik und Poliklinik, Schwerpunkt Kardiologie, Angiologie, Pneumologie, Charité der Humboldt Universität, Berlin
    Med Monatsschr Pharm 27:379-86. 2004
  56. doi request reprint LXR agonism improves TNF-α-induced endothelial dysfunction in the absence of its cholesterol-modulating effects
    Frank Spillmann
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Atherosclerosis 232:1-9. 2014
    ....