C M Spies

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:24-32. 2010
  2. ncbi request reprint How to mechanistically explain the CONDOR study data
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany Electronic address
    Med Hypotheses 84:14-9. 2015
  3. pmc Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    BMC Musculoskelet Disord 15:31. 2014
  4. pmc Energy metabolism and rheumatic diseases: from cell to organism
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 14:216. 2012
  5. ncbi request reprint Glucocorticoids
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Best Pract Res Clin Rheumatol 25:891-900. 2011
  6. ncbi request reprint Prednisone chronotherapy
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Clin Exp Rheumatol 29:S42-5. 2011
  7. ncbi request reprint Methotrexate treatment in large vessel vasculitis and polymyalgia rheumatica
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Clin Exp Rheumatol 28:S172-7. 2010
  8. ncbi request reprint More night than day--circadian rhythms in polymyalgia rheumatica and ankylosing spondylitis
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Berlin, Germany
    J Rheumatol 37:894-9. 2010
  9. ncbi request reprint Pharmacology of glucocorticoids in rheumatoid arthritis
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Curr Opin Pharmacol 10:302-7. 2010
  10. ncbi request reprint Analyses of similarities and differences in glucocorticoid therapy between rheumatoid arthritis and ankylosing spondylitis - a systematic comparison
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Clin Exp Rheumatol 27:S152-8. 2009

Detail Information

Publications13

  1. ncbi request reprint Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:24-32. 2010
    ..It is implied that these effects contribute to the well-known beneficial anti-inflammatory and immunomodulatory effects of glucocorticoid therapy...
  2. ncbi request reprint How to mechanistically explain the CONDOR study data
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany Electronic address
    Med Hypotheses 84:14-9. 2015
    ..g., uncoupling effects). The reduced toxicity appears to be rather a substance-specific characteristic. This is an unconditional reason to carry on investigating these phenomena in experimental and large-scale clinical trials. ..
  3. pmc Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    BMC Musculoskelet Disord 15:31. 2014
    ..To determine whether or not the modulation of the inflammatory response by osteoblasts involves T cells, we studied the effects of disrupted osteoblastic GC-signalling in the T cell-dependent model of antigen-induced arthritis (AIA)...
  4. pmc Energy metabolism and rheumatic diseases: from cell to organism
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 14:216. 2012
    ..We conclude that, on cellular and organism levels, a prolonged energy appeal reaction is an important factor of chronic inflammatory disease etiology...
  5. ncbi request reprint Glucocorticoids
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Best Pract Res Clin Rheumatol 25:891-900. 2011
    ..Improved knowledge of the immunomodulatory role of endogenous glucocorticoids has evolved, and we report on the therapeutic potential of targeting glucocorticoid pre-receptor metabolism for metabolic and inflammatory diseases...
  6. ncbi request reprint Prednisone chronotherapy
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Clin Exp Rheumatol 29:S42-5. 2011
    ..For patients with RA on low to medium doses of prednisone, especially those who continue to experience a long duration of morning stiffness, MR prednisone appears a valuable additional treatment option...
  7. ncbi request reprint Methotrexate treatment in large vessel vasculitis and polymyalgia rheumatica
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Clin Exp Rheumatol 28:S172-7. 2010
    ..Further attempts should be made for a better identification of patients with glucocorticoid-refractory courses and a more precise formulation of guidelines on indication, optimal dosing and duration...
  8. ncbi request reprint More night than day--circadian rhythms in polymyalgia rheumatica and ankylosing spondylitis
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Berlin, Germany
    J Rheumatol 37:894-9. 2010
    ..This review summarizes the current knowledge on circadian rhythms in other rheumatic diseases, focusing on polymyalgia rheumatica and ankylosing spondylitis...
  9. ncbi request reprint Pharmacology of glucocorticoids in rheumatoid arthritis
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Curr Opin Pharmacol 10:302-7. 2010
    ..This short review summarises the current knowledge in this regard, with particular emphasis on recently published articles...
  10. ncbi request reprint Analyses of similarities and differences in glucocorticoid therapy between rheumatoid arthritis and ankylosing spondylitis - a systematic comparison
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Clin Exp Rheumatol 27:S152-8. 2009
    ..Translation of insights on GC action and resistance obtained in RA to AS may contribute to a better understanding of the pathophysiology of both diseases...
  11. ncbi request reprint Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4+ T lymphocytes
    R Dziurla
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:97-105. 2010
    ..Hypoxia seems to facilitate inflammatory reactions and angiogenesis...
  12. ncbi request reprint Pharmacodynamics of glucocorticoids
    C Strehl
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Clin Exp Rheumatol 29:S13-8. 2011
    ....
  13. pmc Membrane glucocorticoid receptors are down regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1-independent expression pathway
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Ann Rheum Dis 65:1139-46. 2006
    ..Caveolin-1 is critical for the transport of plasma membrane oestrogen receptors to the cell surface...