C D Spies

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc S3 guidelines for intensive care in cardiac surgery patients: hemodynamic monitoring and cardiocirculary system
    M Carl
    Department of Anesthesiology and Intensive Care, Charite University Medicine Berlin, Charité Campus Mitte and Campus Virchow Klinikum, Berlin, Germany
    Ger Med Sci 8:Doc12. 2010
  2. doi request reprint Prediction of long-term mortality by preoperative health-related quality-of-life in elderly onco-surgical patients
    Maren Schmidt
    Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charite University Medicine Berlin, Berlin, Germany
    PLoS ONE 9:e85456. 2014
  3. doi request reprint A modified approach to induce predictable congestive heart failure by volume overload in rats
    Sascha Treskatsch
    Department of Anesthesiology and Intensive Care Medicine, Campus Chárite, Mitte and Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 9:e87531. 2014
  4. pmc Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version
    JORG MARTIN
    Department of Anesthesiology and Operative Intensive Care, Klinik am Eichert, Goppingen, Germany
    Ger Med Sci 8:Doc02. 2010
  5. pmc Quality indicators in intensive care medicine: why? Use or burden for the intensivist
    Jan Peter Braun
    Dept of Anaesthesiology and Surgical Intensive Care Medicine, Charite University Medicine Berlin, Germany
    Ger Med Sci 8:Doc22. 2010
  6. pmc The paediatric Confusion Assessment Method for the Intensive Care Unit (pCAM-ICU): translation and cognitive debriefing for the German-speaking area
    Clemens de Grahl
    Charite Universitaetsmedizin Berlin, Department of Anaesthesiology and Intensive Care Medicine, Campus Virchow Klinikum and Campus Charite Mitte, Berlin, Germany
    Ger Med Sci 10:Doc07. 2012
  7. pmc Acetylcholinesterase inhibitors reduce neuroinflammation and -degeneration in the cortex and hippocampus of a surgery stress rat model
    Alexander Kalb
    Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charite, Universitatsmedizin Berlin, Germany
    PLoS ONE 8:e62679. 2013
  8. pmc Health-related quality of life in urban surgical emergency department patients: comparison with a representative German population sample
    Bruno Neuner
    Dept of Anaesthesiology, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany
    Health Qual Life Outcomes 3:77. 2005
  9. pmc Implementing the International Liaison Committee on Resuscitation guidelines on hypothermia after cardiac arrest. The German experience: still a long way to go?
    Michael Sander
    Crit Care 10:407. 2006
  10. pmc Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis
    Michael Sander
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Crit Care 14:R148. 2010

Detail Information

Publications148 found, 100 shown here

  1. pmc S3 guidelines for intensive care in cardiac surgery patients: hemodynamic monitoring and cardiocirculary system
    M Carl
    Department of Anesthesiology and Intensive Care, Charite University Medicine Berlin, Charité Campus Mitte and Campus Virchow Klinikum, Berlin, Germany
    Ger Med Sci 8:Doc12. 2010
    ..The presented key messages of the guidelines were approved after two consensus meetings under the moderation of the Association of the Scientific Medical Societies in Germany (AWMF)...
  2. doi request reprint Prediction of long-term mortality by preoperative health-related quality-of-life in elderly onco-surgical patients
    Maren Schmidt
    Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charite University Medicine Berlin, Berlin, Germany
    PLoS ONE 9:e85456. 2014
    ..Aim of this study was to evaluate the association between preoperative health-related quality of life (HRQoL) and mortality in a cohort of elderly patients (>65 years) with gastrointestinal, gynecological and genitourinary carcinomas...
  3. doi request reprint A modified approach to induce predictable congestive heart failure by volume overload in rats
    Sascha Treskatsch
    Department of Anesthesiology and Intensive Care Medicine, Campus Chárite, Mitte and Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 9:e87531. 2014
    ..Therefore, this modified approach might facilitate the examination of various questions specific to CHF and allow for pharmacological interventions to determine pathophysiological pathways...
  4. pmc Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version
    JORG MARTIN
    Department of Anesthesiology and Operative Intensive Care, Klinik am Eichert, Goppingen, Germany
    Ger Med Sci 8:Doc02. 2010
    ..These guidelines offer treatment recommendations for the ICU team. The implementation of scores and protocols into routine ICU practice is necessary for their success...
  5. pmc Quality indicators in intensive care medicine: why? Use or burden for the intensivist
    Jan Peter Braun
    Dept of Anaesthesiology and Surgical Intensive Care Medicine, Charite University Medicine Berlin, Germany
    Ger Med Sci 8:Doc22. 2010
    ..Different German societies of intensive care medicine have finally agreed on 10 core quality indicators that will be valid for two years and are currently recommended in German intensive care units (ICUs)...
  6. pmc The paediatric Confusion Assessment Method for the Intensive Care Unit (pCAM-ICU): translation and cognitive debriefing for the German-speaking area
    Clemens de Grahl
    Charite Universitaetsmedizin Berlin, Department of Anaesthesiology and Intensive Care Medicine, Campus Virchow Klinikum and Campus Charite Mitte, Berlin, Germany
    Ger Med Sci 10:Doc07. 2012
    ..The purpose of this study was the translation of the English pCAM-ICU into German according to international validated guidelines...
  7. pmc Acetylcholinesterase inhibitors reduce neuroinflammation and -degeneration in the cortex and hippocampus of a surgery stress rat model
    Alexander Kalb
    Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charite, Universitatsmedizin Berlin, Germany
    PLoS ONE 8:e62679. 2013
    ..This combination may represent a tool to break the pathogenesis of POCD...
  8. pmc Health-related quality of life in urban surgical emergency department patients: comparison with a representative German population sample
    Bruno Neuner
    Dept of Anaesthesiology, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany
    Health Qual Life Outcomes 3:77. 2005
    ..Quality of life is associated with substance use as well as socioeconomic status. Little is known about quality of life in substance-abusing young patients with minor trauma...
  9. pmc Implementing the International Liaison Committee on Resuscitation guidelines on hypothermia after cardiac arrest. The German experience: still a long way to go?
    Michael Sander
    Crit Care 10:407. 2006
  10. pmc Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis
    Michael Sander
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Crit Care 14:R148. 2010
    ..The safety profile of TXA has not been extensively studied. Therefore, the aim of this study was to evaluate safety and efficiency of TXA compared with aprotinin in cardiac surgery...
  11. pmc Perioperative indocyanine green clearance is predictive for prolonged intensive care unit stay after coronary artery bypass grafting--an observational study
    Michael Sander
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Crit Care 13:R149. 2009
    ..Secondary objective was to define predictors of prolonged ICU treatment like decreased PDR ICG after surgery...
  12. pmc Bispectral index versus COMFORT score to determine the level of sedation in paediatric intensive care unit patients: a prospective study
    Andreas E Triltsch
    Department of Anesthesiology and Intensive Care Medicine corrected, Campus Benjamin Franklin, Charite University Hospital Berlin, Berlin, Germany
    Crit Care 9:R9-17. 2005
    ..The aim of this prospective observational trial was to evaluate the use of electroencephalographic (EEG) BIS for monitoring sedation in paediatric intensive care unit (PICU) patients...
  13. pmc Levosimendan may improve survival in patients requiring mechanical assist devices for post-cardiotomy heart failure
    Jan Peter Braun
    Department of Anesthesiology and Intensive Care, Campus Charite Mitte, Charite University Hospital, Charite University Medicine Berlin, Germany
    Crit Care 10:R17. 2006
    ..Levosimendan is the only inotropic substance known to improve medium term survival in patients suffering from severe heart failure...
  14. pmc Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study
    Steffen Weber-Carstens
    Clinic of Anesthesiology and Intensive Care Medicine, Charite University Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Crit Care 14:R119. 2010
    ..Non-excitable muscle membrane indicates critical illness myopathy (CIM) during early critical illness. We investigated predisposing risk factors for non-excitable muscle membrane at onset of critical illness...
  15. pmc Infections of respiratory or abdominal origin in ICU patients: what are the differences?
    Elena Volakli
    Dept of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
    Crit Care 14:R32. 2010
    ..We used the Sepsis Occurrence in Acutely ill Patients (SOAP) database to investigate differences in the impact of respiratory tract and abdominal sites of infection on organ failure and survival...
  16. pmc Prediction of volume response under open-chest conditions during coronary artery bypass surgery
    Michael Sander
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Augustenburger Platz 1, 13353 Berlin, Germany
    Crit Care 11:R121. 2007
    ....
  17. pmc Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock
    Vera von Dossow
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Crit Care 8:R312-21. 2004
    ....
  18. pmc Changes in sedation management in German intensive care units between 2002 and 2006: a national follow-up survey
    JORG MARTIN
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Hospital am Eichert, Eichertstrasse 3, 73035 Göppingen, Germany
    Crit Care 11:R124. 2007
    ..The aim of this study, conducted in 2006, was to find out whether changes in sedation management in German intensive care units took place in comparison with our survey from 2002...
  19. pmc The impact of an hematocrit of 20% during normothermic cardiopulmonary bypass for elective low risk coronary artery bypass graft surgery on oxygen delivery and clinical outcome--a randomized controlled study [ISRCTN35655335]
    Christian von Heymann
    Department of Anesthesiology and Intensive Care Medicine, Charite University Hospital Berlin, Charite Campus Mitte, Berlin, Germany
    Crit Care 10:R58. 2006
    ....
  20. pmc Mild hypothermia after near drowning in twin toddlers
    Ortrud Vargas Hein
    Department of Anesthesiology and Intensive Care Medicine, Charite, Campus Mitte, Humboldt University, Berlin, Germany
    Crit Care 8:R353-7. 2004
    ..We report a case of twin toddlers who both suffered near drowning but with different post-trauma treatment and course, and different neurological outcomes...
  21. pmc Time course of endothelial damage in septic shock: prediction of outcome
    Ortrud Vargas Hein
    Department of Anesthesiology and Intensive Care, University Hospital Charite, Campus Mitte, Berlin, Germany
    Crit Care 9:R323-30. 2005
    ..We investigated the predictive value of the mediators IL-6, IL-8, sELAM-1 and sICAM-1 and their time course in intensive care unit patients who developed septic shock with respect to outcome...
  22. pmc Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological surgery: a review and meta-analysis of published data
    Christian von Heymann
    Department of Anesthesiology and Intensive Care Medicine, Charite University Medicine Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Augustenburger Platz 1, 13353 Berlin, Germany
    Crit Care 12:R14. 2008
    ..The purpose of this study was to determine the role of recombinant activated factor VII (rFVIIa) in abdominal, vascular, and urological surgery...
  23. pmc N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: extended case report
    Ortrud Vargas Hein
    Department of Anesthesiology and Intensive Care Medicine Charité, Campus Mitte, Humboldt University Berlin, Germany
    Crit Care 8:R66-71. 2004
    ..Furthermore, the monoethylglycinexylidide (MEGX) test was used to investigate hepatic function...
  24. pmc A positive fluid balance is associated with a worse outcome in patients with acute renal failure
    Didier Payen
    Department of Anesthesiology and Intensive Care, CHU Lariboisière, 2, rue Ambroise Pare, F 75475 Paris Cedex 10, France
    Crit Care 12:R74. 2008
    ..The aim of the present observational study was to analyze the influence of patient characteristics and fluid balance on the outcome of ARF in intensive care unit (ICU) patients...
  25. pmc Comparison of uncalibrated arterial waveform analysis in cardiac surgery patients with thermodilution cardiac output measurements
    Michael Sander
    Department of Anesthesiology and Intensive Care Medicine, Charite University Medicine Berlin, Charite Campus Mitte, Campus Virchow Klinikum, Chariteplatz 1, 10117 Berlin, Germany
    Crit Care 10:R164. 2006
    ....
  26. pmc Gastrointestinal failure in intensive care: a retrospective clinical study in three different intensive care units in Germany and Estonia
    Annika Reintam
    General Intensive Care Unit, Tartu University Clinics, Tartu, Estonia
    BMC Gastroenterol 6:19. 2006
    ..The aim of this study was to evaluate the incidence of gastrointestinal failure (GIF), to identify its risk factors, and to determine its association with ICU mortality...
  27. ncbi request reprint [Fluid therapy--introduction]
    Claudia D Spies
    Universitatsmedizin Berlin, Campus Charite Mitte
    Anasthesiol Intensivmed Notfallmed Schmerzther 41:390-1. 2006
  28. ncbi request reprint [Introduction to the topic: Deficient pain therapy by addict patients]
    C Spies
    Kliniken für Anästhesiologie und operative Intensivmedizin, Campus Charité Mitte und Campus Virchow Klinikum, Charite Universitatsmedizin, Augustenburger Platz 1, 13353 Berlin
    Anaesthesist 55:609-10. 2006
  29. ncbi request reprint Effects of alcohol on the heart
    C D Spies
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Charite, Berlin, Germany
    Curr Opin Crit Care 7:337-43. 2001
    ..Noncompliance to smoking and alcohol restrictions, which are amenable to change, dramatically increases the risk for hospital readmissions among patients with heart failure...
  30. ncbi request reprint [Focal surgery, antibiotic therapy--and then? The role of rhAPC in sepsis]
    C Spies
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Universitatsklinikum Charite, Campus Mitte, Schumannstrasse 20 21, 10117 Berlin
    Kongressbd Dtsch Ges Chir Kongr 119:834-43. 2002
    ..Guidelines for the use in severe sepsis and septic shock in surgical patients (risk of bleeding, costs) are strongly recommended...
  31. ncbi request reprint Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics
    Claudia Spies
    Department of Anesthesiology and Intensive Care Medicine, Charite University Medicine Berlin, Campus Charité Virchow Klinikum and Campus Charité Mitte, Augustenburger Platz 1, 13353 Berlin, Germany
    Am J Respir Crit Care Med 174:408-14. 2006
    ..Long-term alcohol use leads to an altered perioperative hypothalamus-pituitary-adrenal (HPA) axis and immunity...
  32. pmc Gender-related outcome difference is related to course of sepsis on mixed ICUs: a prospective, observational clinical study
    Irit Nachtigall
    Department of Anaesthesiology and Intensive Care, Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Augustenburger Platz 1, 13353 Berlin, Germany
    Crit Care 15:R151. 2011
    ..This study aims to describe the impact of gender on outcome in mixed intensive care units (ICUs) with a special focus on sepsis...
  33. ncbi request reprint Influence of vaccination and surgery on HLA-DR expression in patients with upper aerodigestive tract cancer
    C D Spies
    Department of Anaesthesiology and Intensive Care Medicine, Campus Virchow Klinikum, Charite University Medicine Berlin, Germany
    J Int Med Res 36:296-307. 2008
    ..Vaccination before surgery, therefore, might not help to maintain immune reactivity after surgery...
  34. ncbi request reprint [Standards, guidelines and recommendations for antibiotic therapy]
    Claudia D Spies
    Kliniken für Anästhesiologie und operative Intensivmedizin, Universitatsmedizin Berlin, Germany
    Anasthesiol Intensivmed Notfallmed Schmerzther 42:106-7. 2007
  35. ncbi request reprint Effects of ethanol on cytokine production after surgery in a murine model of gram-negative pneumonia
    Claudia D Spies
    Department of Anesthesiology and Intensive Care Medicine, Campus Virchow Klinikum Charité Campus Mitte, Charite Universitatsmedizin, Berlin, Germany
    Alcohol Clin Exp Res 32:331-8. 2008
    ..We assume that alcoholic animals show increased levels of IL-10 in response to infection and increased IL-6 due to a more pronounced lung pathology...
  36. ncbi request reprint Myocardial ischemia and cytokine response are associated with subsequent onset of infections after noncardiac surgery
    Claudia D Spies
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Charite, Campus Charite Mitte, Humboldt University, Schumannstrasse 20 21, 10117 Berlin, Germany
    Anesth Analg 95:9-18, table of contents. 2002
    ..These findings suggest that immediate cytokine responses due to POMI and type of surgery might be relevant for the later onset of severe infections and sepsis...
  37. doi request reprint A prospective, randomized, double-blind, multicenter study comparing remifentanil with fentanyl in mechanically ventilated patients
    Claudia Spies
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitaetsmedizin Berlin, Campus Charité Mitte and Campus Virchow Klinikum, Berlin, Germany
    Intensive Care Med 37:469-76. 2011
    ..To compare the quality of analgesia provided by a remifentanil-based analgesia regime with that provided by a fentanyl-based regime in critically ill patients...
  38. ncbi request reprint Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients
    Claudia D Spies
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, 10098 Berlin, Germany
    Anesthesiology 100:1088-100. 2004
    ..The aim of this study was to evaluate perioperative T cell-mediated immune parameters as well as cytokine release from whole blood cells after lipopolysaccharide stimulation and its association with postoperative infections...
  39. ncbi request reprint Alcohol withdrawal severity is decreased by symptom-orientated adjusted bolus therapy in the ICU
    Claudia D Spies
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Schumannstrasse 20 21, 10117, Berlin, Germany
    Intensive Care Med 29:2230-8. 2003
    ..continuous infusion adjustment on severity and duration of alcohol withdrawal syndrome (AWS), the medication requirements for AWS treatment, and the effect on ICU stay in surgical intensive care unit (ICU) patients...
  40. ncbi request reprint Perioperative morbidity and mortality in chronic alcoholic patients
    C Spies
    Department of Anesthesiology and Intensive Care Medicine CS, University Hospital Charite, Humboldt University of Berlin, Berlin, Germany
    Alcohol Clin Exp Res 25:164S-170S. 2001
    ....
  41. ncbi request reprint Preferences for shared decision making in chronic pain patients compared with patients during a premedication visit
    C D Spies
    Department of Anesthesiology and Intensive Care, Charite University Medicine Berlin, Berlin, Germany
    Acta Anaesthesiol Scand 50:1019-26. 2006
    ..So far, the patients' preference for involvement in decision making and their desire for information have not been tested in anesthesiological settings...
  42. ncbi request reprint [Anesthesiologic aspects of chronic alcohol abuse]
    C Spies
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Charite, Berlin
    Ther Umsch 57:261-3. 2000
    ....
  43. ncbi request reprint Alcohol withdrawal in the surgical patient: prevention and treatment
    C D Spies
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Universitätsklinikum Charité Campus Mitte, Humboldt Universitat zu Berlin, Germany
    Anesth Analg 88:946-54. 1999
    ..Other approaches to modulate the neuroendocrine-immune axis in patients with an increased risk of postoperative infectious complications look promising but await controlled trials...
  44. ncbi request reprint Effects of remifentanil and fentanyl on the cell-mediated immune response in patients undergoing elective coronary artery bypass graft surgery
    V von Dossow
    Department of Anaesthesiology and Intensive Care Medicine, Campus Virchow Klinikum and Charité Campus Mitte, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Int Med Res 36:1235-47. 2008
    ..Further clinical trials are required to define the influence of choice of intra-operative opioid on post-operative outcome...
  45. ncbi request reprint Remifentanil reduces the incidence of post-operative delirium
    F M Radtke
    Department of Anaesthesia and Intensive Care, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Int Med Res 38:1225-32. 2010
    ..The choice of intraoperative opioid influences the incidence of post-operative delirium. Remifentanil was associated with a lower incidence of post-operative delirium in the early post-operative period...
  46. ncbi request reprint Propofol increased the interleukin-6 to interleukin-10 ratio more than isoflurane after surgery in long-term alcoholic patients
    V von Dossow
    Department of Anaesthesiology and Intensive Care Medicine, Charite University Medicine Berlin, Campus Mitte, Germany
    J Int Med Res 35:395-405. 2007
    ..These results support the undertaking of a properly powered clinical trial to determine if propofol anaesthesia can reduce the postoperative infection rate in this special patient population...
  47. ncbi request reprint Impact of combined C1 esterase inhibitor/coagulation factor XIII or N-acetylcysteine/tirilazad mesylate administration on leucocyte adherence and cytokine release in experimental endotoxaemia
    J Birnbaum
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Charité Mitte and Campus Virchow Klinikum, Berlin, Germany
    J Int Med Res 36:748-59. 2008
    ..There was no significant effect on mesenteric plasma extravasation. In conclusion, the administration of C1-INH + factor XIII and NAC + TM reduced endothelial leucocyte adherence and IL-1beta plasma levels, but increased IL-6 levels...
  48. ncbi request reprint Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients
    H Kern
    Department of Anesthesiology and Intensive Care Medicine, , Campus Mitte, Humboldt-University of Berlin, Schumannstr. 20/21, 10098 Berlin, Germany
    Crit Care Med 29:1519-25. 2001
    ..Therefore, if the inflammatory response should be attenuated in high-risk patients, administration of enoximone in fluid-optimized septic shock patients may be favorable compared with dobutamine...
  49. doi request reprint Motivation of trauma patients to stop smoking after admission to the emergency department
    E Weiss-Gerlach
    Charite Universitatsmedizin Berlin, Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Chariteplatz 1, 10117 Berlin, Germany
    Addict Behav 33:906-18. 2008
    ..2%). At 12 month follow-up, 55 patients (17.9%) had stopped smoking. The HSH was more successful to predict quitters. Multivariate logistic regression with respect to smoking cessation resulted in significant impact of HSH (p = 0.024)...
  50. ncbi request reprint Suppression of interleukin-6 to interleukin-10 ratio in chronic alcoholics: association with postoperative infections
    M Sander
    Department of Anesthesiology and Intensive Care, University Hospital Charite, Campus Charite Mitte, Humboldt University, Schumannstrasse 20 21, 10117 Berlin, Germany
    Intensive Care Med 28:285-92. 2002
    ....
  51. doi request reprint [Delirium in the intensive care unit : Overview for nurses and physicians]
    A Luetz
    Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Charite Universitaetsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Med Klin Intensivmed Notfmed 107:289-97; quiz 298-9. 2012
    ....
  52. doi request reprint Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction
    F M Radtke
    Department of Anaesthesiology and Surgical Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin 10117, Germany
    Br J Anaesth 110:i98-105. 2013
    ..The aim of this parallel group study was to determine whether monitoring depth of anaesthesia influences the incidence of postoperative delirium...
  53. ncbi request reprint Incidence and risk factors for cognitive dysfunction in patients with severe systemic disease
    F M Radtke
    Department of Anaesthesia and Surgical Intensive Care, Charité University of Medicine Berlin, Berlin, Germany
    J Int Med Res 40:612-20. 2012
    ..To determine the relevance of surgery and other causative factors to the incidence of postoperative cognitive dysfunction (POCD) in patients with severe systemic disease...
  54. ncbi request reprint Risk factors for inadequate emergence after anesthesia: emergence delirium and hypoactive emergence
    F M Radtke
    Department of Anesthesiology and Surgical Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Minerva Anestesiol 76:394-403. 2010
    ....
  55. doi request reprint Profound haemodilution during normothermic cardiopulmonary bypass influences neither gastrointestinal permeability nor cytokine release in coronary artery bypass graft surgery
    K Berger
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Augustenburger Platz 1, 13353 Berlin, Germany
    Br J Anaesth 103:511-7. 2009
    ....
  56. doi request reprint [Adherence to treatment guidelines for postoperative nausea and vomiting. How well does knowledge transfer result in improved clinical care?]
    M Franck
    Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Deutschland
    Anaesthesist 59:524-8. 2010
    ..The aim of this study was to find out whether PONV prophylaxis according to our SOP was followed and led to a lower incidence of PONV...
  57. ncbi request reprint Increased endothelial injury in septic patients with coronary artery disease
    H Kern
    Department of Anesthesiology and Intensive Care, , Campus Mitte, Humboldt University of Berlin, Germany
    Chest 119:874-83. 2001
    ..These parameters, however, failed to serve as predictors for unknown CAD or chances for survival in early sepsis...
  58. ncbi request reprint Strategies for diagnosis and treatment of iatrogenic tracheal ruptures
    M Deja
    Department of Anesthesiology and Intensive Care Medicine, Charite, Berlin Medical University, Campus Virchow Klinikum, Campus Charite Mitte, Berlin, Germany
    Minerva Anestesiol 77:1155-66. 2011
    ..Our aim was to comprise a structured diagnostic and treatment protocol for patients suspicious of tracheal injury, including detailed principles of mechanical ventilation and specific indications for conservative or surgical treatment...
  59. ncbi request reprint Documentation of post-operative nausea and vomiting in routine clinical practice
    M Franck
    Department of Anaesthesia and Intensive Care, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Int Med Res 38:1034-41. 2010
    ..A considerable proportion of patients experience PONV after discharge from the recovery room, so the assessment of PONV should cover at least 24 h post-operatively...
  60. ncbi request reprint Thoracic epidural anesthesia combined with general anesthesia: the preferred anesthetic technique for thoracic surgery
    V von Dossow
    Department of Anesthesiology and Operative Intensive Care Medicine, , , Humboldt-University, Berlin, Germany
    Anesth Analg 92:848-54. 2001
    ..Oxygen content in the blood and blood pressure was better maintained in the group receiving the combination of general with regional anesthesia...
  61. doi request reprint [Simulation-based anaesthesia crisis resource management training. Results of a survey on learning success]
    T Schroder
    Kliniken für Anästhesiologie und operative Intensivmedizin, Charite Universitatsmedizin, Campus Virchow Klinikum und Campus Charité Mitte, Chariteplatz 1, 10117, Berlin
    Anaesthesist 58:992-1004. 2009
    ....
  62. ncbi request reprint Current practice of hemodynamic monitoring and vasopressor and inotropic therapy in post-operative cardiac surgery patients in Germany: results from a postal survey
    M Kastrup
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Acta Anaesthesiol Scand 51:347-58. 2007
    ..However, little is known about how monitoring and treatment are currently performed...
  63. ncbi request reprint Hyperactive delirium and blood glucose control in critically ill patients
    A Heymann
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Int Med Res 35:666-77. 2007
    ..In a multivariate analysis, glucose level, alcohol abuse, APACHE II score, complication by hospital-acquired pneumonia and a diagnosis of polytrauma on-admission all significantly influenced the appearance of delirium...
  64. ncbi request reprint [Central induction area. Reduction of non-operative time without additional costs]
    H Krieg
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Campus Charité Mitte und Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin
    Anaesthesist 56:812-9. 2007
    ..The objective of this project was to demonstrate that a reduction in non-operative time through a newly introduced induction area can be achieved without a need for extra personnel...
  65. ncbi request reprint Effects of N-acetylcysteine and tirilazad mesylate on intestinal functional capillary density, leukocyte adherence, mesenteric plasma extravasation and cytokine levels in experimental endotoxemia in rats
    J Birnbaum
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Charité Mitte und Campus Virchow Klinikum, Berlin, Germany
    Clin Hemorheol Microcirc 39:99-111. 2008
    ....
  66. ncbi request reprint Trauma patients' desire for autonomy in medical decision making is impaired by smoking and hazardous alcohol consumption--a bi-national study
    B Neuner
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Berlin, Germany
    J Int Med Res 35:609-14. 2007
    ..Empowerment strategies that encourage smokers or patients with hazardous alcohol consumption to participate in MDM may increase the effectiveness of health promotion and injury prevention efforts in this population...
  67. ncbi request reprint Renal replacement therapy: physical properties of hollow fibers influence efficiency
    H D Düngen
    Department of Anesthesiology and Operative Intensive Care Medicine, Universitaetsklinikum Charité, Humboldt University of Berlin, Germany
    Int J Artif Organs 24:357-66. 2001
    ..The aim of this study was to study the effect of a new filter configuration in terms of TMP and clotting compared with the standard configuration...
  68. ncbi request reprint The value of immune modulating parameters in predicting the progression from peritonitis to septic shock
    B Katja
    Department of Anesthesiology and Intensive Care Medicine, Benjamin Franklin Medical Center, Free University Berlin, Germany
    Shock 15:95-100. 2001
    ..The progression was best predicted by TNF-alpha. Therefore, mediator therapy might be considered in high-risk peritonitis patients who show an exaggerated immune response before the progression to septic shock...
  69. ncbi request reprint Documented intraoperative hypotension according to the three most common definitions does not match the application of antihypotensive medication
    M Franck
    Department of Anaesthesiology and Surgical Intensive Care, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Int Med Res 39:846-56. 2011
    ..Age, physical status and duration and type of surgery showed better correlations with postoperative in-patient stay than IOH...
  70. pmc Emergency department-initiated tobacco control: a randomised controlled trial in an inner city university hospital
    B Neuner
    Charite Universitaetsmedizin Berlin, Department of Anesthesiology and Intensive Care Medicine, Campus Virchow Klinikum and Campus Charite Mitte, Chariteplatz 1, Berlin, Germany
    Tob Control 18:283-93. 2009
    ..Emergency department (ED) patients show high smoking rates. The effects of ED-initiated tobacco control (ETC) on 7-day abstinence at 12 months were investigated...
  71. ncbi request reprint Barrier function of the gut and multiple organ dysfunction after cardiac surgery
    J P Braun
    Department of Anesthesiology and Intensive Care, Charité Campus Mitte and Charité Virchow Klinikum, Charite Universitatsmedizin, Berlin, Germany
    J Int Med Res 35:72-83. 2007
    ..A reduced pre-operative functional mucosal surface may predict the early occurrence of MOD after surgery...
  72. ncbi request reprint Adherence to standard operating procedures is crucial for intensive care unit survival of elderly patients
    I Nachtigall
    Department of Anaesthesiology and Intensive Care, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    J Int Med Res 36:438-59. 2008
    ..8% versus 19.8%, respectively. It was concluded that adherence to SOPs based on evidence-based medicine that consider local resistance rates for antibiotic treatment in elderly ICU patients is associated with a lower mortality rate...
  73. ncbi request reprint [Reduced preoperative fasting periods. Current status after a survey of patients and colleagues]
    J P Breuer
    Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Campus Charité Mitte und Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Deutschland
    Anaesthesist 59:607-13. 2010
    ..A survey of patients and health care workers was carried out in our university clinic to assess the implementation of the new fasting recommendations...
  74. doi request reprint [Process optimization in ENT: clinical pathways and central induction area]
    O Goktas
    Klinik und Poliklinik für Hals Nasen Ohrenheilkunde, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Deutschland
    HNO 58:142-50. 2010
    ..The aim of this study was to examine whether process optimization could be achieved through close interdisciplinary networking with clinical pathways and central induction (CI)...
  75. ncbi request reprint Hirudin versus heparin for anticoagulation in continuous renal replacement therapy
    O Vargas Hein
    Department of Anesthesiology and Intensive Care, University Hospital Charite, Campus Mitte, Schumannstrasse 20 21, 10117 Berlin, Germany
    Intensive Care Med 27:673-9. 2001
    ..To compare the efficacy and safety of hirudin and heparin for anticoagulation during continuous renal replacement therapy (CRRT) in critically ill patients...
  76. ncbi request reprint Evidence-based therapy of severe acute respiratory distress syndrome: an algorithm-guided approach
    M Deja
    Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum and Campus Mitte, Berlin, Germany
    J Int Med Res 36:211-21. 2008
    ..This review summarizes the current evidence base and proposes a new treatment algorithm that aims to prioritize the administration of advanced strategies in a multimodal approach for ARDS...
  77. ncbi request reprint [Anesthesia in extreme obesity]
    T Schroder
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite, Campus Mitte, Humboldt Universitat zu Berlin
    Herz 26:222-8. 2001
    ..After surgery, patients are endangered by a high incidence of obstructive sleep apnea syndrome (50%), pulmonary atelectasis (5%) and acute pulmonary embolism (5-12%)...
  78. ncbi request reprint Narcotrend-assisted propofol/remifentanil anaesthesia vs clinical practice: does it make a difference?
    I Rundshagen
    Department of Anaesthesiology, Universitatsmedizin Berlin, Campus Charite Mitte, Schumannstr, 20 21, D 10117 Berlin, Germany
    Br J Anaesth 99:686-93. 2007
    ..The aim of the present study is to test the hypothesis that the intraoperative level of anaesthetic depth differs if decision-making is guided by Narcotrend monitoring or not...
  79. doi request reprint ["Fast-track" rehabilitation in thoracic surgery. First experiences with a multimodal, interdisciplinary, and proven perioperative treatment course]
    J I Gregor
    Universitätsklinik für Allgemein, Visceral, Gefäss und Thoraxchirurgie, Charite Campus Mitte, Chariteplatz 1, Berlin, Germany
    Chirurg 79:657-64. 2008
    ..Of its use in thoracic surgery however, almost no data exist and the relevance of this concept for pulmonary operations is unknown...
  80. doi request reprint Nervus medianus evoked potentials and bispectral index during repeated transitions from consciousness to unconsciousness
    I Rundshagen
    Department of Anaesthesiology, University Hospital Charite, Berlin, Germany
    Br J Anaesth 101:366-73. 2008
    ..We investigated the relationship between median nerve somatosensory evoked potentials (SSEPs) and the bispectral index (BIS) during alternating periods of consciousness and propofol-induced unconsciousness...
  81. doi request reprint Pre-operative fasting: a nationwide survey of German anaesthesia departments
    J P Breuer
    Department of Anaesthesiology and Intensive Care Medicine, Campus Charité Mitte und Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    Acta Anaesthesiol Scand 54:313-20. 2010
    ..We conducted a nationwide survey to evaluate the current clinical practice in Germany...
  82. doi request reprint [Splitting of supplemental revenues in intensive care medicine]
    T Sawatzki
    Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum und Campus Charité Mitte, Chariteplatz 1, 10117, Berlin
    Anaesthesist 58:1035-40. 2009
    ..Based on the first 2 allocation methods the intensive care unit would receive 20% less supplemental revenues compared to the third allocation method, which supposedly reflects best the actual costs...
  83. ncbi request reprint Intensive care unit stay of more than 14 days after cardiac surgery is associated with non-cardiac organ failure
    O V Hein
    Department of Anaesthesiology and Intensive Care Medicine, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Germany
    J Int Med Res 34:695-703. 2006
    ..Since an ICU stay is associated with a higher hospital and long-term mortality, measures should be taken throughout the entire hospital stay to identify and reduce the risk of organ failure...
  84. ncbi request reprint [The role of anesthesiology in fast track concepts in colonic surgery]
    M Hensel
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Campus Charite Mitte, Universitatsmedizin, Berlin
    Anaesthesist 55:80-92. 2006
    ....
  85. ncbi request reprint [Clinical pathway "laparoscopic prostatectomy". Analysis of anesthesiological procedures in a randomized study]
    J P Braun
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite Universitatsmedizin, Campus Mitte, Schumannstrasse 20 21, 10117 Berlin
    Anaesthesist 54:1186-96. 2005
    ..During this module the indicators of quality such as vigilance, pain, postoperative nausea and vomiting (PONV) and mobilization were measured. Costs were evaluated and analyzed by a bottom-up procedure...
  86. ncbi request reprint Torsemide versus furosemide after continuous renal replacement therapy due to acute renal failure in cardiac surgery patients
    Ortrud Vargas Hein
    Department of Anesthesiology and Intensive Care, University Hospital Charite, Berlin, Germany
    Ren Fail 27:385-92. 2005
    ..Torsemide might show a better dose-dependent diuretic effect in ARF patients after CRRT treatment. Serum creatinine and blood urea nitrogen elimination were less pronounced in the furosemide group...
  87. ncbi request reprint [Implementation of modern operating room management -- experiences made at an university hospital]
    M Hensel
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite Berlin
    Anasthesiol Intensivmed Notfallmed Schmerzther 40:393-405. 2005
    ..Summarizing the results, central operating room management has been proved to be an effective tool to increase the efficiency of workflow processes in the operating room...
  88. ncbi request reprint Clopidogrel-related refractory bleeding after coronary artery bypass graft surgery: a rationale for the use of coagulation factor concentrates?
    C von Heymann
    Department of Anaesthesiology and Intensive Care Medicine, Charite University Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Heart Surg Forum 8:E39-41. 2005
    ..This case suggests that in clopidogrel-related bleeding refractory to conventional hemostatic therapy, hemostasis may be achieved by a stepwise administration of coagulation factor concentrates...
  89. ncbi request reprint [Quality assurance of haemotherapy in anaesthesia. Auswertung eines 3-jahrigen Erfahrungszeitraums]
    C von Heymann
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Charite Mitte
    Anaesthesist 54:107-16. 2005
    ..The measures for quality assurance in haemotherapy developed at the Charite Campus Mitte according to the transfusion law of 1998 are introduced and discussed...
  90. ncbi request reprint [Intrathecal misplacement of an interscalene plexus catheter]
    M Walter
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Mitte
    Anaesthesist 54:215-9. 2005
    ..Blind advancement and deep placement increase the risk of an abnormal catheter position. Intraspinal misplacement should be reliably excluded...
  91. ncbi request reprint Anticoagulation in continuous renal replacement therapy
    O Vargas Hein
    Department of Anesthesiology and Intensive Care, University Hospital Charite, Campus Mitte, Berlin, Germany
    Contrib Nephrol 144:308-16. 2004
  92. ncbi request reprint [The effect of dopexamine and iloprost on plasma disappearance rate of indocyanine green in patients in septic shock]
    J Birnbaum
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Charite, Campus Charite Mitte, Medizinische Fakultat, Humboldt Universitat zu Berlin
    Anaesthesist 52:1014-9. 2003
    ..To evaluate the effect of dopexamine and iloprost on the plasma disappearance rate (PDR) of indocyanine green (ICG) in patients in septic shock in a prospective clinical trial...
  93. ncbi request reprint [Levosimendan. Clinical indications of a new vasoactive substance]
    J P Braun
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Charite, Berlin
    Anaesthesist 53:163-7. 2004
    ..The following article describes the main pharmacological characteristics of levosimendan and summarises the indications for this new drug for physicians working in the field of anaesthesia or intensive care...
  94. ncbi request reprint Aspirin and clopidogrel taken until 2 days prior to coronary artery bypass graft surgery is associated with increased postoperative drainage loss
    C von Heymann
    Department of Anesthesiology and Intensive Care Medicine, Charite University Hospital Berlin, Berlin, Germany
    Thorac Cardiovasc Surg 53:341-5. 2005
    ..We investigated the impact of time between the last intake of aspirin and clopidogrel before CABG surgery and drainage loss, transfusion requirements and rate of reoperation...
  95. ncbi request reprint "Fast-track"-rehabilitation in surgery, a multimodal concept
    C Langelotz
    Department of General, Visceral, Vascular and Thoracic Surgery, Universitatsmedizin Berlin Charite, Campus Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Acta Chir Belg 105:555-9. 2005
    ..With this approach it is possible to accelerate the postoperative convalescence and reduce the rate of general complications markedly (4, 7-10)...
  96. ncbi request reprint Successful treatment of refractory bleeding with recombinant factor VIIa after redo coronary artery bypass graft surgery
    Christian von Heymann
    Department of Anesthesiology, University Hospital Charité Campus Mitte, Berlin, Germany
    J Cardiothorac Vasc Anesth 16:615-6. 2002
  97. ncbi request reprint [Bleeding after cardiac surgery: the role of recombinant factor VIIa]
    C von Heymann
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Hamostaseologie 26:S77-87. 2006
    ..These alterations are thought to explain the high risk of bleeding after cardiopulmonary bypass. Furthermore, the use of rFVIIa in paediatric and adult cardiac surgery is reviewed and critically discussed...
  98. ncbi request reprint Splanchnic oxygen transport, hepatic function and gastrointestinal barrier after normothermic cardiopulmonary bypass
    J P Braun
    Department of Anesthesiology and Intensive Care, University Hospital Charite, Humboldt University, Berlin, Germany
    Acta Anaesthesiol Scand 48:697-703. 2004
    ....
  99. ncbi request reprint [The influence of intraoperative fluid therapy on the postoperative outcome in "fast track" colon surgery]
    C von Heymann
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Berlin
    Anasthesiol Intensivmed Notfallmed Schmerzther 41:E1-7. 2006
    ..To evaluate the association between the intraoperative and postoperative application of different quantities of fluids and the incidence of postoperative complications after "fast-track"-colonic surgery...
  100. ncbi request reprint [Analysis of personnel costs after reorganization of intensive care using calculated diagnosis-related groups comparative data. An investigation at the Charité Berlin]
    J P Braun
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Campus Charité Mitte und Campus Virchow Klinikum, Chariteplatz 1, 10117 Berlin
    Anaesthesist 56:252-8. 2007
    ..The aim of this investigation was to determine if staff costs after this reorganization are financed by modular profits of diagnosis-related groups (DRGs)...
  101. ncbi request reprint Peri-operative decreased cAMP levels in long-term alcoholic patients
    H Schoenfeld
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Int Med Res 34:445-55. 2006
    ..A possible explanation is decreased inhibition through diminished cAMP levels; cGMP and serotonin do not seem to influence peri-operative haemostasis...