Bruno V Sinn

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
    Albrecht Stenzinger
    Institute of Pathology, and National Center for Tumor Diseases NCT, University Hospital Heidelberg, Heidelberg, Germany
    BMC Cancer 13:450. 2013
  2. ncbi request reprint Evaluation of Mucin-1 protein and mRNA expression as prognostic and predictive markers after neoadjuvant chemotherapy for breast cancer
    B V Sinn
    Department of Pathology, Charite Universitatsmedizin Berlin, Berlin
    Ann Oncol 24:2316-24. 2013
  3. pmc Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test
    Ralf Kronenwett
    Sividon Diagnostics GmbH, Nattermannallee 1, 50829, Cologne, Germany
    BMC Cancer 12:456. 2012
  4. ncbi request reprint Evaluation of a hormone receptor-positive ovarian carcinoma subtype with a favourable prognosis by determination of progesterone receptor and oestrogen receptor 1 mRNA expression in formalin-fixed paraffin-embedded tissue
    Bruno V Sinn
    Institute of Pathology, Charite Universitatsmedizin Berlin, Germany
    Histopathology 59:918-27. 2011
  5. ncbi request reprint Vascular endothelial growth factor C mRNA expression is a prognostic factor in epithelial ovarian cancer as detected by kinetic RT-PCR in formalin-fixed paraffin-embedded tissue
    Bruno V Sinn
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Virchows Arch 455:461-7. 2009
  6. ncbi request reprint Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissue
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Endocr Relat Cancer 16:1229-39. 2009
  7. ncbi request reprint Expression of classical NF-kappaB pathway effectors in human ovarian carcinoma
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin
    Histopathology 56:727-39. 2010
  8. ncbi request reprint KRAS mutations in codon 12 or 13 are associated with worse prognosis in pancreatic ductal adenocarcinoma
    Bruno V Sinn
    From the Departments of Pathology, Hematology, Oncology and Tumor Immunology, and General, Visceral, and Transplantation Surgery, Charite Universitatsmedizin Berlin, Berlin and Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany
    Pancreas 43:578-83. 2014
  9. pmc Cutoff Finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization
    Jan Budczies
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e51862. 2012
  10. ncbi request reprint Does long-term survival in patients with pancreatic cancer really exist? Results from the CONKO-001 study
    Marianne Sinn
    Department of Medical Oncology and Haematology, Charite Universitatsmedizin Berlin, Germany
    J Surg Oncol 108:398-402. 2013

Collaborators

Detail Information

Publications13

  1. pmc High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
    Albrecht Stenzinger
    Institute of Pathology, and National Center for Tumor Diseases NCT, University Hospital Heidelberg, Heidelberg, Germany
    BMC Cancer 13:450. 2013
    ..Since data on the role of Sirt1 in pancreatic ductal adenocarcinoma (PDAC) are sparse, we investigated the expression profile and prognostic significance of Sirt1 in vivo as well as cellular effects of Sirt1 inhibition in vitro...
  2. ncbi request reprint Evaluation of Mucin-1 protein and mRNA expression as prognostic and predictive markers after neoadjuvant chemotherapy for breast cancer
    B V Sinn
    Department of Pathology, Charite Universitatsmedizin Berlin, Berlin
    Ann Oncol 24:2316-24. 2013
    ..Mucin-1 (MUC1) is a promising antigen for the development of tumor vaccines. We evaluated the frequency of MUC1 expression and its impact on therapy response and survival after neoadjuvant chemotherapy for breast cancer...
  3. pmc Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test
    Ralf Kronenwett
    Sividon Diagnostics GmbH, Nattermannallee 1, 50829, Cologne, Germany
    BMC Cancer 12:456. 2012
    ..The aim of this study was the analytical validation of the performance characteristics of the assay and its verification in a molecular-pathological routine laboratory...
  4. ncbi request reprint Evaluation of a hormone receptor-positive ovarian carcinoma subtype with a favourable prognosis by determination of progesterone receptor and oestrogen receptor 1 mRNA expression in formalin-fixed paraffin-embedded tissue
    Bruno V Sinn
    Institute of Pathology, Charite Universitatsmedizin Berlin, Germany
    Histopathology 59:918-27. 2011
    ..The aim of this study was to examine the prognostic role of progesterone receptor (PR) protein and mRNA expression...
  5. ncbi request reprint Vascular endothelial growth factor C mRNA expression is a prognostic factor in epithelial ovarian cancer as detected by kinetic RT-PCR in formalin-fixed paraffin-embedded tissue
    Bruno V Sinn
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Virchows Arch 455:461-7. 2009
    ..Our study demonstrates that high VEGF-C expression is associated with aggressive tumor behavior in ovarian cancer. mRNA extracted from paraffin-embedded tumor samples is suitable for VEGF-C gene expression studies...
  6. ncbi request reprint Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissue
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Endocr Relat Cancer 16:1229-39. 2009
    ....
  7. ncbi request reprint Expression of classical NF-kappaB pathway effectors in human ovarian carcinoma
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin
    Histopathology 56:727-39. 2010
    ..However, surprisingly little is known of the expression of effectors of the NF-kappaB pathway in human ovarian cancer in vivo...
  8. ncbi request reprint KRAS mutations in codon 12 or 13 are associated with worse prognosis in pancreatic ductal adenocarcinoma
    Bruno V Sinn
    From the Departments of Pathology, Hematology, Oncology and Tumor Immunology, and General, Visceral, and Transplantation Surgery, Charite Universitatsmedizin Berlin, Berlin and Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany
    Pancreas 43:578-83. 2014
    ..In addition, we attempted to define molecular subgroups with distinct biologic behavior by combination of KRAS sequencing data with p53 protein expression data...
  9. pmc Cutoff Finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization
    Jan Budczies
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e51862. 2012
    ..Cutoff Finder is expected to fill a relevant gap in the available biometric software repertoire and will enable faster optimization of new diagnostic biomarkers. The tool can be accessed at http://molpath.charite.de/cutoff...
  10. ncbi request reprint Does long-term survival in patients with pancreatic cancer really exist? Results from the CONKO-001 study
    Marianne Sinn
    Department of Medical Oncology and Haematology, Charite Universitatsmedizin Berlin, Germany
    J Surg Oncol 108:398-402. 2013
    ..The CONKO-001 study, which established gemcitabine after resection as adjuvant therapy, may provide data to answer this question...
  11. ncbi request reprint Interferon-stimulated gene, 15 kDa (ISG15) in ovarian high-grade serous carcinoma: prognostic impact and link to NF-κB pathway
    Silvia Darb-Esfahani
    Institute of Pathology S D E, B V S, M R, M D, C D Department of Gynecology J S, I B, Charite Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Gynecol Pathol 33:16-22. 2014
    ....
  12. ncbi request reprint High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer
    Frederick Klauschen
    Institute of Pathology, Charite University Medicine Berlin, Germany
    Histopathology 61:409-16. 2012
    ..In the pancreas, PARP expression has so far only been studied in inflammatory conditions. Therefore, in this study, we investigated the relevance of PARP in pancreatic cancer...
  13. ncbi request reprint Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling
    Scarlet F Brockmöller
    Institute of Pathology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Proteome Res 11:850-60. 2012
    ....