Genomes and Genes
Arya M Sharma
Affiliation: Humboldt University
- Catechol-o-methyltransferase and blood pressure in humansJens Jordan
Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
Circulation 106:460-5. 2002..Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown...
- Hypothesis: Beta-adrenergic receptor blockers and weight gain: A systematic analysisA M Sharma
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
Hypertension 37:250-4. 2001..Based on these observations, the first-line use of beta-blockers in obese hypertensive patients should be reviewed. Obesity management in overweight hypertensive patients may be more difficult in the face of beta-blocker treatment...
- Effect of orlistat-induced weight loss on blood pressure and heart rate in obese patients with hypertensionArya M Sharma
Franz Volhard Klinik Charité, Berlin, Germany and Teaching Diabetic Division, University Hospital Geneva, Switzerland
J Hypertens 20:1873-8. 2002..To investigate the effects of long-term weight management with orlistat on blood pressure in obese hypertensive patients...
- Sibutramine in overweight/obese hypertensive patientsA M Sharma
Franz Volhard Clinic Charité, Nephrology and Hypertension, Berlin, Germany
Int J Obes Relat Metab Disord 25:S20-3. 2001..Studies have shown that in the obese, well-controlled hypertensive patient, sibutramine is a safe and well-tolerated therapy offering the many clinical benefits associated with weight reduction in this high-risk population...
- Second International Symposium on Obesity and Hypertension: genetics and molecular mechanisms, 25-27 October 2001, Berlin, GermanyA M Sharma
Franz Volhard Clinic Charité and Max Delbrück Center for Molecular Medicine, Berlin, Germany
Int J Obes Relat Metab Disord 26:1283-8. 2002....
- Choice of drug treatment for obesity-related hypertension: where is the evidence?A M Sharma
Franz Volhard Klinik, Max Delbruck Centre for Molecular Medicine, Berlin, Germany
J Hypertens 19:667-74. 2001....
- [Lowering blood pressure in obese hypertensive patients. Which antihypertensive drugs are suitable]T Pischon
Med Klinik, Franz Volhard Klinik am Max Delbrück Centrum für Molekulare Medizin, Charite, Berlin
MMW Fortschr Med 143:34-8. 2001..Before definitive pronouncements on what constitutes optimal treatment of obese patients can be made, the results of studies looking at hard end points must be available...
- Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressureAndreas L Birkenfeld
Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
Clin Auton Res 15:200-6. 2005..This notion has not been tested in overweight and obese patients...
- Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibitionJens Tank
Clinical Research Center, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
Circulation 107:2949-54. 2003..Norepinephrine transporter (NET) inhibition increases the responsiveness to vasoactive medications and attenuates the response to sympathetic stimuli. The phenomenon may be a result of impaired regulation of sympathetic vasomotor tone...
- Weight loss and the renin-angiotensin-aldosterone systemStefan Engeli
Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
Hypertension 45:356-62. 2005..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
- Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight lossStefan Engeli
HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
Obes Res 12:9-17. 2004..The aim of this study was to determine whether up-regulation of human adipose 11beta-HSD1 in obesity can also be found at the gene expression level...
- The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?Stefan Engeli
HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
Int J Biochem Cell Biol 35:807-25. 2003....
- Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patientsJens Jordan
Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
J Hypertens 23:2313-8. 2005..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
- Paradoxical effect of sibutramine on autonomic cardiovascular regulationAndreas L Birkenfeld
Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
Circulation 106:2459-65. 2002..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease...
- Bound leptin and sympathetic outflow in nonobese menJens Tank
HELIOS Kliniken Berlin, Franz Volhard Cardiovascular Research Center, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
J Clin Endocrinol Metab 88:4955-9. 2003..This relationship cannot be explained by a direct central nervous effect of protein-bound leptin. Instead, protein-bound leptin may increase sympathetic vasomotor tone indirectly via a baroreflex mechanism...
- Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activationJurgen Janke
Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin, Germany
J Hypertens 24:1809-16. 2006..In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans...
- HYDRA: possible determinants of unsatisfactory hypertension control in German primary care patientsU Muscha Steckelings
Center for Cardiovascular Research Institute of Pharmacology and Toxicology, Charite, Berlin, Germany
Blood Press 13:80-8. 2004..These insights into the causes of unsatisfactory hypertension control may help to direct future educational programmes designed to improve hypertension management specifically to these deficits and thereby to improve control rates...
- Angiotensin blockade prevents type 2 diabetes by formation of fat cellsArya M Sharma
HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
Hypertension 40:609-11. 2002..Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes...
- Pressor effect of water drinking in tetraplegic patients may be a spinal reflexJens Tank
HELIOS Kliniken Berlin, Franz Volhard Cardiovascular Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
Hypertension 41:1234-9. 2003..This observation might suggest that water drinking activates postganglionic sympathetic neurons either directly or through a spinal reflex mechanism...
- Hemodynamic and metabolic responses to interstitial angiotensin II in normal weight and obese menMichael Boschmann
Franz Volhard Clinical Research Center, Charite, Universitary Medicine Berlin, Germany
J Hypertens 24:1165-71. 2006..Therefore, we hypothesized that peripheral tissues of obese subjects are hypersensitive to angiotensin (Ang) II...
- European Society of Hypertension Working Group on Obesity: background, aims and perspectivesJens Jordan
Franz Volhard Clinical Research Center and Department of Nephrology, Helios Klinikum Berlin and Medical Faculty of the Charité, Berlin, Germany
J Hypertens 25:897-900. 2007
- Regulation of the nitric oxide system in human adipose tissueStefan Engeli
HELIOS Klinikum Berlin, Franz Volhard Clinic, Charite University Medicine in Berlin, Max Delbruck Center for Molecular Medicine, Berlin, Germany
J Lipid Res 45:1640-8. 2004..Increased eNOS and iNOS expression in adipocytes and local effects of insulin and Ang II may increase adipose tissue production of NO in obesity...
- Water-induced thermogenesisMichael Boschmann
Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, D 13125 Berlin, Germany
J Clin Endocrinol Metab 88:6015-9. 2003..Therefore, the thermogenic effect of water should be considered when estimating energy expenditure, particularly during weight loss programs...
- Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptorsJurgen Janke
Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
Diabetes 51:1699-707. 2002..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes...
- Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensivesMichael Boschmann
Franz Volhard Clinical Research Center, Charite Campus Buch, HELIOS Klinikum, Berlin, Germany
Hypertension 46:130-6. 2005..These findings may be explained in part by monocyte/macrophage infiltration of adipose tissue, which appears to interfere with insulin responsiveness...
- Association between adiponectin and mediators of inflammation in obese womenStefan Engeli
HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
Diabetes 52:942-7. 2003....
- Baroreflex buffering and susceptibility to vasoactive drugsJens Jordan
Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
Circulation 105:1459-64. 2002..Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not known...
- Periadventitial fat releases a vascular relaxing factorMatthias Löhn
HELIOS Klinikum Berlin, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
FASEB J 16:1057-63. 2002..We suggest that perivascular adventitial adipose tissue releases a transferable adventitium-derived relaxing factor that acts by tyrosine kinase-dependent activation of K+ channels in vascular smooth muscle cells...
- Reduced vagal activity in salt-sensitive subjects during mental challengeKonrad Buchholz
Division of Psychosomatic Medicine, Benjamin Franklin Medical Center, Free University of Berlin, Berlin, Germany
Am J Hypertens 16:531-6. 2003..Stress-induced HR acceleration may result from sympathetic activation or vagal withdrawal. We studied the importance of vagal withdrawal for the increased stress responsiveness of salt-sensitive subjects...
- Optimizing blood pressure control in the obese patientTobias Pischon
Franz Volhard Clinic Charité, Wiltbergstrasse 50, 13125 Berlin, Germany
Curr Hypertens Rep 4:358-62. 2002..The role of antiobesity drugs in the management of the obese hypertensive patient also remains to be defined...
- Salt sensitivity, anxiety, and irritability predict blood pressure increase over five years in healthy malesHans Christian Deter
Department of Psychosomatic Medicine and Psychotherapy, Benjamin Franklin Medical Center, Free University of Berlin, Berlin, Germany
Clin Exp Hypertens 28:17-27. 2006..009) and 58% (diastolic ABP, p < 0.0001) of variance. We concluded that anxiety and irritability are important predictors of blood pressure increase over time in healthy males...
- Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressureAndreas Busjahn
Franz Volhard Clinic, HELIOS Kliniken Berlin and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
Hypertension 40:256-60. 2002..This combined effect of the polymorphisms was confirmed in an independent sample of 260 young normotensive men. We conclude that the SGK1 gene is relevant to blood pressure regulation and probably to hypertension in man...
- Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritisHarm Peters
Division of Nephrology, Charite, Campus Mitte, Humboldt University, Berlin, Germany
J Hypertens 21:771-80. 2003....
- A gene expression analysis in rat kidney following high and low salt intakePeter Barta
Max Delbruck Center for Molecular Medicine, Humboldt University of Berlin, Berlin, Germany
J Hypertens 20:1115-20. 2002..The effects of salt intake on renal regulation have been investigated for decades. To find new pathways and to demonstrate the utility of oligonucleotide expression arrays, we studied whole kidneys...
- Recent developments in the treatment of obesity-related hypertensionTobias Pischon
Franz Volhard Clinic HELIOS Klinikum Berlin Buch, Charite, Medical Faculty of the Humboldt University Berlin, Max Delbruck Center for Molecular Medicine, Germany
Curr Opin Nephrol Hypertens 11:497-502. 2002..Obesity is a major public health issue, and hypertension is one of the most common associated co-morbidities. Here, recent developments in the treatment of obesity-related hypertension, published during the past year, are reviewed...
- Heterogeneity of autonomic regulation in hypertension and neurovascular contactJens Jordan
HELIOS Klinikum Berlin, Franz Volhard Clinic and Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
J Hypertens 20:701-6. 2002..We tested the hypothesis that similar abnormalities are present in patients with essential hypertension who have NVC...
- The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulationMaik Gollasch
HELIOS Klinikum Berlin Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
J Hypertens 20:927-33. 2002..We tested the hypothesis that variants in the gene (KCNMB1) coding for the BK beta1 subunit are associated with baroreflex function...
- Obesity prevalence from a European perspective: a systematic reviewAnne Berghöfer
Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
BMC Public Health 8:200. 2008..We therefore aimed to identify and discuss current epidemiological data on the prevalence of obesity in European countries...
- High prevalence and poor control of hypertension in primary care: cross-sectional studyArya M Sharma
Franz Volhard Clinic Charité, Berlin, Germany
J Hypertens 22:479-86. 2004....
- Selective norepinephrine reuptake inhibition as a human model of orthostatic intoleranceChristoph Schroeder
Clinical Research Center, Helios Klinkum Berlin, Germany
Circulation 105:347-53. 2002..Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance...
- Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertensionKerstin Gorzelniak
Helios Klinkum Berlin, Franz Volhard Clinic Charité and Max Delbrück Center for Molecular Medicine, Humboldt University of Berlin, Germany
J Hypertens 20:965-73. 2002..The aim of this work was to study the expression of renin-angiotensin system genes in adipose tissue of obese hypertensive subjects and the hormonal regulation of these genes...
- Role of CYP2C9 genetic variants for salt sensitivity and the regulation of the renin-angiotensin-aldosterone system in normotensive menJuliane Bolbrinker
Institute of Clinical Pharmacology and Toxicology, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
J Hypertens 29:56-61. 2011..We tested the relevance of CYP2C9 genotypes for regulation of plasma renin activity (PRA), plasma aldosterone concentrations and blood pressure (BP) in response to changes in salt intake in normotensive individuals...
- Ethnic origin determines the impact of genetic variants in dopamine receptor gene (DRD1) concerning essential hypertensionJoachim Beige
Department of Nephrology, Charite, Berlin, Germany
Am J Hypertens 17:1184-7. 2004..Thus, racial differences may play an important role concerning the association of variants in the dopamine receptor type 1 gene with essential hypertension...
- Neurovascular contact and blood pressure response in young, healthy, normotensive menHenriette Hohenbleicher
Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitatsklinikum Benjamin Franklin, Berlin, Germany
Am J Hypertens 15:119-24. 2002..We also studied blood pressure, heart rate reactivity, and changes in baroreflex sensitivity in response to mental and physical stress in a subset of subjects with positive and negative brainstem findings...
- Resistin gene expression in human adipocytes is not related to insulin resistanceJurgen Janke
Franz Volhard Clinic Charité, the Max Delbrück Center for Molecular Medicine, Berlin, Germany
Obes Res 10:1-5. 2002..Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance...
- Substantial changes in epicardial fat thickness after weight loss in severely obese subjectsGianluca Iacobellis
1Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario, Canada
Obesity (Silver Spring) 16:1693-7. 2008..Measurement of echocardiographic epicardial fat thickness may provide an additional tool in understanding the metabolic risk associated with variation in fat distribution...
- Can PPARgamma agonists have a role in the management of obesity-related hypertension?Vasudhevan T Chetty
Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Vascul Pharmacol 45:46-53. 2006..This review will highlight the role of TZDs in various models of hypertension and discuss their potential role in the management of obesity-related hypertension...
- Long-term weight loss and changes in blood pressureArya M Sharma
Curr Hypertens Rep 4:11-2. 2002
- A weighty issue: medication as a cornerstone of medical obesity managementArya M Sharma
University of Alberta, Royal Alexandra Hospital, 10240 Kingsway Ave, 406 CSC, Edmonton, AB T5H 3V9
Can Fam Physician 54:498-9, 500-1. 2008
- Relation of subepicardial adipose tissue to carotid intima-media thickness in patients with human immunodeficiency virusGianluca Iacobellis
Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Cardiol 99:1470-2. 2007..81, p <0.01). In conclusion, this study suggests, for the first time, that epicardial adipose tissue, an index of cardiac adiposity, may be significantly related to subclinical atherosclerosis in HIV-infected patients...
- Hypertension in lean and obese individuals: an evenly or unevenly dangerous conditionGianluca Iacobellis
Nutr Metab Cardiovasc Dis 17:243-6. 2007
- 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]David C W Lau
Department of Medicine, Julia McFarlane Diabetes Research Centre, Diabetes and Endocrine Research Group, University of Calgary, Calgary, Alta
CMAJ 176:S1-13. 2007
- Activation of the peripheral endocannabinoid system in human obesityStefan Engeli
Franz Volhard Clinical Research Center, Charite Campus Buch, 13125 Berlin, Germany
Diabetes 54:2838-43. 2005..Our findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity...
- Management of hypertension in overweight and obese patients: a practical guide for cliniciansFrancesco Dentali
St Joseph s Hospital, Room F 541, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
Curr Hypertens Rep 7:330-6. 2005..Additional studies to further clarify the management of these patients are warranted...
- Genetics of obesity and obesity-related hypertensionAndreas Hamann
Department of Internal Medicine, University of Heidelberg, Germany
Semin Nephrol 22:100-4. 2002..This knowledge should help develop new strategies for the treatment of obesity and associated risk factors for hypertension and related cardiovascular disorders...
- The management of hypertension in the overweight and obese patient: is weight reduction sufficient?James D Douketis
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Drugs 64:795-803. 2004..Additional studies are needed to determine the long-term (>1 year) efficacy and safety of antihypertensive and anti-obesity management strategies in the overweight and obese hypertensive patient...
- Is there a rationale for angiotensin blockade in the management of obesity hypertension?Arya M Sharma
McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, ON, Canada
Hypertension 44:12-9. 2004....
- Managing big issues on lean evidence: treating obesity hypertensionArya M Sharma
Nephrol Dial Transplant 17:353-5. 2002
- Potential for sibutramine-yohimbine interaction?Jens Jordan
Lancet 361:1826. 2003
- Hypertension in overweight and obese primary care patients is highly prevalent and poorly controlledPeter Bramlage
Institute of Clinical Pharmacology, Institute of Clinical Psychology and Psychotherapy, Technical University, Dresden
Am J Hypertens 17:904-10. 2004..The objective of this study was to assess the prevalence of hypertension and the diagnosis, treatment status, and control rates of hypertension in obese patients as compared to patients with normal weight...
- Effect of forced titration of nebivolol on response rate in obese hypertensive patientsTobias Pischon
Am J Hypertens 16:98-100. 2003
- Emerging concepts in the pathophysiology and treatment of obesity-associated hypertensionStefan Engeli
Franz Volhard Clinic, Helios Klinikum Buch Charité, Medical Faculty of the Humboldt University Berlin, Germany
Curr Opin Cardiol 17:355-9. 2002....
- Obesity and cardiovascular disease: pathogenic mechanisms and potential benefits of weight reductionJames D Douketis
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Semin Vasc Med 5:25-33. 2005....
- Influences of AT1 receptor blockade on tissue metabolism in obese menMichael Boschmann
Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
Am J Physiol Regul Integr Comp Physiol 290:R219-23. 2006..Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs...
- Norepinephrine transporter function and autonomic control of metabolismMichael Boschmann
German Institute of Human Nutrition, 14558 Potsdam, Germany
J Clin Endocrinol Metab 87:5130-7. 2002..This effect cannot be explained by increased systemic or adipose tissue norepinephrine concentrations. Instead, NET inhibition may sensitize adipose tissue to beta-adrenergic stimulation...
- Emergency department equipment for obese patients: perceptions of adequacyNavneet Singh
Honours Program Cardiovascular Obesity Research and Management, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
J Adv Nurs 59:140-5. 2007....
- Treatment of obesity: a challenging taskArya M Sharma
Department of Medicine, Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, Hamilton, Canada
Contrib Nephrol 151:212-20. 2006..Successful obesity treatment should be defined as long-term weight loss maintenance. In this chapter, we briefly review the current evidences regarding the treatment of obesity...
- The value of current interventions for obesityArya M Sharma
Cardiovascular Obesity Research and Management in Michael deGroote School of Medicine, McMaster University, Hamilton, ON, Canada
Nat Clin Pract Cardiovasc Med 5:S3-9. 2008..If this effect can be demonstrated in humans, this type of agent might become the treatment of choice for obese or overweight people at risk of type 2 diabetes...
- Matrix analysis for the dissection of interactions of G-protein beta3 subunit C825T genotype, allograft function, and posttransplant hypertension in kidney transplantationJoachim Beige
Division of Endocrinology and Nephrology, Department of Internal Medicine, Universitatsklinikum Benjamin Franklin, Freie Universitaet Berlin, Germany
Am J Kidney Dis 40:1319-24. 2002..The authors, therefore, applied matrix analyses to account for interactions between genetic and environmental factors influencing kidney allograft function...
- Different "weight" of cardiac and general adiposity in predicting left ventricle morphologyGianluca Iacobellis
Department of Medicine, Cardiovascular Obesity Research and Management, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada
Obesity (Silver Spring) 14:1679-84. 2006..Nevertheless, the close anatomical and functional relationship of epicardial adipose tissue to the adjacent myocardium should readily allow local, paracrine interactions between these tissues...
- The relationship of body mass index to outcomes after percutaneous coronary interventionMamdouh M Shubair
Department of Medicine, McMaster University, Hamilton Health Sciences General Site, Hamilton, Ontario, Canada
J Interv Cardiol 19:388-95. 2006..To evaluate the effect of body mass index (BMI) on in-hospital outcomes in patients undergoing percutaneous coronary intervention (PCI) at a tertiary care hospital center in Ontario, Canada...
- Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anionYu Jing Gao
Smooth Muscle Research Program and Department of Anaesthesia, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
Cardiovasc Res 71:363-73. 2006..In this study, we examined if PVAT releases other vasoactive factors in response to perivascular nerve activation by electrical field stimulation (EFS)...
- The obese patient with diabetes mellitus: from research targets to treatment optionsArya M Sharma
Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Med 119:S17-23. 2006..Clinical trials with telmisartan are currently investigating the effects of RAS blockade on insulin sensitivity in humans...
- Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control studySalim Yusuf
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
Lancet 366:1640-9. 2005..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure...
- Plasma-renin response to isotonic volume contraction in young salt-sensitive normotensive menUlrike Schorr
Franz Volhard Klinik at the Max Delbrück Center for Molecular Medicine, Universitatsklinikum Charite, Humboldt Universitat zu Berlin, Germany
Am J Hypertens 15:48-52. 2002..These findings point to an intrinsic difference in the regulation of renin release between salt-sensitive and salt-resistant subjects that may account for the different BP responses to changes in dietary sodium intake...
- Interleukin-6 g.-174G>C promoter polymorphism is associated with obesity in the EPIC-Potsdam StudyKerstin Klipstein-Grobusch
Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal
Obesity (Silver Spring) 14:14-8. 2006..044) and was most pronounced in subjects with the CC genotype, suggesting that the IL-6 g.-174G>C promoter polymorphism is a susceptibility or modifying locus for common obesity and weight gain...