Arya M Sharma

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Catechol-o-methyltransferase and blood pressure in humans
    Jens Jordan
    Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:460-5. 2002
  2. ncbi request reprint Hypothesis: Beta-adrenergic receptor blockers and weight gain: A systematic analysis
    A M Sharma
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Hypertension 37:250-4. 2001
  3. ncbi request reprint Choice of drug treatment for obesity-related hypertension: where is the evidence?
    A M Sharma
    Franz Volhard Klinik, Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    J Hypertens 19:667-74. 2001
  4. ncbi request reprint [Lowering blood pressure in obese hypertensive patients. Which antihypertensive drugs are suitable]
    T Pischon
    Med Klinik, Franz Volhard Klinik am Max Delbrück Centrum für Molekulare Medizin, Charite, Berlin
    MMW Fortschr Med 143:34-8. 2001
  5. ncbi request reprint Effect of orlistat-induced weight loss on blood pressure and heart rate in obese patients with hypertension
    Arya M Sharma
    Franz Volhard Klinik Charité, Berlin, Germany and Teaching Diabetic Division, University Hospital Geneva, Switzerland
    J Hypertens 20:1873-8. 2002
  6. ncbi request reprint Sibutramine in overweight/obese hypertensive patients
    A M Sharma
    Franz Volhard Clinic Charité, Nephrology and Hypertension, Berlin, Germany
    Int J Obes Relat Metab Disord 25:S20-3. 2001
  7. ncbi request reprint Second International Symposium on Obesity and Hypertension: genetics and molecular mechanisms, 25-27 October 2001, Berlin, Germany
    A M Sharma
    Franz Volhard Clinic Charité and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Int J Obes Relat Metab Disord 26:1283-8. 2002
  8. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005
  9. ncbi request reprint Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
  10. ncbi request reprint Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Obes Res 12:9-17. 2004

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Catechol-o-methyltransferase and blood pressure in humans
    Jens Jordan
    Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:460-5. 2002
    ..Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown...
  2. ncbi request reprint Hypothesis: Beta-adrenergic receptor blockers and weight gain: A systematic analysis
    A M Sharma
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Hypertension 37:250-4. 2001
    ..Based on these observations, the first-line use of beta-blockers in obese hypertensive patients should be reviewed. Obesity management in overweight hypertensive patients may be more difficult in the face of beta-blocker treatment...
  3. ncbi request reprint Choice of drug treatment for obesity-related hypertension: where is the evidence?
    A M Sharma
    Franz Volhard Klinik, Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    J Hypertens 19:667-74. 2001
    ....
  4. ncbi request reprint [Lowering blood pressure in obese hypertensive patients. Which antihypertensive drugs are suitable]
    T Pischon
    Med Klinik, Franz Volhard Klinik am Max Delbrück Centrum für Molekulare Medizin, Charite, Berlin
    MMW Fortschr Med 143:34-8. 2001
    ..Before definitive pronouncements on what constitutes optimal treatment of obese patients can be made, the results of studies looking at hard end points must be available...
  5. ncbi request reprint Effect of orlistat-induced weight loss on blood pressure and heart rate in obese patients with hypertension
    Arya M Sharma
    Franz Volhard Klinik Charité, Berlin, Germany and Teaching Diabetic Division, University Hospital Geneva, Switzerland
    J Hypertens 20:1873-8. 2002
    ..To investigate the effects of long-term weight management with orlistat on blood pressure in obese hypertensive patients...
  6. ncbi request reprint Sibutramine in overweight/obese hypertensive patients
    A M Sharma
    Franz Volhard Clinic Charité, Nephrology and Hypertension, Berlin, Germany
    Int J Obes Relat Metab Disord 25:S20-3. 2001
    ..Studies have shown that in the obese, well-controlled hypertensive patient, sibutramine is a safe and well-tolerated therapy offering the many clinical benefits associated with weight reduction in this high-risk population...
  7. ncbi request reprint Second International Symposium on Obesity and Hypertension: genetics and molecular mechanisms, 25-27 October 2001, Berlin, Germany
    A M Sharma
    Franz Volhard Clinic Charité and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Int J Obes Relat Metab Disord 26:1283-8. 2002
    ....
  8. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005
    ..This notion has not been tested in overweight and obese patients...
  9. ncbi request reprint Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
    ..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
  10. ncbi request reprint Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Obes Res 12:9-17. 2004
    ..The aim of this study was to determine whether up-regulation of human adipose 11beta-HSD1 in obesity can also be found at the gene expression level...
  11. ncbi request reprint Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
    ..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
  12. ncbi request reprint The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
    Int J Biochem Cell Biol 35:807-25. 2003
    ....
  13. ncbi request reprint Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation
    Jurgen Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin, Germany
    J Hypertens 24:1809-16. 2006
    ..In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans...
  14. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2459-65. 2002
    ..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease...
  15. ncbi request reprint Bound leptin and sympathetic outflow in nonobese men
    Jens Tank
    HELIOS Kliniken Berlin, Franz Volhard Cardiovascular Research Center, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
    J Clin Endocrinol Metab 88:4955-9. 2003
    ..This relationship cannot be explained by a direct central nervous effect of protein-bound leptin. Instead, protein-bound leptin may increase sympathetic vasomotor tone indirectly via a baroreflex mechanism...
  16. ncbi request reprint HYDRA: possible determinants of unsatisfactory hypertension control in German primary care patients
    U Muscha Steckelings
    Center for Cardiovascular Research Institute of Pharmacology and Toxicology, Charite, Berlin, Germany
    Blood Press 13:80-8. 2004
    ..These insights into the causes of unsatisfactory hypertension control may help to direct future educational programmes designed to improve hypertension management specifically to these deficits and thereby to improve control rates...
  17. ncbi request reprint Angiotensin blockade prevents type 2 diabetes by formation of fat cells
    Arya M Sharma
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 40:609-11. 2002
    ..Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes...
  18. ncbi request reprint Regulation of the nitric oxide system in human adipose tissue
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Charite University Medicine in Berlin, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Lipid Res 45:1640-8. 2004
    ..Increased eNOS and iNOS expression in adipocytes and local effects of insulin and Ang II may increase adipose tissue production of NO in obesity...
  19. ncbi request reprint European Society of Hypertension Working Group on Obesity: background, aims and perspectives
    Jens Jordan
    Franz Volhard Clinical Research Center and Department of Nephrology, Helios Klinikum Berlin and Medical Faculty of the Charité, Berlin, Germany
    J Hypertens 25:897-900. 2007
  20. ncbi request reprint Pressor effect of water drinking in tetraplegic patients may be a spinal reflex
    Jens Tank
    HELIOS Kliniken Berlin, Franz Volhard Cardiovascular Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Hypertension 41:1234-9. 2003
    ..This observation might suggest that water drinking activates postganglionic sympathetic neurons either directly or through a spinal reflex mechanism...
  21. ncbi request reprint Association between adiponectin and mediators of inflammation in obese women
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Diabetes 52:942-7. 2003
    ....
  22. ncbi request reprint Hemodynamic and metabolic responses to interstitial angiotensin II in normal weight and obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite, Universitary Medicine Berlin, Germany
    J Hypertens 24:1165-71. 2006
    ..Therefore, we hypothesized that peripheral tissues of obese subjects are hypersensitive to angiotensin (Ang) II...
  23. ncbi request reprint Baroreflex buffering and susceptibility to vasoactive drugs
    Jens Jordan
    Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 105:1459-64. 2002
    ..Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not known...
  24. ncbi request reprint Reduced vagal activity in salt-sensitive subjects during mental challenge
    Konrad Buchholz
    Division of Psychosomatic Medicine, Benjamin Franklin Medical Center, Free University of Berlin, Berlin, Germany
    Am J Hypertens 16:531-6. 2003
    ..Stress-induced HR acceleration may result from sympathetic activation or vagal withdrawal. We studied the importance of vagal withdrawal for the increased stress responsiveness of salt-sensitive subjects...
  25. ncbi request reprint Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensives
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite Campus Buch, HELIOS Klinikum, Berlin, Germany
    Hypertension 46:130-6. 2005
    ..These findings may be explained in part by monocyte/macrophage infiltration of adipose tissue, which appears to interfere with insulin responsiveness...
  26. ncbi request reprint Periadventitial fat releases a vascular relaxing factor
    Matthias Löhn
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    FASEB J 16:1057-63. 2002
    ..We suggest that perivascular adventitial adipose tissue releases a transferable adventitium-derived relaxing factor that acts by tyrosine kinase-dependent activation of K+ channels in vascular smooth muscle cells...
  27. ncbi request reprint Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritis
    Harm Peters
    Division of Nephrology, Charite, Campus Mitte, Humboldt University, Berlin, Germany
    J Hypertens 21:771-80. 2003
    ....
  28. ncbi request reprint Salt sensitivity, anxiety, and irritability predict blood pressure increase over five years in healthy males
    Hans Christian Deter
    Department of Psychosomatic Medicine and Psychotherapy, Benjamin Franklin Medical Center, Free University of Berlin, Berlin, Germany
    Clin Exp Hypertens 28:17-27. 2006
    ..009) and 58% (diastolic ABP, p < 0.0001) of variance. We concluded that anxiety and irritability are important predictors of blood pressure increase over time in healthy males...
  29. ncbi request reprint Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure
    Andreas Busjahn
    Franz Volhard Clinic, HELIOS Kliniken Berlin and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 40:256-60. 2002
    ..This combined effect of the polymorphisms was confirmed in an independent sample of 260 young normotensive men. We conclude that the SGK1 gene is relevant to blood pressure regulation and probably to hypertension in man...
  30. pmc Obesity prevalence from a European perspective: a systematic review
    Anne Berghöfer
    Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    BMC Public Health 8:200. 2008
    ..We therefore aimed to identify and discuss current epidemiological data on the prevalence of obesity in European countries...
  31. ncbi request reprint The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation
    Maik Gollasch
    HELIOS Klinikum Berlin Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Hypertens 20:927-33. 2002
    ..We tested the hypothesis that variants in the gene (KCNMB1) coding for the BK beta1 subunit are associated with baroreflex function...
  32. ncbi request reprint Heterogeneity of autonomic regulation in hypertension and neurovascular contact
    Jens Jordan
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    J Hypertens 20:701-6. 2002
    ..We tested the hypothesis that similar abnormalities are present in patients with essential hypertension who have NVC...
  33. ncbi request reprint High prevalence and poor control of hypertension in primary care: cross-sectional study
    Arya M Sharma
    Franz Volhard Clinic Charité, Berlin, Germany
    J Hypertens 22:479-86. 2004
    ....
  34. ncbi request reprint Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance
    Christoph Schroeder
    Clinical Research Center, Helios Klinkum Berlin, Germany
    Circulation 105:347-53. 2002
    ..Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance...
  35. ncbi request reprint Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors
    Jurgen Janke
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Diabetes 51:1699-707. 2002
    ..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes...
  36. ncbi request reprint Ethnic origin determines the impact of genetic variants in dopamine receptor gene (DRD1) concerning essential hypertension
    Joachim Beige
    Department of Nephrology, Charite, Berlin, Germany
    Am J Hypertens 17:1184-7. 2004
    ..Thus, racial differences may play an important role concerning the association of variants in the dopamine receptor type 1 gene with essential hypertension...
  37. doi request reprint Role of CYP2C9 genetic variants for salt sensitivity and the regulation of the renin-angiotensin-aldosterone system in normotensive men
    Juliane Bolbrinker
    Institute of Clinical Pharmacology and Toxicology, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens 29:56-61. 2011
    ..We tested the relevance of CYP2C9 genotypes for regulation of plasma renin activity (PRA), plasma aldosterone concentrations and blood pressure (BP) in response to changes in salt intake in normotensive individuals...
  38. ncbi request reprint Neurovascular contact and blood pressure response in young, healthy, normotensive men
    Henriette Hohenbleicher
    Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitatsklinikum Benjamin Franklin, Berlin, Germany
    Am J Hypertens 15:119-24. 2002
    ..We also studied blood pressure, heart rate reactivity, and changes in baroreflex sensitivity in response to mental and physical stress in a subset of subjects with positive and negative brainstem findings...
  39. ncbi request reprint A gene expression analysis in rat kidney following high and low salt intake
    Peter Barta
    Max Delbruck Center for Molecular Medicine, Humboldt University of Berlin, Berlin, Germany
    J Hypertens 20:1115-20. 2002
    ..The effects of salt intake on renal regulation have been investigated for decades. To find new pathways and to demonstrate the utility of oligonucleotide expression arrays, we studied whole kidneys...
  40. ncbi request reprint Resistin gene expression in human adipocytes is not related to insulin resistance
    Jurgen Janke
    Franz Volhard Clinic Charité, the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Obes Res 10:1-5. 2002
    ..Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance...
  41. pmc Activation of the peripheral endocannabinoid system in human obesity
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, 13125 Berlin, Germany
    Diabetes 54:2838-43. 2005
    ..Our findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity...
  42. ncbi request reprint Management of hypertension in overweight and obese patients: a practical guide for clinicians
    Francesco Dentali
    St Joseph s Hospital, Room F 541, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Curr Hypertens Rep 7:330-6. 2005
    ..Additional studies to further clarify the management of these patients are warranted...
  43. ncbi request reprint Influences of AT1 receptor blockade on tissue metabolism in obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R219-23. 2006
    ..Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs...
  44. ncbi request reprint Hypertension in lean and obese individuals: an evenly or unevenly dangerous condition
    Gianluca Iacobellis
    Nutr Metab Cardiovasc Dis 17:243-6. 2007
  45. ncbi request reprint Can PPARgamma agonists have a role in the management of obesity-related hypertension?
    Vasudhevan T Chetty
    Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Vascul Pharmacol 45:46-53. 2006
    ..This review will highlight the role of TZDs in various models of hypertension and discuss their potential role in the management of obesity-related hypertension...
  46. pmc A weighty issue: medication as a cornerstone of medical obesity management
    Arya M Sharma
    University of Alberta, Royal Alexandra Hospital, 10240 Kingsway Ave, 406 CSC, Edmonton, AB T5H 3V9
    Can Fam Physician 54:498-9, 500-1. 2008
  47. ncbi request reprint Relation of subepicardial adipose tissue to carotid intima-media thickness in patients with human immunodeficiency virus
    Gianluca Iacobellis
    Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 99:1470-2. 2007
    ..81, p <0.01). In conclusion, this study suggests, for the first time, that epicardial adipose tissue, an index of cardiac adiposity, may be significantly related to subclinical atherosclerosis in HIV-infected patients...
  48. doi request reprint Substantial changes in epicardial fat thickness after weight loss in severely obese subjects
    Gianluca Iacobellis
    1Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:1693-7. 2008
    ..Measurement of echocardiographic epicardial fat thickness may provide an additional tool in understanding the metabolic risk associated with variation in fat distribution...
  49. pmc 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]
    David C W Lau
    Department of Medicine, Julia McFarlane Diabetes Research Centre, Diabetes and Endocrine Research Group, University of Calgary, Calgary, Alta
    CMAJ 176:S1-13. 2007
  50. ncbi request reprint Obesity and cardiovascular disease: pathogenic mechanisms and potential benefits of weight reduction
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Vasc Med 5:25-33. 2005
    ....
  51. ncbi request reprint Recent developments in the treatment of obesity-related hypertension
    Tobias Pischon
    Franz Volhard Clinic HELIOS Klinikum Berlin Buch, Charite, Medical Faculty of the Humboldt University Berlin, Max Delbruck Center for Molecular Medicine, Germany
    Curr Opin Nephrol Hypertens 11:497-502. 2002
    ..Obesity is a major public health issue, and hypertension is one of the most common associated co-morbidities. Here, recent developments in the treatment of obesity-related hypertension, published during the past year, are reviewed...
  52. ncbi request reprint Norepinephrine transporter function and autonomic control of metabolism
    Michael Boschmann
    German Institute of Human Nutrition, 14558 Potsdam, Germany
    J Clin Endocrinol Metab 87:5130-7. 2002
    ..This effect cannot be explained by increased systemic or adipose tissue norepinephrine concentrations. Instead, NET inhibition may sensitize adipose tissue to beta-adrenergic stimulation...
  53. ncbi request reprint Emerging concepts in the pathophysiology and treatment of obesity-associated hypertension
    Stefan Engeli
    Franz Volhard Clinic, Helios Klinikum Buch Charité, Medical Faculty of the Humboldt University Berlin, Germany
    Curr Opin Cardiol 17:355-9. 2002
    ....
  54. ncbi request reprint Managing big issues on lean evidence: treating obesity hypertension
    Arya M Sharma
    Nephrol Dial Transplant 17:353-5. 2002
  55. ncbi request reprint Potential for sibutramine-yohimbine interaction?
    Jens Jordan
    Lancet 361:1826. 2003
  56. ncbi request reprint Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition
    Jens Tank
    Clinical Research Center, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
    Circulation 107:2949-54. 2003
    ..Norepinephrine transporter (NET) inhibition increases the responsiveness to vasoactive medications and attenuates the response to sympathetic stimuli. The phenomenon may be a result of impaired regulation of sympathetic vasomotor tone...
  57. ncbi request reprint Long-term weight loss and changes in blood pressure
    Arya M Sharma
    Curr Hypertens Rep 4:11-2. 2002
  58. ncbi request reprint Genetics of obesity and obesity-related hypertension
    Andreas Hamann
    Department of Internal Medicine, University of Heidelberg, Germany
    Semin Nephrol 22:100-4. 2002
    ..This knowledge should help develop new strategies for the treatment of obesity and associated risk factors for hypertension and related cardiovascular disorders...
  59. ncbi request reprint The management of hypertension in the overweight and obese patient: is weight reduction sufficient?
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Drugs 64:795-803. 2004
    ..Additional studies are needed to determine the long-term (>1 year) efficacy and safety of antihypertensive and anti-obesity management strategies in the overweight and obese hypertensive patient...
  60. ncbi request reprint Is there a rationale for angiotensin blockade in the management of obesity hypertension?
    Arya M Sharma
    McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, ON, Canada
    Hypertension 44:12-9. 2004
    ....
  61. ncbi request reprint Hypertension in overweight and obese primary care patients is highly prevalent and poorly controlled
    Peter Bramlage
    Institute of Clinical Pharmacology, Institute of Clinical Psychology and Psychotherapy, Technical University, Dresden
    Am J Hypertens 17:904-10. 2004
    ..The objective of this study was to assess the prevalence of hypertension and the diagnosis, treatment status, and control rates of hypertension in obese patients as compared to patients with normal weight...
  62. ncbi request reprint Effect of forced titration of nebivolol on response rate in obese hypertensive patients
    Tobias Pischon
    Am J Hypertens 16:98-100. 2003
  63. ncbi request reprint Optimizing blood pressure control in the obese patient
    Tobias Pischon
    Franz Volhard Clinic Charité, Wiltbergstrasse 50, 13125 Berlin, Germany
    Curr Hypertens Rep 4:358-62. 2002
    ..The role of antiobesity drugs in the management of the obese hypertensive patient also remains to be defined...
  64. ncbi request reprint Plasma-renin response to isotonic volume contraction in young salt-sensitive normotensive men
    Ulrike Schorr
    Franz Volhard Klinik at the Max Delbrück Center for Molecular Medicine, Universitatsklinikum Charite, Humboldt Universitat zu Berlin, Germany
    Am J Hypertens 15:48-52. 2002
    ..These findings point to an intrinsic difference in the regulation of renin release between salt-sensitive and salt-resistant subjects that may account for the different BP responses to changes in dietary sodium intake...
  65. doi request reprint The value of current interventions for obesity
    Arya M Sharma
    Cardiovascular Obesity Research and Management in Michael deGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Nat Clin Pract Cardiovasc Med 5:S3-9. 2008
    ..If this effect can be demonstrated in humans, this type of agent might become the treatment of choice for obese or overweight people at risk of type 2 diabetes...
  66. ncbi request reprint Emergency department equipment for obese patients: perceptions of adequacy
    Navneet Singh
    Honours Program Cardiovascular Obesity Research and Management, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Adv Nurs 59:140-5. 2007
    ....
  67. ncbi request reprint Different "weight" of cardiac and general adiposity in predicting left ventricle morphology
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 14:1679-84. 2006
    ..Nevertheless, the close anatomical and functional relationship of epicardial adipose tissue to the adjacent myocardium should readily allow local, paracrine interactions between these tissues...
  68. ncbi request reprint The relationship of body mass index to outcomes after percutaneous coronary intervention
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton Health Sciences General Site, Hamilton, Ontario, Canada
    J Interv Cardiol 19:388-95. 2006
    ..To evaluate the effect of body mass index (BMI) on in-hospital outcomes in patients undergoing percutaneous coronary intervention (PCI) at a tertiary care hospital center in Ontario, Canada...
  69. ncbi request reprint Treatment of obesity: a challenging task
    Arya M Sharma
    Department of Medicine, Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, Hamilton, Canada
    Contrib Nephrol 151:212-20. 2006
    ..Successful obesity treatment should be defined as long-term weight loss maintenance. In this chapter, we briefly review the current evidences regarding the treatment of obesity...
  70. ncbi request reprint Matrix analysis for the dissection of interactions of G-protein beta3 subunit C825T genotype, allograft function, and posttransplant hypertension in kidney transplantation
    Joachim Beige
    Division of Endocrinology and Nephrology, Department of Internal Medicine, Universitatsklinikum Benjamin Franklin, Freie Universitaet Berlin, Germany
    Am J Kidney Dis 40:1319-24. 2002
    ..The authors, therefore, applied matrix analyses to account for interactions between genetic and environmental factors influencing kidney allograft function...
  71. ncbi request reprint Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion
    Yu Jing Gao
    Smooth Muscle Research Program and Department of Anaesthesia, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Cardiovasc Res 71:363-73. 2006
    ..In this study, we examined if PVAT releases other vasoactive factors in response to perivascular nerve activation by electrical field stimulation (EFS)...
  72. ncbi request reprint The obese patient with diabetes mellitus: from research targets to treatment options
    Arya M Sharma
    Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Med 119:S17-23. 2006
    ..Clinical trials with telmisartan are currently investigating the effects of RAS blockade on insulin sensitivity in humans...
  73. ncbi request reprint Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
    ..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure...
  74. ncbi request reprint Interleukin-6 g.-174G>C promoter polymorphism is associated with obesity in the EPIC-Potsdam Study
    Kerstin Klipstein-Grobusch
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal
    Obesity (Silver Spring) 14:14-8. 2006
    ..044) and was most pronounced in subjects with the CC genotype, suggesting that the IL-6 g.-174G>C promoter polymorphism is a susceptibility or modifying locus for common obesity and weight gain...