Research Topics
Genomes and GenesSpecies | S SchwartzSummaryAffiliation: Humboldt University Country: Germany Publications
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Publications
No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasmsThomas Burmeister
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
Retrovirology 4:11. 2007..The primer sequences were based on highly interspecies-conserved virus genome regions. We used this PCR to detect Deltaretroviruses in samples from adult patients with a variety of rare T-cell neoplasms in Germany...- An intron 9 containing splice variant of PAX2Antonia Busse
Department of Medicine III, Charite, Campus Benjamin Franklin, Berlin, Germany
J Transl Med 7:36. 2009..However, PAX2 expression was frequently identified in neoplasia responsible for the growth and survival of cancer cells. Due to alternative splicing of exon 6, exon 10 and exon 12 four isoforms of PAX2 are described so far... 
Poor efficacy of amphotericin B-based therapy in CNS aspergillosisStefan Schwartz
Medizinische Klinik III, Charite Campus Benjamin Franklin, Freie Universitat, Berlin, Germany
Mycoses 50:196-200. 2007..In conclusion, treatment with amphotericin B and itraconazole has negligible efficacy in CNS aspergillosis...- Glucarpidase (carboxypeptidase g2) intervention in adult and elderly cancer patients with renal dysfunction and delayed methotrexate elimination after high-dose methotrexate therapyStefan Schwartz
Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Oncologist 12:1299-308. 2007..We evaluated the effects of glucarpidase intervention in adult and elderly patients with delayed MTX elimination... 
The efficacy of voriconazole in the treatment of 192 fungal central nervous system infections: a retrospective analysisS Schwartz
Medizinische Klinik III, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
Infection 39:201-10. 2011..The efficacy of voriconazole against fungal central nervous system (CNS) infections was examined retrospectively...- Improved outcome in central nervous system aspergillosis, using voriconazole treatmentStefan Schwartz
Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Blood 106:2641-5. 2005..We conclude from this large cohort of patients that voriconazole treatment together with neurosurgical management, whenever feasible, is currently the best approach to treat patients with CNS aspergillosis... - Cerebral aspergillosis: tissue penetration is the keyS Schwartz
Medizinische Klinik III, Charite Campus Benjamin Franklin, Berlin, Germany
Med Mycol 47:S387-93. 2009.... - Norovirus gastroenteritis causes severe and lethal complications after chemotherapy and hematopoietic stem cell transplantationStefan Schwartz
Medizinische Klinik III, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
Blood 117:5850-6. 2011..NV-GE is a major threat to patients with chemotherapy or HSCT, and meticulous measures are warranted to prevent transmission of NV to these patients... - CNS-aspergillosis: are there new treatment options?S Schwartz
Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Freie Universitat, Hindenburgdamm 30, D 12200 Berlin, Germany
Mycoses 46:8-14. 2003..However, additional clinical data are needed to determine more precisely the role of voriconazole in CNS aspergillosis. In this review, we have compiled the available pharmacological and clinical data on CNS aspergillosis... - Carboxypeptidase G2 rescue in a 79 year-old patient with cranial lymphoma after high-dose methotrexate induced acute renal failureA Krackhardt
Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Freie Universitat Berlin, Universitäsklinikum Benjamin Franklin, Germany
Leuk Lymphoma 35:631-5. 1999..With the help of CPG2, sufficient and potentially curative therapy with HD-MTX may also be provided to patients with a high risk of renal failure... - [Experience with voriconazole in invasive aspergillosis]E Thiel
Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Freie Universitat, Hindenburgdamm 30, D 12200 Berlin, Germany
Mycoses 46:3-7. 2003..In patients with invasive aspergillosis the therapy response with voriconazole is about 45% even in otherwise therapy-resistant cases... - Intensified strategies to control vancomycin-resistant enterococci in immunocompromised patientsM Schmidt-Hieber
Department of Hematology, Oncology and Transfusion Medicine, Universitatsmedizin Berlin, Charite Campus Benjamin Franklin, Berlin, Germany
Int J Hematol 86:158-62. 2007..Premature discontinuation of infection-control measures may cause recurrence of the VRE spread... - Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: results of the German multicenter trials GMALL 03/87 and 04/89W D Ludwig
Medizinische Fakultät Charité, Humboldt Universitat, Robert Rossle Klinik, Berlin, Germany the Klinikum der Philipps Universität, Marburg, Germany Universitätsklinikum, Heidelberg, Germany
Blood 92:1898-909. 1998..These data indicate that intensification of postremission treatment may improve the prognosis of adult pro-B ALL, including patients with a t(4;11)... - Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study groupU Baak
Charite Campus Benjamin Franklin, Medizinische Klinik III, Berlin, Germany
Leukemia 22:1154-60. 2008..Thus, patients with aberrant HOX11L2 expression should be considered early as candidates for intensified treatment regimes... - Low-dose liposomal amphotericin B in the prevention of invasive fungal infections in patients with prolonged neutropenia: results from a randomized, single-center trialO Penack
Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
Ann Oncol 17:1306-12. 2006.... - Possible regulation of Wilms' tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA-1 in human acute myeloid leukaemiasJan M Siehl
Medizinische Klinik III Haematology, Oncology and Transfusion Medicine, Universitatsklinikum Benjamin Franklin, Freie Universitat, Berlin, Germany
Br J Haematol 123:235-42. 2003..In two-thirds of leukaemias from our series, the basis of WT1 upregulation cannot be explained by the simple upregulation of the known WT1 activators... - Molecular heterogeneity of sporadic adult Burkitt-type leukemia/lymphoma as revealed by PCR and cytogenetics: correlation with morphology, immunology and clinical featuresT Burmeister
Charite, Campus Benjamin Franklin, Medizinische Klinik III, Berlin, Germany
Leukemia 19:1391-8. 2005..A total of 34 patients were treated according to the GMALL B-ALL therapy protocols and there was no significant difference in overall survival between patients with or without t(8;14)... - BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemiaS Heesch
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Berlin, Germany
Leukemia 24:1429-36. 2010..In contrast to BAALC, which likely represents only a surrogate marker of treatment failure in acute leukemia, IGFBP7 regulates the proliferation of leukemic cells and might be involved in chemotherapy resistance... - A PCR primer system for detecting oncoretroviruses based on conserved DNA sequence motifs of animal retroviruses and its application to human leukaemias and lymphomasT Burmeister
Freie Universitat Berlin, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
J Gen Virol 82:2205-13. 2001..The retrovirus detection system developed here may be used to confirm suspected retroviral involvement in other (malignant or nonmalignant) human diseases as well as to identify new animal retroviruses... - Monitoring minimal residual disease by quantification of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrationsT Burmeister
Medizinische Klinik III, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, Berlin, Germany
Leukemia 20:451-7. 2006..An accurate and absolute quantification of the MRD level is possible. No reference to housekeeping genes is necessary and the target structure is much more stable than any mRNA fusion transcript... - Effects of an endurance and resistance exercise program on persistent cancer-related fatigue after treatmentF Dimeo
Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
Ann Oncol 19:1495-9. 2008..However, there is a lack of information about the effects of this intervention on persistent cancer-related fatigue. Therefore, we assessed the effects of an exercise program on cancer-related fatigue after treatment... - Combined automated cell and flow cytometric analysis enables recognition of persistent polyclonal B-cell lymphocytosis (PPBL), a study of 25 patientsM Schmidt-Hieber
Medizinische Klinik III, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
Ann Hematol 87:829-36. 2008..The observation of malignant lymphoma in a single patient implicates that evolution into a clonal malignant transformation may occasionally occur in PPBL... - Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemiaThomas Burmeister
Med Klinik für Hämatologie Onkologie Hindenburgdamm 30, 12200 Berlin, Germany
Haematologica 95:241-6. 2010..However, the prognostic impact of other rarer fusion genes is less well established in adult acute lymphoblastic leukemia than in the childhood form... - Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemiaClaudia D Baldus
Charite, University Hospital Berlin, Campus Benjamin Franklin, Department of Hematology and Oncology, Hindenburgdamm 30 12203 Berlin, Germany
Haematologica 94:1383-90. 2009..However, the results of studies on the prognostic significance of NOTCH1 mutations in adult T-lymphoblastic leukemia remain controversial... - Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemiaThomas Burmeister
Charite Universitatsmedizin Berlin, Campus, Benjamin Franklin, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
Haematologica 92:1699-702. 2007..This corresponds to a prevalence of 1-2% of all BCR-ABL-positive cases. The clinical courses are reported and diagnostic proposals are made... - Chronic norovirus infection in renal transplant recipientsTimm H Westhoff
Department of Nephrology, Charite Campus Benjamin Franklin, Berlin, Germany
Nephrol Dial Transplant 24:1051-3. 2009..Norovirus should therefore be considered in the differential diagnosis of both acute and chronic diarrhoea after transplantation. Reduction of immunosuppression may be indicated to allow virus elimination in symptomatic cases... - CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapyLars Fischer
Charite Campus Benjamin Franklin, Medizinische Klinik III, Berlin
Haematologica 94:224-9. 2009..Expression of CD56 has been associated with poor prognosis in acute myeloid leukemia and aggressive lymphoma... - The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study groupThomas Burmeister
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin CBF, Medizinische Klinik III, Berlin, Germany
Blood 113:4011-5. 2009..Characteristic features of MLL(+) patients were significantly lower CD10 expression, expression of the NG2 antigen, a higher white blood count at diagnosis, and female sex. Proposals are made for diagnostic assessment... - Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcomeAntonia Busse
Department of Medicine III, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Ann Hematol 88:1199-205. 2009..Cox regression analysis, considering ALL phenotype as well as molecular-cytogenetic subsets, revealed no independent prognostic role of WT1 expression level for disease-free and overall survival... - NUP214-ABL1 in adult T-ALL: the GMALL study group experienceThomas Burmeister
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
Blood 108:3556-9. 2006..Based on the results, we have established and tested a novel PCR method for simplified detection of the NUP214-ABL1 fusion gene... - Expression of interleukin 15 in primary adult acute lymphoblastic leukemiaShuling Wu
Department of Hematology, Oncology and Transfusion Medicine, Campus Benjamin Franklin, Charity Medical Center, Hindenburgdamm 30, 12203 Berlin, Germany
Cancer 116:387-92. 2010..We determined the expression of IL-15 in lymphoblasts and evaluated its potential impact on the outcome in adult acute lymphoblastic leukemia (ALL)... - Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcomeClaudia D Baldus
Department of Hematology and Oncology, Charite, University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany
J Clin Oncol 25:3739-45. 2007..We hypothesized that like ERG, BAALC expression might be of prognostic significance in acute T-lymphoblastic leukemia (T-ALL) and that ERG and BAALC expression together would better identify the patient's risk profile... - CNS aspergillosis: recognition, diagnosis and managementMarkus Ruhnke
Department of Internal Medicine, Charite Campus Mitte, Berlin, Germany
CNS Drugs 21:659-76. 2007..A combined medical and neurosurgical treatment should be considered in all patients with this disease... - Skewed expression of natural-killer (NK)-associated antigens on lymphoproliferations of large granular lymphocytes (LGL)Lars Fischer
Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
Hematol Oncol 24:78-85. 2006..We consistently found a skewed expression pattern of novel NK markers as a pathological feature of LGLL. These antigens should be included in the diagnostic workup of this rare disease... - Hydrops lysosomalis generalisatus--an underestimated side effect of hydroxyethyl starch therapy?Martin Schmidt-Hieber
Medizinische Klinik III Hämatologie, Onkologie und Transfusionsmedizin, Charite Campus Benjamin Franklin, Berlin, Germany
Eur J Haematol 77:83-5. 2006..We found severe infiltration of foamy cell degenerated macrophages in both organ systems, indicating that sequelae of HES therapy have to be included in the differential diagnosis of bone marrow and liver dysfunction... - CD10- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL)Beate Gleissner
Department of Internal Medicine III, Campus Benjamin Franklin, Charite Universitatsmedizin, Hindenburgdamm 30, 12200 Berlin, Germany
Blood 106:4054-6. 2005..Our data identify CD10- cytoplasmic immunoglobulin-positive pre-B ALL as a rare (2.2%) but distinct immuno-subtype of adult ALL that is characterized by a high MLL rearrangement rate and a worse outcome... - Retrospective study of prognostic factors in non-Hodgkin lymphoma secondarily involving the central nervous systemKristoph Jahnke
Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Ann Hematol 85:45-50. 2006..In conclusion, long-term survival can be achieved in patients with secondary CNS lymphoma. LDH at CNS manifestation and a CNS response to therapy were significantly associated with survival... - High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adultsClaudia D Baldus
Department of Hematology, Oncology and Transfusion Medicine, Charite, Campus Benjamin Franklin, University Hospital Berlin, Hindenburgdamm 30, 12203 Berlin, Germany
J Clin Oncol 24:4714-20. 2006..The adverse prognosis in T-ALL has not been attributed to cytogenetic or molecular aberrations. We have determined the prognostic impact of the oncogenic transcription factor ERG in T-ALL... - Update on the treatment of cerebral aspergillosisS Schwartz
Medizinische Klinik III, , Campus Benjamin Franklin, , Berlin, Germany
Ann Hematol 83:S42-4. 2004..An intense neurosurgical management and higher doses of voriconazole might further improve the outcome in CNS aspergillosis, but this needs to be evaluated in future studies... - Expression of the C-kit receptor (CD117) is a feature of almost all subtypes of de novo acute myeloblastic leukemia (AML), including cytogenetically good-risk AML, and lacks prognostic significanceS Schwartz
Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Klinikum Benjamin Franklin, Freie Universitat, Berlin, Germany
Leuk Lymphoma 34:85-94. 1999..We found no evidence of an adverse prognosis in AML patients with c-kit receptor expression. Analysis for c-kit receptor expression does not appear to add information to established prognostic parameters in AML... - Physical performance, depression, immune status and fatigue in patients with hematological malignancies after treatmentF Dimeo
Institute of Sports Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
Ann Oncol 15:1237-42. 2004..However, there is no conclusive evidence regarding the role of the immune system in the origin of fatigue in cancer patients... - Pegylated asparaginase in combination with high-dose methotrexate for consolidation in adult acute lymphoblastic leukaemia in first remission: a pilot studyO Rosen
Department of Haematology/Oncology, , Berlin, Germany
Br J Haematol 123:836-41. 2003..PEG-ASP was well tolerated. Despite the long half-life of PEG-ASP, neither pancreatic nor central nervous toxicities occurred among the 26 adult patients treated in this pilot study... - Expression of the human homologue of rat NG2 in adult acute lymphoblastic leukemia: close association with MLL rearrangement and a CD10(-)/CD24(-)/CD65s(+)/CD15(+) B-cell phenotypeS Schwartz
Medizinische Klinik III, , Onkologie und Transfusionsmedizin, Klinikum Benjamin Franklin, , Berlin, Germany
Leukemia 17:1589-95. 2003..As NG2 is negative in non-malignant hematopoietic cells, this novel antigen might also serve in future studies as a powerful marker in monitoring minimal residual disease... - Insertional polymorphisms of endogenous HERV-K113 and HERV-K115 retroviruses in breast cancer patients and age-matched controlsThomas Burmeister
Medizinische Klinik III, , 12200 Berlin, Germany
AIDS Res Hum Retroviruses 20:1223-9. 2004..This suggests that the two HERV-Ks do not play a pathogenetic role in the majority of breast cancer patients, though they may be involved in a minority of patients. The results are discussed... - Intramedullary abscess in a patient with disseminated Scedosporium apiospermum infectionThomas Fietz
Free University of Berlin, University Hospital Benjamin Franklin, Department of Medicine III, Berlin, Germany
Br J Haematol 120:724. 2003 - Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)Barbara Wassmann
Department of Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany
Blood 108:1469-77. 2006..Both schedules of imatinib have acceptable toxicity and facilitate SCT in CR1 in the majority of patients, but concurrent administration of imatinib and chemotherapy has greater antileukemic efficacy... - A 57-nucleotide upstream early polyadenylation element in human papillomavirus type 16 interacts with hFip1, CstF-64, hnRNP C1/C2, and polypyrimidine tract binding proteinXiaomin Zhao
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
J Virol 79:4270-88. 2005..These mRNAs would therefore be more efficiently translated into E1 and E4 than previously described HPV-16 E1 and E4 mRNAs on which E1 and E4 are preceded by both E6 and E7 AUGs... - Cell lineage assignment of cytogenetic findings in acute lymphoblastic leukemia using combined immunomagnetic cell separation and chromosome preparationHarald Rieder
Haematologica 88:1317-20. 2003..We used a combination of immunomagnetic cell separation and chromosome preparation (ICSCP) to focus on the metaphases of interest and to assign the chromosome findings to CD19+ or CD7+ leukemia cells... - Identification of a 17-nucleotide splicing enhancer in HPV-16 L1 that counteracts the effect of multiple hnRNP A1-binding splicing silencersXiaomin Zhao
Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Husargatan 3, Box 582, 751 23 Uppsala, Sweden
Virology 369:351-63. 2007..hnRNP A1 is undetectable in terminally differentiated cells that can express HPV-16 late genes, which supports the conclusion that high levels of hnRNP A1 inhibit HPV-16 L1 expression... - HPV-16 L1 genes with inactivated negative RNA elements induce potent immune responsesErik Rollman
Department of Virology, Swedish Institute for Infectious Disease Control, Solna, Sweden
Virology 322:182-9. 2004..The modified HPV-16 L1 DNA that induced anti-HPV-16 immunity may be seen as a complementary approach to protein subunit immunization against papillomavirus... - Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHRWalter Raasch
Institute of Experimental and Clinical Pharmacology and Toxicology, University Clinic of Schleswig Holstein, Campus Lubeck, Germany
J Hypertens 22:611-8. 2004..03-10 mg/kg per day), the calcium-antagonist mibefradil (1-150 mg/kg per day) or combinations thereof. Systolic blood pressure (SBP), left ventricular weight (LVW) and the cardiac activity/mRNA levels of ACE were determined... - Patients' age and BCR-ABL frequency in adult B-precursor ALL: a retrospective analysis from the GMALL study groupThomas Burmeister
Blood 112:918-9. 2008