Florian Schlagenhauf

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Charite University Medical Center, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Psychopharmacology (Berl) 196:673-84. 2008
  2. doi request reprint Striatal dysfunction during reversal learning in unmedicated schizophrenia patients
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Germany Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Electronic address
    Neuroimage 89:171-80. 2014
  3. doi request reprint Switching schizophrenia patients from typical neuroleptics to aripiprazole: effects on working memory dependent functional activation
    Florian Schlagenhauf
    Department of Psychiatry, Charite Universitaetsmedizin Berlin, Campus Mitte, Germany
    Schizophr Res 118:189-200. 2010
  4. doi request reprint Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
    Biol Psychiatry 65:1032-9. 2009
  5. doi request reprint Switching schizophrenia patients from typical neuroleptics to olanzapine: effects on BOLD response during attention and working memory
    Florian Schlagenhauf
    Department of Psychiatry, Charite Universitaetsmedizin Berlin, Campus Mitte, Germany
    Eur Neuropsychopharmacol 18:589-99. 2008
  6. doi request reprint Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics
    Anne Beck
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Biol Psychiatry 66:734-42. 2009
  7. doi request reprint 5-HTT genotype effect on prefrontal-amygdala coupling differs between major depression and controls
    Eva Friedel
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Psychopharmacology (Berl) 205:261-71. 2009
  8. ncbi request reprint Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics
    Georg Juckel
    Department of Psychiatry, Charite University Medical Center, Campus Charité Mitte CCM, Schumannstr 20 21, Berlin 10117, Germany
    Psychopharmacology (Berl) 187:222-8. 2006
  9. doi request reprint Childhood methylphenidate treatment of ADHD and response to affective stimuli
    Lorna Schlochtermeier
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Neuropsychopharmacol 21:646-54. 2011
  10. doi request reprint A preliminary study of increased amygdala activation to positive affective stimuli in mania
    Felix Bermpohl
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Bipolar Disord 11:70-5. 2009

Detail Information

Publications32

  1. ncbi request reprint Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Charite University Medical Center, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Psychopharmacology (Berl) 196:673-84. 2008
    ..This may not be the case with newer neuroleptics such as olanzapine, which show less dopamine D2 receptor blockade and a faster off-rate from the receptor...
  2. doi request reprint Striatal dysfunction during reversal learning in unmedicated schizophrenia patients
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Germany Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Electronic address
    Neuroimage 89:171-80. 2014
    ..This result highlights VS dysfunction is tightly linked to a reward-related reversal learning deficit in early, unmedicated schizophrenia patients. ..
  3. doi request reprint Switching schizophrenia patients from typical neuroleptics to aripiprazole: effects on working memory dependent functional activation
    Florian Schlagenhauf
    Department of Psychiatry, Charite Universitaetsmedizin Berlin, Campus Mitte, Germany
    Schizophr Res 118:189-200. 2010
    ..However, little is known about specific medication effects on the modulation of frontal activation during WM performance...
  4. doi request reprint Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
    Biol Psychiatry 65:1032-9. 2009
    ..Increased attribution of incentive salience to neutral or aversive stimuli might be associated with dysfunction of neuronal processing of positive and negative reinforcement and contribute to the formation of delusions in schizophrenia...
  5. doi request reprint Switching schizophrenia patients from typical neuroleptics to olanzapine: effects on BOLD response during attention and working memory
    Florian Schlagenhauf
    Department of Psychiatry, Charite Universitaetsmedizin Berlin, Campus Mitte, Germany
    Eur Neuropsychopharmacol 18:589-99. 2008
    ..However, medication status had influences on the activation during attentional task (0-back), emphasizing the importance of baseline selection in pharmacological fMRI studies...
  6. doi request reprint Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics
    Anne Beck
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Biol Psychiatry 66:734-42. 2009
    ..We explored whether functional brain activation during anticipation of incentive stimuli is associated with impulsiveness in detoxified alcoholics and healthy control subjects...
  7. doi request reprint 5-HTT genotype effect on prefrontal-amygdala coupling differs between major depression and controls
    Eva Friedel
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Psychopharmacology (Berl) 205:261-71. 2009
    ..This prefrontal-limbic interaction has been shown to be modulated by serotonin (5-HTT) genotype, indicating a higher risk for major depressive disorder (MDD) with increasing number of 5-HTT low-expression alleles...
  8. ncbi request reprint Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics
    Georg Juckel
    Department of Psychiatry, Charite University Medical Center, Campus Charité Mitte CCM, Schumannstr 20 21, Berlin 10117, Germany
    Psychopharmacology (Berl) 187:222-8. 2006
    ..Dysfunction of the dopaminergic reward system may contribute to negative symptoms in schizophrenia...
  9. doi request reprint Childhood methylphenidate treatment of ADHD and response to affective stimuli
    Lorna Schlochtermeier
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Neuropsychopharmacol 21:646-54. 2011
    ..Further prospective studies need to clarify direct and indirect mechanisms of MPH treatment that may contribute to emotional processing, which is dysfunctional in males without pharmacological treatment in childhood...
  10. doi request reprint A preliminary study of increased amygdala activation to positive affective stimuli in mania
    Felix Bermpohl
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Bipolar Disord 11:70-5. 2009
    ..The present study in hypomanic and manic patients explored how amygdala responses to affective stimuli depend on the valence of the stimuli presented...
  11. pmc Ventral striatal prediction error signaling is associated with dopamine synthesis capacity and fluid intelligence
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Germany
    Hum Brain Mapp 34:1490-9. 2013
    ....
  12. doi request reprint Context insensitivity during positive and negative emotional expectancy in depression assessed with functional magnetic resonance imaging
    Melanie Feeser
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Psychiatry Res 212:28-35. 2013
    ..This hyporeactivity may contribute to clinical features like anergia, apathy, and loss of motivation in the context of both positive and negative incentives...
  13. doi request reprint Ventral striatal activation during reward processing in subjects with ultra-high risk for schizophrenia
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany
    Neuropsychobiology 66:50-6. 2012
    ....
  14. ncbi request reprint Different neural systems adjust motor behavior in response to reward and punishment
    Jana Wrase
    Department of Psychiatry, Charité Universitätsmedizin Berlin Charité Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Neuroimage 36:1253-62. 2007
    ..Our results provide evidence that different but somewhat overlapping circuits mediate the same behavioral adaptation when it is driven by different incentive outcomes...
  15. pmc Dopaminergic dysfunction in schizophrenia: salience attribution revisited
    Andreas Heinz
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Charite Campus Mitte, 10117 Berlin, Germany
    Schizophr Bull 36:472-85. 2010
    ....
  16. doi request reprint Hyporeactivity of ventral striatum towards incentive stimuli in unmedicated depressed patients normalizes after treatment with escitalopram
    Meline Stoy
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Psychopharmacol 26:677-88. 2012
    ..These findings suggest that MDD patients show ventral striatal hyporesponsiveness during incentive cue processing, which normalizes after successful treatment...
  17. pmc Regional patterns and clinical correlates of basal ganglia morphology in non-medicated schizophrenia
    Martina Ballmaier
    Department of Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany
    Schizophr Res 106:140-7. 2008
    ....
  18. doi request reprint Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipation
    Katharina Schmack
    Department of Psychiatry, Charite University Medicine, Chariteplatz 1, 10117 Berlin, Germany
    Neuroimage 42:1631-8. 2008
    ..Current evidence and our results are compatible with an interpretation that construes this effect of COMT genotype on striatal reactivity as a result of a cortico-striatal interaction...
  19. ncbi request reprint Altered amygdala activation in schizophrenia patients during emotion processing
    Anne Pankow
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Germany Electronic address
    Schizophr Res 150:101-6. 2013
    ..These results might represent a correlate of altered emotional experience in schizophrenia patients who are known to report less positive and more negative affective states in daily life situations...
  20. doi request reprint Effect of brain structure, brain function, and brain connectivity on relapse in alcohol-dependent patients
    Anne Beck
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin, Campus Mitte, Berlin, Germany
    Arch Gen Psychiatry 69:842-52. 2012
    ..In alcohol-dependent patients, brain atrophy and functional brain activation elicited by alcohol-associated stimuli may predict relapse. However, to date, the interaction between both factors has not been studied...
  21. doi request reprint Reward processing in male adults with childhood ADHD--a comparison between drug-naïve and methylphenidate-treated subjects
    Meline Stoy
    Department of Psychiatry and Psychotherapy Campus Charité Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Psychopharmacology (Berl) 215:467-81. 2011
    ..Dysfunctional reward processing has been proposed as a main deficit in attention-deficit/hyperactivity disorder (ADHD), which could be modulated by treatment with methylphenidate (MPH)...
  22. doi request reprint Dopamine in amygdala gates limbic processing of aversive stimuli in humans
    Thorsten Kienast
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Nat Neurosci 11:1381-2. 2008
    ..Our results suggest that individual dopamine storage capacity in amygdala subserves modulation of emotional processing in amygdala and dorsal cingulate, thereby contributing to individual differences in anxious temperament...
  23. doi request reprint Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia
    Lorenz Deserno
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Neurosci 32:12-20. 2012
    ..Moreover, this study in a large sample of patients reveals a mechanism underlying prefrontal inefficiency and cognitive deficits in schizophrenia, thereby providing direct experimental evidence for the dysconnectivity hypothesis...
  24. ncbi request reprint Dysfunction of ventral striatal reward prediction in schizophrenia
    Georg Juckel
    Department of Psychiatry, Charite University Medical Center, Campus Charite Mitte, CCM, Schumannstr 20 21, 10117 Berlin, Germany
    Neuroimage 29:409-16. 2006
    ..We used functional magnetic resonance imaging (fMRI) to assess the BOLD response in the ventral striatum of unmedicated schizophrenics during presentation of reward-indicating and loss-indicating stimuli...
  25. ncbi request reprint Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics
    Jana Wrase
    Department of Psychiatry and Psychotherapy, Charite, Universitatsmedizin Berlin, Charité Campus Mitte CCM, Berlin, Germany
    Neuroimage 35:787-94. 2007
    ..This may lead alcoholics to crave the pharmacological effects of alcohol to a greater extent than other conventional rewards. The present study investigated neural mechanisms underlying these phenomena...
  26. ncbi request reprint Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder
    Andreas Strohle
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Neuroimage 39:966-72. 2008
    ..These findings suggest that male adults with ADHD show neural signs of abnormal reward processing. Future studies will have to investigate whether these dysfunctional patterns might be normalized by treatment...
  27. doi request reprint Implicit motivational value and salience are processed in distinct areas of orbitofrontal cortex
    Marcus Rothkirch
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Chariteplatz 1, D 10117 Berlin, Germany
    Neuroimage 62:1717-25. 2012
    ....
  28. doi request reprint Decline in prefrontal catecholamine synthesis explains age-related changes in cognitive speed beyond regional grey matter atrophy
    Jan Kalbitzer
    Department of Psychiatry and Psychotherapy, Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Eur J Nucl Med Mol Imaging 39:1462-6. 2012
    ..Age-related decline in cognitive speed has been associated with prefrontal dopamine D1 receptor availability, but the contribution of presynaptic dopamine and noradrenaline innervation to age-related changes in cognition is unknown...
  29. doi request reprint Regional cerebral glucose metabolism and anxiety symptoms in bipolar depression: effects of levothyroxine
    Michael Bauer
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Psychiatry Res 181:71-6. 2010
    ..Results indicate that comorbid anxiety symptoms have specific regional cerebral metabolic correlates in bipolar depression and cannot only be explained exclusively by the depressive state of the patients...
  30. pmc Hemispheric asymmetry for affective stimulus processing in healthy subjects--a fMRI study
    Esther Beraha
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    PLoS ONE 7:e46931. 2012
    ..However, experimental evidence for these hypotheses remains inconclusive, partly because direct comparisons between hemispheres are scarce...
  31. doi request reprint Novelty seeking modulates medial prefrontal activity during the anticipation of emotional stimuli
    Felix Bermpohl
    Berenson Allen Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Psychiatry Res 164:81-5. 2008
    ..BOLD responses to emotional expectancy were positively correlated with novelty-seeking scores in the medial prefrontal cortex. This correlation was strongest for the sub-dimension of exploratory excitability...
  32. ncbi request reprint Orbitofrontal cortical dysfunction in akinetic catatonia: a functional magnetic resonance imaging study during negative emotional stimulation
    Georg Northoff
    University of Magdeburg, Department of Psychiatry, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Schizophr Bull 30:405-27. 2004
    ..Because we investigated postacute patients, orbitofrontal cortical alterations may be interpreted as a trait marker predisposing for development of catatonic syndrome in schizophrenic or affective psychosis...