Genomes and Genes
N E Savaskan
Affiliation: Humboldt University
- Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitisOrhan Aktas
Institute of Neuroimmunology, Neuroscience Research Center, Charite, Berlin, Germany
J Immunol 173:5794-800. 2004..Thus, a natural green tea constituent may open up a new therapeutic avenue for young disabled adults with inflammatory brain disease by combining, on one hand, anti-inflammatory and, on the other hand, neuroprotective capacities...
- Impaired postnatal development of hippocampal neurons and axon projections in the Emx2-/- mutantsNicolai E Savaskan
Department of Cell and Neurobiology, Institute of Anatomy, Berlin, Germany
J Neurochem 83:1196-207. 2002..Our data indicate that Emx2 is essential for the terminal differentiation of granular cells and the correct formation of extrinsic and intrinsic hippocampal connections...
- Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene familyNicolai E Savaskan
PRGs Research Group, Institute of Cell Biology and Neurobiology, Center for Anatomy, Philippstrasse 12, Charité University Medical School Berlin, D 10115 Berlin, Germany
Eur J Neurosci 19:212-20. 2004..In summary, our findings feature a new member of the PRG family which shows dynamic expression regulation during brain development and neuronal excitation...
- Entorhinal cortex lesion studied with the novel dye fluoro-jadeN E Savaskan
Department of Cell and Neurobiology, Institute of Anatomy, Humboldt University Hospital Charité, Philippstr 12, 10115, Berlin, Germany
Brain Res 864:44-51. 2000..We conclude that Fluoro-Jade is an early and sensitive marker for studying degenerating neurites in the hippocampal system...
- Molecules involved in reactive sprouting in the hippocampusN E Savaskan
The Institute of Anatomy, Department of Cell and Neurobiology, Humboldt University Medical School Charité, Berlin, Germany
Rev Neurosci 12:195-215. 2001..Isolation and analysis of the molecules involved in these mechanisms are important steps in understanding the potential and limitations of regeneration in the CNS...
- Selenium deficiency increases susceptibility to glutamate-induced excitotoxicityNicolai E Savaskan
Institute of Anatomy, Department of Cell and Neurobiology, Humboldt University Medical School Charité, D 10115 Berlin, Germany
FASEB J 17:112-4. 2003..These findings indicate the importance of selenium for prevention and therapy of excitotoxic brain damage...
- Perforant path lesion induces up-regulation of stathmin messenger RNA, but not SCG10 messenger RNA, in the adult rat hippocampusA U Bräuer
Department of Cell Biology and Neurobiology, Humboldt University Medical School Charité, Institute of Anatomy, Philippstr 12, 10115, Berlin, Germany
Neuroscience 102:515-26. 2001..The present study provides evidence that the induction of specific growth-associated proteins is differentially regulated in the hippocampus...
- Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesionA U Bräuer
Department of Cell and Neurobiology, Humboldt University Hospital, Charite, Institute of Anatomy, 10115 Berlin, Germany
FASEB J 15:2689-701. 2001..Hence, denervation of the hippocampus decreases HCN1 and concomitantly the Ih activity in hilar neurons, and the recovery of h-current activation kinetics occurs parallel to postlesion sprouting...
- Target- and maturation-specific membrane-associated molecules determine the ingrowth of entorhinal fibers into the hippocampusT Skutella
Institute of Anatomy, Department of Cell and Neurobiology, Humboldt University Hospital Charité, Berlin, 10098, Germany
Dev Biol 211:277-92. 1999..The data presented demonstrate that outgrowth of entorhinal fibers on hippocampal membranes is target and maturation dependent...
- A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targetingE Stein
Institute of Anatomy, Department of Cell and Neurobiology, Humboldt University Hospital Charité, 10098 Berlin, Germany
J Neurosci 19:8885-93. 1999....
- Myelination in the hippocampus during development and following lesionS Meier
Institute of Cell Biology and Neurobiology, Center for Anatomy, Charité University Medical School Berlin, Philippstr 12, 10115, Berlin, Germany
Cell Mol Life Sci 61:1082-94. 2004..Therefore, our quantitative analysis of mature axons and myelination effectively reflects the readjusted axonal density and possible electrophysiological balance following lesion...
- A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sproutingAnja U Bräuer
Institute of Anatomy, Department of Cell Biology and Neurobiology, Philippstr 12, Humboldt University Medical School Charité, D 10115 Berlin, Germany
Nat Neurosci 6:572-8. 2003..Thus, we propose a novel mechanism by which axons are able to control phospholipid-mediated signaling and overcome the growth-inhibiting, phospholipid-rich environment of the extracellular space...
- Cholecystokinin expression after hippocampal deafferentiation: molecular evidence revealed by differential display-reverse transcription-polymerase chain reactionA U Bräuer
Department of Cell and Neurobiology, Oskar Hertwig House, Humboldt University Medical School Charité, Philippstrasse 12, Philippstrasse 12, D 10115 Berlin, Germany
Neuroscience 121:111-21. 2003....
- Identification of neuronal cell death in a model of degeneration in the hippocampusIlker Y Eyupoglu
Institute of Anatomy, Department of Cell and Neurobiology, Charité Campus Miffe, Humboldt University Medical School Charité, 10098 Berlin, Germany
Brain Res Brain Res Protoc 11:1-8. 2003..Treatment of microglial and BV-2 cells with an excess of L-glutamate induces cell death which could be detected by propidium iodide staining, but not by Fluoro-Jade, demonstrating its specificity to monitor neuronal cell death...
- The neurobiology of selenium: lessons from transgenic miceUlrich Schweizer
Neurobiology of Selenium, Neuroscience Research Center, Charité University Medical School Berlin, Germany
J Nutr 134:707-10. 2004..Given that genes for at least 25 selenoproteins have been identified in the human genome, and most of these are expressed in the brain, their specific roles for normal brain function and neurological diseases remain to be elucidated...
- Molecular actions of selenium in the brain: neuroprotective mechanisms of an essential trace elementAnja U Bräuer
Institute of Cell Biology and Neurobiology, Center for Anatomy, Charite University Medical School, Berlin, Germany
Rev Neurosci 15:19-32. 2004..Understanding the mechanisms of selenium action will be crucial to determining its potential as a preventive and therapeutic agent against excitatory brain damage...
- Molecular analysis of Nogo expression in the hippocampus during development and following lesion and seizureSusan Meier
Institute of Anatomy, Department of Cell Biology and Neurobiology, Humboldt University Hospital Charité, Oskar Hertwig House, Philippstr 12, Berlin, 10098 Germany
FASEB J 17:1153-5. 2003....
- Selenium and brain function: a poorly recognized liaisonUlrich Schweizer
Neurobiology of Selenium, Neuroscience Research Center, Charite, University Medical School, Berlin, Germany
Brain Res Brain Res Rev 45:164-78. 2004..Here we review the role of Se for the brain under physiological as well as pathophysiological conditions and highlight recent findings which open new vistas on an old essential trace element...
- Dissection of mitogenic and neurodegenerative actions of cystine and glutamate in malignant gliomasN E Savaskan
Institute of Cell Biology and Neurobiology, Charite Universitatsmedizin Berlin, Berlin, Germany
Oncogene 30:43-53. 2011....
- Identification of macrophage/microglia activation factor (MAF) associated with late endosomes/lysosomes in microglial cellsAnja U Bräuer
Institute of Cell Biology and Neurobiology, Center for Anatomy, Charité University Medical School Berlin, Philippstr 12, D 10115 Berlin, Germany
FEBS Lett 563:41-8. 2004..In conclusion, these results imply that MAF is involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion...
- Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesionMichael Schafer
Max Delbrueck Centre for Molecular Medicine, Developmental Neurobiology Group, D 13092 Berlin, Germany
Mol Cell Neurosci 29:580-90. 2005..These results suggest a function for neurotractin/kilon as a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation...
- The role of phospholipid hydroperoxide glutathione peroxidase isoforms in murine embryogenesisAstrid Borchert
Institute of Biochemistry, University Medicine Berlin Charite, Monbijoustrasse 2, D 10117 Berlin, Germany
J Biol Chem 281:19655-64. 2006..These findings may explain in part intrauterine lethality of GPx4 knock-out mice...
- Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticityGergana P Peeva
Department of Anatomy I, University of Cologne, Germany
Eur J Neurosci 24:2152-62. 2006..Our findings suggest that enhanced plasticity in the CNS and an augmented regenerative response of the injured motoneurons contribute to better functional recovery in blind rats...
- Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammalsYan Zhang
Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588, USA
J Biol Chem 283:2427-38. 2008..Overall, this study suggests that the main functions of selenium in mammals are confined to certain neurons in the brain...
- The role of selenite on microglial migrationLisa Dalla Puppa
Hahn Meitner Institute, Department of Molecular Trace Element Research in the Life Sciences, Glienicker Str 100, 14109 Berlin, Germany
Ann N Y Acad Sci 1096:179-83. 2007..Thus, the antimigratory effects of selenium may attenuate the secondary cell death cascade by preventing microglial invasion...
- Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injuryNicolai E Savaskan
Division of Cellular Biochemistry, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Free Radic Biol Med 43:191-201. 2007..We hypothesize that astrocytic upregulation of GPx4 in response to injury is part of a protective cascade counteracting further cell damage...
- Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural functionNicolai E Savaskan
Division of Cellular Biochemistry, The Netherlands Cancer Institute, NL 1066 CX Amsterdam, The Netherlands
Biol Chem 388:1007-17. 2007..Here we review recent findings on GPx4 with emphasis on its molecular structure and function and consider potential mechanisms that underlie neural development and neuropathological conditions...
- Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275Ilker Y Eyupoglu
Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
Mol Cancer Ther 5:1248-55. 2006..Furthermore, its propensity to pass the blood-brain barrier and to increase the protein level of acetylated histone H3 in brain tissue identifies MS-275 as a promising candidate drug in the treatment of malignant gliomas...