A S Sarrafzadeh

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Matrix metalloproteinase-9 concentration in the cerebral extracellular fluid of patients during the acute phase of aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Faculty of Medicine, University of Geneva, Switzerland
    Neurol Res 34:455-61. 2012
  2. doi request reprint Cerebral glucose and spreading depolarization in patients with aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Department of Neurosurgery, Charite University Medicine, Berlin, Germany
    Acta Neurochir Suppl 115:143-7. 2013
  3. pmc Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage
    Florian Schlenk
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Augustenburger Platz, 13353 Berlin, Germany
    Crit Care 12:R9. 2008
  4. pmc Cerebral microdialysis for detection of bacterial meningitis in aneurysmal subarachnoid hemorrhage patients: a cohort study
    Florian Schlenk
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Crit Care 13:R2. 2009
  5. pmc Imaging of hypoxic-ischemic penumbra with (18)F-fluoromisonidazole PET/CT and measurement of related cerebral metabolism in aneurysmal subarachnoid hemorrhage
    Asita S Sarrafzadeh
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Cereb Blood Flow Metab 30:36-45. 2010
  6. doi request reprint Relevance of cerebral interleukin-6 after aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Department of Neurosurgery, Campus Virchow Medical Center, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Neurocrit Care 13:339-46. 2010
  7. doi request reprint Immunodepression after aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Stroke 42:53-8. 2011
  8. ncbi request reprint [Aneurysmal subarachnoid hemorrhage. Significance and complications]
    A S Sarrafzadeh
    Campus Virchow Klinikum, Klinik für Neurochirurgie, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin
    Anaesthesist 56:957-66; quiz 967. 2007
  9. ncbi request reprint Bedside microdialysis for early detection of cerebral hypoxia in traumatic brain injury
    A S Sarrafzadeh
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Humboldt University of Berlin, Germany
    Neurosurg Focus 9:e2. 2000
  10. ncbi request reprint Ibn Sina (Avicenna). Historical note
    A S Sarrafzadeh
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Humboldt University, Museum of Islamic Art, Berlin, Germany
    Neurosurg Focus 11:E5. 2001

Detail Information

Publications27

  1. doi request reprint Matrix metalloproteinase-9 concentration in the cerebral extracellular fluid of patients during the acute phase of aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Faculty of Medicine, University of Geneva, Switzerland
    Neurol Res 34:455-61. 2012
    ..The authors investigated MMP-9 concentration in brain extracellular fluid of aSAH patients and assessed whether this enzyme could have a predictive value for the risk of DCI...
  2. doi request reprint Cerebral glucose and spreading depolarization in patients with aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Department of Neurosurgery, Charite University Medicine, Berlin, Germany
    Acta Neurochir Suppl 115:143-7. 2013
    ..Rapid-sampling MD techniques and analyses of SD clusters may elucidate more detail of the relationship between SD and brain energy metabolism...
  3. pmc Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage
    Florian Schlenk
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Augustenburger Platz, 13353 Berlin, Germany
    Crit Care 12:R9. 2008
    ..The aim of this study was to determine the effect of insulin treatment for glucose control on cerebral metabolism in SAH patients...
  4. pmc Cerebral microdialysis for detection of bacterial meningitis in aneurysmal subarachnoid hemorrhage patients: a cohort study
    Florian Schlenk
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Crit Care 13:R2. 2009
    ..Microdialysis (MD) is a technique for monitoring cerebral metabolism in patients with SAH. A cohort study was performed to investigate the value of MD for the diagnosis of BM...
  5. pmc Imaging of hypoxic-ischemic penumbra with (18)F-fluoromisonidazole PET/CT and measurement of related cerebral metabolism in aneurysmal subarachnoid hemorrhage
    Asita S Sarrafzadeh
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Cereb Blood Flow Metab 30:36-45. 2010
    ..This technique has the potential to improve our understanding of the role of cellular hypoxia in aneurysmal SAH...
  6. doi request reprint Relevance of cerebral interleukin-6 after aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Department of Neurosurgery, Campus Virchow Medical Center, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Neurocrit Care 13:339-46. 2010
    ....
  7. doi request reprint Immunodepression after aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Stroke 42:53-8. 2011
    ..This pilot study aimed to assess the presence of immunodepression and its association with infections after aSAH...
  8. ncbi request reprint [Aneurysmal subarachnoid hemorrhage. Significance and complications]
    A S Sarrafzadeh
    Campus Virchow Klinikum, Klinik für Neurochirurgie, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin
    Anaesthesist 56:957-66; quiz 967. 2007
    ..Possible neuromonitoring techniques to improve diagnosis and therapy for treatment of symptomatic vasospasm as well as extracranial complications are discussed...
  9. ncbi request reprint Bedside microdialysis for early detection of cerebral hypoxia in traumatic brain injury
    A S Sarrafzadeh
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Humboldt University of Berlin, Germany
    Neurosurg Focus 9:e2. 2000
    ..The authors evaluated the use of bedside cerebral online microdialysis for the detection of impending and present cerebral hypoxia in patients who had sustained traumatic brain injury...
  10. ncbi request reprint Ibn Sina (Avicenna). Historical note
    A S Sarrafzadeh
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Humboldt University, Museum of Islamic Art, Berlin, Germany
    Neurosurg Focus 11:E5. 2001
    ..In this article the authors present a unique picture of the neurosurgical technique of Ibn Sina and briefly summarize his life and work...
  11. ncbi request reprint Cerebral metabolism and intracranial hypertension in high grade aneurysmal subarachnoid haemorrhage patients
    A S Sarrafzadeh
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Humboldt University of Berlin, Berlin, Germany
    Acta Neurochir Suppl 95:89-92. 2005
    ..We concluded that intracranial hypertension in associated with an anaerobic cerebral metabolism indicated cerebral ischemia in high grade SAH patients...
  12. ncbi request reprint Poor-grade aneurysmal subarachnoid hemorrhage: relationship of cerebral metabolism to outcome
    Asita Sarrafzadeh
    Department of Neurosurgery and Institute of Medical Biometry, Charite Virchow Medical Center, Humboldt University of Berlin, Germany
    J Neurosurg 100:400-6. 2004
    ....
  13. ncbi request reprint Cerebral ischemia in aneurysmal subarachnoid hemorrhage: a correlative microdialysis-PET study
    Asita S Sarrafzadeh
    Charité Campus Virchow Medical Clinic, Humboldt University of Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Stroke 35:638-43. 2004
    ..The main objective of this study was to investigate whether pathological MD parameters reflect a reduced regional CBF (rCBF) determined by 15O-H2O PET...
  14. ncbi request reprint Metabolic changes during impending and manifest cerebral hypoxia in traumatic brain injury
    A S Sarrafzadeh
    Department of Neurosurgery, Charite Virchow Medical Center, Humboldt University of Berlin, Germany
    Br J Neurosurg 17:340-6. 2003
    ..A PtiO2 < 10 mmHg can induce metabolic changes with increase of glutamate and lactate. The presence of anaerobic cerebral metabolism probably depends on duration and severity of the hypoxic episode...
  15. ncbi request reprint Secondary insults in severe head injury--do multiply injured patients do worse?
    A S Sarrafzadeh
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Humboldt University Berlin, Austenburger Platz 1, 13353 Berlin, Germany
    Crit Care Med 29:1116-23. 2001
    ..To study the occurrence of secondary insults and the influence of extracranial injuries on cerebral oxygenation and outcome in patients with closed severe head injury (Glasgow Coma Scale score < or =8)...
  16. ncbi request reprint Bedside microdialysis: a tool to monitor cerebral metabolism in subarachnoid hemorrhage patients?
    Asita S Sarrafzadeh
    Clinic of Neurosurgery, Charité Campus Virchow Medical Clinic, Humboldt University of Berlin, Berlin, Germany
    Crit Care Med 30:1062-70. 2002
    ....
  17. ncbi request reprint Neuromonitoring: brain oxygenation and microdialysis
    Asita S Sarrafzadeh
    Department of Neurosurgery, Charité Campus Virchow Medical Clinic, Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Neurol Neurosci Rep 3:517-23. 2003
    ..Pitfalls of the techniques and their future potential are discussed...
  18. ncbi request reprint Acute focal neurological deficits in aneurysmal subarachnoid hemorrhage: relation of clinical course, CT findings, and metabolite abnormalities monitored with bedside microdialysis
    Asita Sarrafzadeh
    Department of Neurosurgery, Virchow Medical Clinic, Humboldt University of Berlin, Berlin, Germany
    Stroke 34:1382-8. 2003
    ....
  19. ncbi request reprint Role of bedside microdialysis in the diagnosis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage
    A W Unterberg
    Department of Neurosurgery and Radiology, Charite, Humboldt University, Berlin, Germany
    J Neurosurg 94:740-9. 2001
    ..The aims of the present study were to correlate clinical course, microdialysis-recorded data, transcranial Doppler (TCD) ultrasonography findings, and angiographic findings in patients with SAH...
  20. ncbi request reprint Detection of secondary insults by brain tissue pO2 and bedside microdialysis in severe head injury
    A S Sarrafzadeh
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Humboldt University of Berlin, Germany
    Acta Neurochir Suppl 81:319-21. 2002
    ..We conclude that early metabolic detection of cerebral hypoxia before a critical decrease in brain tissue PtiO2 is seen and possibly allows earlier changes in treatment (e.g. reduction of hyperventilation therapy)...
  21. ncbi request reprint Relation of cerebral energy metabolism and extracellular nitrite and nitrate concentrations in patients after aneurysmal subarachnoid hemorrhage
    O W Sakowitz
    Department of Neurosurgery, , Berlin, Germany
    J Cereb Blood Flow Metab 21:1067-76. 2001
    ..On the basis of the current findings, however, subsequent development of DIND cannot be explained by a lack of vasodilatory NO alone...
  22. ncbi request reprint Temporal profiles of extracellular nitric oxide metabolites following aneurysmal subarachnoid hemorrhage
    O W Sakowitz
    Department of Neurosurgery, Charite Humboldt University Berlin, Berlin, Germany
    Acta Neurochir Suppl 81:351-4. 2002
    ..This is in agreement with hypothetical NO scavenging by products of hemolysis. However, subsequent development of DIND cannot be explained by a lack of vasodilatory NO alone...
  23. ncbi request reprint Impact of hyperglycemia on neurological deficits and extracellular glucose levels in aneurysmal subarachnoid hemorrhage patients
    Antje Kerner
    Department of Neurosurgery, Virchow Medical Center, Universitatsmedizin Berlin, Germany
    Neurol Res 29:647-53. 2007
    ..The objective of this study was to investigate energy metabolism in the extracellular/cerebrospinal fluid and blood in relation to outcome...
  24. doi request reprint Relevance of intracranial hypertension for cerebral metabolism in aneurysmal subarachnoid hemorrhage. Clinical article
    Alexandra Nagel
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neurosurg 111:94-101. 2009
    ..Its impact on cerebral metabolism, ICP therapy, and outcome has rarely been studied in patients with aneurysmal subarachnoid hemorrhage (aSAH); such an assessment is the authors' goal in the present study...
  25. doi request reprint Inpatient hyperglycemia following aneurysmal subarachnoid hemorrhage: relation to cerebral metabolism and outcome
    Florian Schlenk
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurocrit Care 11:56-63. 2009
    ..This study aimed to identify a threshold for blood glucose predicting unfavorable outcome, and to evaluate differences in cerebral metabolism in normo and hyperglycemic SAH patients...
  26. ncbi request reprint Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations
    Jens P Dreier
    Department of Experimental Neurology and Neurology, Charite University Medicine, Berlin, Germany
    Brain 129:3224-37. 2006
    ..In view of experimental evidence and the present clinical results, we suggest that spreading depolarizations with prolonged depressions are a promising target for treatment development in SAH and ischaemic stroke...
  27. ncbi request reprint Effects of mannitol bolus administration on intracranial pressure, cerebral extracellular metabolites, and tissue oxygenation in severely head-injured patients
    Oliver W Sakowitz
    Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    J Trauma 62:292-8. 2007
    ....