Affiliation: Humboldt University
Salanova M, Gelfi C, Moriggi M, Vasso M, ViganÃ² A, Minafra L, et al
. Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis. FASEB J. 2014;28:4748-63 pubmed publisher
..RVE appears to be a highly efficient countermeasure protocol against muscle atrophy and ultrastructural and molecular dysregulation induced by chronic disuse. ..
Salanova M, Schiffl G, Rittweger J, Felsenberg D, Blottner D. Ryanodine receptor type-1 (RyR1) expression and protein S-nitrosylation pattern in human soleus myofibres following bed rest and exercise countermeasure. Histochem Cell Biol. 2008;130:105-18 pubmed publisher
..We conclude that following extended body deconditioning in bed rest, RVE countermeasure maintained normal RyR1 expression and nitrosylation patterns required for adequate E-CC in human performance control. ..
Salanova M, Schiffl G, Blottner D. Atypical fast SERCA1a protein expression in slow myofibers and differential S-nitrosylation prevented by exercise during long term bed rest. Histochem Cell Biol. 2009;132:383-94 pubmed publisher
..Exercise preserved myofiber type-specific SERCA1a expression and S-nitrosylation in VL and SOL in a different way, suggesting muscle-specific responses to the countermeasure protocol applied during bed rest. ..
Salanova M, Bortoloso E, Schiffl G, Gutsmann M, Belavy D, Felsenberg D, et al
. Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise. FASEB J. 2011;25:4312-25 pubmed publisher
..Homer2 is localized at the NMJ and is part of the calcineurin-NFATc1 signaling pathway. RVE has additional benefit over RE as countermeasure preventing disuse-induced neuromuscular maladaptation during bedrest. ..