Affiliation: Humboldt University
- [Diagnosis, prophylaxis and therapy of osteoporosis in juvenile idiopathic arthritis: consensus statement of the German Association for Pediatric Rheumatology]J Roth
Pädiatrische Pneumologie und Immunologie, SPZ Rheumatologie, Charite Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
Z Rheumatol 66:434-40. 2007..In this review, the diagnostic and therapeutic options are described and summarized in an algorithm...
- Musculoskeletal abnormalities in juvenile idiopathic arthritis--a 4-year longitudinal studyJ Roth
Charite Virchow Klinikum, SPZ Rheumatologie, Augustenburger Platz 1, 13353 Berlin, Germany
Rheumatology (Oxford) 46:1180-4. 2007..The most prominent changes are a reduction in muscle cross sectional area (CSA) and muscle force. The aim of this study was to assess the evolution of these changes throughout the course of the disease...
- Musculoskeletal abnormalities of the forearm in patients with juvenile idiopathic arthritis relate mainly to bone geometryJohannes Roth
University Children s Hospital, Tuebingen, Germany
Arthritis Rheum 50:1277-85. 2004..This study was undertaken to obtain a more detailed understanding of the musculoskeletal system in JIA by analyzing bone density, bone geometry, and muscle force as the most important factor in bone development...
- Osteoporosis in juvenile idiopathic arthritis--a practical approach to diagnosis and therapyJohannes Roth
Department of Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany
Eur J Pediatr 166:775-84. 2007..In this review, diagnostic and therapeutic options are being described and possibilities to incorporate them into clinical practice are suggested...
- Uncommon synovial cysts in childrenJohannes Roth
Pediatric Rheumatology, Charite Universitaetsmedizin, Berlin, Germany
Eur J Pediatr 165:178-81. 2006..Ultrasonography is the initial and follow-up imaging method of choice, which can be supplemented by MRI in unusual cases. Apart from treatment for arthritis, no specific therapeutic interventions were required in the present cases...
- The clinical course of a child with CINCA/NOMID syndrome improved during and after treatment with thalidomideT Kallinich
Department of Paediatrics, Pulmonology and Immunology, Charite University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
Scand J Rheumatol 34:246-9. 2005..We propose that thalidomide can be beneficial in select patients with CINCA syndrome...
- Neutrophil-derived S100A12 as novel biomarker of inflammation in familial Mediterranean feverTilmann Kallinich
Department of Pediatric Pneumology and Immunology, Charite Universitaetsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
Ann Rheum Dis 69:677-82. 2010..The aim of this study was to analyse the role of S100A12 in the detection of inflammation in patients with FMF...
- Panoramic X-rays. Comprehensive radiodiagnostics or radiation protection at all costs?Helga Landau
Department of Orthodontics and Dentofacial Orthopedics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, Germany
J Orofac Orthop 66:78-82. 2005..This example of juvenile idiopathic arthritis with TMJ involvement shows that visualization of the condylar processes is indispensable...
- Dynamics of body composition and bone in patients with juvenile idiopathic arthritis treated with growth hormoneSusanne Bechtold
Division of Pediatric Endocrinology, University Children s Hospital, D 80337 Munich, Germany
J Clin Endocrinol Metab 95:178-85. 2010..The objectives of this study were to demonstrate the effects of GH treatment on regional body composition and bone geometry at final height in patients with juvenile idiopathic arthritis (JIA)...
- Natural history of growth and body composition in juvenile idiopathic arthritisS Bechtold
Division of Pediatric Endocrinology, University Children s Hospital, Munich, Germany
Horm Res 72:13-9. 2009..In recent years, the deficits in bone mass have been related, in part, to the deficits in muscle mass, which are prevalent in these patients...
- Similar effects of long-term exogenous growth hormone (GH) on bone and muscle parameters: a pQCT study of GH-deficient and small-for-gestational-age (SGA) childrenRoland Schweizer
Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076, Tubingen, Germany
Bone 41:875-81. 2007..Treatment with GH in short children has focused on height development. Little is known about the concomitant changes in muscle mass, bone structure and bone strength...
- Determination of the peptide binding motif and high-affinity ligands for HLA-DQ4 using synthetic peptide librariesThomas Volz
University Children s Hospital, Tuebingen, Germany
Hum Immunol 65:594-601. 2004..It is, however, different from binding motifs of neutral or protective HLA-DQ molecules. Our results further support the idea of differential peptide presentation in the pathogenesis of oligoarthritic JIA...
- Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrationsDirk Foell
Institute of Experimental Dermatology and Department of Pediatrics, University of Muenster, Muenster, Germany
Arthritis Rheum 50:1286-95. 2004..The aim of our study was to determine neutrophil activation in juvenile rheumatoid arthritis (JRA) by analyzing S100A12 (EN-RAGE; calgranulin C), a proinflammatory protein secreted by human neutrophils...
- Acute Kawasaki disease is associated with reverse regulation of soluble receptor for advance glycation end products and its proinflammatory ligand S100A12Helmut Wittkowski
Interdisciplinary Centre for Clinical Research, Department of Pediatrics, University of Muenster, University Hospital, Albert Schweitzer Strasse 33, Muenster, Germany
Arthritis Rheum 56:4174-81. 2007..The aim of this study was to investigate circulating sRAGE in an acute inflammatory disorder and to compare these data directly with concentrations of the proinflammatory RAGE ligand S100A12...
- Effects of intra-articular corticosteroids and anti-TNF therapy on neutrophil activation in rheumatoid arthritisHelmut Wittkowski
Interdisciplinary Centre of Clinical Research, University of Munster, Röntgenstr 21, D 48149 Munster, Germany
Ann Rheum Dis 66:1020-5. 2007..The aim of this project was to analyse the effect of intra-articular corticosteroids or systemic anti-TNF treatment on synovial expression and serum levels of S100A12 in rheumatoid arthritis (RA)...
- Bone mass in adolescents with early-onset juvenile idiopathic arthritis: comment on the article by Lien et alJohannes Roth
Arthritis Rheum 50:2036. 2004
- Mechanisms of disease: a 'DAMP' view of inflammatory arthritisDirk Foell
Department of Pediatrics, University of Muenster, Muenster, Germany
Nat Clin Pract Rheumatol 3:382-90. 2007....
- Expression of myeloid-related protein-8 and -14 in patients with acute Kawasaki diseaseKeiich Hirono
Department of Pediatrics, Toyama University, Toyama, Japan
J Am Coll Cardiol 48:1257-64. 2006..This study investigated patients with acute Kawasaki disease (KD) to validate myeloid-related protein (MRP)-8/MRP-14 as a marker of disease activity and severity of coronary artery lesion development...
- Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytesJan Ehrchen
Institute of Experimental Dermatology, University of Muenster, Germany
Blood 109:1265-74. 2007..Thus, GC treatment did not cause a global suppression of monocytic effector functions but results in differentiation of a specific anti-inflammatory phenotype which seems to be actively involved in resolution of inflammatory reactions...
- Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cationsThomas Vogl
Institute of Experimental Dermatology, University of Muenster, Roentgenstrasse 21, 48149 Muenster, Germany
Biochim Biophys Acta 1763:1298-306. 2006..The zinc-induced tetramer is structurally very similar to the calcium-induced tetramer. Thus, like calcium, zinc acts as a regulatory factor in S100A8/S100A9-dependent signaling pathways...
- Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shockThomas Vogl
Institute of Experimental Dermatology, University of Munster, D 48129 Munster, Germany
Nat Med 13:1042-9. 2007..Therefore Mrp8-Mrp14 complexes are new inflammatory components that amplify phagocyte activation during sepsis upstream of TNFalpha-dependent effects...
- Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activityNadja Leukert
Institute of Experimental Dermatology, University of Muenster, Roentgenstr 21, 48149 Muenster, Germany
J Mol Biol 359:961-72. 2006..This is the first report showing a functional relevance of calcium-induced higher-order oligomerization in the S100 family...
- TNF induces distinct gene expression programs in microvascular and macrovascular human endothelial cellsDorothee Viemann
Department of Experimental Dermatology and Interdisciplinary Clinical Research Center, University of Munster, Röntgenstr 21, 48149 Munster, Germany
J Leukoc Biol 80:174-85. 2006..The establishment of EC type-specific expression patterns may thus provide the basis for a selective manipulation of specific endothelial subtypes in different inflammatory diseases...
- Increased perivascular synovial membrane expression of myeloid-related proteins in psoriatic arthritisDavid Kane
Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
Arthritis Rheum 48:1676-85. 2003....
- Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritisMichael Frosch
Institute of Experimental Dermatology and Department of Pediatrics, University of Munster, Munster, Germany
Arthritis Rheum 48:2622-6. 2003....
- Expression of MRP8 and MRP14 by macrophages is a marker for severe forms of glomerulonephritisMichael Frosch
Institute of Experimental Dermatology, University of Munster, Röntgenstr 21, D 48149, Munster, Germany
J Leukoc Biol 75:198-206. 2004..In addition, our findings reflect differences in the inflammatory mechanisms underlying the various forms of GN, as they revealed that distinct macrophage subpopulations prevail in the different forms of GN...
- Transcriptional profiling of IKK2/NF-kappa B- and p38 MAP kinase-dependent gene expression in TNF-alpha-stimulated primary human endothelial cellsDorothee Viemann
Department of Experimental Dermatology, University Hospital Munster, Muenster, Germany
Blood 103:3365-73. 2004..Thus, these results define a list of primary candidates for targeted modulation of endothelial functions during inflammation...
- High expression of myeloid-related proteins 8 and 14 characterizes an inflammatorily active but ineffective response of macrophages during leprosyCord H Sunderkötter
Institute of Experimental Dermatology, University of Munster, Munster, Germany
Immunology 111:472-80. 2004....
- Phagocyte-specific calcium-binding S100 proteins as clinical laboratory markers of inflammationDirk Foell
Department of Pediatrics, University of Munster, Munster, Germany
Clin Chim Acta 344:37-51. 2004..In this review, pro-inflammatory functions of S100 proteins and their usefulness as biomarkers of inflammation are presented...
- Neutrophil-derived S100A12 is profoundly upregulated in the early stage of acute Kawasaki diseaseFei Ye
Department of Pediatrics, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0134, Japan
Am J Cardiol 94:840-4. 2004..S100A12 expression in neutrophils appears to reflect responsiveness to IVIG treatment and is possibly involved in the pathophysiology of acute vasculitis...
- Proinflammatory S100 proteins in arthritis and autoimmune diseaseDirk Foell
Interdisciplinary Center for Clinical Research, University of Muenster, Muenster, Germany
Arthritis Rheum 50:3762-71. 2004
- Differential expression and response to anti-TNFalpha treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritisLeen De Rycke
Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
J Pathol 206:17-27. 2005....
- Early activation of cutaneous vessels and epithelial cells is characteristic of acute systemic onset juvenile idiopathic arthritisMichael Frosch
Institute of Experimental Dermatology, University of Munster, Germany
Exp Dermatol 14:259-65. 2005..Their differential expression further points to distinct roles of the individual molecules in inflammatory processes...
- Systemic juvenile rheumatoid arthritis: cognitive function and social adjustmentReinhold Feldmann
Department of Pediatrics, University Hospital of Munster, Munster, Germany
Ann Neurol 58:605-9. 2005..Cognitive performance and social adjustment of young patients with SJRA are not affected by disease activity and duration...
- Expression of surfactant protein-C, S100A8, S100A9, and B cell markers in renal allografts: investigation of the prognostic valueMichael Eikmans
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
J Am Soc Nephrol 16:3771-86. 2005..Messenger RNA transcripts complement the biopsy in the prediction of graft function deterioration...
- Immunomodulatory effects of etanercept on peripheral joint synovitis in the spondylarthropathiesElli Kruithof
Ghent University Hospital, Ghent, Belgium
Arthritis Rheum 52:3898-909. 2005....
- S100A12 (EN-RAGE) in monitoring Kawasaki diseaseDirk Foell
Department of Paediatrics, University Hospital Munster, Von Esmarch Str 58, 48149, Munster, Germany
Lancet 361:1270-2. 2003..0001). Since the interaction of S100A12 with multiligand receptors has a key role in inflammatory responses, this protein could serve as a novel target for future therapeutic interventions in inflammatory disorders...