Affiliation: Humboldt University
Lüderitz L, Dehne T, Sittinger M, Ringe J. Dose-Dependent Effect of Mesenchymal Stromal Cell Recruiting Chemokine CCL25 on Porcine Tissue-Engineered Healthy and Osteoarthritic Cartilage. Int J Mol Sci. 2018;20: pubmed publisher
..In concentrations lower than 500 nmol/L, CCL25 seems to be a candidate for in situ cartilage repair therapy approaches. ..
Hemmati Sadeghi S, Ringe J, Dehne T, Haag R, Sittinger M. Hyaluronic Acid Influence on Normal and Osteoarthritic Tissue-Engineered Cartilage. Int J Mol Sci. 2018;19: pubmed publisher
..On the cellular level, no inhibiting or activating effect of HA was shown. Microarray data demonstrated a minor impact of HA on gene expression level. ..
Schubert A, Smink J, Arp M, Ringe J, Hegewald A, Sittinger M. Quality Assessment of Surgical Disc Samples Discriminates Human Annulus Fibrosus and Nucleus Pulposus on Tissue and Molecular Level. Int J Mol Sci. 2018;19: pubmed publisher
Stich S, Möller A, Cabraja M, Krüger J, Hondke S, Endres M, et al
. Chemokine CCL25 Induces Migration and Extracellular Matrix Production of Anulus Fibrosus-Derived Cells. Int J Mol Sci. 2018;19: pubmed publisher
..CCL25 could additionally induce migration of AF-cells in a chemotaxis assay and therefore possibly aid in regeneration processes after disc herniation by recruiting AF-cells. ..
Ringe J, Strassburg S, Neumann K, Endres M, Notter M, Burmester G, et al
. Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2. J Cell Biochem. 2007;101:135-46 pubmed
..In combination with already known data on MSC recruitment and differentiation these are promising results towards in situ regenerative medicine approaches based on guiding of MSC to sites of degenerated tissues. ..
Ringe J, Leinhase I, Stich S, Loch A, Neumann K, Haisch A, et al
. Human mastoid periosteum-derived stem cells: promising candidates for skeletal tissue engineering. J Tissue Eng Regen Med. 2008;2:136-46 pubmed publisher
..These results suggest MSC-like PCs from mastoid as candidates for therapy of complex skeletal defects...
Hamidouche Z, Fromigue O, Ringe J, Häupl T, Marie P. Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation. BMC Cell Biol. 2010;11:44 pubmed publisher
Dehne T, Karlsson C, Ringe J, Sittinger M, Lindahl A. Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation. Arthritis Res Ther. 2009;11:R133 pubmed publisher
..Our findings suggest that the chondrogenic capacity is not significantly affected by OA, and OA chondrocytes fulfill the requirements for matrix-associated ACT. ..