Research Topics
Species | G RiemekastenSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Erectile dysfunction is frequent in systemic sclerosis and associated with severe disease: a study of the EULAR Scleroderma Trial and Research groupChingching Foocharoen
Department of Rheumatology, Basel University, Burgfelderstrasse 101, Basel 4012, Switzerland
Arthritis Res Ther 14:R37. 2012..Erectile dysfunction (ED) is common in men with systemic sclerosis (SSc) but the demographics, risk factors and treatment coverage for ED are not well known...- Frequency of disease-associated and other nuclear autoantibodies in patients of the German Network for Systemic Scleroderma: correlation with characteristic clinical featuresRudolf Mierau
Laboratory at Rheumaklinik Aachen, Hauptstrasse 21, Aachen, D 52066, Germany
Arthritis Res Ther 13:R172. 2011..In the present study, we analysed in detail nuclear autoantibodies and their associations in systemic sclerosis (SSc) patients included in the German Network for Systemic Scleroderma Registry... - Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: a Doppler Tissue and Speckle Tracking echocardiography studySebastian Schattke
Universitatsmedizin Berlin, Medical Clinic for Cardiology and Angiology, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
Cardiovasc Ultrasound 8:3. 2010..The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV) systolic dysfunction in patients with systemic sclerosis (SSc) without pulmonary hypertension... - Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patientsKatharina Hanke
Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin, Humboldt University Berlin, Chariteplatz 1, Berlin 10117, Germany
Arthritis Res Ther 11:R22. 2009..Furthermore, it remains speculative whether commercially available test systems detecting only anti-PM/Scl-100 antibodies are sufficient in SSc patients... - Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patientsKatrin Schmidt
Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, Germany
Arthritis Res Ther 11:R111. 2009..The aim of the current study was to identify specific changes in cytokine levels that may serve as disease markers and possible targets for therapy... - Diagnostic value of anti-topoisomerase I antibodies in a large monocentric cohortKatharina Hanke
Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin 10117, Germany
Arthritis Res Ther 11:R28. 2009..In the present study, the detection of anti-topoisomerase I (anti-topo I) autoantibodies was evaluated for diagnosis and risk assessment of systemic sclerosis (SSc) patients in a well characterized large monocentric cohort... - High frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacyNicolas Hunzelmann
Department of Dermatology and Venerology, University of Cologne, Cologne, Germany
Arthritis Res Ther 11:R30. 2009..The objective of this study was to determine the extent to which SSc patients are treated with corticosteroids and immunosuppressive agents... - Clinical and serological evaluation of a novel CENP-A peptide based ELISAMichael Mahler
Dr Fooke Laboratorien, Mainstrasse 85, 41469 Neuss, Germany
Arthritis Res Ther 12:R99. 2010..Historically, ACA were detected by indirect immunofluorescence (IIF) on HEp-2 cells and confirmed by immunoassays using recombinant CENP-B. The objective of this study was to evaluate a novel CENP-A peptide ELISA... 
Key autoantigens in SLEG Riemekasten
Rheumatology (Oxford) 44:975-82. 2005- [Clinical risk-adapted therapies in systemic sclerosis]G Riemekasten
Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie der Charité Universitätsmedizin, Centrum 12, Charite Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
Z Rheumatol 66:672-4, 676-8. 2007..The paper also highlights possible future treatment options, including vasoactive, cellular and immune suppressant treatments... 
Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosusJan Broder Engler
Department of Rheumatology and Clinical Immunology, University Hospital Charite, Berlin, Germany
Ann Rheum Dis 70:2176-83. 2011..The authors assess autoreactive CD4 T cells in a representative SLE collective (n=38) by flow cytometry and study the influence of regulatory T cells (Treg) on their antigenic challenge...- Intravenous injection of a D1 protein of the Smith proteins postpones murine lupus and induces type 1 regulatory T cellsGabriela Riemekasten
Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
J Immunol 173:5835-42. 2004..In conclusion, these results indicate that SmD1 83-119 peptide may play a dominant role in the activation of helper and regulatory T cells that influence autoantibody generation and murine lupus... - Strong acceleration of murine lupus by injection of the SmD1(83-119) peptideG Riemekasten
Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Germany
Arthritis Rheum 44:2435-45. 2001..The aim of the present study was to analyze the influence of the SmD1 C-terminus on the generation of pathogenic anti-dsDNA antibodies in a murine model of SLE... - Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulationG Riemekasten
Department of Rheumatology and Clinical Immunology, Humboldt University of Berlin, Germany
Lupus 11:204-7. 2002..Immune complex 'independent' and other mechanisms of vascular injury and states of hypercoagulability will be discussed... - [Medicinal vasoactive therapy of microcirculation disorders in rheumatoid arthritis]G Riemekasten
Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charit, , EUSTAR-Zentrum, Schumannstrasse 20/21, 10117 Berlin
Z Rheumatol 64:123-36. 2005 - T cell reactivity against the SmD1(83-119) C terminal peptide in patients with systemic lupus erythematosusG Riemekasten
Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstr 20 21, D 10117 Berlin, Germany
Ann Rheum Dis 61:779-85. 2002..The SmD1(83-119) peptide is a major target of the B cell response in patients with systemic lupus erythematosus (SLE)... - Vasoactive therapies in systemic sclerosisG Riemekasten
MD Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstr 20 21, D 10117 Berlin, Germany
Rheumatology (Oxford) 45:iii49-51. 2006..This review summarizes evidence-based therapy recommendations... - Identification and characterization of SmD183-119-reactive T cells that provide T cell help for pathogenic anti-double-stranded DNA antibodiesGabriela Riemekasten
University of California, Los Angeles, USA
Arthritis Rheum 48:475-85. 2003..This study was undertaken to test the hypothesis that SmD1(83-119)-reactive T cells play a crucial role in the generation of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies... - Casein is an essential cofactor in autoantibody reactivity directed against the C-terminal SmD1 peptide AA 83-119 in systemic lupus erythematosusGabriela Riemekasten
Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
Immunobiology 206:537-45. 2002..In conclusion, casein seems to be an important cofactor in autoantibody reactivity directed against the C-terminal SmD1(83-119) peptide and probably functions by changing the conformation of the peptide's critical epitope... - The systemic and SmD183-119-autoantigen-specific cytokine memory of Th cells in SLE patientsS Langer
Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstr 20 21, D 10117 Berlin, Germany
Rheumatology (Oxford) 46:238-45. 2007.... - Neutrophil respiratory burst is decreased in scleroderma and normalized by near-infrared mediated hyperthermiaJ Foerster
Department of Dermatology, Charite Hospital, Berlin, Germany
Clin Exp Dermatol 31:799-806. 2006..The production of reactive oxygen species (ROS) by fibroblasts has been suggested to contribute to scleroderma pathogenesis. Infrared-mediated hyperthermia has recently been shown to be of benefit in scleroderma... - CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patientsP Enghard
Charite University Hospital, Berlin, Germany
Arthritis Rheum 60:199-206. 2009.... - T cell cytokine imbalance towards production of IFN-gamma and IL-10 in NZB/W F1 lupus-prone mice is associated with autoantibody levels and nephritisP Enghard
Department of Rheumatology and Clinical Immunology, , Berlin, Germany
Scand J Rheumatol 35:209-16. 2006..CONCLUSION: The association between the frequencies of T cells expressing IFN-gamma and IL-10 and clinical findings suggests a key role for these cells in the pathogenesis of lupus... - Enhanced serum prolactin (PRL) in patients with systemic lupus erythematosus: PRL levels are related to the disease activityA M Jacobi
Department of Medicine, , Berlin, Germany
Lupus 10:554-61. 2001..These results were confirmed by follow-up examinations. Moderate hyperprolactinaemia is present in a subset of patients with SLE and serum PRL correlates with clinical and serological disease activity... - Circulating nerve growth factor in primary and secondary Raynaud's syndrome - results of a pilot studyP Klein-Weigel
DRK Kliniken, Klinik für Innere Medizin Schwerpunkt Angiologie, Berlin, Germany
Vasa 38:39-45. 2009..In this pilot study we examined circulating concentrations of nerve growth factor (NGF) in controls and patients suffering from primary or secondary Raynaud's syndrome and determined their relation to digital vasospasm... - Skin sclerosis is only of limited value to identify SSc patients with severe manifestations--an analysis of a distinct patient subgroup of the German Systemic Sclerosis Network (DNSS) RegisterL G Hanitsch
Clinic of Rheumatology and Clinical Immunology, Charite Universitatsmedizin, Charite, Berlin, Germany
Rheumatology (Oxford) 48:70-3. 2009..In SSc, diagnosis and classification is based mainly on skin sclerosis. Herein, we investigated in a large multicentre cohort, to what extent skin sclerosis reflects organ involvement and additional clinical symptoms... - Subset size, activation threshold and distribution of autoreactive MZ and FO B cells do not differ in a sex-specific manner in the NZB/W F1 murine lupus model: an experimental mouse studyP Enghard
Nephrology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
Lupus 20:1240-9. 2011..Here, we compared the splenic B-cell compartments, their autoreactivity and activation threshold of female and male NZB/W F1, a murine lupus model reflecting the sex bias observed in patients with SLE... - Inflamed kidneys of NZB / W mice are a major site for the homeostasis of plasma cellsG Cassese
Deutsches Rheuma-Forschungszentrum, Berlin, Germany
Eur J Immunol 31:2726-32. 2001..These experiments identify the inflamed kidneys of NZB / W mice as a site of prime relevance for the homeostasis of plasma cells, irrespective of their specificity... - [Anti-Sm antibodies--marker antibodies in systemic lupus erythematosus (SLE)]F Hiepe
, 10117 Berlin, Germany
Z Rheumatol 61:306-7. 2002 - [Recommendations of the German Society of Rheumatology on therapy of Raynaud syndrome and acral ulcerations]G Riemekasten
Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charit, Schumannstrasse 20/21, 10117 Berlin, Germany
Z Rheumatol 64:90-2. 2005 - Infrared-monitored cold response in the assessment of Raynaud's phenomenonJ Foerster
Clinic for Dermatology, Charite, Berlin, Germany
Clin Exp Dermatol 31:6-12. 2006..We have previously shown that fingertip re-warming after cold challenge follows a first-order transient response curve that can be described by a single variable, designated tau... - [Towards an implementation of guidelines for the therapy of systemic sclerosis (scleroderma): between desire and reality]M O Becker
Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie, Charite Universitatsmedizin, Berlin, Chariteplatz 1, 10117, Berlin, Deutschland
Z Rheumatol 69:310-7. 2010..g. the German Network for Systemic Sclerosis, DNSS, and EUSTAR) will raise the standards of evidence-based therapy for systemic sclerosis in the future by analyzing large data sets and performing clinical trials... - [Critical limb ischemia in systemic sclerosis]M O Becker
Medizinische Klinik mit Schwerpunkt Rheumatologie und klin Immunologie, Universitätsmedizin Charité, Chariteplatz 1, 10117, Berlin, Deutschland
Z Rheumatol 71:261-9. 2012..An interdisciplinary approach to the diagnosis and therapy of these lesions is mandatory. Therapy goals are the prevention of further ischemia and, if possible, revascularization as well as optimal pain management... - [Modern treatment of collagen disease]G Riemekasten
Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, , Berlin, Germany
Z Rheumatol 66:661. 2007 - Anticentromere-A and anticentromere-B antibodies show high concordance and similar clinical associations in patients with systemic sclerosisKatharina Hanke
Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
J Rheumatol 37:2548-52. 2010..To determine the diagnostic sensitivity and specificity and the clinical usefulness of parallel anticentromere-A and anticentromere-B antibody (anti-CENP-A and anti-CENP-B) testing in patients with systemic sclerosis (SSc)... - [Regulatory T cells in rheumatic diseases]J Humrich
Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie,
Dtsch Med Wochenschr 131:2288-91. 2006 - Non organ based laboratory markers in systemic sclerosisN J McHugh
Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath BA1 1RL, UK
Clin Exp Rheumatol 21:S32-8. 2003..Autoantibody measurement and general inflammatory markers were considered the minimum requirements, with other markers needing further evaluation... - Long-term effects of bosentan on quality of life, survival, safety and tolerability in pulmonary arterial hypertension related to connective tissue diseasesC P Denton
Center for Rheumatology, Royal Free Hospital, Pond Street, Rheumatology Unit, Lower Ground Floor, London NW3 2QG, UK
Ann Rheum Dis 67:1222-8. 2008..This study investigated the long-term effects of bosentan, an oral endothelin ET(A)/ET(B) receptor antagonist, in patients with pulmonary arterial hypertension (PAH) exclusively related to connective tissue diseases (CTD)... - [Therapy for Reynaud syndrome]G Riemekasten
Z Rheumatol 65:80. 2006 - The binding of lupus-derived autoantibodies to the C-terminal peptide (83-119) of the major SmD1 autoantigen can be mediated by double-stranded DNA and nucleosomesJ W Dieker
Nephrology Research Laboratory, Nijmegen Centre for Molecular Life Sciences, Division of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Ann Rheum Dis 65:1525-8. 2006.... - Lack of association between three vascular endothelial growth factor gene polymorphisms and systemic sclerosis: results from a multicenter EUSTAR study of European Caucasian patientsY Allanore
Hopital Cochin, Service de Rhumatologie A, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
Ann Rheum Dis 66:257-9. 2007..Systemic sclerosis (SSc) is characterised by disturbed vessel morphology and an overproduction of vascular endothelial growth factor (VEGF). The VEGF gene located on chromosome 6p21.3 has several polymorphisms... - Targeting activated T cells: successful use of anti-CD25 monoclonal antibody basiliximab in a patient with systemic sclerosisH U Scherer
Ann Rheum Dis 65:1245-7. 2006 - [Pulmonary arterial hypertension in collagen disease: experiences of the German Network for Systemic Scleroderma]N Hunzelmann
Klinik für Dermatologie und Venerologie, Klinikum der Universität zu Köln, Kerpener Strasse 62, 50937 Koln
Dtsch Med Wochenschr 131:S325-7. 2006..Drugs that lower the level of PHT also have a favourable effect on other signs of scleroderma... - Pathophysiology and clinical consequences of Raynaud's phenomenon related to systemic sclerosisC Sunderkotter
Department of Dermatology and Venereology, University Hospital Munster, Von Esmarch Str 58, 48149 Munster, Germany
Rheumatology (Oxford) 45:iii33-5. 2006..They should also have a positive impact on the course of SSc in general... - [Organ-specific diagnosis in patients with systemic sclerosis: Recommendations of the German Network for Systemic Sclerosis (DNSS)]N Hunzelmann
Klinik und Poliklinik fur Dermatologie und Venerologie, Klinikum der Universität zu Köln, 50924 Köln, Deutschland
Z Rheumatol 67:334-6, 337-40. 2008.... - [Raynaud phenomenon in dermatology. Part 1: Pathophysiology and diagnostic approach]C Sunderkotter
Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Munster, Von Esmarch Strasse 58, 48129 Munster
Hautarzt 57:819-28; quiz 829. 2006..Secondary RP (associated with SSc) additionally features morphological alterations with compromise of the vessel lumen. As RP can result in severe discomfort and complications, timely diagnosis and treatment is essential... - [Raynaud phenomenon in dermatology : Part 2: therapy]C Sunderkotter
Klinik und Poliklinik fur Dermatologie, Universitätsklinik Münster, Von Esmarch Strasse 58, 48129, Munster, Deutschland
Hautarzt 57:927-38; quiz 941. 2006..In patients with secondary SSc-associated RP, timely therapy can reduce the percentage of complications such as ulcers or amputations. In addition, timely treatment of RP possibly retards ensuing fibrotic processes... - Long-lived plasma cells in immunity and inflammationA E Hauser
Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany
Ann N Y Acad Sci 987:266-9. 2003 - Submaximal exercise testing in the assessment of interstitial lung disease secondary to systemic sclerosis: reproducibility and correlations of the 6-min walk testM H Buch
University of Michigan Scleroderma Program, 3918 Taubman Centre, Box 0358, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0358, USA
Ann Rheum Dis 66:169-73. 2007..Aim: To evaluate the usefulness of the 6MWT in a cohort of patients with ILD secondary to systemic sclerosis (SSc) and to correlate with established physiological parameters...