P Reinke

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint CCAAT/enhancer-binding proteins alpha and beta negatively influence the capacity of tumor necrosis factor alpha to up-regulate the human cytomegalovirus IE1/2 enhancer/promoter by nuclear factor kappaB during monocyte differentiation
    S Prosch
    Departments of Virology, Humboldt University, Medical School Charite, D 10098 Berlin, Germany
    J Biol Chem 276:40712-20. 2001
  2. ncbi request reprint Human adenovirus and human cytomegalovirus infections in preterm newborns: no association with bronchopulmonary dysplasia
    Susanna Prösch
    Department of Virology, Humboldt University, Medical School Charite, D 10098 Berlin, Germany
    Pediatr Res 52:219-24. 2002
  3. ncbi request reprint Heightened expression of the cytotoxicity receptor NKG2D correlates with acute and chronic nephropathy after kidney transplantation
    M Seiler
    Institute of Medical Immunology, Universitätsmedizin Charité, Campus Mitte, Berlin, Germany
    Am J Transplant 7:423-33. 2007
  4. ncbi request reprint Proteasome inhibitors: a novel tool to suppress human cytomegalovirus replication and virus-induced immune modulation
    Susanna Prösch
    Institutes of Virology, University Hospital Charite, Humboldt University, Berlin, Germany
    Antivir Ther 8:555-67. 2003
  5. ncbi request reprint A novel link between stress and human cytomegalovirus (HCMV) infection: sympathetic hyperactivity stimulates HCMV activation
    S Prosch
    Department of Medical Virology, Humboldt University, Berlin, D 10098, Germany
    Virology 272:357-65. 2000
  6. ncbi request reprint Human cytomegalovirus reactivation in bone-marrow-derived granulocyte/monocyte progenitor cells and mature monocytes
    S Prosch
    Department of Virology, School of Medicine Charite, Humboldt University, Berlin, Germany
    Intervirology 42:308-13. 1999
  7. ncbi request reprint TCR repertoire analysis by next generation sequencing allows complex differential diagnosis of T cell-related pathology
    M Dziubianau
    Berlin Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany
    Am J Transplant 13:2842-54. 2013
  8. doi request reprint Treatment of PTLD with rituximab and CHOP reduces the risk of renal graft impairment after reduction of immunosuppression
    R Trappe
    Department of Hematology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Transplant 9:2331-7. 2009
  9. ncbi request reprint Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides
    F Kern
    Institut fur Medizinische Immunologie, Charite, Berlin, Germany
    Eur J Immunol 30:1676-82. 2000
  10. doi request reprint Cytomegalovirus-specific regulatory and effector T cells share TCR clonality--possible relation to repetitive CMV infections
    S Schwele
    Institute of Medical Immunology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Am J Transplant 12:669-81. 2012

Detail Information

Publications44

  1. ncbi request reprint CCAAT/enhancer-binding proteins alpha and beta negatively influence the capacity of tumor necrosis factor alpha to up-regulate the human cytomegalovirus IE1/2 enhancer/promoter by nuclear factor kappaB during monocyte differentiation
    S Prosch
    Departments of Virology, Humboldt University, Medical School Charite, D 10098 Berlin, Germany
    J Biol Chem 276:40712-20. 2001
    ..Our results show that cell differentiation factors may interfere with TNFalpha-induced human cytomegalovirus gene (re)activation...
  2. ncbi request reprint Human adenovirus and human cytomegalovirus infections in preterm newborns: no association with bronchopulmonary dysplasia
    Susanna Prösch
    Department of Virology, Humboldt University, Medical School Charite, D 10098 Berlin, Germany
    Pediatr Res 52:219-24. 2002
    ..In summary, our findings indicate that HAdV and HCMV infection are frequent in preterm newborns with very low birth weight; however, a causal association with the development of BPD seems unlikely...
  3. ncbi request reprint Heightened expression of the cytotoxicity receptor NKG2D correlates with acute and chronic nephropathy after kidney transplantation
    M Seiler
    Institute of Medical Immunology, Universitätsmedizin Charité, Campus Mitte, Berlin, Germany
    Am J Transplant 7:423-33. 2007
    ..Significant elevated levels of NKG2D mRNA could be further detected in urine sediment prior to aRx, suggesting this receptor as a new candidate marker for the diagnosis of acute and chronic allograft rejection...
  4. ncbi request reprint Proteasome inhibitors: a novel tool to suppress human cytomegalovirus replication and virus-induced immune modulation
    Susanna Prösch
    Institutes of Virology, University Hospital Charite, Humboldt University, Berlin, Germany
    Antivir Ther 8:555-67. 2003
    ..These data suggest that short-term therapy with proteasome inhibitors might be an alternative strategy to prevent (re)activation, replication and immune modulatory activity of HCMV in patients with systemic inflammation...
  5. ncbi request reprint A novel link between stress and human cytomegalovirus (HCMV) infection: sympathetic hyperactivity stimulates HCMV activation
    S Prosch
    Department of Medical Virology, Humboldt University, Berlin, D 10098, Germany
    Virology 272:357-65. 2000
    ..Epinephrine also enhanced HCMV gene expression in infected THP-1 cells by about 50% in three of four experiments. These data suggest that HCMV, like HSV-1 and VZV, can be (re)activated under stress conditions...
  6. ncbi request reprint Human cytomegalovirus reactivation in bone-marrow-derived granulocyte/monocyte progenitor cells and mature monocytes
    S Prosch
    Department of Virology, School of Medicine Charite, Humboldt University, Berlin, Germany
    Intervirology 42:308-13. 1999
    ....
  7. ncbi request reprint TCR repertoire analysis by next generation sequencing allows complex differential diagnosis of T cell-related pathology
    M Dziubianau
    Berlin Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany
    Am J Transplant 13:2842-54. 2013
    ..We believe that the established approach will provide insights into the regulation of virus-specific/anti-tumor immunity and has high diagnostic potential in the clinical routine. ..
  8. doi request reprint Treatment of PTLD with rituximab and CHOP reduces the risk of renal graft impairment after reduction of immunosuppression
    R Trappe
    Department of Hematology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Transplant 9:2331-7. 2009
    ..The immunosuppressive effect of single agent rituximab may partially compensate the negative impact of IR on the graft function. Thus, it is possible to reduce immunosuppression when using chemotherapy to treat PTLD...
  9. ncbi request reprint Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides
    F Kern
    Institut fur Medizinische Immunologie, Charite, Berlin, Germany
    Eur J Immunol 30:1676-82. 2000
    ..Similar pools may be applied to examine the role of proteins from other pathogens, in autoimmune disease or following vaccination...
  10. doi request reprint Cytomegalovirus-specific regulatory and effector T cells share TCR clonality--possible relation to repetitive CMV infections
    S Schwele
    Institute of Medical Immunology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Am J Transplant 12:669-81. 2012
    ..These findings directly demonstrate that Teff and iTreg can differentiate from one "mother" clone with specificity to the same viral epitope and indicate that peripheral iTreg generation is related to frequent antigen appearance...
  11. ncbi request reprint Immune reconstitution and cytomegalovirus infection after allogeneic stem cell transplantation: the important impact of in vivo T cell depletion
    Martin Schmidt-Hieber
    Medical Department III Hematology, Oncology and Transfusion Medicine, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Int J Hematol 91:877-85. 2010
    ..01). Our data indicate that the type of in vivo TCD (alemtuzumab or ATG) differentially influences both the CMV infection risk and CD4(+)/CD8(+) T cell reconstitution kinetics in patients after allo-SCT...
  12. ncbi request reprint Adoptive T-cell therapy of a lung transplanted patient with severe CMV disease and resistance to antiviral therapy
    G Brestrich
    Department of Nephrology and Internal Intensive Care, Universitatsmedizin, Berlin, Germany
    Am J Transplant 9:1679-84. 2009
    ..Further studies have to elucidate the most potent strategies to generate antigen-specific T cells with high functional capacity and robust long-term persistence...
  13. ncbi request reprint Immunization of liver and renal transplant recipients: a seroepidemiological and sociodemographic survey
    C Chesi
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Transpl Infect Dis 11:507-12. 2009
    ..3%) and RTX-R (86.8%), and considerably lower for diphtheria, hepatitis A, and influenza. Immunization rates are too low in SOT recipients. Improvement will depend on a more active role of health care providers...
  14. ncbi request reprint Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms
    F Kern
    Institut für Medizinische Immunologie Charité Campus Mitte, Humboldt Universitat zu Berlin, Berlin, Germany
    Eur J Immunol 29:2908-15. 1999
    ..This subpopulation likely includes the fully differentiated memory cells responsible for the long-term immune defense against HCMV reactivation...
  15. doi request reprint BK virus-specific immunity kinetics: a predictor of recovery from polyomavirus BK-associated nephropathy
    T Schachtner
    Department of Nephrology and Internal Intensive Care, Charite University Medicine Berlin, Campus Virchow Clinic, Berlin, Germany
    Am J Transplant 11:2443-52. 2011
    ..05). Our results suggest prognostic values of BKV-specific immune monitoring to identify those patients at risk of BKV-associated nephropathy and to aid in the management of therapeutic interventions...
  16. ncbi request reprint Development of Kaposi's sarcoma under sirolimus-based immunosuppression and successful treatment with imiquimod
    N Babel
    Department of Nephrology and Internal Intensive Care, Campus Virchow Clinic, Charite University Medicine, Berlin, Germany
    Transpl Infect Dis 10:59-62. 2008
    ..The following is a description of KS development under immunosuppressive therapy with sirolimus, and the successful treatment of KS lesions utilizing the topical application of imiquimod 5% cream, an immune response modifier...
  17. ncbi request reprint Reticulocytes and their immature fraction do not detect acute rejection after kidney transplantation
    A Weimann
    Central Institute of Laboratory Medicine and Pathobiochemistry, Charite Hospital, Campus Virchow Clinic, Berlin, Germany
    Transplant Proc 39:514-7. 2007
    ..Therefore, a decrease of reticulocyte counts and of young reticulocytes might indicate the emergence of an acute rejection episode. This pilot study examined the value of reticulocyte parameters as indicators of acute rejection episodes...
  18. ncbi request reprint Acute esophageal necrosis (black esophagus) in the renal transplant recipient: manifestation of primary cytomegalovirus infection
    R Trappe
    Department of Hematology and Oncology, Charite University Hospital Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transpl Infect Dis 9:42-5. 2007
    ....
  19. ncbi request reprint ATG versus basiliximab induction therapy in renal allograft recipients receiving a dual immunosuppressive regimen: one-year results
    S G Tullius
    Department of General and Transplantation Surgery, Charite, Virchow Clinic, Berlin, Germany
    Transplant Proc 35:2100-1. 2003
  20. ncbi request reprint NF-kappaB--a potential therapeutic target for inhibition of human cytomegalovirus (re)activation?
    Susanna Prösch
    Institute of Virology, University Hospital Charite, Humboldt University, D 10098 Berlin, Germany
    Biol Chem 383:1601-9. 2002
    ....
  21. doi request reprint Prophylaxis of recurrent urinary tract infection after renal transplantation by cranberry juice and L-methionine
    N Pagonas
    Department of Nephrology, Charite Campus Benjamin Franklin, Berlin, Germany
    Transplant Proc 44:3017-21. 2012
    ..Data on the efficacy of cranberry and L-methionine, however, are controversial in the general population; there are few data in renal transplant recipients...
  22. doi request reprint Conversion from cyclosporine to everolimus at 4.5 months posttransplant: 3-year results from the randomized ZEUS study
    K Budde
    Department of Nephrology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Transplant 12:1528-40. 2012
    ..There was a significantly higher rate of rejection in the everolimus arm but this did not exert a deleterious effect by 3 years posttransplant...
  23. doi request reprint Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients
    S Schubert
    Department of Congenital Heart Defects Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Pediatr Transplant 13:54-62. 2009
    ....
  24. ncbi request reprint Early post-transplant urinary IP-10 expression after kidney transplantation is predictive of short- and long-term graft function
    M Matz
    Institute of Medical Immunology, Universitätsmedizin Charité Campus Mitte, Berlin, Germany
    Kidney Int 69:1683-90. 2006
    ..These data reveal a correlation between elevated IP-10 expression in urine at early time points post-transplantation and intragraft immune activation that leads to acute rejection and compromised long-term graft function...
  25. ncbi request reprint Rat cytomegalovirus infection interferes with anti-CD4 mAb-(RIB 5/2) mediated tolerance and induces chronic allograft damage
    A Pascher
    Department of Visceral and Transplantation Surgery, Charite Universitaetsmedizin Berlin, Campus Virchow, Berlin, Germany, and Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, MA, USA
    Am J Transplant 6:2035-45. 2006
    ..RCMV interferes with anti-CD4 mAb-induced tolerance and leads to chronic allograft damage. The data we presented suggest a potentially important role of viral infections and their prophylaxis in clinical TI protocols...
  26. ncbi request reprint Immunomodulatory therapies: challenges of individualized therapy strategies
    H D Volk
    Institute for Medical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Ernst Schering Found Symp Proc . 2006
    ..Herein we report on new biomarkerguided studies in the immunosuppressive treatment of transplant patients and patients with autoimmune disease and we discuss its benefits and pitfalls...
  27. ncbi request reprint Measurement of anti-human cytomegalovirus T cell reactivity in transplant recipients and its potential clinical use: a mini-review
    F Kern
    Institut fur Medizinische Immunologie, Charité Medizinische Fakultät der Humboldt Universität zu Berlin, Berlin, Deutschland
    Intervirology 42:322-4. 1999
    ..We also discuss a number of preconditions for integrating such testing into the clinical routine...
  28. ncbi request reprint Intragraft overexpression of interleukin-4 is neither sufficient nor essential for tolerance induction to cardiac allografts in a high-responder strain combination
    T Ritter
    Institute of Medical Immunology and Clinic of Nephrology and Internal Intensive Care, Charite, Humboldt University Berlin, Germany
    Transplantation 68:1427-31. 1999
    ..Whether IL-4 mediated immune deviation contributes to transplantation tolerance is not clear so far...
  29. pmc Target structures of the CD8(+)-T-cell response to human cytomegalovirus: the 72-kilodalton major immediate-early protein revisited
    F Kern
    Institut fur Medizinische Immunologie, Medizinische Fakultät der Humboldt Universität zu Berlin Charité, 10098 Berlin, Germany
    J Virol 73:8179-84. 1999
    ..In summary, our results suggest that IE-1 is far more important as a CD8(+)-T-cell target than current opinion suggests...
  30. ncbi request reprint Monoclonal gammopathy of undetermined significance (MGUS) is associated with an increased frequency of Epstein-Barr Virus (EBV) latently infected B lymphocytes in long-term renal transplant patients
    N Babel
    Department of Nephrology and Internal Intensive Care, Clinic of Internal Medicine, Charite Campus Virchow, Humboldt University of Berlin, D 13353 Berlin, Germany
    Transplant Proc 36:2679-82. 2004
    ..These data suggest that transplant patients with MGUS demonstrate a more sufficient control of EBV-infected B-cells. Nevertheless, EBV monitoring should be performed in patients with EBV-associated MGUS for early detection of later PTLD...
  31. ncbi request reprint Accurate prediction of kidney allograft outcome based on creatinine course in the first 6 months posttransplant
    L Fritsche
    Dept Nephrology, Charite, Berlin, Germany
    Transplant Proc 37:731-3. 2005
    ..These patients may benefit from therapeutic measures tailored for this high-risk setting...
  32. ncbi request reprint Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD)
    S H K Oertel
    University Medicine of Berlin, Charite Campus Virchow Clinic, Department of Internal Medicine, Berlin, Germany
    Am J Transplant 5:2901-6. 2005
    ..Two patients relapsed, at intervals 3 and 5 months after obtaining complete remission. Rituximab proved to be well tolerated and effective in the treatment of PTLD...
  33. ncbi request reprint HLA type-independent method to monitor polyoma BK virus-specific CD4 and CD8 T-cell immunity
    M H Hammer
    Interdisciplinary Transplant Laboratory, Department of Nephrology and Institute of Medical Immunology, Charite Universitatsmedizin Berlin, Germany
    Am J Transplant 6:625-31. 2006
    ..The method can be used to assess the impact of decreased immunosuppression on BKV immunity and to clarify the role of specific T cells in the pathogenesis of PVAN. We strongly recommend its implementation in future clinical studies...
  34. doi request reprint Reduction of gastrointestinal complications in renal graft recipients after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium
    P Reinke
    Department of Nephrology, University Hospital Charite, Berlin, Germany
    Transplant Proc 43:1641-6. 2011
    ..In conclusion, conversion from MMF to EC-MPS reduces GI complications in renal graft recipients, reduces the patients' physical discomfort, and maintains their quality of life. (ClinicalTrials.gov number NCT00149968.)...
  35. pmc Human cytomegalovirus reactivation during lactation and mother-to-child transmission in preterm infants
    Johannes Meier
    Humboldt University, Medical School Charite, Institute of Virology, Schumannstrasse 20 21, D 10117 Berlin, Germany
    J Clin Microbiol 43:1318-24. 2005
    ..In summary, our study confirmed a very high incidence of HCMV reactivation in mothers during lactation and a significant risk of transmission to preterm infants with the possibility of severe disease in these babies...
  36. doi request reprint Novel GMP-compatible protocol employing an allogeneic B cell bank for clonal expansion of allospecific natural regulatory T cells
    S Landwehr-Kenzel
    Berlin Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany Berlin Brandenburg School for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany Department of Pediatric Pulmonology and Immunology, Charite University Medicine Berlin, Berlin, Germany
    Am J Transplant 14:594-606. 2014
    ..This novel method offers a simple approach for expanding antigen-specific nTreg and is characterized by high replicability and easy transferability to full GMP standards. ..
  37. doi request reprint Impaired insulin sensitivity as an underlying mechanism linking hepatitis C and posttransplant diabetes mellitus in kidney recipients
    S Baid-Agrawal
    Division of Nephrology and Medical Intensive Care, Department of Medicine, Berlin, Germany
    Am J Transplant 9:2777-84. 2009
    ....
  38. ncbi request reprint Immunogenicity and safety of hepatitis A vaccine in liver and renal transplant recipients
    K Stark
    Institute of Tropical Medicine, Charite, Humboldt University, 14050 Berlin, Germany
    J Infect Dis 180:2014-7. 1999
    ..The vaccine was well tolerated. Hepatitis A vaccine can be recommended to LTX and RTX patients, but the patients should receive a full course of 2 doses before imminent exposure...
  39. ncbi request reprint High prevalence of cardiotropic viruses in myocardial tissue from explanted hearts of heart transplant recipients and heart donors: a 3-year retrospective study from a German patients' pool
    Oliver Donoso Mantke
    Centre for Biological Safety, Robert Koch Institute, Berlin, Germany
    J Heart Lung Transplant 24:1632-8. 2005
    ....
  40. doi request reprint Percutaneous computer tomography-guided ethanol sympathicolysis for the treatment of resistant arterial hypertension
    F Streitparth
    Department of Radiology, Charite, Humboldt University Medical School, Augustenburger Platz 1, 13353, Berlin, Germany
    Cardiovasc Intervent Radiol 37:513-8. 2014
    ..As an alternative to catheter-based radiofrequency (RF) ablation, renal sympathicolysis can also be achieved by image-guided percutaneous injection of ethanol around the renal artery...
  41. ncbi request reprint Kaletra single agent HAART after intolerance of NRTI- and NNRTI-containing regimens following kidney transplantation
    D Schurmann
    Dept of Infectious Diseases and Respiratory Medicine, Charite, Universitatsmedizin Berlin, Augustenburger Platz, Berlin, Germany
    Infection 35:194-6. 2007
    ..Kaletra was well tolerated and resulted in sustained viral load suppression below the limit of detection for at least 36 months...
  42. ncbi request reprint Living kidney donation: anemia and inflammation in the early postoperative period
    D J Hampel
    Department of Medicine, Division of Nephrology and Intensive Care Medicine, Charite Universitatsmedizin Berlin Campus Virchow Klinikum, Berlin, Germany
    Transplant Proc 38:661-3. 2006
    ..These parameters improved during the hospital stay, in some cases they achieved the prenephrectomy level at discharge. These data may assist in interpreting laboratory results after nephrectomy among living kidney donors...
  43. ncbi request reprint Induction of pre-transplant Epstein-Barr virus (EBV) infection by donor blood transfusion in EBV-seronegative recipients may reduce risk of post-transplant lymphoproliferative disease in adolescent renal transplant patients: report of two cases
    N Babel
    Interdisciplinary Transplant Research Laboratory, Charite University Medicine, Berlin, Germany
    Transpl Infect Dis 7:133-6. 2005
    ....
  44. ncbi request reprint Downregulation of the epidermal growth factor receptor by human cytomegalovirus infection in human fetal lung fibroblasts
    Thomas Beutler
    Institute of Virology and Department of Neonatology, University Hospital Charite, Humboldt University, Berlin, Germany
    Am J Respir Cell Mol Biol 28:86-94. 2003
    ..From these data it can be hypothesized that the pathogenesis of HCMV lung infection involves down-regulation of EGF-R and that congenital HCMV infection may cause retardation in lung maturation and surfactant protein synthesis...