K Raile

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Diabetes caused by insulin gene (INS) deletion: clinical characteristics of homozygous and heterozygous individuals
    Klemens Raile
    Department of Pediatric Endocrinology and Diabetes, Charite Children s Hospital, Universitatsmedizin Berlin, Charite Campus Virchow, Augustenburger Platz 1, D 13353 Berlin, Germany
    Eur J Endocrinol 165:255-60. 2011
  2. doi request reprint Expanded clinical spectrum in hepatocyte nuclear factor 1b-maturity-onset diabetes of the young
    Klemens Raile
    Department of Pediatric Endocrinology and Diabetes, Charite Campus Virchow, 13353 Berlin, Germany
    J Clin Endocrinol Metab 94:2658-64. 2009
  3. ncbi request reprint Diabetic nephropathy in 27,805 children, adolescents, and adults with type 1 diabetes: effect of diabetes duration, A1C, hypertension, dyslipidemia, diabetes onset, and sex
    Klemens Raile
    Department of Pediatric Endocrinology and Diabetes, Charite Children s Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
    Diabetes Care 30:2523-8. 2007
  4. ncbi request reprint Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells
    K Raile
    Hospital for Children and Adolescents, Leipzig, Germany
    Regul Pept 135:30-8. 2006
  5. ncbi request reprint Clinical and functional characteristics of the human Arg59Ter insulin-like growth factor i receptor (IGF1R) mutation: implications for a gene dosage effect of the human IGF1R
    K Raile
    Pediatric Endocrinology and Diabetes, Charite Universitatsmedizin Berlin, Augustenburgerplatz 1, D 13353 Berlin, Germany
    J Clin Endocrinol Metab 91:2264-71. 2006
  6. ncbi request reprint Clinical examples of disturbed IGF signaling: intrauterine and postnatal growth retardation due to mutations of the insulin-like growth factor I receptor (IGF-IR) gene
    W Kiess
    Hospital for Children and Adolescents, University of Leipzig, Oststr 21 25, D 04317, Leipzig, Germany
    Rev Endocr Metab Disord 6:183-7. 2005
  7. ncbi request reprint Obesity in childhood and adolescence: clinical diagnosis and management
    W Kiess
    Hospital for Children and Adolescents, University of Leipzig, Germany
    J Pediatr Endocrinol Metab 14:1431-40. 2001
  8. ncbi request reprint Insulin-like growth factor I (IGF-I) stimulates proliferation but also increases caspase-3 activity, Annexin-V binding, and DNA-fragmentation in human MG63 osteosarcoma cells: co-activation of pro- and anti-apoptotic pathways by IGF-I
    K Raile
    Research Laboratory, Hospital for Children and Adolescents, Faculty of Medicine, University of Leipzig, Leipzig, Germany
    Horm Metab Res 35:786-93. 2003
  9. ncbi request reprint IGFs, basic FGF, and glucose modulate proliferation and apoptosis induced by IFNgamma but not by IL-1beta in rat INS-1E beta-cells
    K Raile
    Research Laboratory, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Horm Metab Res 35:407-14. 2003
  10. doi request reprint Daily insulin requirement of children and adolescents with type 1 diabetes: effect of age, gender, body mass index and mode of therapy
    Susanna Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 158:543-9. 2008

Detail Information

Publications18

  1. doi request reprint Diabetes caused by insulin gene (INS) deletion: clinical characteristics of homozygous and heterozygous individuals
    Klemens Raile
    Department of Pediatric Endocrinology and Diabetes, Charite Children s Hospital, Universitatsmedizin Berlin, Charite Campus Virchow, Augustenburger Platz 1, D 13353 Berlin, Germany
    Eur J Endocrinol 165:255-60. 2011
    ..The molecular mechanism of complete INS deletion has recently been published and we now add clinical data of homozygous and heterozygous subjects as well as the detailed mapping of the 646 bp deletion of the INS gene...
  2. doi request reprint Expanded clinical spectrum in hepatocyte nuclear factor 1b-maturity-onset diabetes of the young
    Klemens Raile
    Department of Pediatric Endocrinology and Diabetes, Charite Campus Virchow, 13353 Berlin, Germany
    J Clin Endocrinol Metab 94:2658-64. 2009
    ..We aimed to investigate detailed clinical features and the type of HNF1B gene anomaly in five pediatric cases with HNF1B-MODY...
  3. ncbi request reprint Diabetic nephropathy in 27,805 children, adolescents, and adults with type 1 diabetes: effect of diabetes duration, A1C, hypertension, dyslipidemia, diabetes onset, and sex
    Klemens Raile
    Department of Pediatric Endocrinology and Diabetes, Charite Children s Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
    Diabetes Care 30:2523-8. 2007
    ..To give an up-to-date profile of nephropathy and the involvement of risk factors in a large, prospective cohort of patients with type 1 diabetes and largely pediatric and adolescent onset of disease...
  4. ncbi request reprint Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells
    K Raile
    Hospital for Children and Adolescents, Leipzig, Germany
    Regul Pept 135:30-8. 2006
    ..We therefore investigated whether or not glucose concentration influences expression of TrkA and p75NTR in rat islets and in INS-1E beta-cells at the mRNA and protein level (INS-1E)...
  5. ncbi request reprint Clinical and functional characteristics of the human Arg59Ter insulin-like growth factor i receptor (IGF1R) mutation: implications for a gene dosage effect of the human IGF1R
    K Raile
    Pediatric Endocrinology and Diabetes, Charite Universitatsmedizin Berlin, Augustenburgerplatz 1, D 13353 Berlin, Germany
    J Clin Endocrinol Metab 91:2264-71. 2006
    ..Signaling via the IGF-I receptor (IGF-IR) is crucial for normal prenatal and postnatal growth. The heterozygous IGF-IR mutation Arg59Ter resulted in reduced IGF-IR expression and represents haploinsufficiency of the human IGF1R gene...
  6. ncbi request reprint Clinical examples of disturbed IGF signaling: intrauterine and postnatal growth retardation due to mutations of the insulin-like growth factor I receptor (IGF-IR) gene
    W Kiess
    Hospital for Children and Adolescents, University of Leipzig, Oststr 21 25, D 04317, Leipzig, Germany
    Rev Endocr Metab Disord 6:183-7. 2005
  7. ncbi request reprint Obesity in childhood and adolescence: clinical diagnosis and management
    W Kiess
    Hospital for Children and Adolescents, University of Leipzig, Germany
    J Pediatr Endocrinol Metab 14:1431-40. 2001
    ..This review aims to increase awareness of the health burden and economic dimension of the epidemic of childhood obesity that is occurring around the globe...
  8. ncbi request reprint Insulin-like growth factor I (IGF-I) stimulates proliferation but also increases caspase-3 activity, Annexin-V binding, and DNA-fragmentation in human MG63 osteosarcoma cells: co-activation of pro- and anti-apoptotic pathways by IGF-I
    K Raile
    Research Laboratory, Hospital for Children and Adolescents, Faculty of Medicine, University of Leipzig, Leipzig, Germany
    Horm Metab Res 35:786-93. 2003
    ..Furthermore, in sarcomas or carcinomas showing clinical association to IGF-I levels and malignancy, IGF-I dependent apoptosis and proliferation could be a significant mechanism of malignant tumour growth...
  9. ncbi request reprint IGFs, basic FGF, and glucose modulate proliferation and apoptosis induced by IFNgamma but not by IL-1beta in rat INS-1E beta-cells
    K Raile
    Research Laboratory, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Horm Metab Res 35:407-14. 2003
    ..Cytokines IFNg and IL-1beta differentially interfere with intracellular signaling cascades stimulated by IGFs and bFGF or glucose, respectively...
  10. doi request reprint Daily insulin requirement of children and adolescents with type 1 diabetes: effect of age, gender, body mass index and mode of therapy
    Susanna Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 158:543-9. 2008
    ..The purpose of this study was to generate insulin dose (ID) percentiles for children and adolescents with type 1 diabetes mellitus (DM1) having the opportunity to assess this important parameter in relation to age and sex...
  11. doi request reprint Protein phosphatase 1 (PP-1)-dependent inhibition of insulin secretion by leptin in INS-1 pancreatic β-cells and human pancreatic islets
    Peter Kuehnen
    Institute of Experimental Pediatric Endocrinology, Charite Children s Hospital, Universitatsmedizin Berlin, Berlin, Germany
    Endocrinology 152:1800-8. 2011
    ....
  12. ncbi request reprint Type 2 diabetes mellitus in children and adolescents: a review from a European perspective
    W Kiess
    Hospital for Children and Adolescents, University of Leipzig, Germany
    Horm Res 59:77-84. 2003
    ....
  13. ncbi request reprint IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation
    M Jennifer Abuzzahab
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    N Engl J Med 349:2211-22. 2003
    ..We postulated that mutations in the gene for the insulin-like growth factor I receptor (IGF-IR) might underlie some cases of prenatal and postnatal growth failure...
  14. ncbi request reprint Insulin detemir offers improved glycemic control compared with NPH insulin in people with type 1 diabetes
    Wieland Kiess
    Diabetes Care 27:2567-8. 2004
  15. ncbi request reprint Delayed pubertal onset and development in German children and adolescents with type 1 diabetes: cross-sectional analysis of recent data from the DPV diabetes documentation and quality management system
    Tilman Rohrer
    Pediatric Diabetes Unit, Department of Pediatric and Adolescent Medicine, Saarland University Hospital, Homburg Saar, Germany
    Eur J Endocrinol 157:647-53. 2007
    ....
  16. doi request reprint Tracking and prediction of arterial blood pressure from childhood to young adulthood in 868 patients with type 1 diabetes: a multicenter longitudinal survey in Germany and Austria
    Ina Knerr
    Children s and Adolescents Hospital, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    Diabetes Care 31:726-7. 2008
    ..Arterial blood pressure was followed in 868 patients with type 1 diabetes aged 6.0-19.9 years in 95 centers in Germany and Austria...
  17. ncbi request reprint Early manifestation of type 1 diabetes in children is a risk factor for changed bone geometry: data using peripheral quantitative computed tomography
    Susanne Bechtold
    Division of Pediatric Endocrinology, University Children s Hospital, Lindwurmstrasse 4, D 80337 Munich, Germany
    Pediatrics 118:e627-34. 2006
    ..To detect possible abnormalities in bone mineralization, geometry, and muscle bone unit, we measured selective parameters in children with type 1 diabetes using peripheral quantitative computed tomography...
  18. ncbi request reprint Type 2 diabetes mellitus in children and adolescents--the beginning of a renal catastrophe?
    Wieland Kiess
    Nephrol Dial Transplant 19:2693-6. 2004