Axel Pruss

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi Effects of lyophilization on the infectivity of enveloped and non-enveloped viruses in bone tissue
    Christine Uhlenhaut
    Center for Biological Safety, Robert Koch-Institut, Nordufer 20, 13353 Berlin, Germany
    Biomaterials 26:6558-64. 2005
  2. ncbi Detection of a new weak A blood-group allele (Aw11)
    A Pruss
    Institute of Transfusion Medicine Universitätsmedizin Berlin, Berlin, Germany
    Vox Sang 90:195-7. 2006
  3. ncbi Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis
    Carsten P Bramlage
    Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Arthritis Res Ther 8:R58. 2006
  4. ncbi Tissue donation and virus safety: more nucleic acid amplification testing is needed
    A Pruss
    Institute of Transfusion Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transpl Infect Dis 12:375-86. 2010
  5. ncbi Virus inactivation in bone tissue transplants (femoral heads) by moist heat with the 'Marburg bone bank system'
    Axel Pruss
    Institute for Transfusion Medicine Tissue Bank, University Hospital Charite, CCM, Schumannstrasse 20 21, 10117, Berlin, Germany
    Biologicals 31:75-82. 2003
  6. ncbi A method for the determination of the residual chloroform in defatted cancellous bone transplants
    Ulrich Kalus
    Institute for Transfusion Medicine Tissue Bank, University Hospital Charite, Berlin, Germany
    Cell Tissue Bank 6:71-5. 2005
  7. ncbi Acute intravascular hemolysis after transfusion of a chimeric RBC unit
    Axel Pruss
    Institute for Transfusion Medicine, Clinic for Anesthesiology, University Hospital Charite, Humboldt University, Berlin, Germany
    Transfusion 43:1449-51. 2003
  8. ncbi Immune hemolysis-serological and clinical aspects
    A Pruss
    Institute for Transfusion Medicine, University Hospital Charite, Medical Faculty of the Humboldt University of Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Clin Exp Med 3:55-64. 2003
  9. ncbi Validation of the 'Marburg bone bank system' for thermodisinfection of allogenic femoral head transplants using selected bacteria, fungi, and spores
    Axel Pruss
    Institute for Transfusion Medicine Tissue Bank, University Hospital Charite, CCM, Medical Faculty of Humboldt University, Schumannstr 20 21, Berlin D 10117, Germany
    Biologicals 31:287-94. 2003
  10. ncbi Peracetic acid-ethanol treatment of allogeneic avital bone tissue transplants--a reliable sterilization method
    Axel Pruss
    Institute for Transfusion Medicine Tissue Bank, University Hospital Charite, Berlin, Germany
    Ann Transplant 8:34-42. 2003

Detail Information

Publications69

  1. ncbi Effects of lyophilization on the infectivity of enveloped and non-enveloped viruses in bone tissue
    Christine Uhlenhaut
    Center for Biological Safety, Robert Koch-Institut, Nordufer 20, 13353 Berlin, Germany
    Biomaterials 26:6558-64. 2005
    ..Lyophilization of cell-free or cell-associated virus is not sufficient to inactivate viruses completely. However, lyophilization could have an additive effect in line with other production steps used in the manufacturing process...
  2. ncbi Detection of a new weak A blood-group allele (Aw11)
    A Pruss
    Institute of Transfusion Medicine Universitätsmedizin Berlin, Berlin, Germany
    Vox Sang 90:195-7. 2006
    ..Weak ABO variants may escape tests using unlicensed sera...
  3. ncbi Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis
    Carsten P Bramlage
    Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Arthritis Res Ther 8:R58. 2006
    ..In comparison with previous reports, these data underline the complex impact of these factors on homeostasis and remodeling in joint physiology and pathology...
  4. ncbi Tissue donation and virus safety: more nucleic acid amplification testing is needed
    A Pruss
    Institute of Transfusion Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transpl Infect Dis 12:375-86. 2010
    ..In view of numerous synergistic effects with transfusion medicine, it would be advantageous for tissue banks to cooperate with blood bank laboratories in performing virological tests...
  5. ncbi Virus inactivation in bone tissue transplants (femoral heads) by moist heat with the 'Marburg bone bank system'
    Axel Pruss
    Institute for Transfusion Medicine Tissue Bank, University Hospital Charite, CCM, Schumannstrasse 20 21, 10117, Berlin, Germany
    Biologicals 31:75-82. 2003
    ..To further increase virus safety of cadaveric bone transplants, it is recommended that multi-organ donors are tested by nucleic acid testing (i.e. polymerase chain reaction) for HIV, HBV and HCV genome...
  6. ncbi A method for the determination of the residual chloroform in defatted cancellous bone transplants
    Ulrich Kalus
    Institute for Transfusion Medicine Tissue Bank, University Hospital Charite, Berlin, Germany
    Cell Tissue Bank 6:71-5. 2005
    ..For the necessary routine quality checks on the production process, a gas chromatography method has been developed that determines the level of chloroform in cancellous bone, for which the detection limit is 0.003 ppm...
  7. ncbi Acute intravascular hemolysis after transfusion of a chimeric RBC unit
    Axel Pruss
    Institute for Transfusion Medicine, Clinic for Anesthesiology, University Hospital Charite, Humboldt University, Berlin, Germany
    Transfusion 43:1449-51. 2003
    ..Natural blood cell chimerism rarely occurs in humans. The case of a patient who developed transfusion reaction due to the transfusion of chimeric RBCs is reported...
  8. ncbi Immune hemolysis-serological and clinical aspects
    A Pruss
    Institute for Transfusion Medicine, University Hospital Charite, Medical Faculty of the Humboldt University of Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Clin Exp Med 3:55-64. 2003
    ..Finally, current and partly experimental therapeutic strategies of immune hemolytic anemias are summarized...
  9. ncbi Validation of the 'Marburg bone bank system' for thermodisinfection of allogenic femoral head transplants using selected bacteria, fungi, and spores
    Axel Pruss
    Institute for Transfusion Medicine Tissue Bank, University Hospital Charite, CCM, Medical Faculty of Humboldt University, Schumannstr 20 21, Berlin D 10117, Germany
    Biologicals 31:287-94. 2003
    ..To further increase the safety of the thermally treated femoral heads, we recommend that the medical history and present state of the donor, as well as the necessary serological tests should be taken into account...
  10. ncbi Peracetic acid-ethanol treatment of allogeneic avital bone tissue transplants--a reliable sterilization method
    Axel Pruss
    Institute for Transfusion Medicine Tissue Bank, University Hospital Charite, Berlin, Germany
    Ann Transplant 8:34-42. 2003
    ....
  11. ncbi Universal leukodepletion of blood components results in a significant reduction of febrile non-hemolytic but not allergic transfusion reactions
    Axel Pruss
    Institute for Transfusion Medicine Tissue Bank, University Hospital Charite, Campus Charite Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Transfus Apher Sci 30:41-6. 2004
    ..Universal leukodepletion of blood components to prevent acute non-hemolytic transfusion reactions (NHTRs) is still a subject of debate...
  12. ncbi [Musculoskeletal tissue banks. Legal foundations and graft safety]
    A Prub
    Gewebebank, Institut fur Transfusionsmedizin, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin
    Orthopade 37:749-55. 2008
    ..Whenever possible, a validated inactivation procedure should be included in the manufacturing process of musculoskeletal tissue transplants...
  13. ncbi [Influence of European regulations on quality, safety and availability of cell and tissue allografts in Germany]
    A Pruss
    Institute of Transfusion Medicine, Tissue Bank, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin
    Handchir Mikrochir Plast Chir 39:81-7. 2007
    ..This paper assesses the impact of these new pieces of legislation on the quality, safety and availability of human cell and tissue transplants in terms of the current situation and future prospects in Germany...
  14. ncbi Thawed solvent/detergent-treated plasma: too precious to be wasted after 6 hours?
    Mareike Kristina Keller
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum and Campus Charite Mitte, Berlin, Germany
    Blood Transfus 10:360-7. 2012
    ..The purpose of this study was to evaluate stability of clotting factors and inhibitors in thawed S/D-plasma stored at 4 °C for 6 days...
  15. ncbi A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression
    Djin Ye Oh
    Institute for Microbiology and Hygiene, Charite University Medical Center, Berlin, Germany
    AIDS 23:297-307. 2009
    ..TLR7 recognizes RNA of various viruses including HIV. The objective of this study was to examine the influence of individual genetic variations of TLR7 on the susceptibility to and progression of HIV disease...
  16. ncbi Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiation
    Tilo Dehne
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Gene 462:8-17. 2010
    ..Cultivation longer than 6 weeks leads to progressing dedifferentiation of chondrocytes that should be considered on long-term evaluations...
  17. ncbi No influence of collagenous proteins of Achilles tendon, skin and cartilage on the virus-inactivating efficacy of peracetic acid-ethanol
    Sven Scheffler
    Center for Musculoskeletal Surgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, Germany
    Biologicals 35:355-9. 2007
    ..PAA-ethanol used in the production process at the Charité tissue bank can therefore be recommended for treatment of non-osseous musculoskeletal tissues...
  18. ncbi Validation of a hospital-laboratory workstation for immunohematologic methods
    Helge Schoenfeld
    Department of Anesthesiology and Intensive Care Medicine and the Institute of Transfusion Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transfusion 50:26-31. 2010
    ..The principle of EMT is based on magnetization of red blood cells and avoids centrifugation and washing steps...
  19. ncbi Lyophilised plasma: evaluation of clotting factor activity over 6 days after reconstitution for transfusion
    Helge Schoenfeld
    Institute of Transfusion Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Clin Pathol 63:726-30. 2010
    ..This study evaluated clotting factor and inhibitor activity in reconstituted lyophilised plasma after storage for up to 6 days at 4 degrees C...
  20. ncbi Activity of clotting factors in fresh-frozen plasma during storage at 4 degrees C over 6 days
    Christian von Heymann
    Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Germany
    Transfusion 49:913-20. 2009
    ..Fresh-frozen plasma (FFP) requires thawing, which delays availability. We investigated clotting factor activity and bacterial contamination of FFP when stored at 4 degrees C +/- 2 degrees C for 6 days...
  21. ncbi Effect of electron beam irradiation on biomechanical properties of patellar tendon allografts in anterior cruciate ligament reconstruction
    Arnd T Hoburg
    Sports Medicine and Arthroscopy Service, Hospital for Orthopaedic Surgery and Traumatology, Campus Mitte, Charite, University Medicine Berlin, Chariteplatz 1, Berlin, Germany
    Am J Sports Med 38:1134-40. 2010
    ..However, mechanical tissue properties are compromised by most current sterilization procedures, so that uncompromised sterilization of allografts is difficult to achieve. Hypothesis/..
  22. ncbi Association between alloantibody specificity and autoantibodies to red blood cells
    Norbert Ahrens
    Labor 28 and the Institute for Transfusion Medicine, Charite University Medicine, Berlin, Germany
    Transfusion 48:20-4. 2008
    ..Alloantibodies (ALLOs) to red blood cells (RBCs) are frequently associated with autoantibodies (AABs). An association between ALLO specificity and AABs has not yet been described...
  23. ncbi Human platelet-rich plasma stimulates migration and chondrogenic differentiation of human subchondral progenitor cells
    Jan Philipp Krüger
    TransTissue Technologies GmbH, Chariteplatz 1, 10117 Berlin, Germany
    J Orthop Res 30:845-52. 2012
    ..These results suggest that human PRP may enhance the migration and stimulate the chondrogenic differentiation of human subchondral progenitor cells known from microfracture...
  24. ncbi Abnormalities in peripheral B cell memory of patients with primary Sjögren's syndrome
    Arne Hansen
    Department of Medicine Outpatients Department, Charite University Hospital, Berlin, Germany
    Arthritis Rheum 50:1897-908. 2004
    ..To delineate disturbances in peripheral B cell memory in primary Sjögren's syndrome (SS)...
  25. ncbi Coexistence of autoantibodies and alloantibodies to red blood cells due to blood transfusion
    Norbert Ahrens
    Institute for Transfusion Medicine, Charite University Medicine, Berlin, Germany
    Transfusion 47:813-6. 2007
    ..Autoantibodies (AUTO) to red blood cells (RBCs) are frequently associated with alloantibodies (ALLO). The mechanism for the coexistence of these antibodies is obscure...
  26. ncbi Sterilization with electron beam irradiation influences the biomechanical properties and the early remodeling of tendon allografts for reconstruction of the anterior cruciate ligament (ACL)
    Tanja Schmidt
    Julius Wolff Institut, Charite Universitatsmedizin Berlin, Berlin, Germany
    Cell Tissue Bank 13:387-400. 2012
    ..Therefore, high dose Ebeam irradiation investigated in this paper cannot be recommended for soft tissue allograft sterilization...
  27. ncbi Thawing procedures and the time course of clotting factor activity in fresh-frozen plasma: a controlled laboratory investigation
    Christian von Heymann
    Department of Anesthesiology and Intensive Care Medicine, Charite University Hospital Berlin, Charite Campus Mitte, Berlin, Germany
    Anesth Analg 103:969-74. 2006
    ..In an experimental procedure, FFP was thawed under running warm water at 42 degrees C...
  28. ncbi Evaluation of immunohematologic routine methods using the new erythrocyte-magnetized technology on the QWALYS 2 system
    Helge Schoenfeld
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, Germany
    Transfusion 49:1347-52. 2009
    ..Its new erythrocyte-magnetized technology (EMT) is based on the use of magnetic nanoparticles and avoids centrifugation and washing steps...
  29. ncbi Noninfectious transfusion of platelets donated before detection of human immunodeficiency virus RNA in plasma
    Ulrich Kalus
    Institute of Transfusion Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transfusion 49:435-9. 2009
    ..It is unknown whether human immunodeficiency virus (HIV) can be transmitted via blood products donated after primary HIV-1 infection before the detection of viral RNA in plasma...
  30. ncbi Effect of gamma irradiation on human cortical bone transplants contaminated with enveloped and non-enveloped viruses
    Axel Pruss
    Institute for Transfusion Medicine, Tissue Bank, University Hospital Charit, Medical Faculty of the Humboldt-University Berlin, Berlin, Germany
    Biologicals 30:125-33. 2002
    ..We therefore recommend a dose of 34 kGy for the sterilisation of frozen bone transplants...
  31. ncbi Failure of bedside ABO testing is still the most common cause of incorrect blood transfusion in the Barcode era
    Norbert Ahrens
    Institute for Transfusion Medicine, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
    Transfus Apher Sci 33:25-9. 2005
    ..ABO-incompatible red blood cell (RBC) transfusions are a major risk in transfusion medicine. Identification of factors leading to this hazard is important to improve transfusion safety...
  32. ncbi Validation of the sterilization procedure of allogeneic avital bone transplants using peracetic acid-ethanol
    A Pruss
    Institute for Transfusion Medicine, Tissue Bank, , Medical Faculty of Humboldt-University, Berlin, Germany
    Biologicals 29:59-66. 2001
    ..Spores of Aspergillus niger were also completely inactivated. The PES procedure proved to be a reliable method for the sterilization of human bone transplants derived from spongiosa...
  33. ncbi CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual
    Djin Ye Oh
    Institute of Microbiology and Hygiene, Charite University Medical Center, Berlin, Germany
    PLoS ONE 3:e2747. 2008
    ..Homozygosity (Delta32/Delta32) for the 32 bp deletion in the chemokine receptor 5 (CCR5) gene is associated with strong resistance against HIV infection. Heterozygosity is associated with protection of HIV-1 disease progression...
  34. ncbi Tissue-engineered cartilage of porcine and human origin as in vitro test system in arthritis research
    Axel R Göhring
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Dept of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, Berlin, Germany
    Biotechnol Prog 26:1116-25. 2010
    ..Therefore, we demonstrate that engineered cartilage of porcine and human origin represents a powerful in vitro model for cartilage in vivo...
  35. ncbi Remodeling of ACL allografts is inhibited by peracetic acid sterilization
    Sven U Scheffler
    Sports Medicine and Arthroscopy Service, Department for Orthopaedic Surgery and Traumatology, Center for Musculoskeletal Surgery, Charite University Medicine Berlin, Charite Platz 1, 10117 Berlin, Germany
    Clin Orthop Relat Res 466:1810-8. 2008
    ..We conclude PAA sterilization currently should not be used to sterilize soft tissue grafts typically used in ACL reconstruction...
  36. ncbi Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals
    Florian Kern
    Institut für Medizinische Immunologie der Charité, Campus Mitte, 10098 Berlin, Germany
    J Infect Dis 185:1709-16. 2002
    ..Several new T cell epitopes were identified...
  37. ncbi Cryopreserved human B cells as an alternative source for single cell mRNA analysis
    Arne Hansen
    Outpatients Department of Medicine, Charite University Medicine Berlin, Germany
    Cell Tissue Bank 6:299-308. 2005
    ..However, the settings for both FACS analysis and RT-PCR should be re-evaluated for each distinct subpopulation and target mRNA of interest when analyzing post-thawed cells...
  38. ncbi Molecular signatures and new candidates to target the pathogenesis of rheumatoid arthritis
    U Ungethuem
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, CharitéUniversitätsmedizin Berlin, Germany
    Physiol Genomics 42:267-82. 2010
    ....
  39. ncbi [Reconstruction of the extensor mechanism using a free, allogenic, freeze-dried patellar graft]
    D Krocker
    Klinik für Orthopädie, Centrum für Muskuloskeletale Chirurgie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin
    Unfallchirurg 110:563-6. 2007
    ..Allograft reconstruction of a deficient extensor mechanism is sufficient using an allogenic, freeze-dried patellar graft sterilized with peracetic acid. The reduced risk of infection is an advantage over fresh-frozen grafts...
  40. ncbi Quantification of growth factors in allogenic bone grafts extracted with three different methods
    B Wildemann
    Center for Musculoskeletal Surgery, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Cell Tissue Bank 8:107-14. 2007
    ..Several studies showed the antimicrobiological efficacy of this method. Aim of this study was the quantification of growth factors necessary for bone formation in PES sterilized allografts (n = 9)...
  41. ncbi Significance of autoantibodies in neonatal lupus erythematosus
    T Dorner
    Department of Medicine Rheumatology and Clinical Immunology, Charite Medical School, Humboldt University, Berlin, Germany
    Int Arch Allergy Immunol 123:58-66. 2000
    ..Current knowledge about the involved autoantibody-autoantigen systems, including recent therapeutic concepts of these autoimmune syndromes, is summarized...
  42. ncbi Influence of blood donation on levels of water-soluble vitamins
    U Kalus
    Institute of Transfusion Medicine, Charite University Medicine Berlin, Berlin, Germany
    Transfus Med 18:360-5. 2008
    ..Blood donation does not decrease the level of water-soluble vitamins. Vitamin deficiencies occur in apparently healthy first-time as well as in repeat blood donors and can be prevented by vitamin supplementation...
  43. ncbi Tumor necrosis factor alpha enhances the adenoviral transduction of CD34+ hematopoietic progenitor cells
    A Moldenhauer
    Institute for Transfusion Medicine, Charite Universitatsmedizin Berlin, Germany
    Stem Cells 22:283-91. 2004
    ..This finding correlates with increased Ad capping at the cell surface and suggests an alteration of Ad trafficking...
  44. ncbi [Perioperative antithrombotic prophylaxis in varicose vein surgery]
    B Baumann-Baretti
    Institut fur Transfusionsmedizin, Charite Berlin
    Zentralbl Chir 127:752-4. 2002
    ..In case of other acquired or hereditary risk factors antithrombotic prophylaxis in varicose vein surgery with low molecular weight heparin should be used. Compression elastic stockings are obligatory...
  45. ncbi Monoclonal gammopathy of undetermined significance (MGUS) is associated with an increased frequency of Epstein-Barr Virus (EBV) latently infected B lymphocytes in long-term renal transplant patients
    N Babel
    Department of Nephrology and Internal Intensive Care, Clinic of Internal Medicine, Charite Campus Virchow, Humboldt University of Berlin, D 13353 Berlin, Germany
    Transplant Proc 36:2679-82. 2004
    ..These data suggest that transplant patients with MGUS demonstrate a more sufficient control of EBV-infected B-cells. Nevertheless, EBV monitoring should be performed in patients with EBV-associated MGUS for early detection of later PTLD...
  46. ncbi Comparison of immunoglobulin heavy chain rearrangements between peripheral and glandular B cells in a patient with primary Sjögren's syndrome
    A Hansen
    Department of Medicine, University Hospital Charite, Schumannstr 20 21, D 10098 Berlin, Germany
    Scand J Immunol 57:470-9. 2003
    ..Notably, one of the glandular clonal rearrangements (using VH1-08) was also detected in the patient's peripheral repertoire...
  47. ncbi Biomechanical comparison of human bone-patellar tendon-bone grafts after sterilization with peracetic acid ethanol
    S U Scheffler
    Sports Traumatology and Arthroscopy Service, Center for Musculoskeletal Surgery, University Hospital Charite, Berlin, Germany
    Cell Tissue Bank 6:109-15. 2005
    ..The findings of this study provide baseline data for future in vitro and in vivo analyses of this promising new sterilization technique for soft-tissue allografts...
  48. ncbi Perturbations in the impact of mutational activity on Vlambda genes in systemic lupus erythematosus
    T Dorner
    Department of Medicine, University Hospital Charite, Berlin, Germany
    Arthritis Res 3:368-74. 2001
    ..The enhanced and abnormal mutational activity along with disturbances in selection may play a role in the emergence of autoreactivity in this patient with SLE...
  49. ncbi Antibodies against protein Z and fetal loss: current perspectives
    T Dorner
    Coagulation Unit, Institute of Transfusion Medicine, Charite University Medicine Berlin, Free University and Humboldt University Berlin, Schumannstrasse 20 21, D 10098, Berlin, Germany
    Clin Exp Med 5:50-4. 2005
    ..The current diagnostic relevance and therapeutic consequences of these parameters will be discussed...
  50. ncbi Preactivated monocytes from hypertensive patients as a factor for atherosclerosis?
    Y Dörffel
    Outpatient Clinics of Internal Medicine, Charite, Medical Faculty, Humboldt University, Luisenstrasse 11 13, 10098 Berlin, Germany
    Atherosclerosis 157:151-60. 2001
    ..In monocytes, peak levels of PMA and Ang II induced CL analysis were significantly higher in patients (P<0.005). These data indicate that preactivated monocytes from hypertensives may be of pathogenic importance in atherosclerosis...
  51. ncbi [Consequence of European Directive 2004/23/EC for bone banks in Germany]
    A Pruss
    Gewebebank, ,
    Orthopade 34:1160, 1162-6, 1168. 2005
    ....
  52. ncbi [Quality assurance of haemotherapy in anaesthesia. Auswertung eines 3-jahrigen Erfahrungszeitraums]
    C von Heymann
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Charite Mitte
    Anaesthesist 54:107-16. 2005
    ..The measures for quality assurance in haemotherapy developed at the Charite Campus Mitte according to the transfusion law of 1998 are introduced and discussed...
  53. ncbi Dissemination of a Sjögren's syndrome-associated extranodal marginal-zone B cell lymphoma: circulating lymphoma cells and invariant mutation pattern of nodal Ig heavy- and light-chain variable-region gene rearrangements
    A Hansen
    Dept of Medicine and Outpatient Department, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, 10098 Berlin, Germany
    Arthritis Rheum 54:127-37. 2006
    ..We undertook this study to analyze lymphoma progression and dissemination outside of the MALT-type lesions...
  54. ncbi Allogenic versus autologous cancellous bone in lumbar segmental spondylodesis: a randomized prospective study
    Michael Putzier
    Klinik für Orthopädie, Centrum für Muskuloskeletale Chirurgie, Charite, Universitatsmedizin Berlin, Charite Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Eur Spine J 18:687-95. 2009
    ..The results demonstrated an equivalent clinical outcome, as well as similar fusion rates following a 12-month period. This is in despite of a delayed consolidation process...
  55. ncbi Chronic lymphocytic leukemia preceded by cold agglutinin disease: intraclonal immunoglobulin light-chain diversity in V(H)4-34 expressing single leukemic B cells
    Sarka Ruzickova
    Deutsches Rheumaforschungszentrum, Berlin, Germany
    Blood 100:3419-22. 2002
    ..Of note, our findings suggest that this B-CLL had developed from the patient's CA-producing B-cell population...
  56. ncbi A practical concept for preoperative identification of patients with impaired primary hemostasis
    Juergen Koscielny
    Institute for Transfusion Medicine, Charite Humboldt University, Schumannstr 20 21, 10117 Berlin, Germany
    Clin Appl Thromb Hemost 10:195-204. 2004
    ..4%). The use of a standardized questionnaire and, if indicated, the PFA-100: C/E and/or other specific tests not only ensure the detection of impaired hemostasis in almost every case but also a significant reduction of the cost...
  57. ncbi Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue
    Bruno Stuhlmuller
    Department of Internal Medicine, Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Tucholskystrasse 2, D 10117 Berlin, Germany
    Am J Pathol 163:901-11. 2003
    ....
  58. ncbi Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases
    Ulrich Kalus
    Humboldt University, Berlin, School of Medicine, Institute for Transfusion Medicine, , Berlin, Germany
    Phytother Res 17:1209-14. 2003
    ..Black seed oil therefore proved to be an effective adjuvant for the treatment of allergic diseases...
  59. ncbi Increased RBC autoantibody production in pregnancy
    B Hoppe
    Blood Bank, Department of Internal Medicine, , Humboldt University, Berlin, Germany
    Transfusion 41:1559-61. 2001
    ..The resultant autoantibodies do not appear to cause significant RBC destruction. Further studies are required for precise characterization of this phenomenon...
  60. ncbi Agonistic AT(1) receptor autoantibodies and monocyte stimulation in hypertensive patients
    Yvonne Dörffel
    Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Am J Hypertens 16:827-33. 2003
    ..The adhesiveness of the monocytes to endothelial cell layers, tissue factor expression, and chemiluminescence were determined...
  61. ncbi Mid-term clinical results using a tissue-engineered pulmonary valve to reconstruct the right ventricular outflow tract during the Ross procedure
    Pascal M Dohmen
    Department of Cardiovascular Surgery, Charite Hospital, Medical University Berlin, Berlin, Germany
    Ann Thorac Surg 84:729-36. 2007
    ..This study was performed to collect prospective safety and effectiveness data of the Ross procedure using a tissue-engineered heart valve to reconstruct the right ventricular outflow tract...
  62. ncbi Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome
    Annett M Jacobi
    Department of Internal Medicine/Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Arthritis Res 4:R4. 2002
    ..These results suggest a role of antigen-activated and selected B cells in the local autoimmune process in SS...
  63. ncbi Immunoglobulin Vkappa light chain gene analysis in patients with Sjögren's syndrome
    C Heimbächer
    University Hospital Charite, Berlin, Germany
    Arthritis Rheum 44:626-37. 2001
    ..This study was undertaken to determine whether there are primary deviations of immunoglobulin V gene usage, differences in somatic hypermutation, defects of selection, or indications for perturbances of B cell maturation in SS...
  64. ncbi Subclinical activation of latent cytomegalovirus (CMV) infection and anti-CMV immune response in patients with atopic dermatitis
    W D Docke
    Institute of Medical Immunology, Department of Dermatology, University Hospital Charite, Berlin Humboldt University, D 10098 Berlin, Germany
    Br J Dermatol 148:954-63. 2003
    ..This, however, is of interest because of the high prevalence of latent infections in the general population, the frequent reactivation in inflammatory diseases, and the immunomodulating capacity of CMV...
  65. ncbi A functional toll-like receptor 8 variant is associated with HIV disease restriction
    D Y Oh
    Institute of Microbiology and Hygiene, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Infect Dis 198:701-9. 2008
    ..Presently, very little is known about the influence of TLR8 genetic variation on susceptibility to and progression of HIV disease...
  66. ncbi Infections associated with musculoskeletal-tissue allografts
    Axel Pruss
    N Engl J Med 351:1358-60; author reply 1358-60. 2004
  67. ncbi Novel system for worldwide qualified transport of red blood cell concentrates (RBC) under extreme environmental conditions
    Thomas Klose
    Blood Doner Service, German Federal Armed Forces Koblenz, Germany
    Clin Lab 54:25-8. 2008
  68. ncbi Identification of dialysis patients with panel-reactive memory T cells before kidney transplantation using an allogeneic cell bank
    Holger Andree
    Department of Nephrology and Intensive Care, , Augustenburger Platz 1, Berlin D-13353, Germany
    J Am Soc Nephrol 17:573-80. 2006
    ..Pretransplantation PRT testing of recipients might improve individual risk assessment to make individualized therapy decisions...
  69. ncbi Influence of below atmospheric pressure on the pharmaceutical quality of red blood cell concentrates (RBCs) during transport and storage
    Thomas Klose
    , Germany
    Clin Lab 52:57-61. 2006