A Plagemann

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally
    Karen Schellong
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    PLoS ONE 7:e47776. 2012
  2. pmc Increase of long-term 'diabesity' risk, hyperphagia, and altered hypothalamic neuropeptide expression in neonatally overnourished 'small-for-gestational-age' (SGA) rats
    Karen Schellong
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    PLoS ONE 8:e78799. 2013
  3. doi request reprint Rapid neonatal weight gain increases risk of childhood overweight in offspring of diabetic mothers
    Andreas Plagemann
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite, University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Perinat Med 40:557-63. 2012
  4. doi request reprint Early postnatal life as a critical time window for determination of long-term metabolic health
    Andreas Plagemann
    Division of Experimental Obstetrics, Clinic of Obstetrics, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Best Pract Res Clin Endocrinol Metab 26:641-53. 2012
  5. doi request reprint Maternal diabetes and perinatal programming
    A Plagemann
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, Germany
    Early Hum Dev 87:743-7. 2011
  6. ncbi request reprint Perinatal programming and functional teratogenesis: impact on body weight regulation and obesity
    Andreas Plagemann
    Experimental Obstetrics, Clinic of Obstetrics, Charite, University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Physiol Behav 86:661-8. 2005
  7. doi request reprint Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding
    Andreas Plagemann
    Division of Experimental Obstetrics, Clinic of Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Perinat Med 38:393-400. 2010
  8. pmc Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome
    Andreas Plagemann
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Physiol 587:4963-76. 2009
  9. doi request reprint [Fetal programming by disturbed intrauterine environment - fundamental mechanisms exemplified by the regulation of body weight and metabolism]
    Andreas Plagemann
    Arbeitsgruppe Experimentelle Geburtsmedizin, Klinik fur Geburtsmedizin, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Deutschland
    Gynakol Geburtshilfliche Rundsch 48:215-24. 2008
  10. ncbi request reprint DDT in human milk and mental capacities in children at school age: an additional view on PISA 2000
    Günter Dörner
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Neuro Endocrinol Lett 23:427-31. 2002

Collaborators

Detail Information

Publications73

  1. pmc Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally
    Karen Schellong
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    PLoS ONE 7:e47776. 2012
    ..In order to check this important assumption of developmental and preventive medicine, we performed a systematic review and comprehensive meta-analysis...
  2. pmc Increase of long-term 'diabesity' risk, hyperphagia, and altered hypothalamic neuropeptide expression in neonatally overnourished 'small-for-gestational-age' (SGA) rats
    Karen Schellong
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    PLoS ONE 8:e78799. 2013
    ..Alterations in adult food intake have been suggested to be causally involved. Responsible mechanisms remain unclear...
  3. doi request reprint Rapid neonatal weight gain increases risk of childhood overweight in offspring of diabetic mothers
    Andreas Plagemann
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite, University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Perinat Med 40:557-63. 2012
    ..However, the role of early postnatal weight gain for later overweight has not been addressed so far in ODM. We investigated whether increased weight gain during the first 4 months is related to later overweight in ODM...
  4. doi request reprint Early postnatal life as a critical time window for determination of long-term metabolic health
    Andreas Plagemann
    Division of Experimental Obstetrics, Clinic of Obstetrics, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Best Pract Res Clin Endocrinol Metab 26:641-53. 2012
    ..This opens a variety of opportunities and challenges to primarily prevent chronic diseases, e.g. the metabolic syndrome...
  5. doi request reprint Maternal diabetes and perinatal programming
    A Plagemann
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, Germany
    Early Hum Dev 87:743-7. 2011
    ..These measures might serve as causal approaches of a genuine prevention to the benefit of long-term offspring health...
  6. ncbi request reprint Perinatal programming and functional teratogenesis: impact on body weight regulation and obesity
    Andreas Plagemann
    Experimental Obstetrics, Clinic of Obstetrics, Charite, University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Physiol Behav 86:661-8. 2005
    ....
  7. doi request reprint Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding
    Andreas Plagemann
    Division of Experimental Obstetrics, Clinic of Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Perinat Med 38:393-400. 2010
    ..g., due to induction of hypothalamic insulin resistance. We investigated acquired alterations of the DNA methylation pattern of the hypothalamic insulin receptor promoter (IRP) which might be an underlying molecular mechanism...
  8. pmc Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome
    Andreas Plagemann
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Physiol 587:4963-76. 2009
    ..Our findings reveal overfeeding as an epigenetic risk factor of obesity programming and consecutive diabetic and cardiovascular disorders and diseases, in terms of the metabolic syndrome...
  9. doi request reprint [Fetal programming by disturbed intrauterine environment - fundamental mechanisms exemplified by the regulation of body weight and metabolism]
    Andreas Plagemann
    Arbeitsgruppe Experimentelle Geburtsmedizin, Klinik fur Geburtsmedizin, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Deutschland
    Gynakol Geburtshilfliche Rundsch 48:215-24. 2008
    ..The resultant far-reaching potential for primary prevention of chronic diseases as well as the paradigmatic character of these hypotheses and observations for the general understanding of health and disease are highlighted...
  10. ncbi request reprint DDT in human milk and mental capacities in children at school age: an additional view on PISA 2000
    Günter Dörner
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Neuro Endocrinol Lett 23:427-31. 2002
    ..To investigate a possible lasting impact of dichlorodiphenyl trichloroethane (DDT) exposure in neonatal life on mental capacities in later life...
  11. doi request reprint A matter of insulin: developmental programming of body weight regulation
    A Plagemann
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite University Medicine Berlin, Berlin, Germany
    J Matern Fetal Neonatal Med 21:143-8. 2008
    ..These measures might serve as causal approaches to a genuine primary prevention...
  12. doi request reprint The diabetic pregnancy, macrosomia, and perinatal nutritional programming
    A Plagemann
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    Nestle Nutr Workshop Ser Pediatr Program 61:91-102. 2008
    ..These measures might serve as causal approaches to a genuine primary prevention...
  13. ncbi request reprint 'Fetal programming' and 'functional teratogenesis': on epigenetic mechanisms and prevention of perinatally acquired lasting health risks
    Andreas Plagemann
    Clinic of Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Perinat Med 32:297-305. 2004
    ....
  14. ncbi request reprint Long-term impact of neonatal breast-feeding on body weight and glucose tolerance in children of diabetic mothers
    Andreas Plagemann
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Berlin, Germany
    Diabetes Care 25:16-22. 2002
    ..In population-based studies, breast-feeding has been shown to be protective against obesity and diabetes later in life. To date, the role of breast-feeding on offspring of diabetic mothers (ODM) has not been investigated in this context...
  15. ncbi request reprint Reduction of cholecystokinin-8S-neurons in the paraventricular hypothalamic nucleus of neonatally overfed weanling rats
    A Plagemann
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Berlin, Germany
    Neurosci Lett 258:13-6. 1998
    ..Long-term consequences on CCK-related neuroendocrine regulations could be suggested, including those affecting food intake and body weight gain...
  16. ncbi request reprint Increased number of galanin-neurons in the paraventricular hypothalamic nucleus of neonatally overfed weanling rats
    A Plagemann
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Schumannstr 20 21, 10098, Berlin, Germany
    Brain Res 818:160-3. 1999
    ..Our results might indicate malformation of hypothalamic galaninergic neurons due to neonatal overfeeding and hyperinsulinism, respectively, in rats...
  17. ncbi request reprint Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally overfed rats
    A Plagemann
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Schumannstr 20 21, 10098, Berlin, Germany
    Brain Res 836:146-55. 1999
    ..In conclusion, neonatally acquired persisting malformation of hypothalamic galaninergic neurons, induced by early overfeeding and hyperinsulinism, might promote the development of overweight and syndrome X-like alterations during life...
  18. ncbi request reprint Observations on the orexigenic hypothalamic neuropeptide Y-system in neonatally overfed weanling rats
    A Plagemann
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Berlin, Germany
    J Neuroendocrinol 11:541-6. 1999
    ..Since the NPY system is functionally mature already at this age, these findings might indicate an acquired resistance of the hypothalamic NPY system to increased levels of insulin and/or leptin in early postnatally overfed SL rats...
  19. ncbi request reprint Cholecystokinin-8S levels in discrete hypothalamic nuclei of weanling rats exposed to maternal protein malnutrition
    A Plagemann
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Berlin, Germany
    Regul Pept 85:109-13. 1999
    ....
  20. ncbi request reprint Hypothalamic neuropeptide Y levels in weaning offspring of low-protein malnourished mother rats
    A Plagemann
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Berlin, 10098, Germany
    Neuropeptides 34:1-6. 2000
    ..Furthermore a disturbed NPYergic regulation of the VMN is suggested, possibly contributing to alterations of the hypothalamic regulation of body weight and metabolism in LP offspring during life...
  21. ncbi request reprint Impact of early neonatal breast-feeding on psychomotor and neuropsychological development in children of diabetic mothers
    Andreas Plagemann
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    Diabetes Care 28:573-8. 2005
    ..Here, we investigated the influence of early neonatal intake of DBM on neurodevelopment in ODM...
  22. ncbi request reprint Perinatal nutrition and hormone-dependent programming of food intake
    A Plagemann
    Clinic of Obstetrics, Charite University Medicine Berlin, Germany
    Horm Res 65:83-9. 2006
    ....
  23. ncbi request reprint Overweight and increased diabetes susceptibility in neonatally insulin-treated adult rats
    T Harder
    Institute of Experimental Endocrinology, Humboldt University Medical School Charit, Berlin, Germany
    Endocr Regul 33:25-31. 1999
    ....
  24. doi request reprint Intrauterine growth restriction in a rodent model and developmental programming of the metabolic syndrome: a critical appraisal of the experimental evidence
    U Neitzke
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, Germany
    Placenta 29:246-54. 2008
    ..This may lead to new strategies of primary prevention of diabetes, obesity, and the metabolic syndrome...
  25. ncbi request reprint Perinatal 'programming' of insulin resistance in childhood: critical impact of neonatal insulin and low birth weight in a risk population
    T Harder
    Institute of Experimental Endocrinology, , Berlin, Germany
    Diabet Med 18:634-9. 2001
    ..Perinatal and neonatal insulin, known to be of critical importance for long-term outcome, should be evaluated in future studies on the 'small baby syndrome'...
  26. ncbi request reprint 'Programming' of orexigenic and anorexigenic hypothalamic neurons in offspring of treated and untreated diabetic mother rats
    Kerstin Franke
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Brain Res 1031:276-83. 2005
    ..These acquired alterations are preventable by treatment of maternal GD...
  27. ncbi request reprint Increased inhibition by agouti-related peptide of ventromedial hypothalamic neurons in rats overweight due to early postnatal overfeeding
    Yuzhen Li
    Johannes Müller Institut für Physiologie, Charite, Tucholskystrasse 2, D 10117 Berlin, Germany
    Neurosci Lett 330:33-6. 2002
    ..This increased inhibition of VMH neurons by AGRP in early postnatally overnourished rats might contribute to the changed regulation leading to a persistent overweight condition throughout life...
  28. ncbi request reprint Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life
    G Dorner
    Bereich Charité der Humboldt Universität, Institut für Experimentelle Endokrinologie, Berlin, Germany
    Horm Metab Res 26:213-21. 1994
    ....
  29. ncbi request reprint Maternal and paternal family history of diabetes in women with gestational diabetes or insulin-dependent diabetes mellitus type I
    T Harder
    Institute of Experimental Endocrinology, , Schumannstrasse 20/21, D-10098 Berlin, Germany
    Gynecol Obstet Invest 51:160-4. 2001
    ....
  30. ncbi request reprint Pancreatic islet transplantation in diabetic pregnant rats prevents acquired malformation of the ventromedial hypothalamic nucleus in their offspring
    T Harder
    Institute of Experimental Endocrinology, , Schumannstrasse 20/21, 10098 Berlin, Germany
    Neurosci Lett 299:85-8. 2001
    ..In conclusion, prevention of VMN malformation in offspring of islet-transplanted diabetic mothers might be co-responsible for normalization of their glucose homeostasis during life...
  31. ncbi request reprint GABAA receptor antagonists prevent abnormalities in leptin, insulin and amylin actions on paraventricular hypothalamic neurons of overweight rats
    Helga Davidowa
    Institut fur Neurophysiologie, Charite Universitatsmedizin Berlin, Germany
    Eur J Neurosci 23:1248-54. 2006
    ..In conclusion, changes in neuronal wiring with GABAergic interneurons seem to contribute to a persistently reduced negative feedback of adiposity signals in early postnatally overfed rats...
  32. doi request reprint Birth weight, early weight gain, and subsequent risk of type 1 diabetes: systematic review and meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Epidemiol 169:1428-36. 2009
    ..This meta-analysis indicates that high birth weight and increased early weight gain are risk factors for type 1 diabetes...
  33. doi request reprint Growth restricting effects of a single course of antenatal betamethasone treatment and the role of human placental lactogen
    T Braun
    Department of Obstetrics, Charite University Berlin, Campus Virchow, Berlin, Germany
    Placenta 34:407-15. 2013
    ..We therefore hypothesized that also in humans a single course of BET administration is associated with a reduction of PL, associated with a deceleration in fetal growth...
  34. ncbi request reprint Different responses of ventromedial hypothalamic neurons to leptin in normal and early postnatally overfed rats
    H Davidowa
    Johannes Mueller Institute of Physiology, Charite, Humboldt University Berlin, Germany
    Neurosci Lett 293:21-4. 2000
    ..05, n = 39), whereas neurons of overweight SL rats were mainly inhibited (Wt, P < 0.001, n = 33). This clearly altered response to leptin in neonatally overnourished rats might contribute to their persistent overweight throughout life...
  35. ncbi request reprint Long-term impact of breast-feeding on body weight and glucose tolerance in children of diabetic mothers: role of the late neonatal period and early infancy
    Elke Rodekamp
    Clinic of Obstetrics, Head of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, 13353 Berlin, Germany
    Diabetes Care 28:1457-62. 2005
    ..Here, we investigate whether DBM intake during the late neonatal period and early infancy also influences later adipogenic and diabetogenic risk in ODM...
  36. ncbi request reprint Secular trends in neonatal macrosomia in Berlin: influences of potential determinants
    Renate L Bergmann
    Department of Obstetrics, Charité Virchow Hospitals of the Humboldt University, Berlin, and Robert Koch Institute, Berlin, Germany
    Paediatr Perinat Epidemiol 17:244-9. 2003
    ..37.[3.22, 3.53]) and for recognised diabetes (1.85.[1.69, 2.04]). It is speculated that this increase in the prevalence of neonatal macrosomia may contribute to the secular trend of overweight and obesity under affluent living conditions...
  37. ncbi request reprint Impact of breast-feeding on psychomotor and neuropsychological development in children of diabetic mothers: role of the late neonatal period
    Elke Rodekamp
    Clinic of Obstetrics, Research Groups Experimental Obstetrics, Charite University Medicine Berlin, Germany
    J Perinat Med 34:490-6. 2006
    ..Late neonatal DBM ingestion (2nd-4th week), however, not independently influenced the risk of overweight. We investigated whether late neonatal DBM ingestion might independently influence neuro-development...
  38. ncbi request reprint Action of CCK and 5-HT on lateral hypothalamic neurons depends on early postnatal nutrition
    U Zippel
    Johannes Mueller Institute of Physiology, Faculty of Medicine, Charite, Humboldt University Berlin, Germany
    Nutr Neurosci 4:143-52. 2001
    ..At least in males, a changed responsiveness and type of response to cholecystokinin of lateral hypothalamic neurons might be involved in this altered regulation...
  39. ncbi request reprint Cross-fostering to diabetic rat dams affects early development of mediobasal hypothalamic nuclei regulating food intake, body weight, and metabolism
    Sonja Fahrenkrog
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Nutr 134:648-54. 2004
    ....
  40. ncbi request reprint Insulin resistance of hypothalamic arcuate neurons in neonatally overfed rats
    Helga Davidowa
    Institut fur Neurophysiologie, Charite, Universitatsmedizin Berlin, Germany
    Neuroreport 18:521-4. 2007
    ..This can be regarded as insulin resistance, which is induced during early development and persists in later life...
  41. ncbi request reprint Altered neuronal responses to feeding-relevant peptides as sign of developmental plasticity in the hypothalamic regulatory system of body weight
    Helga Davidowa
    Johannes Mueller Institute of Physiology, Faculty of Medicine, Institute of Experimental Endocrinology, Faculty of Medicine Charite, Humboldt University Berlin, Germany
    Zh Vyssh Nerv Deiat Im I P Pavlova 53:663-70. 2003
    ....
  42. doi request reprint Birth weight and subsequent risk of childhood primary brain tumors: a meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Am J Epidemiol 168:366-73. 2008
    ..60). No association was found for ependymoma. These findings indicate that birth weight is related to the development of childhood brain tumors, with high birth weight being a risk factor for the two most common types of brain tumors...
  43. ncbi request reprint Hypothalamic neurons of postnatally overfed, overweight rats respond differentially to corticotropin-releasing hormones
    Helga Davidowa
    Johannes Mueller Institute of Physiology, Charite University Medicine Berlin, Campus Charite Mitte, Tucholskystr 2, D 10117 Berlin, Germany
    Neurosci Lett 371:64-8. 2004
    ....
  44. ncbi request reprint Determinants of fetal growth at different periods of pregnancies complicated by gestational diabetes mellitus or impaired glucose tolerance
    Ute M Schaefer-Graf
    Department of Obstetrics, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Diabetes Care 26:193-8. 2003
    ..To determine maternal parameters with the strongest influence on fetal growth in different periods of pregnancies complicated by an abnormal glucose tolerance test (GTT)...
  45. ncbi request reprint Action of prolactin, prolactin-releasing peptide and orexins on hypothalamic neurons of adult, early postnatally overfed rats
    Helga Davidowa
    Institut fur Neurophysiologie, Charite Universitatsmedizin Berlin, Tucholskystr 2, D 10117 Berlin, Germany
    Neuro Endocrinol Lett 26:453-8. 2005
    ..These peptides are described to have an effect on food intake and body weight regulation. Prolactin is co-synthesized in lateral hypothalamic neurons together with orexins that were also analyzed in this study...
  46. ncbi request reprint The main effect of cocaine- and amphetamine-regulated transcript (CART) peptide on hypothalamic neuronal activity depends on the nutritional state of rats
    Helga Davidowa
    Johannes Mueller Institute of Physiology, Charite University Medicine Berlin, Germany
    Neuro Endocrinol Lett 26:29-34. 2005
    ..The study proved the hypothesis that neurons of the hypothalamic regulatory system of body weight differentially react to CART in dependence of the nutritional state of the animal: overweight, fed or short-term fasting...
  47. ncbi request reprint Arcuate neurons of overweight rats differ in their responses to amylin from controls
    Helga Davidowa
    Johannes Mueller Institute of Physiology, Charite University Medicine Berlin, Tucholskystr 2, D 10117 Berlin, Germany
    Neuroreport 15:2801-5. 2004
    ..The difference in the type of response to amylin shown by arcuate neurons of overweight rats can be regarded as expression of neonatally programmed neurochemical plasticity of the regulatory system of body weight...
  48. ncbi request reprint Differential involvement of dopamine D1 and D2 receptors and inhibition by dopamine of hypothalamic VMN neurons in early postnatally overfed juvenile rats
    Helga Davidowa
    Johannes Mueller Institute of Physiology, Faculty of Medicine, Charite, Humboldt University Berlin, Germany
    Nutr Neurosci 5:27-36. 2002
    ....
  49. ncbi request reprint Independent association between leptin and blood pressure during third trimester in normal and gestational diabetic pregnancies
    Kai J Buhling
    Clinic of Obstetrics, Campus Virchow Klinikum, Charite University Medicine Berlin, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Eur J Obstet Gynecol Reprod Biol 119:180-4. 2005
    ..To assess the relationship between plasma leptin concentration during third trimester of pregnancy and blood pressure, independent of body mass index at examination and other potential confounders...
  50. ncbi request reprint Birth weight and risk of neuroblastoma: a meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Epidemiol 39:746-56. 2010
    ..Previous studies investigated whether birth weight is associated with risk of neuroblastoma, with conflictive results. We conducted a meta-analysis to quantitatively summarize the published evidence...
  51. ncbi request reprint Hypothalamic ventromedial and arcuate neurons of normal and postnatally overnourished rats differ in their responses to melanin-concentrating hormone
    Helga Davidowa
    Johannes Mueller Institute of Physiology, Faculty of Medicine Charite, Humboldt University Berlin, Tucholskystr 2, D 10117, Berlin, Germany
    Regul Pept 108:103-11. 2002
    ....
  52. ncbi request reprint Duration of breastfeeding and risk of overweight: a meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine, Berlin, Germany
    Am J Epidemiol 162:397-403. 2005
    ..94, 0.98). The definitions of overweight and age had no influence. These findings strongly support a dose-dependent association between longer duration of breastfeeding and decrease in risk of overweight...
  53. ncbi request reprint Altered responses to orexigenic (AGRP, MCH) and anorexigenic (alpha-MSH, CART) neuropeptides of paraventricular hypothalamic neurons in early postnatally overfed rats
    Helga Davidowa
    Johannes Mueller Institute of Physiology, Faculty of Medicine Charite, Humboldt University Berlin, Tucholskystr 2, D 10117 Berlin, Germany
    Eur J Neurosci 18:613-21. 2003
    ....
  54. ncbi request reprint Prevention by maternal pancreatic islet transplantation of hypothalamic malformation in offspring of diabetic mother rats is already detectable at weaning
    Thomas Harder
    Clinic of Obstetrics, Division of Experimental Obstetrics, Humboldt University Medical School Charité, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Neurosci Lett 352:163-6. 2003
    ..In conclusion, prevention of VMN malformation in offspring of islet-transplanted diabetic mothers is a direct consequence of normalized maternal metabolism during critical perinatal development...
  55. ncbi request reprint Genetic and epigenetic effects on sexual brain organization mediated by sex hormones
    G Dorner
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Schumannstr 20 21, 10098 Berlin, Germany
    Neuro Endocrinol Lett 22:403-9. 2001
    ..Finally, some data suggest that endocrine disrupters may also be able to affect the development of sexual orientation...
  56. doi request reprint Uterine vascular function in a transgenic preeclampsia rat model
    Stefan Verlohren
    Department of Obstetrics, Franz Volhard Clinic, Berlin, Germany
    Hypertension 51:547-53. 2008
    ..Renin-angiotensin system activation-induced preeclampsia is associated with altered placentation, modified resistance index, and endothelial dysfunction. A disturbed prostacyclin:thromboxane ratio could be an important mediator...
  57. ncbi request reprint Birth weight and subsequent risk of type 2 diabetes: a meta-analysis
    Thomas Harder
    Obstetrics Clinic, Experimental Obstetrics Research Group, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    Am J Epidemiol 165:849-57. 2007
    ..These findings indicate that there exists a relation between birth weight and later-life risk of type 2 diabetes which is not linearly inverse but U-shaped...
  58. ncbi request reprint Infant weight gain and later blood pressure
    Thomas Harder
    Circulation 106:e58; author reply e58. 2002
  59. ncbi request reprint The changing face and implications of childhood obesity
    Andreas Plagemann
    N Engl J Med 350:2414-6; author reply 2414-6. 2004
  60. ncbi request reprint Premature birth and insulin resistance
    Andreas Plagemann
    N Engl J Med 352:939-40; author reply 939-40. 2005
  61. ncbi request reprint The intrauterine environmental adipogenesis
    Thomas Harder
    J Pediatr 144:551; author reply 551-2. 2004
  62. ncbi request reprint Differential response to NPY of PVH and dopamine-responsive VMH neurons in overweight rats
    Helga Davidowa
    Johannes Mueller Institute of Physiology, Faculty of Medicine Charite, Humboldt University Berlin, Germany
    Neuroreport 13:1523-7. 2002
    ..The altered response of PVH neurons to the feeding-inducing NPY and the increased inhibition by NPY and dopamine in the VMH might contribute to the persisting hyperphagia and overweight of postnatally overnourished rats...
  63. ncbi request reprint Birth weight and parental BMI predict overweight in children from mothers with gestational diabetes
    Ute M Schaefer-Graf
    Department of Obstetrics, Vivantes Medical Center Berlin Neukölln, Rudower Strasse 48, D 12351 Berlin, Germany
    Diabetes Care 28:1745-50. 2005
    ..To investigate the growth of children from pregnancies with gestational diabetes mellitus (GDM) and its association with antenatal maternal, fetal, and recent anthropometric parameters of mother and father...
  64. ncbi request reprint Letter by Harder et al regarding article, "Low birth weight, a risk factor for cardiovascular diseases in later life, is already associated with elevated fetal glycosylated hemoglobin at birth"
    Thomas Harder
    Circulation 115:e462; author reply e463-4. 2007
  65. ncbi request reprint Altered action of dopamine and cholecystokinin on lateral hypothalamic neurons in rats raised under different feeding conditions
    Ursula Zippel
    Johannes Mueller Institute of Physiology, Charite, Humboldt University Berlin, Tucholskystr 2, D 10117 Berlin, Germany
    Behav Brain Res 147:89-94. 2003
    ..The increased neuronal responsiveness to exogenous DA and CCK in neonatally overfed SL rats may indicate a decreased activity of these endogenous signals which normally contribute to limitation of energy intake...
  66. ncbi request reprint Developmental programming of the hypothalamus: a matter of insulin. A comment on: Horvath, T. L., Bruning, J. C.: Developmental programming of the hypothalamus: a matter of fat. Nat. Med. (2006) 12: 52-53
    Andreas Plagemann
    Neuro Endocrinol Lett 27:70-2. 2006
  67. ncbi request reprint Breast-feeding and risk for childhood obesity: response to Mayer-Davis et al
    Andreas Plagemann
    Diabetes Care 30:451-2; author reply 452. 2007
  68. ncbi request reprint Differences between meta-analyses on breastfeeding and obesity support causality of the association
    Thomas Harder
    Pediatrics 117:987; author reply 987-8. 2006
  69. ncbi request reprint Low birth weight and blood pressure: the role of neonatal factors in the "small-baby-syndrome"
    Thomas Harder
    J Pediatr 146:148-9; author reply 149. 2005
  70. ncbi request reprint Re: "Association of a woman's own birth weight with her subsequent risk for pregnancy-induced hypertension"
    Thomas Harder
    Am J Epidemiol 160:507-8; author reply 508. 2004
  71. ncbi request reprint Letter regarding article by Stettler et al, "Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula"
    Andreas Plagemann
    Circulation 112:e110. 2005
  72. ncbi request reprint Birth weight and intima-media thickness
    Thomas Harder
    Epidemiology 16:421-2; author reply 422-3. 2005
  73. ncbi request reprint Where is the evidence that low birthweight leads to obesity?
    Thomas Harder
    Lancet 369:1859. 2007