Olaf Penack

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets
    O Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Leukemia 19:835-40. 2005
  2. ncbi request reprint Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO)
    Olaf Penack
    Department of Hematology, Oncology and Tumourimmunology, Charite Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Ann Hematol 93:1083-95. 2014
  3. ncbi request reprint The type of ATG matters -- natural killer cells are influenced differentially by Thymoglobulin, Lymphoglobulin and ATG-Fresenius
    Olaf Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Transpl Immunol 18:85-7. 2007
  4. doi request reprint Aspergillus galactomannan testing in patients with long-term neutropenia: implications for clinical management
    O Penack
    Department of Hematology and Oncology, Charite Campus Benjamin Franklin, Berlin, Germany
    Ann Oncol 19:984-9. 2008
  5. pmc Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth
    Olaf Penack
    Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, 12200 Berlin, Germany
    J Natl Cancer Inst 102:894-908. 2010
  6. doi request reprint Management of sepsis in neutropenic patients: guidelines from the infectious diseases working party of the German Society of Hematology and Oncology
    O Penack
    Department of Hematology and Oncology, Charite Campus Benjamin Franklin, Berlin
    Ann Oncol 22:1019-29. 2011
  7. ncbi request reprint A novel method to quantify and characterize leukemia-reactive natural killer cells in patients undergoing allogeneic hematopoietic stem cell transplantation following conventional or reduced-dose conditioning
    Olaf Penack
    Department of Hematology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Int J Hematol 85:326-32. 2007
  8. ncbi request reprint Low-dose liposomal amphotericin B in the prevention of invasive fungal infections in patients with prolonged neutropenia: results from a randomized, single-center trial
    O Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Ann Oncol 17:1306-12. 2006
  9. ncbi request reprint Cost-benefit assessment of antifungal prophylaxis with liposomal amphotericin B in neutropenic patients
    Olaf Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Onkologie 30:621-6. 2007
  10. ncbi request reprint Management of sepsis in neutropenia: guidelines of the infectious diseases working party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
    Olaf Penack
    Klinik für Hämatologie, Onkologie and Transfusionsmedizin, Charite Campus Benjamin Franklin, Berlin, Germany German Society ofHematology and Oncology
    Ann Hematol 85:424-33. 2006

Detail Information

Publications23

  1. ncbi request reprint CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets
    O Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Leukemia 19:835-40. 2005
    ..Our results indicate that the CD107a assay represents a promising new method for the quantification and characterization of cells exhibiting natural cytotoxicity...
  2. ncbi request reprint Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO)
    Olaf Penack
    Department of Hematology, Oncology and Tumourimmunology, Charite Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Ann Hematol 93:1083-95. 2014
    ..Our aim is to give evidence-based recommendations for haematologist, oncologists and intensive care physicians on how to manage adult patients with neutropenia and sepsis. ..
  3. ncbi request reprint The type of ATG matters -- natural killer cells are influenced differentially by Thymoglobulin, Lymphoglobulin and ATG-Fresenius
    Olaf Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Transpl Immunol 18:85-7. 2007
    ..Randomized trials addressing the impact of different ATGs on lymphocyte subpopulations in the clinical setting are urgently warranted...
  4. doi request reprint Aspergillus galactomannan testing in patients with long-term neutropenia: implications for clinical management
    O Penack
    Department of Hematology and Oncology, Charite Campus Benjamin Franklin, Berlin, Germany
    Ann Oncol 19:984-9. 2008
    ..Our data also show that GEI testing in BAL can be useful for early diagnosis of IA in patients with hematological malignancies and pulmonary infiltrates...
  5. pmc Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth
    Olaf Penack
    Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, 12200 Berlin, Germany
    J Natl Cancer Inst 102:894-908. 2010
    ....
  6. doi request reprint Management of sepsis in neutropenic patients: guidelines from the infectious diseases working party of the German Society of Hematology and Oncology
    O Penack
    Department of Hematology and Oncology, Charite Campus Benjamin Franklin, Berlin
    Ann Oncol 22:1019-29. 2011
    ..The guidelines are written for clinicians involved in care of cancer patients and focus on pathophysiology, diagnosis and treatment of sepsis during neutropenia...
  7. ncbi request reprint A novel method to quantify and characterize leukemia-reactive natural killer cells in patients undergoing allogeneic hematopoietic stem cell transplantation following conventional or reduced-dose conditioning
    Olaf Penack
    Department of Hematology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Int J Hematol 85:326-32. 2007
    ..Using this method, we found that NK cells had high antitumor cytotoxic activity after nonmyeloablative conditioning, which may contribute to the effectiveness of nonmyeloablative conditioning...
  8. ncbi request reprint Low-dose liposomal amphotericin B in the prevention of invasive fungal infections in patients with prolonged neutropenia: results from a randomized, single-center trial
    O Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Ann Oncol 17:1306-12. 2006
    ....
  9. ncbi request reprint Cost-benefit assessment of antifungal prophylaxis with liposomal amphotericin B in neutropenic patients
    Olaf Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Onkologie 30:621-6. 2007
    ..2 vs. 4.6%, p < 0.001) in high-risk patients with hematological malignancies and prolonged neutropenia...
  10. ncbi request reprint Management of sepsis in neutropenia: guidelines of the infectious diseases working party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
    Olaf Penack
    Klinik für Hämatologie, Onkologie and Transfusionsmedizin, Charite Campus Benjamin Franklin, Berlin, Germany German Society ofHematology and Oncology
    Ann Hematol 85:424-33. 2006
    ..The guidelines are written for clinicians and focus on pathophysiology, diagnosis, and treatment of sepsis. The manuscript contains evidence-based recommendations for the assessment of the quality and strength of the data...
  11. ncbi request reprint Mast cell leukaemia
    Olaf Penack
    Haematology, Oncology and Transfusion Medicine, Charité Campus Benjamin Franklim, Berlin, Germany
    Br J Haematol 131:416. 2005
  12. ncbi request reprint Air embolism simulating atypical pneumonia
    Olaf Penack
    Department of Internal Medicine III, Charite University Medicine Berlin, Germany
    Br J Haematol 130:468. 2005
  13. ncbi request reprint Value of surveillance blood cultures in neutropenic patients--a pilot study
    Olaf Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Jpn J Infect Dis 58:171-3. 2005
    ..These results suggest that further prospective studies are warranted to determine the clinical usefulness of surveillance with BC in neutropenic patients...
  14. doi request reprint The importance of neovascularization and its inhibition for allogeneic hematopoietic stem cell transplantation
    Olaf Penack
    Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Blood 117:4181-9. 2011
    ..This perspective covers current knowledge of the role of neovascularization during GVHD as well as GVT and its implications for HSCT...
  15. ncbi request reprint The anti-lymphoma effect of antibody-mediated immunotherapy is based on an increased degranulation of peripheral blood natural killer (NK) cells
    Lars Fischer
    Department of Hematology, Oncology and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Exp Hematol 34:753-9. 2006
    ..Due to methodical difficulties, little is yet known about the relevant cell subpopulations and effector mechanisms leading to tumor lysis in ADCC...
  16. ncbi request reprint False-positive Aspergillus antigen testing due to application of piperacillin/tazobactam--is it still an issue?
    Olaf Penack
    Hematology and Oncology, Campus Benjamin Franklin, D 12200 Berlin, Germany
    Diagn Microbiol Infect Dis 60:117-20. 2008
    ..We found that false-positive GEI results can be avoided by performance of blood sampling before PT administration and by using separate sites for blood sampling and for administration of antibiotics...
  17. doi request reprint Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100
    Franziska Leonhardt
    Department of Hematology and Oncology, FreiburgUniversity Medical Center, Albert Ludwigs University of Freiburg, Freiburg, Germany
    Blood 121:3307-18. 2013
    ..We identify negative regulation of GvHD-related neovascularization by miR-100, which indicates common pathomechanistic features of GvHD and ischemia...
  18. doi request reprint Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors
    Olaf Penack
    Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Blood 115:1865-72. 2010
    ..This review covers current knowledge of the role of PAMPs and PRRs in the control of adaptive immune responses during inflammatory diseases, particularly GVHD...
  19. doi request reprint Danger signals activating innate immunity in graft-versus-host disease
    Robert Zeiser
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Hugstetterstr 55, 79106 Freiburg, Germany
    J Mol Med (Berl) 89:833-45. 2011
    ..This review covers both the impact of endogenous and exogenous danger signals activating innate immunity in GvHD...
  20. ncbi request reprint Bloodstream infections in neutropenic patients: early detection of pathogens and directed antimicrobial therapy due to surveillance blood cultures
    O Penack
    Department of Haematology, Oncology, and Transfusion Medicine, Campus Benjamin Franklin, Charite, University of Medicine, Berlin, Germany
    Ann Oncol 18:1870-4. 2007
    ..5 days, P = 0.004). In conclusion we detected causative microorganisms in more than one-third of BSIs prior to onset of clinical manifestation. The impact of surveillance BCs on the outcome has to be assessed in randomized studies...
  21. ncbi request reprint Serotherapy with thymoglobulin and alemtuzumab differentially influences frequency and function of natural killer cells after allogeneic stem cell transplantation
    O Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite, Berlin, Germany
    Bone Marrow Transplant 41:377-83. 2008
    ..Prolonged immunosuppression with increased risk of infections and tumor relapse are a potential threat to patients undergoing HCST and receiving alemtuzumab as T-cell depletion...
  22. ncbi request reprint Cladribine therapy in a patient with an aleukemic subvariant of mast cell leukemia
    Olaf Penack
    Ann Hematol 84:692-3. 2005
  23. ncbi request reprint Lack of evidence that false-positive Aspergillus galactomannan antigen test results are due to treatment with piperacillin-tazobactam
    Olaf Penack
    Clin Infect Dis 39:1401-2; author reply 1402-3. 2004