Matthias Peiser

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity
    Matthias Peiser
    Institute of Molecular Biology and Bioinformatics, Charite CBF, Berlin, Germany
    J Leukoc Biol 83:1118-27. 2008
  2. doi request reprint Classification of sensitizing and irritative potential in a combined in-vitro assay
    Reinhard Wanner
    Institute of Clinical Pharmacology and Toxicology, Charite, Berlin, Germany
    Toxicol Appl Pharmacol 245:211-8. 2010
  3. doi request reprint TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23
    Ehsan Aliahmadi
    Charite University Medicine Berlin, Institute of Molecular Biology and Bioinformatics, Berlin, Germany
    Eur J Immunol 39:1221-30. 2009
  4. doi request reprint Evaluation of selected biomarkers for the detection of chemical sensitization in human skin: a comparative study applying THP-1, MUTZ-3 and primary dendritic cells in culture
    Manuel Hitzler
    German Federal Institute for Risk Assessment BfR, Department of Product Safety, Berlin, Germany
    Toxicol In Vitro 27:1659-69. 2013
  5. doi request reprint On the role of co-inhibitory molecules in dendritic cell: T helper cell coculture assays aimed to detect chemical-induced contact allergy
    Matthias Peiser
    Department of Product Safety, German Federal Institute for Risk Assessment BfR, Max Dohrn Strasse 8 10, 10589, Berlin, Germany
    EXS 104:115-35. 2014
  6. pmc Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy
    Manuel Hitzler
    German Federal Institute for Risk Assessment BfR, Department of Product Safety, Berlin, Germany
    PLoS ONE 7:e46776. 2012
  7. doi request reprint A new dendritic cell type suitable as sentinel of contact allergens
    Maximilian Schreiner
    Institute of Molecular Biology and Bioinformatics, Charite, Berlin, Germany
    Toxicology 249:146-52. 2008
  8. ncbi request reprint Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19
    Victoria Hoene
    Institute of Molecular Biology and Bioinformatics, Charite CBF, Arnimallee 22, 14195 Berlin, Germany
    J Leukoc Biol 80:1328-36. 2006
  9. ncbi request reprint ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells
    Esther J Witsch
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Eur J Immunol 32:2680-6. 2002
  10. ncbi request reprint Keratinocytes rapidly readjust ceramide-sphingomyelin homeostasis and contain a phosphatidylcholine-sphingomyelin transacylase
    Reinhard Wanner
    Institut fur Molekularbiologie und Biochemie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 122:773-82. 2004

Collaborators

Detail Information

Publications12

  1. doi request reprint Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity
    Matthias Peiser
    Institute of Molecular Biology and Bioinformatics, Charite CBF, Berlin, Germany
    J Leukoc Biol 83:1118-27. 2008
    ..Collectively, our results show that TLR2 expressed by LCs mediates inflammatory responses to lipopeptides, which implicates a central role in sensing pathogens in human skin...
  2. doi request reprint Classification of sensitizing and irritative potential in a combined in-vitro assay
    Reinhard Wanner
    Institute of Clinical Pharmacology and Toxicology, Charite, Berlin, Germany
    Toxicol Appl Pharmacol 245:211-8. 2010
    ....
  3. doi request reprint TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23
    Ehsan Aliahmadi
    Charite University Medicine Berlin, Institute of Molecular Biology and Bioinformatics, Berlin, Germany
    Eur J Immunol 39:1221-30. 2009
    ..Interestingly, blockage of TLR2 on PGN-stimulated MoLC prevented polarization of Th cells into Th17 cells. Thus, our findings indicate a role of TLR2 in eliciting Th17 immune responses in inflamed skin...
  4. doi request reprint Evaluation of selected biomarkers for the detection of chemical sensitization in human skin: a comparative study applying THP-1, MUTZ-3 and primary dendritic cells in culture
    Manuel Hitzler
    German Federal Institute for Risk Assessment BfR, Department of Product Safety, Berlin, Germany
    Toxicol In Vitro 27:1659-69. 2013
    ....
  5. doi request reprint On the role of co-inhibitory molecules in dendritic cell: T helper cell coculture assays aimed to detect chemical-induced contact allergy
    Matthias Peiser
    Department of Product Safety, German Federal Institute for Risk Assessment BfR, Max Dohrn Strasse 8 10, 10589, Berlin, Germany
    EXS 104:115-35. 2014
    ..In conclusion, inhibitory ligands of DC surface receptors and/or their cognate receptors on T cells could serve as useful tools in cell-based assays, directly influencing toxicological endpoints such as sensitization. ..
  6. pmc Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy
    Manuel Hitzler
    German Federal Institute for Risk Assessment BfR, Department of Product Safety, Berlin, Germany
    PLoS ONE 7:e46776. 2012
    ..Our findings suggest that PD-L1 on LCs plays a crucial role in type IV allergic reactions and in response to bacterial stimuli by controlling the nature of inflammatory Th cell responses...
  7. doi request reprint A new dendritic cell type suitable as sentinel of contact allergens
    Maximilian Schreiner
    Institute of Molecular Biology and Bioinformatics, Charite, Berlin, Germany
    Toxicology 249:146-52. 2008
    ..Animal-based assays do not meet this requirement. The LCSA provides dose-response information, thereby allowing prediction of the relative ability of a substance to induce sensitization...
  8. ncbi request reprint Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19
    Victoria Hoene
    Institute of Molecular Biology and Bioinformatics, Charite CBF, Arnimallee 22, 14195 Berlin, Germany
    J Leukoc Biol 80:1328-36. 2006
    ..Microarray analysis pointed to a participation of Type I IFNs. In fact, D19-stimulated moDC secreted considerable amounts of IFN-alpha. This indicates that moDC themselves sense viral and bacterial DNA and do not need help from pDC...
  9. ncbi request reprint ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells
    Esther J Witsch
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Eur J Immunol 32:2680-6. 2002
    ..Our data thus indicate a selective regulation of IL-10 secretion by ICOS on re-activation of effector T cells with professional antigen-presenting cells (bearing CD80 and CD86) in lymphoid tissue...
  10. ncbi request reprint Keratinocytes rapidly readjust ceramide-sphingomyelin homeostasis and contain a phosphatidylcholine-sphingomyelin transacylase
    Reinhard Wanner
    Institut fur Molekularbiologie und Biochemie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 122:773-82. 2004
    ..A transferase of that kind would allow rapid adjustment of local lipid composition in response to acutely changed conditions. In addition, this transferase might have a function in the formation of the epidermal permeability barrier...
  11. ncbi request reprint Human epidermal Langerhans cells differ from monocyte-derived Langerhans cells in CD80 expression and in secretion of IL-12 after CD40 cross-linking
    Matthias Peiser
    Institute of Molecular Biology and Biochemistry, Free University of Berlin, Arnimallee 22, D 14195 Berlin, Germany
    J Leukoc Biol 76:616-22. 2004
    ..In difference to MoLCs, LCs resisted activation by CD40L and LPS in terms of IL-12 production. This shows that natural and generated LCs share similar features but differ in relevant functions...
  12. ncbi request reprint CD1a and CD1c cell sorting yields a homogeneous population of immature human Langerhans cells
    Matthias Peiser
    Department of Dermatology and Allergy, Charite, Humboldt University of Berlin, D 10117 Berlin, Germany
    J Immunol Methods 279:41-53. 2003
    ..We conclude that human epidermal LCs obtained by the CD1c cell-sorting protocol are optimal candidates with which to elucidate the properties and capabilities of immature cells and to develop immunotherapeutic vaccines...