Matthias Peiser

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity
    Matthias Peiser
    Institute of Molecular Biology and Bioinformatics, Charite CBF, Berlin, Germany
    J Leukoc Biol 83:1118-27. 2008
  2. ncbi Classification of sensitizing and irritative potential in a combined in-vitro assay
    Reinhard Wanner
    Institute of Clinical Pharmacology and Toxicology, Charite, Berlin, Germany
    Toxicol Appl Pharmacol 245:211-8. 2010
  3. ncbi TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23
    Ehsan Aliahmadi
    Charite University Medicine Berlin, Institute of Molecular Biology and Bioinformatics, Berlin, Germany
    Eur J Immunol 39:1221-30. 2009
  4. ncbi A new dendritic cell type suitable as sentinel of contact allergens
    Maximilian Schreiner
    Institute of Molecular Biology and Bioinformatics, Charite, Berlin, Germany
    Toxicology 249:146-52. 2008
  5. ncbi Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19
    Victoria Hoene
    Institute of Molecular Biology and Bioinformatics, , Arnimallee 22, 14195 Berlin, Germany
    J Leukoc Biol 80:1328-36. 2006
  6. ncbi ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells
    Esther J Witsch
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Eur J Immunol 32:2680-6. 2002
  7. ncbi Keratinocytes rapidly readjust ceramide-sphingomyelin homeostasis and contain a phosphatidylcholine-sphingomyelin transacylase
    Reinhard Wanner
    Institut fur Molekularbiologie und Biochemie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 122:773-82. 2004
  8. ncbi Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy
    Manuel Hitzler
    German Federal Institute for Risk Assessment BfR, Department of Product Safety, Berlin, Germany
    PLoS ONE 7:e46776. 2012
  9. ncbi Human epidermal Langerhans cells differ from monocyte-derived Langerhans cells in CD80 expression and in secretion of IL-12 after CD40 cross-linking
    Matthias Peiser
    Institute of Molecular Biology and Biochemistry, Free University of Berlin, Arnimallee 22, D 14195 Berlin, Germany
    J Leukoc Biol 76:616-22. 2004
  10. ncbi CD1a and CD1c cell sorting yields a homogeneous population of immature human Langerhans cells
    Matthias Peiser
    Department of Dermatology and Allergy, Charit, Humboldt-University of Berlin, D-10117 Berlin, Germany
    J Immunol Methods 279:41-53. 2003

Collaborators

Detail Information

Publications10

  1. ncbi Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity
    Matthias Peiser
    Institute of Molecular Biology and Bioinformatics, Charite CBF, Berlin, Germany
    J Leukoc Biol 83:1118-27. 2008
    ..Collectively, our results show that TLR2 expressed by LCs mediates inflammatory responses to lipopeptides, which implicates a central role in sensing pathogens in human skin...
  2. ncbi Classification of sensitizing and irritative potential in a combined in-vitro assay
    Reinhard Wanner
    Institute of Clinical Pharmacology and Toxicology, Charite, Berlin, Germany
    Toxicol Appl Pharmacol 245:211-8. 2010
    ....
  3. ncbi TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23
    Ehsan Aliahmadi
    Charite University Medicine Berlin, Institute of Molecular Biology and Bioinformatics, Berlin, Germany
    Eur J Immunol 39:1221-30. 2009
    ..Interestingly, blockage of TLR2 on PGN-stimulated MoLC prevented polarization of Th cells into Th17 cells. Thus, our findings indicate a role of TLR2 in eliciting Th17 immune responses in inflamed skin...
  4. ncbi A new dendritic cell type suitable as sentinel of contact allergens
    Maximilian Schreiner
    Institute of Molecular Biology and Bioinformatics, Charite, Berlin, Germany
    Toxicology 249:146-52. 2008
    ..Animal-based assays do not meet this requirement. The LCSA provides dose-response information, thereby allowing prediction of the relative ability of a substance to induce sensitization...
  5. ncbi Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19
    Victoria Hoene
    Institute of Molecular Biology and Bioinformatics, , Arnimallee 22, 14195 Berlin, Germany
    J Leukoc Biol 80:1328-36. 2006
    ..Microarray analysis pointed to a participation of Type I IFNs. In fact, D19-stimulated moDC secreted considerable amounts of IFN-alpha. This indicates that moDC themselves sense viral and bacterial DNA and do not need help from pDC...
  6. ncbi ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells
    Esther J Witsch
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Eur J Immunol 32:2680-6. 2002
    ..Our data thus indicate a selective regulation of IL-10 secretion by ICOS on re-activation of effector T cells with professional antigen-presenting cells (bearing CD80 and CD86) in lymphoid tissue...
  7. ncbi Keratinocytes rapidly readjust ceramide-sphingomyelin homeostasis and contain a phosphatidylcholine-sphingomyelin transacylase
    Reinhard Wanner
    Institut fur Molekularbiologie und Biochemie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 122:773-82. 2004
    ..A transferase of that kind would allow rapid adjustment of local lipid composition in response to acutely changed conditions. In addition, this transferase might have a function in the formation of the epidermal permeability barrier...
  8. ncbi Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy
    Manuel Hitzler
    German Federal Institute for Risk Assessment BfR, Department of Product Safety, Berlin, Germany
    PLoS ONE 7:e46776. 2012
    ..Our findings suggest that PD-L1 on LCs plays a crucial role in type IV allergic reactions and in response to bacterial stimuli by controlling the nature of inflammatory Th cell responses...
  9. ncbi Human epidermal Langerhans cells differ from monocyte-derived Langerhans cells in CD80 expression and in secretion of IL-12 after CD40 cross-linking
    Matthias Peiser
    Institute of Molecular Biology and Biochemistry, Free University of Berlin, Arnimallee 22, D 14195 Berlin, Germany
    J Leukoc Biol 76:616-22. 2004
    ..In difference to MoLCs, LCs resisted activation by CD40L and LPS in terms of IL-12 production. This shows that natural and generated LCs share similar features but differ in relevant functions...
  10. ncbi CD1a and CD1c cell sorting yields a homogeneous population of immature human Langerhans cells
    Matthias Peiser
    Department of Dermatology and Allergy, Charit, Humboldt-University of Berlin, D-10117 Berlin, Germany
    J Immunol Methods 279:41-53. 2003
    ..We conclude that human epidermal LCs obtained by the CD1c cell-sorting protocol are optimal candidates with which to elucidate the properties and capabilities of immature cells and to develop immunotherapeutic vaccines...