Alexa Patzelt

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Drug delivery to hair follicles
    Alexa Patzelt
    Center for Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venerology and Allergology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Expert Opin Drug Deliv 10:787-97. 2013
  2. doi request reprint In vivo investigations on the penetration of various oils and their influence on the skin barrier
    A Patzelt
    Charite Universitatsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Berlin, Germany
    Skin Res Technol 18:364-9. 2012
  3. doi request reprint Differential stripping demonstrates a significant reduction of the hair follicle reservoir in vitro compared to in vivo
    Alexa Patzelt
    Department of Dermatology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, Germany
    Eur J Pharm Biopharm 70:234-8. 2008
  4. doi request reprint Selective follicular targeting by modification of the particle sizes
    Alexa Patzelt
    Charite Universitatsmedizin Berlin, Department of Dermatology and Allergology, Center of Experimental and Cutaneous Physiology CCP, Berlin, Germany
    J Control Release 150:45-8. 2011
  5. doi request reprint Follicular transport route--research progress and future perspectives
    Fanny Knorr
    Center of Experimental and Applied Cutaneous Physiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 71:173-80. 2009
  6. doi request reprint In vivo distribution of carotenoids in different anatomical locations of human skin: comparative assessment with two different Raman spectroscopy methods
    Maxim E Darvin
    Center of Experimental Applied Cutaneous Physiology, Department of Dermatology and Allergology, Charite Universitatsmedizin, Berlin, Germany
    Exp Dermatol 18:1060-3. 2009
  7. doi request reprint Determination of the protection efficacy and homogeneity of the distribution of sunscreens applied onto skin pre-treated with cosmetic products
    Hans Jürgen Weigmann
    Department of Dermatology, Center of Experimental and Applied Cutaneous Physiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Skin Res Technol 18:245-50. 2012
  8. doi request reprint Raman spectroscopic analysis of the carotenoid concentration in egg yolks depending on the feeding and housing conditions of the laying hens
    Karoline Hesterberg
    Charite University Hospital Berlin, Department of Dermatology and Allergology, Center of Experimental and Cutaneous Physiology CCP, Berlin, Germany
    J Biophotonics 5:33-9. 2012
  9. doi request reprint Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study
    Maxim E Darvin
    Charite Universitatsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Berlin, Germany
    J Dermatol Sci 64:53-8. 2011
  10. doi request reprint Follicular and percutaneous penetration pathways of topically applied minoxidil foam
    Ulrike Blume-Peytavi
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 76:450-3. 2010

Collaborators

Detail Information

Publications31

  1. doi request reprint Drug delivery to hair follicles
    Alexa Patzelt
    Center for Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venerology and Allergology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Expert Opin Drug Deliv 10:787-97. 2013
    ..They are closely surrounded by capillaries and antigen-presenting cells, are associated with the sebaceous glands and are the host of stem cells in the bulge region of the hair follicle...
  2. doi request reprint In vivo investigations on the penetration of various oils and their influence on the skin barrier
    A Patzelt
    Charite Universitatsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Berlin, Germany
    Skin Res Technol 18:364-9. 2012
    ..The skin represents a potent barrier to the environment, which can be enhanced by the topical application of skin care products, such as oil and oil-based formulations by moisturizing the skin...
  3. doi request reprint Differential stripping demonstrates a significant reduction of the hair follicle reservoir in vitro compared to in vivo
    Alexa Patzelt
    Department of Dermatology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, Germany
    Eur J Pharm Biopharm 70:234-8. 2008
    ..It can thus be assumed that excised skin models are suitable for penetration studies only to a limited extent, as follicular penetration is greatly diminished due to the contraction of the elastic fibres of the skin...
  4. doi request reprint Selective follicular targeting by modification of the particle sizes
    Alexa Patzelt
    Charite Universitatsmedizin Berlin, Department of Dermatology and Allergology, Center of Experimental and Cutaneous Physiology CCP, Berlin, Germany
    J Control Release 150:45-8. 2011
    ..For the human terminal hair follicle, the situation can be expected to be similar due to a similar size ratio of the hair follicles...
  5. doi request reprint Follicular transport route--research progress and future perspectives
    Fanny Knorr
    Center of Experimental and Applied Cutaneous Physiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 71:173-80. 2009
    ..This review summarizes the recent progress in this field, and underlines the necessity for pilot studies in human volunteers to further the development of clinical applications for follicular targeting...
  6. doi request reprint In vivo distribution of carotenoids in different anatomical locations of human skin: comparative assessment with two different Raman spectroscopy methods
    Maxim E Darvin
    Center of Experimental Applied Cutaneous Physiology, Department of Dermatology and Allergology, Charite Universitatsmedizin, Berlin, Germany
    Exp Dermatol 18:1060-3. 2009
    ..Most of the antioxidants cannot be produced by the human organism. Thus, they have to be incorporated by food and beverages...
  7. doi request reprint Determination of the protection efficacy and homogeneity of the distribution of sunscreens applied onto skin pre-treated with cosmetic products
    Hans Jürgen Weigmann
    Department of Dermatology, Center of Experimental and Applied Cutaneous Physiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Skin Res Technol 18:245-50. 2012
    ..The aim of this study was to investigate the influence of a skin pre-treatment with body lotion on the layout of the formulations...
  8. doi request reprint Raman spectroscopic analysis of the carotenoid concentration in egg yolks depending on the feeding and housing conditions of the laying hens
    Karoline Hesterberg
    Charite University Hospital Berlin, Department of Dermatology and Allergology, Center of Experimental and Cutaneous Physiology CCP, Berlin, Germany
    J Biophotonics 5:33-9. 2012
    ..001). The kinetics of the carotenoid concentration in the egg yolks, depending on fodder, housing and weather conditions, were investigated...
  9. doi request reprint Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study
    Maxim E Darvin
    Charite Universitatsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Berlin, Germany
    J Dermatol Sci 64:53-8. 2011
    ..The best prevention of the destructive action of free radicals in human skin is textile coverings, topical sunscreens and the development of a high antioxidative protective network...
  10. doi request reprint Follicular and percutaneous penetration pathways of topically applied minoxidil foam
    Ulrike Blume-Peytavi
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 76:450-3. 2010
    ..Hair follicles are surrounded by a dense network of blood capillaries and dendritic cells and have stem cells in their immediate vicinity, making them ideal targets for drug delivery...
  11. doi request reprint Strategy of topical vaccination with nanoparticles
    Sascha Jung
    Charite Universitatsmedizin Berlin, Department of Dermatology, Center for Experimental and Applied Cutaneous Physiology, Chariteplatz 1, Berlin D 10117, Germany
    J Biomed Opt 14:021001. 2009
    ..Penetration depth of negatively charged liposomes did not exceed 50% of the total follicle length. The fluorescence dyes were mainly detected in the hair follicle; only a small amount of dye was found in the upper parts of the epidermis...
  12. pmc Permeation of topically applied caffeine through human skin--a comparison of in vivo and in vitro data
    Sindy Trauer
    Department of Dermatology, Charite Universitatsmedizin Berlin, Berlin 10117, Germany
    Br J Clin Pharmacol 68:181-6. 2009
    ..The aim of the present study was to investigate the follicular penetration of caffeine in vitro and to compare the data with the in vivo results determined previously under similar conditions...
  13. doi request reprint One-year study on the variation of carotenoid antioxidant substances in living human skin: influence of dietary supplementation and stress factors
    Maxim E Darvin
    Charite Universitatsmedizin Berlin, Department of Dermatology, Chariteplatz 1, 10117 Berlin, Germany
    J Biomed Opt 13:044028. 2008
    ..During the summer and autumn months, an increase in the level of carotenoids in the skin was measured for all volunteers. The average "seasonal increase" of the carotenoid content in the skin was determined to be 1.26-fold...
  14. doi request reprint Topical vaccination with functionalized particles targeting dendritic cells
    Renato B Baleeiro
    Department of Dermatology, Venerology and Allergology, Charite Universitatsmedizin Berlin, Humboldt Universität zu Berlin and Freie Universität Berlin, Berlin, Germany
    J Invest Dermatol 133:1933-41. 2013
    ..The microparticle vaccine principle can be applied to different antigen formats such as peptides and proteins, or nucleic acids coding for the antigens. ..
  15. ncbi request reprint Comparison of two in vitro models for the analysis of follicular penetration and its prevention by barrier emulsions
    Jurgen Lademann
    Department of Dermatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 72:600-4. 2009
    ..The results give further indication that in vitro studies based on membranes of excised skin are not suitable for the investigation of the follicular penetration pathway of topically applied substances...
  16. doi request reprint Effects of a topically applied wound ointment on epidermal wound healing studied by in vivo fluorescence laser scanning microscopy analysis
    Bernhard Lange-Asschenfeldt
    Charite Universitatsmedizin Berlin, University Medical School, Department of Dermatology, Venerology and Allergology and Skin Cancer Center, Berlin, 10117, Germany
    J Biomed Opt 14:054001. 2009
    ..This technique allows monitoring of the kinetics of wound healing noninvasively and over time, while offering new insights into the potential effects of topically applied drugs on the process of tissue repair...
  17. doi request reprint Influence of massage and occlusion on the ex vivo skin penetration of rigid liposomes and invasomes
    Sindy Trauer
    Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Charite Universitatsmedizin Berlin, Germany Zebet at Federal Institute of Risk Assessment BfR, Berlin, Germany
    Eur J Pharm Biopharm 86:301-6. 2014
    ..Occlusion may reduce the efficacy of follicular penetration depending on the specific liposomal preparation. Rigidity in particular appears to be a relevant parameter. ..
  18. doi request reprint Raman spectroscopic analysis of the increase of the carotenoid antioxidant concentration in human skin after a 1-week diet with ecological eggs
    Karoline Hesterberg
    Charite Universitatsmedizin Berlin, Department of Dermatology and Allergy, Center of Experimental and Applied Cutaneous Physiology, Chariteplatz 1, Berlin 10117, Germany
    J Biomed Opt 14:024039. 2009
    ..But in the case of egg consumption, ecological eggs from hens kept on pasture should be preferred to also receive a benefit for the skin...
  19. doi request reprint Determination of the cuticula thickness of human and porcine hairs and their potential influence on the penetration of nanoparticles into the hair follicles
    Juergen Lademann
    Charite Universitatsmedizin Berlin, Center of Applied Cutaneous Physiology, Department of Dermatology, Berlin, Berlin D 10117, Germany
    J Biomed Opt 14:021014. 2009
    ..530 nm), while the thickness of the cuticula obtained from porcine ear bristles were slightly thinner (approx. 320 nm)...
  20. doi request reprint Approach towards developing a novel procedure to selectively quantify topically applied substances in the hair follicles of the model tissue porcine ear skin
    Fanny Knorr
    Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Dermatol 22:417-8. 2013
    ..Approximately 5% of the topically applied dye was recovered from the hair follicles, which is in accordance with a previous study...
  21. doi request reprint Confocal laser-scanning microscopy of capillaries in normal and psoriatic skin
    Rami Archid
    Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Biomed Opt 17:101511. 2012
    ..The diameter of the vessels could be seen as a well-quantifiable indicator for the state of psoriatic skin. CLSM could be useful for therapeutic monitoring to delay possible recurrences...
  22. doi request reprint Risk assessment of the application of a plasma jet in dermatology
    Juergen Lademann
    Charite Universitatsmedizin Berlin, Center of Experimental and Cutaneous Physiology, Department of Dermatology and Allergology, Chariteplatz 1, Berlin 10117, Germany
    J Biomed Opt 14:054025. 2009
    ..Additionally, thermal damage of the tissue by the plasma can be excluded. The results of the risk assessment stimulate the in vivo application of the investigated plasma jet in the treatment of chronic wounds...
  23. doi request reprint Hair shaft abnormalities in alopecia areata evaluated by optical coherence tomography
    Natalie Garcia Bartels
    Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charite Universitatsmedizin Berlin, Berlin, Germany
    Skin Res Technol 17:201-5. 2011
    ..The aim of this study was to evaluate whether OCT is useful for the evaluation of hair shaft abnormalities in AA...
  24. doi request reprint Efficient prevention strategy against the development of a palmar-plantar erythrodysesthesia during chemotherapy
    Juergen Lademann
    Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Skin Pharmacol Physiol 27:66-70. 2014
    ....
  25. pmc The role of hair follicles in the percutaneous absorption of caffeine
    Nina Otberg
    Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Charite Universitaetsmedizin, Berlin, Germany
    Br J Clin Pharmacol 65:488-92. 2008
    ..Occlusion [6] and skin thickness [7] seem to have little influence on the penetration of caffeine. However, percutaneous absorption rates for caffeine exhibit regional skin differences in humans in vivo[1]...
  26. doi request reprint Comparison of human and porcine skin for characterization of sunscreens
    Hans Jürgen Weigmann
    Charite Universitatsmedizin Berlin, Department of Dermatology, Center of Experimental and Applied Cutaneous Physiology, Chariteplatz 1, 10117 Berlin, Germany
    J Biomed Opt 14:024027. 2009
    ..98. The results demonstrate the possibility for the use of porcine skin to determine the protection efficacy of sunscreens...
  27. doi request reprint Optical coherent tomography: promising in vivo measurement of hair shaft cross section
    Natalie Garcia Bartels
    Charité Universitätsmedizin Berlin, Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité Campus Mitte, Charitéplatz 1, Berlin, 10117 Germany
    J Biomed Opt 16:096003. 2011
    ..This technique offers a unique opportunity for in vivo measurement and a follow-up of the kinetics of hair shaft thickness in humans during medical therapy...
  28. ncbi request reprint The pathogenetic mechanism of anthracycline-induced palmar-plantar erythrodysesthesia
    A Martschick
    Department of Gynecology and Obstetrics, Charite Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, 10117 Berlin, Germany
    Anticancer Res 29:2307-13. 2009
    ..Unfortunately, their implementation in therapy is limited due to severe side-effects such as palmar-plantar erythrodysesthesia (PPE)...
  29. doi request reprint Cutaneous concentration of lycopene correlates significantly with the roughness of the skin
    Maxim Darvin
    Charite Universitatsmedizin Berlin, Department of Dermatology, Berlin, Germany
    Eur J Pharm Biopharm 69:943-7. 2008
    ..843). These findings indicate that higher levels of antioxidants in the skin effectively lead to lower levels of skin roughness, and therefore support our hypothesis...
  30. pmc In vivo analysis of wound healing by optical methods
    Alena Alborova
    Center of Applied Cutaneous Physiology CCP, Department of Dermatology and Allergology, Charite Universitatsmedizin, Berlin, Germany
    GMS Krankenhhyg Interdiszip 3:Doc10. 2008
    ..The course of wound healing determined by laser scanning microscopy was correlated with numerical values, allowing the numerical characterization of the wound healing process...
  31. ncbi request reprint Comparative study of hair follicle morphology in eight mammalian species and humans
    Susanne Mangelsdorf
    Department of Dermatology, Venerology and Allergology, Charite Universitatsmedizin Berlin, 10117, Berlin, Germany
    Skin Res Technol 20:147-54. 2014
    ....