Andreas Pascher

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Endocrine tumours of the gastrointestinal tract. Transplantation in the management of metastatic endocrine tumours
    Andreas Pascher
    Klinik fUr Allgemein, Visceral und Transplantationschirurgie, Universitatsmedizin Berlin, Charite, Campus Virchow Klinikum, Germany
    Best Pract Res Clin Gastroenterol 19:637-48. 2005
  2. pmc Protocol TOP-Study (tacrolimus organ perfusion): a prospective randomized multicenter trial to reduce ischemia reperfusion injury in transplantation of marginal liver grafts with an ex vivo tacrolimus perfusion
    Sebastian Pratschke
    Department of Surgery, University of Munich Hospital, Campus Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Transplant Res 2:3. 2013
  3. pmc Irreversible liver failure: treatment by transplantation: part 3 of a series on liver cirrhosis
    Andreas Pascher
    Department of General, Visceral, and Transplant Surgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Dtsch Arztebl Int 110:167-73. 2013
  4. ncbi request reprint Primary and secondary hepatic manifestation of neuroendocrine tumors
    A Pascher
    Department for General, Visceral and Transplantation Surgery, Charite, Berlin, Germany
    Langenbecks Arch Surg 385:265-70. 2000
  5. ncbi request reprint Anti-TNF-alpha therapy for acute rejection in intestinal transplantation
    A Pascher
    Department of General and Transplantation Surgery, Charite, Campus Virchow Clinic, Berlin, Germany
    Transplant Proc 37:1635-6. 2005
  6. ncbi request reprint Successful infliximab treatment of steroid and OKT3 refractory acute cellular rejection in two patients after intestinal transplantation
    Andreas Pascher
    Department of General and Transplantation Surgery, Charite, Campus Virchow Clinic, Berlin, Germany
    Transplantation 76:615-8. 2003
  7. doi request reprint Present status and future perspectives of intestinal transplantation
    Andreas Pascher
    Department of Visceral and Transplantation Surgery, Universitaetsmedizin Berlin Charité, Berlin, Germany
    Transpl Int 21:401-14. 2008
  8. ncbi request reprint CMV, EBV, HHV6, and HHV7 infections after intestinal transplantation without specific antiviral prophylaxis
    A Pascher
    Departments of General and Transplantation Surgery, Berlin, Germany
    Transplant Proc 36:381-2. 2004
  9. ncbi request reprint Rat cytomegalovirus infection interferes with anti-CD4 mAb-(RIB 5/2) mediated tolerance and induces chronic allograft damage
    A Pascher
    Department of Visceral and Transplantation Surgery, Charite Universitaetsmedizin Berlin, Campus Virchow, Berlin, Germany, and Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, MA, USA
    Am J Transplant 6:2035-45. 2006
  10. ncbi request reprint [Clinical results of intestinal and multivisceral transplantation at the Charité, Berlin. A case series]
    A Pascher
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie
    Dtsch Med Wochenschr 130:387-92. 2005

Detail Information

Publications96

  1. ncbi request reprint Endocrine tumours of the gastrointestinal tract. Transplantation in the management of metastatic endocrine tumours
    Andreas Pascher
    Klinik fUr Allgemein, Visceral und Transplantationschirurgie, Universitatsmedizin Berlin, Charite, Campus Virchow Klinikum, Germany
    Best Pract Res Clin Gastroenterol 19:637-48. 2005
    ..Orthotopic liver transplantation for patients with remission of disease or stable disease under medical treatment, and orthotopic liver transplantation for palliative reasons, should be restricted to selected individual cases...
  2. pmc Protocol TOP-Study (tacrolimus organ perfusion): a prospective randomized multicenter trial to reduce ischemia reperfusion injury in transplantation of marginal liver grafts with an ex vivo tacrolimus perfusion
    Sebastian Pratschke
    Department of Surgery, University of Munich Hospital, Campus Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Transplant Res 2:3. 2013
    ..Therefore, the aim of the present study is to examine the effects of an ex vivo tacrolimus perfusion on IRI in transplantation of EDC liver grafts...
  3. pmc Irreversible liver failure: treatment by transplantation: part 3 of a series on liver cirrhosis
    Andreas Pascher
    Department of General, Visceral, and Transplant Surgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Dtsch Arztebl Int 110:167-73. 2013
    ..Liver transplantation is the only established, causally directed treatment for irreversible chronic or acute liver failure...
  4. ncbi request reprint Primary and secondary hepatic manifestation of neuroendocrine tumors
    A Pascher
    Department for General, Visceral and Transplantation Surgery, Charite, Berlin, Germany
    Langenbecks Arch Surg 385:265-70. 2000
    ..Since hepatic metastasis predominates and endocrine symptoms correlate with functional tumor mass, hepatic resection may improve prognosis or even cure patients...
  5. ncbi request reprint Anti-TNF-alpha therapy for acute rejection in intestinal transplantation
    A Pascher
    Department of General and Transplantation Surgery, Charite, Campus Virchow Clinic, Berlin, Germany
    Transplant Proc 37:1635-6. 2005
    ..We present our experience with infliximab rescue therapy for steroid- and OKT3-resistant rejection after intestinal transplantation (ITx)...
  6. ncbi request reprint Successful infliximab treatment of steroid and OKT3 refractory acute cellular rejection in two patients after intestinal transplantation
    Andreas Pascher
    Department of General and Transplantation Surgery, Charite, Campus Virchow Clinic, Berlin, Germany
    Transplantation 76:615-8. 2003
    ..Both patients recovered. In conclusion, infliximab has proven to be an effective rescue therapy in a selected group of patients with steroid and OKT3 refractory severe acute rejection after intestinal transplantation...
  7. doi request reprint Present status and future perspectives of intestinal transplantation
    Andreas Pascher
    Department of Visceral and Transplantation Surgery, Universitaetsmedizin Berlin Charité, Berlin, Germany
    Transpl Int 21:401-14. 2008
    ..The improvement of patient- and graft survival over the last few years together with data on the cost effectiveness of ITx, following 2 years after transplantation, may require a redefinition of the indication for ITx...
  8. ncbi request reprint CMV, EBV, HHV6, and HHV7 infections after intestinal transplantation without specific antiviral prophylaxis
    A Pascher
    Departments of General and Transplantation Surgery, Berlin, Germany
    Transplant Proc 36:381-2. 2004
    ..To analyze the incidence and relevance of viral infections after intestinal transplantation (ITx) without specific antiviral prophylaxis...
  9. ncbi request reprint Rat cytomegalovirus infection interferes with anti-CD4 mAb-(RIB 5/2) mediated tolerance and induces chronic allograft damage
    A Pascher
    Department of Visceral and Transplantation Surgery, Charite Universitaetsmedizin Berlin, Campus Virchow, Berlin, Germany, and Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, MA, USA
    Am J Transplant 6:2035-45. 2006
    ..RCMV interferes with anti-CD4 mAb-induced tolerance and leads to chronic allograft damage. The data we presented suggest a potentially important role of viral infections and their prophylaxis in clinical TI protocols...
  10. ncbi request reprint [Clinical results of intestinal and multivisceral transplantation at the Charité, Berlin. A case series]
    A Pascher
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie
    Dtsch Med Wochenschr 130:387-92. 2005
    ..Long-term survival after ITx has been improved significantly during the last years. The experience with ITx at the Charite, Campus Virchow Klinikum, are described and discussed...
  11. ncbi request reprint Biologics in the treatment of transplant rejection and ischemia/reperfusion injury: new applications for TNFalpha inhibitors?
    Andreas Pascher
    Department of Visceral and Transplantation Surgery, Charite Universitaetsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    BioDrugs 19:211-31. 2005
    ..Randomized controlled trials in patients undergoing solid-organ transplantation are needed to further elucidate the clinical value of TNFalpha inhibition...
  12. ncbi request reprint Bile duct complications after liver transplantation
    Andreas Pascher
    Department of General, Visceral, and Transplantation Surgery, Universitatsmedizin Berlin, Berlin, Germany
    Transpl Int 18:627-42. 2005
    ..In the following the spectrum of specific bile duct complications after OLT and their treatment options will be reviewed...
  13. ncbi request reprint Analysis of allogeneic versus xenogeneic auxiliary organ perfusion in liver failure reveals superior efficacy of human livers
    A Pascher
    Int J Artif Organs 25:1006-12. 2002
    ..To compare the efficacy of allogeneic and xenogeneic extracorporeal liver perfusion (ECLP)...
  14. ncbi request reprint Transplantation of an eight-organ multivisceral graft in a patient with frozen abdomen after complicated Crohn's disease
    Andreas Pascher
    Department of Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, Berlin 13353, Germany
    World J Gastroenterol 12:4431-4. 2006
    ..The patient recovered completely and discharged 2.5 mo and was doing well 30 mo after MVTx. This is one of the very rare cases in which a complete mulitivisceral graft of eight abdominal organs was transplanted orthotopically...
  15. ncbi request reprint Extracorporeal liver perfusion as hepatic assist in acute liver failure: a review of world experience
    Andreas Pascher
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Charite, Campus Virchow Klinikum der Humboldt Universität zu Berlin, Berlin, Germany
    Xenotransplantation 9:309-24. 2002
    ..In order to create a basis for comparing the value of the existing different hepatic assist methods this article offers a systematic review of the world experience with allogeneic or xenogeneic extracorporeal liver perfusion (ECLP)...
  16. ncbi request reprint Donor evaluation, donor risks, donor outcome, and donor quality of life in adult-to-adult living donor liver transplantation
    Andreas Pascher
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow, Medizinische Fakultat der Humboldt Universitat zu Berlin, Berlin, Germany
    Liver Transpl 8:829-37. 2002
    ..The donor selection process plays a pivotal role in preventing complications. The discussion of potential risks, especially potential life-threatening risks, must be an integral part of informed consent...
  17. doi request reprint Potent early immune response after kidney transplantation in patients of the European senior transplant program
    Johann Pratschke
    Department of General, Visceral, and Transplantation Surgery, Charite Virchow Clinic, Universitatsmedizin Berlin, Germany
    Transplantation 87:992-1000. 2009
    ..Age-adapted immunosuppressive protocols considering these changes are currently not established. This study analyzed the age-dependent immune response after human kidney transplantation...
  18. doi request reprint Cold ischemia does not interfere with tolerance induction
    Anja Reutzel-Selke
    Department of Surgery, Charite, Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
    Transplantation 87:1116-24. 2009
    ..Ischemia/reperfusion injury activates innate immunity, which in turn may prevent tolerance induction. We asked whether prolonged cold ischemia interferes with successful tolerance induction...
  19. doi request reprint Donor brain death significantly interferes with tolerance induction protocols
    Maja Francuski
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
    Transpl Int 22:482-93. 2009
    ..RIB 5/2 treatment significantly improved graft function in recipients of living donor grafts; however, it was not effective in recipients of brain-dead donor organs...
  20. doi request reprint Influence of donor- and recipient-specific factors on the postoperative course after combined pancreas-kidney transplantation
    Peter Thomas Fellmer
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow, Berlin, Germany
    Langenbecks Arch Surg 395:19-25. 2010
    ..Pancreas transplantation is associated with postoperative complications. We defined and identified donor- and recipient-specific factors related to postoperative complications...
  21. doi request reprint Symptomatic lymphoceles after kidney transplantation - multivariate analysis of risk factors and outcome after laparoscopic fenestration
    Frank Ulrich
    Department of General, Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin, Campus Virchow Clinical Centre, Berlin, Germany
    Clin Transplant 24:273-80. 2010
    ..We conclude that diabetes is an independent risk factor for lymphocele development, and laparoscopic fenestration should be the treatment of choice for larger and symptomatic lymphoceles, as it is safe and offers a low recurrence rate...
  22. doi request reprint Methylprednisolone therapy in deceased donors reduces inflammation in the donor liver and improves outcome after liver transplantation: a prospective randomized controlled trial
    Katja Kotsch
    Institute of Medical Immunology, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Ann Surg 248:1042-50. 2008
    ..To investigate potential beneficial effects of donor treatment with methylprednisolone on organ function and outcome after liver transplantation...
  23. ncbi request reprint Extended indications in living-donor liver transplantation: bile duct cancer
    Sven Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Transplantation 80:S101-4. 2005
    ..Living donor liver transplantation may be beneficial in selected patients suffering from Klatskin tumors, whereas caution should prevail when considering intrahepatic cholangiocarcinoma...
  24. doi request reprint Novel markers in zero-hour kidney biopsies indicate graft quality and clinical outcome
    Katja Kotsch
    Institute of Medical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transplantation 90:958-65. 2010
    ..To uncover novel candidate markers characteristic of subtle inflammation and immune activation present during the intraoperative period, we investigated messenger RNA (mRNA) gene expression profiles in renal zero biopsies...
  25. doi request reprint Incidence of and risk factors for ischemic-type biliary lesions following orthotopic liver transplantation
    Christoph Heidenhain
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow, University Medicine Berlin Augustenburger Platz 1, Berlin, Germany
    Transpl Int 23:14-22. 2010
    ..We further advocate that all organ procurement teams perform pressure perfusion on harvested organs...
  26. doi request reprint Long-term outcome of ATG vs. Basiliximab induction
    Frank Ulrich
    Department of Visceral, General and Transplantation Surgery, Charite Universitatsmedizin Berlin, Germany
    Eur J Clin Invest 41:971-8. 2011
    ..An evaluation of the long-term efficacy and incidence of adverse events after induction therapy with antithymocyte globulin (ATG) vs. Basiliximab in renal transplant patients...
  27. doi request reprint Ischemic preconditioning produces systemic protective and adoptively transferable effects
    Anja Reutzel-Selke
    Department of General, Visceral, and Transplant Surgery, Charite, Campus Virchow Clinic, Universitatsmedizin Berlin, Berlin, Germany
    Kidney Int 74:622-30. 2008
    ..These results show that renal ischemic preconditioning is associated with time-dependent local and systemically transferable protection...
  28. ncbi request reprint Induction of carbon monoxide in donor animals prior to organ procurement reduces graft immunogenicity and inhibits chronic allograft dysfunction
    Paulo Ney Aguiar Martins
    Division of Transplant Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Transplantation 82:938-44. 2006
    ..Nonspecific inflammatory damages occurring prior to organ transplantation reduce long-term graft survival. Here, we tested the beneficial effects of carbon monoxide (CO) induction by methylene chloride (MC)...
  29. ncbi request reprint Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis in a European center
    Sven Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, University Medicine Berlin, Germany
    Liver Transpl 13:896-903. 2007
    ..So far, the outcome of the patients is in favor of a careful extension of the selection criteria for HCC in cirrhosis...
  30. ncbi request reprint Alterations of the immune response with increasing recipient age are associated with reduced long-term organ graft function of rat kidney allografts
    Andreas Pascher
    Department of General Surgery, Charite Campus Virchow, Berlin, Germany
    Transplantation 76:1560-8. 2003
    ..Clinically, an increasing number of older recipients are listed for transplantation. We examined recipient age-associated alterations of the immune response and their effects on graft function...
  31. doi request reprint Long-term outcome of liver resection and transplantation for Caroli disease and syndrome
    Frank Ulrich
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow Clinical Centre, Berlin, Germany
    Ann Surg 247:357-64. 2008
    ....
  32. doi request reprint Biliary reconstruction using a side-to-side choledochocholedochostomy with or without T-tube in deceased donor liver transplantation: a prospective randomized trial
    Sascha Weiss
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow Clinical Center, Universitatsmedizin Berlin, 13353 Berlin, Germany
    Ann Surg 250:766-71. 2009
    ..The optimal method of reconstruction remains controversial. The aim of the study was to assess biliary complications after liver transplantation using a choledochocholedochostomy with or without a temporary T-tube...
  33. doi request reprint Review of nonimmunological causes for deteriorated graft function and graft loss after transplantation
    Johann Pratschke
    Department of General, Visceral and Transplantation Surgery, Universitatsmedizin Berlin, Berlin, Germany
    Transpl Int 21:512-22. 2008
    ..We review nonimmunological causes for deteriorated graft function and graft loss after solid organ transplantation...
  34. ncbi request reprint Late graft loss after intestinal transplantation in an adult patient as a result of necrotizing enterocolitis
    Andreas Pascher
    Department of General and Transplantation Surgery, Charite, Campus Virchow, Berlin, Germany
    Am J Transplant 3:1033-5. 2003
    ....
  35. ncbi request reprint The impact of immune-activating processes following transplantation on chronic allograft nephropathy
    Christoph Heidenhain
    Department of General and Transplantation Surgery Charité Campus Virchow Clinic, Berlin, Germany
    Kidney Int 64:1125-33. 2003
    ..However, only very little information is presently available on the influence of systemic immune-activating processes following organ engraftment...
  36. ncbi request reprint Immunosuppressive management following intestinal transplantation in adult patients
    A R Mueller
    Department of Surgery, Charite, Campus Virchow Clinic, Humboldt University of Berlin, Berlin, Germany
    Transplant Proc 35:2075-7. 2003
  37. ncbi request reprint [Living donor liver transplantation from the perspective of the donor: results of a psychosomatic investigation]
    Marc Walter
    Medizinische Klinik mit Schwerpunkt Psychosomatik der Charité, Berlin, Germany
    Z Psychosom Med Psychother 51:331-45. 2005
    ..The aims were to describe the clinical problems before and after transplantation and to contribute to the discussion of ethical issues based on empirical findings...
  38. ncbi request reprint Impaired psychosocial outcome of donors after living donor liver transplantation: a qualitative case study
    Marc Walter
    Department of Internal Medicine Psychosomatics, Charite University Medicine Berlin, Berlin, and Department of Psychosomatic Medicine and Psychotherapy, Otto von Guericke University Hospital, Madgeburg, Germany
    Clin Transplant 20:410-5. 2006
    ..Adequate medical and psychological treatment opportunities for these donors should be provided...
  39. doi request reprint Eighteen years of liver transplantation experience in patients with advanced Budd-Chiari syndrome
    Frank Ulrich
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow Clinical Centre, Berlin, Germany
    Liver Transpl 14:144-50. 2008
    ..In conclusion, patients with reversible hepatic damage should be treated by combined strategies, including medical therapy and surgical or interventional shunting...
  40. ncbi request reprint Short-term anti-CD4 plus anti-TNF-alpha receptor treatment in allogeneic small bowel transplantation results in long-term survival
    Jan M Langrehr
    Department of General, Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Berlin, Germany
    Transplantation 84:639-46. 2007
    ....
  41. ncbi request reprint Use of inferior mesenteric vein for venous anastomosis in clinical small bowel transplantation
    K P Platz
    Department of Surgery, Charite, Campus Virchow Clinic, Humboldt University of Berlin, Berlin, Germany
    Transplant Proc 34:906-7. 2002
  42. ncbi request reprint Monitoring of immunosuppression after clinical small bowel transplantation
    A Pascher
    Department of Surgery, Charite, Campus Virchow, Medizinische Fakultat der Humboldt Universitat zu Berlin, Berlin, Germany
    Transplant Proc 34:931-3. 2002
  43. doi request reprint Waitlist characteristics of patients at a single-center intestinal and multivisceral transplant program
    Undine A Gerlach
    Department of General, Visceral, and Transplantation Surgery, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Transpl Int 26:392-401. 2013
    ..MVTX-candidates have a high waitlist mortality for different reasons. However, the current allocation policy for MVTX does not mirror the severity of disease and may therefore contribute to high waitlist mortality...
  44. doi request reprint Elevation of CD4+ differentiated memory T cells is associated with acute cellular and antibody-mediated rejection after liver transplantation
    Undine A Gerlach
    Department of Visceral and Transplant Surgery, Charite Universitatsmedizin, Augustenburger Platz 1, Berlin, Germany
    Transplantation 95:1512-20. 2013
    ..There is also increasing evidence that the presence of preexisting memory T cells can affect antigraft immune responses...
  45. doi request reprint Management of biliary complications following living donor liver transplantation--a single center experience
    Sven Kohler
    Department of Transplant Surgery, Charite Universitaetsmedizin Berlin, Campus Virchow Clinic, Berlin, Germany
    Langenbecks Arch Surg 394:1025-31. 2009
    ..Biliary complications (BC) after living donor liver transplantation (LDLT) are reported in up to 32%. We retrospectively reviewed the biliary reconstruction after 95 LDLT...
  46. doi request reprint Can we use biomarkers and functional assays to implement personalized therapies in transplantation?
    Birgit Sawitzki
    Institute of Medical Immunology, Campus Charite Mitte, Charite University Medicine, Berlin, Germany
    Transplantation 87:1595-601. 2009
    ..The predictive power of these parameters has to be tested in prospective multicenter trials...
  47. ncbi request reprint Aspergillus spondylodiscitis after multivisceral transplantation
    Undine A Gerlach
    Department of General, Visceral and Transplant Surgery, Charite Universitaetsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Ann Transplant 14:52-7. 2009
    ..Typical pathogens are staphylococcus aureus and enterobacteria; fungal spondylodiscitis is uncommon...
  48. doi request reprint The utility of extended criteria donor organs in severely ill liver transplant recipients
    Jens Mittler
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow Clinic, University Medicine Berlin, Berlin, Germany
    Transplantation 86:895-6. 2008
    ..Especially in the setting of ECD liver transplantation, strategies to improve graft quality and mitigate preservation and reperfusion injury may prove beneficial and play an important role in the future...
  49. ncbi request reprint Modifications of immune regulations with increasing donor & recipient age
    Andreas Pascher
    Department of General Surgery, Charite Campus Virchow, Berlin, Germany
    Ann Transplant 9:72-3. 2004
    ..Although our experimental data need to be confirmed clinically, they suggest a modified and age-adapted immunosuppression in elderly recipients during the early posttransplant period...
  50. ncbi request reprint The APACHE III score as preoperative indicator of patient outcome in liver transplantation after fulminant hepatic failure
    Panagiotis Fikatas
    Department of General, Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Ann Transplant 16:18-25. 2011
    ..The purpose of this study was to assess whether APACHE II and III scores would provide prognosis of posttransplant mortality...
  51. ncbi request reprint Age and immune response in organ transplantation
    Paulo N A Martins
    Department of General and Transplantation Surgery, Charite Virchow Clinic, Humboldt University, Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Transplantation 79:127-32. 2005
    ..Here, we are going to review the immunologic changes associated with the aging process relevant for transplantation and their impact on immunosuppressive protocols, organ allocation policies, and transplantation outcome...
  52. doi request reprint Graft versus host disease after liver transplantation - a single center experience and review of literature
    Sven Kohler
    Department of Visceral and Transplant Surgery, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Transpl Int 21:441-51. 2008
    ..All patients died because of either haemorrhage or uncontrollable infections. In our experience, GvHD has been an extremely rare, albeit deleterious clinical condition, which was resistant to classical immunosuppressive rescue regimens...
  53. ncbi request reprint Extracorporeal liver support based on primary human liver cells and albumin dialysis--treatment of a patient with primary graft non-function
    Igor M Sauer
    Charite Campus Virchow, Klinik fUr Allgemein, Visceral und Transplantationschirurgie, Medical Faculty of the Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    J Hepatol 39:649-53. 2003
    ..The bioreactor was integrated into an extracorporeal circuit with continuous single pass albumin dialysis and continuous veno-venuous hemodiafiltration for detoxification and fluid reduction...
  54. ncbi request reprint Clinical small bowel transplantation: focus on mucosal barrier function
    A R Mueller
    Department of Surgery, Charite, Campus Virchow Clinic, Humboldt University of Berlin, Berlin, Germany
    Transplant Proc 34:926-8. 2002
  55. ncbi request reprint Ethical considerations regarding living donation for patients with malignant liver tumors
    A Pascher
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow, Medizinische Fakultat, Humboldt Universitat zu Berlin, Augustenburgerplatz 1, 13353 Berlin, Germany
    Transplant Proc 35:1169-71. 2003
  56. ncbi request reprint Surgical strategies and predictors of outcome for malignant neuroendocrine tumors of the pancreas
    Marcus Bahra
    General, Visceral and Transplantation Surgery Clinic, Charite, Campus Virchow Hospital, Humboldt University, Berlin, Germany
    J Gastroenterol Hepatol 22:930-5. 2007
    ..The aim of this study was to retrospectively review all patients who underwent pancreatic resection for malignant neuroendocrine tumor of the pancreas at the one department from 1989 to 2003...
  57. ncbi request reprint In vitro comparison of the molecular adsorbent recirculation system (MARS) and single-pass albumin dialysis (SPAD)
    Igor M Sauer
    Charité Campus Virchow General, Visceral and Transplantation Surgery, Universitary Medicine Berlin, a joint institution of the Freie Universität and Humboldt Universität, Berlin, Germany
    Hepatology 39:1408-14. 2004
    ..However, MARS in continuous veno-venous hemodialysis mode was significantly less efficient in removing ammonia than MARS in CVVHDF mode. In conclusion, the detoxification capacity of SPAD is similar to or even greater than that of MARS...
  58. ncbi request reprint Survival without biliary complications after liver transplant for primary sclerosing cholangitis
    Martina T Mogl
    Department of General, Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Clin Transplant 11:510-21. 2013
    ..We evaluated long-term outcomes in patients who had liver transplant for primary sclerosing cholangitis...
  59. ncbi request reprint Continuously microscopically observed and process-controlled cell culture within the SlideReactor: proof of a new concept for cell characterization
    Ruth Schwartlander
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Germany
    Tissue Eng 13:187-96. 2007
    ..The SlideReactor may serve as a simple and cost-efficient tool for cell characterization and optimization of cell-culture conditions...
  60. ncbi request reprint Living-donor liver transplantation--European experiences
    Utz Settmacher
    Department of General, Visceral and Transplantation Surgery, Charite, Virchow Clinic, Humboldt University of Berlin, Augustenbuger Platz 1, 13353 Berlin, Germany
    Nephrol Dial Transplant 19:iv16-21. 2004
    ..LRLTx has been shown to be a good option for patients with liver disease in which a long waiting time is not permitted...
  61. ncbi request reprint Immunosuppressive management following small bowel transplantation
    Andrea Raffaella Mueller
    Department of Surgery, Charite, Campus Virchow Clinic, Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Transplant Proc 34:1894-6. 2002
  62. ncbi request reprint [Intensive care treatment following transplant surgery]
    S Kohler
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, 13353 Berlin
    Chirurg 77:687-95. 2006
    ....
  63. ncbi request reprint Modified surgical technique in clinical small bowel transplantation: donor and recipient management
    A R Mueller
    Department of Surgery, Charite, Campus Virchow Clinic, Humboldt University of Berlin, Berlin, Germany
    Transplant Proc 34:2265-7. 2002
  64. doi request reprint Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis
    Tobias Mueller
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Liver Int 31:1574-88. 2011
    ..Tight control of PRR signalling provides tolerance to physiological amounts of intestinal endotoxins in human bile to avoid constant innate immune activation in BECs...
  65. ncbi request reprint Biliary complications after deceased-donor orthotopic liver transplantation
    Andreas Pascher
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow, Universitaetsmedizin Berlin, Augustenburgerplatz 1, 13353 Berlin, Germany
    J Hepatobiliary Pancreat Surg 13:487-96. 2006
    ..The etiology and spectrum of bile duct complications, their diagnosis, and their treatment will be reviewed in this article...
  66. ncbi request reprint Intrahepatic cholangiocarcinoma: indication for transplantation
    Andreas Pascher
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie CharitE, Campus Virchow Klinikum der Humboldt Universität zu Berlin, Augustenburgerplatz 1, 13353 Berlin, Germany
    J Hepatobiliary Pancreat Surg 10:282-7. 2003
    ..A discussion of the role of liver transplantation (LTx) for intrahepatic (IH)-CCC will be presented, based on a review of the international literature...
  67. ncbi request reprint Psychosocial outcome of living donors after living donor liver transplantation: a pilot study
    Marc Walter
    Clinic for Internal Medicine, Psychosomatics Psychotherapy, Charite, Campus Mitte, Humboldt University, Berlin, Germany
    Clin Transplant 16:339-44. 2002
    ..The pronounced complaints appears to indicate psychological tension and distress in some donors following donation...
  68. ncbi request reprint Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature
    Antonino Spinelli
    Department of Ge neral, Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    World J Gastroenterol 12:2293-6. 2006
    ..Clinicians should include XGC among the possible differential diagnoses of masses in liver hilum...
  69. ncbi request reprint [Living donor liver transplantation of the right liver lobe between adults]
    T Steinmuller
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Charite, Campus Virchow, Medizinische Fakultat der Humboldt Universitat zu Berlin, Germany
    Dtsch Med Wochenschr 127:1067-71. 2002
    ..Donor safety and risks are important criteria influencing the further development. We report our experience with 43 adult-to-adult right lobe living donor liver transplantations...
  70. ncbi request reprint New dietary concepts in small bowel transplantation
    R J Schulz
    Hepatology, Gastroenterology, Charite, Campus Virchow Klinikum, Medizinische Fakultat der Humboldt Universitat zu Berlin, 13353, Berlin, Germany
    Transplant Proc 34:893-5. 2002
  71. ncbi request reprint Primary human liver cells as source for modular extracorporeal liver support--a preliminary report
    I M Sauer
    Klinik fUr Allgemein, Visceral und Transplantationschirurgie, Charite, Campus Virchow, Humboldt University, Berlin, Germany
    Int J Artif Organs 25:1001-5. 2002
    ..The overall treatment time was 7-144 hours. No adverse events were observed. Initial clinical applications of the bioreactor evidenced the technical feasibility and safety of the system...
  72. ncbi request reprint Liver transplantation as ultimate tool to treat portal hypertension
    J Klupp
    Charite, Campus Virchow Clinic, Berlin, Germany
    Dig Dis 23:65-71. 2005
    ..This review evaluates the indication of liver transplantation in the treatment of portal hypertension...
  73. ncbi request reprint [Psychological and somatic aspects of living liver donors: preoperative assessment and postoperative course]
    M Walter
    Medizinische Klinik mit Schwerpunkt Psychosomatik, Charite Universitatsmedizin Berlin, Campus Mitte und Campus Virchow Klinikum, Berlin
    Dtsch Med Wochenschr 130:1749-55. 2005
    ..Thus far, only few empirical studies have been published on the situation of donors who are faced with the risk of medical complications after resection of the right hepatic lobe...
  74. ncbi request reprint Living-donation liver transplantation for hepatocellular carcinoma: time to drop the limitations?
    T Steinmuller
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Universitätsklinikum Charité der Humboldt Universität zu Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transplant Proc 34:2263-4. 2002
  75. ncbi request reprint Immediate recovery of renal function after orthotopic liver transplantation in a patient with hepatorenal syndrome requiring hemodialysis for more than 8 months
    C Storm
    Department of Nephrology and Medical Intensive Care, Charit Campus Virchow, University Hospital of Humboldt University Berlin, Berlin, Germany
    Transplant Proc 39:544-6. 2007
    ..This underlined that renal replacement therapy in HRS should be considered as a possible bridging method to liver transplantation even for longer periods...
  76. ncbi request reprint Adult living donor liver transplantation: living donation of the right liver lobe
    J Mittler
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Langenbecks Arch Surg 392:657-62. 2007
    ..In European and North American countries, LDLT for adult recipients is mainly performed with right lobe grafts. Indications, when compared to deceased donor liver transplantation, are controversial...
  77. ncbi request reprint [Accuracy of the CT-estimated weight of the right hepatic lobe prior to living related liver donation (LRLD) for predicting the intraoperatively measured weight of the graft]
    A J Lemke
    Universitatsklinikum Charite, Campus Virchow Klinikum, Klinik fur Strahlenheilkunde, Berlin
    Rofo 175:1232-8. 2003
    ..The expected graft weight is one of the main determinants for donor selection. This study investigates the accuracy of preoperatively performed CT-volumetry to predict the actual weight of the right liver lobe graft...
  78. ncbi request reprint Complication rate of pancreas retransplantation after simultaneous pancreas-kidney transplantation compared with pancreas after kidney transplantation
    P Fellmer
    Klinik f Allgemein, Visceral und Transplantationschirurgie, Charité Berlin Campus Virchow Klinikum, Berlin, Germany
    Transplant Proc 39:563-4. 2007
    ..The study despite the small number of cases shows a high complication rate after pancreas retransplantation. Nevertheless, pancreatic retransplantation should be considered in selected patients...
  79. ncbi request reprint Psychosocial stress of living donors after living donor liver transplantation
    M Walter
    Clinic for Internal Medicine Psychosomatics Psychotherapy, Charite Campus Mitte, Charite Campus Virchow, Humboldt University Berlin, Berlin, Germany
    Transplant Proc 34:3291-2. 2002
  80. ncbi request reprint Evidence of psychosocial influences on acute rejection after liver transplantation
    M Walter
    Clinic for Internal Medicine Psychosomatics, Charite, Humboldt University Berlin, Berlin, Germany
    Transplant Proc 34:3298-301. 2002
  81. ncbi request reprint Technique of bile duct reconstruction and management of biliary complications in right lobe living donor liver transplantation
    U Settmacher
    Department of General, Visceral, and Transplantation Surgery, Charite Berlin, Campus Virchow Klinikum, Berlin, Germany
    Clin Transplant 17:37-42. 2003
    ..Biliary complications were treated by percutaneous drainage or surgical revision in all cases...
  82. ncbi request reprint Brain death activates donor organs and is associated with a worse I/R injury after liver transplantation
    S Weiss
    Department of Surgery, Charite, Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
    Am J Transplant 7:1584-93. 2007
    ..Based on our clinical data, we demonstrate that brain death and the events that precede it are associated with a significant upregulation of inflammatory cytokines and lead to a worse ischemia/reperfusion injury after transplantation...
  83. ncbi request reprint Clinical extracorporeal hybrid liver support--phase I study with primary porcine liver cells
    I M Sauer
    General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University Berlin, Berlin, Germany
    Xenotransplantation 10:460-9. 2003
    ..The bioreactor technology has been integrated into a modular extracorporeal liver support (MELS) system, combining biologic liver support with artificial detoxification technology...
  84. ncbi request reprint An unhappy triad: hemochromatosis, porphyria cutanea tarda and hepatocellular carcinoma-a case report
    Martina T Mogl
    Department of Surgery, Charite Campus Virchow Klinikum, Augustenburger Platz 1, Berlin 13353, Germany
    World J Gastroenterol 13:1998-2001. 2007
    ..Thus progression of fibrosis may be prevented and liver regeneration supported...
  85. doi request reprint Technical advances for abdominal wall closure after intestinal and multivisceral transplantation
    Undine A Gerlach
    Department of General, Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Curr Opin Organ Transplant 17:258-67. 2012
    ....
  86. ncbi request reprint Well-differentiated neuroendocrine carcinoma mimicking an echinococcus cyst of the liver in CT-MRI findings with hepatocyte specific contrast material
    Michaela Krohn
    Klinik fur Strahlenheilkunde, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin, Germany
    J Gastrointestin Liver Dis 20:439-42. 2011
    ....
  87. doi request reprint Efficacy and safety of subcutaneous human HBV-immunoglobulin (Zutectra) in liver transplantation: an open, prospective, single-arm phase III study
    Ali Yahyazadeh
    Department of General, Visceral and Transplantation Surgery, Charite University Medicine Berlin, Berlin, Germany
    Transpl Int 24:441-50. 2011
    ....
  88. ncbi request reprint Induction of carbon monoxide in the donor reduces graft immunogenicity and chronic graft deterioration
    P N A Martins
    Department of General and Transplantation Surgery, Charite, Campus Virchow Clinic, Berlin, Germany
    Transplant Proc 37:379-81. 2005
    ..We showed that donor and long-term recipient treatment with MC improved graft function and reduced histological signs of chronic rejection. Carbon monoxide may be a promising agent to improve graft quality and long-term graft function...
  89. ncbi request reprint Induction of heme oxygenase-1 in the donor reduces graft immunogenicity
    P N A Martins
    Departments of General and Transplantation Surgery and Medical Immunology, Charite, Berlin, Germany
    Transplant Proc 37:384-6. 2005
    ..Thus, induction of HO-1 reduced graft immunogenicity. These mechanisms may explain the protective effects of HO-1 induction...
  90. ncbi request reprint Grafts from elderly donors elicit a stronger immune response in the early period posttransplantation: a study in a rat model
    A Reutzel-Selke
    Department of General and Transplantation Surgery, University of Medicine Berlin, Charite, Virchow Clinic, Berlin, Germany
    Transplant Proc 37:382-3. 2005
    ..Older grafts elicit a stronger immune response during the early period posttransplantation. This process is associated with an increased immunogenicity in older grafts. Clinical immunosuppressive protocols need to consider these effects...
  91. ncbi request reprint Living related liver transplantation: preoperative magnetic resonance imaging for assessment of hepatic vasculature of donor candidates
    F Streitparth
    Department of Radiology, Charite Medical University Center, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Acta Radiol 48:20-6. 2007
    ..To evaluate the accuracy of magnetic resonance angiography (MRA) for preoperative assessment of hepatic vascular anatomy in liver donors before living related liver transplantation...
  92. doi request reprint A comparison of three scores to screen for delirium on the surgical ward
    Finn M Radtke
    Department of Anesthesiology and Surgical Intensive Care Medicine, Campus Charite Mitte, Charite Universitaetsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    World J Surg 34:487-94. 2010
    ..Postoperative delirium is associated with adverse outcome. The aim of this study was to find a valid and easy-to-use tool to screen for postoperative delirium on the surgical ward...
  93. ncbi request reprint Donor age intensifies the early immune response after transplantation
    A Reutzel-Selke
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Berlin, Germany
    Kidney Int 71:629-36. 2007
    ..By 6 months, recipients of young donor grafts produced comparable or more intense alloantigen-specific immune responses. Older donor grafts elicit a stronger immune response in the early period after transplantation...
  94. doi request reprint High weight differences between donor and recipient affect early kidney graft function--a role for enhanced IL-6 signaling
    W Gong
    Institute of Medical Immunology, Charite University Medicine, Campus Mitte, Berlin, Germany
    Am J Transplant 9:1742-51. 2009
    ..These findings have strong clinical implication as anti-IL6R treatment of patients receiving grafts from lower-weight donors could be used to improve primary graft function...
  95. doi request reprint The German NET-registry: an audit on the diagnosis and therapy of neuroendocrine tumors
    Ursula Ploeckinger
    Department of Hepatology and Gastroenterology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neuroendocrinology 90:349-63. 2009
    ..German NET Registry compiled information for Germany pertaining to three questions: who provides care for NET patients; does the care comply with proposed guidelines, and are the results comparable to those described in the literature?..
  96. ncbi request reprint Immune reactivity is more suppressed in patients with alcoholic liver disease than in patients with virus-induced cirrhosis after CRH stimulation
    Verena Eggers
    Department of Anesthesiology and Intensive Care Medicine, Campus Charite Mitte, University Hospital Charite, Germany
    Alcohol Clin Exp Res 30:140-9. 2006
    ..The aim of this study was to investigate the preoperative stress-like response to corticotrophin-releasing-hormone challenge (CRH) of patients with ALD compared with patients with VIC and their immune sequelae...