Christian Otte

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Statin use and risk of depression in patients with coronary heart disease: longitudinal data from the Heart and Soul Study
    Christian Otte
    Department of Psychiatry, Campus Benjamin Franklin, Charite University Medical Center, Berlin, Germany
    J Clin Psychiatry 73:610-5. 2012
  2. pmc Cognitive behavioral therapy in anxiety disorders: current state of the evidence
    Christian Otte
    Department of Psychiatry, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Dialogues Clin Neurosci 13:413-21. 2011
  3. doi request reprint Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the Heart and Soul study
    Christian Otte
    Department of Psychiatry, University Medical Center, 20246 Hamburg Eppendorf, Germany
    J Clin Endocrinol Metab 95:2885-91. 2010
  4. doi request reprint Changes in cortisol secretion during antidepressive treatment and cognitive improvement in patients with major depression: a longitudinal study
    Kim Hinkelmann
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Psychoneuroendocrinology 37:685-92. 2012
  5. doi request reprint Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD
    Katja Wingenfeld
    Department of Psychiatry, Charite University Berlin, Campus Benjamin Franklin, Berlin, Germany
    Psychoneuroendocrinology 37:1048-56. 2012
  6. doi request reprint Hair cortisol and cortisol awakening response are associated with criteria of the metabolic syndrome in opposite directions
    Linn K Kuehl
    Department of Psychiatry and Psychotherapy, Charité University Medical School Berlin, Campus Benjamin Franklin, Berlin, Germany Electronic address
    Psychoneuroendocrinology 51:365-70. 2015
  7. doi request reprint Hair testosterone and visuospatial memory in middle-aged men and women with and without depressive symptoms
    Lucia Dettenborn
    Department of Medical Psychology, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    Psychoneuroendocrinology 38:2373-7. 2013
  8. doi request reprint Noradrenergic blockade and memory in patients with major depression and healthy participants
    Anja Kuffel
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf and Schön Klinik Hamburg Eilbek, Hamburg, Germany
    Psychoneuroendocrinology 40:86-90. 2014
  9. doi request reprint Cortisol response to experimental pain in patients with chronic low back pain and patients with major depression
    Christoph Muhtz
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf and Schön Klinik Hamburg Eilbek, Hamburg, Germany
    Pain Med 14:498-503. 2013
  10. pmc Glucocorticoid receptor gene and depression in patients with coronary heart disease: the Heart and Soul Study-2009 Curt Richter Award Winner
    Christian Otte
    Department of Psychiatry, University Medical Center Hamburg Eppendorf, Germany
    Psychoneuroendocrinology 34:1574-81. 2009

Collaborators

Detail Information

Publications23

  1. doi request reprint Statin use and risk of depression in patients with coronary heart disease: longitudinal data from the Heart and Soul Study
    Christian Otte
    Department of Psychiatry, Campus Benjamin Franklin, Charite University Medical Center, Berlin, Germany
    J Clin Psychiatry 73:610-5. 2012
    ..Statins are among the most commonly prescribed medications worldwide. Although their benefits for cardiovascular disease are well established, the effects of statins on depressive symptoms are unknown...
  2. pmc Cognitive behavioral therapy in anxiety disorders: current state of the evidence
    Christian Otte
    Department of Psychiatry, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Dialogues Clin Neurosci 13:413-21. 2011
    ..In conclusion, CBT appears to be both efficacious and effective in the treatment of anxiety disorders, but more high-quality studies are needed to better estimate the magnitude of the effect...
  3. doi request reprint Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the Heart and Soul study
    Christian Otte
    Department of Psychiatry, University Medical Center, 20246 Hamburg Eppendorf, Germany
    J Clin Endocrinol Metab 95:2885-91. 2010
    ..A common haplotype of the glucocorticoid receptor (GR) gene has been associated with increased susceptibility to coronary heart disease (CHD). Whether this haplotype predisposes to heart failure (HF) is unknown...
  4. doi request reprint Changes in cortisol secretion during antidepressive treatment and cognitive improvement in patients with major depression: a longitudinal study
    Kim Hinkelmann
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Psychoneuroendocrinology 37:685-92. 2012
    ..Here, we longitudinally examined if changes in cortisol secretion during treatment are associated with improvement of cognition...
  5. doi request reprint Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD
    Katja Wingenfeld
    Department of Psychiatry, Charite University Berlin, Campus Benjamin Franklin, Berlin, Germany
    Psychoneuroendocrinology 37:1048-56. 2012
    ..In healthy participants, administration of cortisol impairs declarative memory retrieval. Only a few studies have investigated these effects in PTSD yielding mixed results...
  6. doi request reprint Hair cortisol and cortisol awakening response are associated with criteria of the metabolic syndrome in opposite directions
    Linn K Kuehl
    Department of Psychiatry and Psychotherapy, Charité University Medical School Berlin, Campus Benjamin Franklin, Berlin, Germany Electronic address
    Psychoneuroendocrinology 51:365-70. 2015
    ..29, p=.03) and systolic blood pressure (r=-.32, p=.02). Our results indicate that higher hair cortisol and hair cortisone levels but lower CAR values are associated with an unfavorable metabolic and cardiovascular risk profile. ..
  7. doi request reprint Hair testosterone and visuospatial memory in middle-aged men and women with and without depressive symptoms
    Lucia Dettenborn
    Department of Medical Psychology, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    Psychoneuroendocrinology 38:2373-7. 2013
    ..We examined hair testosterone and its association with verbal and visuospatial memory in middle-aged men and women with and without major depression...
  8. doi request reprint Noradrenergic blockade and memory in patients with major depression and healthy participants
    Anja Kuffel
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf and Schön Klinik Hamburg Eilbek, Hamburg, Germany
    Psychoneuroendocrinology 40:86-90. 2014
    ..In the current study, we further examined the role of noradrenaline on memory in MDD by administering clonidine that activates presynaptic α2 receptors and thereby globally suppresses the noradrenergic output...
  9. doi request reprint Cortisol response to experimental pain in patients with chronic low back pain and patients with major depression
    Christoph Muhtz
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf and Schön Klinik Hamburg Eilbek, Hamburg, Germany
    Pain Med 14:498-503. 2013
    ..However, little is known about the effects of experimentally induced acute pain on cortisol secretion in patients with chronic pain and depression...
  10. pmc Glucocorticoid receptor gene and depression in patients with coronary heart disease: the Heart and Soul Study-2009 Curt Richter Award Winner
    Christian Otte
    Department of Psychiatry, University Medical Center Hamburg Eppendorf, Germany
    Psychoneuroendocrinology 34:1574-81. 2009
    ..3-9.4, p=0.01). These associations persisted after adjusting for potentially confounding variables. A common GR haplotype was associated with depression in a gene-dosage dependent manner and might be a vulnerability factor for depression...
  11. doi request reprint Stimulation of the mineralocorticoid receptor improves memory in young and elderly healthy individuals
    Kim Hinkelmann
    Department of Psychiatry and Psychotherapy, Charite University Medical Center, Campus Benjamin Franklin, Berlin, Germany Electronic address
    Neurobiol Aging 36:919-24. 2015
    ..In concert with the previous studies, our data suggest a role of the MR in memory function. A cognitive enhancing effect by MR stimulation warrants future studies. ..
  12. doi request reprint Effects of noradrenergic stimulation on memory in patients with major depressive disorder
    Katja Wingenfeld
    Department of Psychiatry, Charite University Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Stress 16:191-201. 2013
    ..The mechanism by which yohimbine leads to stronger memory consolidation in depressed patients compared with healthy controls remains to be elucidated...
  13. doi request reprint C-reactive protein, pre- and postdexamethasone cortisol levels in post-traumatic stress disorder
    Carsten Spitzer
    Carsten Spitzer, Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf and Schön Klinik Hamburg Eilbek, Hamburg, Germany, and Asklepios Fachklinikum Tiefenbrunn, Rosdorf, Germany
    Nord J Psychiatry 68:296-9. 2014
    ....
  14. doi request reprint Mineralocorticoid receptor stimulation improves cognitive function and decreases cortisol secretion in depressed patients and healthy individuals
    Christian Otte
    Department of Psychiatry and Psychotherapy, Charite University Medical Center, Campus Benjamin Franklin, Berlin, Germany
    Neuropsychopharmacology 40:386-93. 2015
    ..Our data suggest a crucial role of MR in verbal memory and executive function and demonstrate the possibility to improve cognition in depressed patients and healthy individuals through MR stimulation. ..
  15. pmc Enhanced emotional empathy after mineralocorticoid receptor stimulation in women with borderline personality disorder and healthy women
    Katja Wingenfeld
    Department of Psychiatry and Psychotherapy, Charité University Medical School Berlin, Campus Benjamin Franklin, Berlin, Germany
    Neuropsychopharmacology 39:1799-804. 2014
    ..Stimulation of MR enhanced emotional empathy in healthy women and in BPD patients. Whether fludrocortisone might have a therapeutic role in psychotherapeutic processes, remains to be elucidated. ..
  16. doi request reprint Association of a common mineralocorticoid receptor gene polymorphism with salivary cortisol in healthy adults
    Christoph Muhtz
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Psychoneuroendocrinology 36:298-301. 2011
    ..This polymorphism may contribute to the interindividual variability in stress responsiveness and might be involved in stress-related disorders...
  17. doi request reprint Hydrocortisone impairs working memory in healthy humans, but not in patients with major depressive disorder
    Kirsten Terfehr
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf and Schön Klinik Hamburg Eilbek, Hamburg, Germany
    Psychopharmacology (Berl) 215:71-9. 2011
    ..The purpose of our study was to investigate whether the finding of missing effects of acute cortisol administration on memory performance in MDD is also seen when examining prefrontal-based working memory...
  18. pmc Effect of current and lifetime posttraumatic stress disorder on 24-h urinary catecholamines and cortisol: Results from the Mind Your Heart Study
    Katja Wingenfeld
    Department of Psychiatry, Charité University Medical School Berlin, Campus Benjamin Franklin, Berlin, Germany
    Psychoneuroendocrinology 52:83-91. 2015
    ..This study provides evidence for increased norepinephrine secretion and decreased cortisol in PTSD. Future longitudinal studies are needed to determine whether these changes contribute to adverse health outcomes in patients with PTSD. ..
  19. doi request reprint Cognitive impairment in major depression: association with salivary cortisol
    Kim Hinkelmann
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Biol Psychiatry 66:879-85. 2009
    ..Several studies have separately examined cortisol secretion and cognitive deficits in depression. However, only few studies have assessed their association in the same patients producing inconclusive results...
  20. doi request reprint When time stands still: an integrative review on the role of chronodisruption in posttraumatic stress disorder
    Agorastos Agorastos
    aDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany bVeterans Affairs Center of Excellence for Stress and Mental Health cDepartment of Psychiatry, University of California dVA San Diego Healthcare System, San Diego, California, USA eDepartment of Psychiatry and Psychotherapy, Charite University Medical Center, Campus Benjamin Franklin, Berlin, Germany
    Curr Opin Psychiatry 27:385-92. 2014
    ..This article focuses on the role of circadian misalignment in the pathophysiology of posttraumatic stress disorder (PTSD)...
  21. doi request reprint Decreased hydrocortisone sensitivity of T cell function in multiple sclerosis-associated major depression
    Anja Fischer
    Institute for Neuroimmunology and Clinical Multiple Sclerosis Research, Center for Molecular Neurobiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Psychoneuroendocrinology 37:1712-8. 2012
    ..To our knowledge, this study provides first evidence for altered steroid sensitivity of T cells from MS patients with comorbid MDD possibly due to MR dysregulation...
  22. pmc Incomplete remission in depression: role of psychiatric and somatic comorbidity
    Christian Otte
    Department of Psychiatry, University Medical Center Hamburg Eppendorf, Germany
    Dialogues Clin Neurosci 10:453-60. 2008
    ..These findings raise important research and treatment issues regarding the generalizability from randomized controlled trials that to exclude patients tend to exclude patients with comorbidity...
  23. pmc Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Am J Psychiatry 164:1379-84. 2007
    ..Whether the short allele increases risk for depression associated with the stress of a chronic illness has not been established...